期刊
RSC ADVANCES
卷 3, 期 44, 页码 21596-21603出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ra43838d
关键词
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资金
- National Basic Research Program of China (973 Program) [2010CB933504]
- National Natural Science Foundation of China [21137002, 21077068]
In this report, a cancer-targeting nanoconstruct enters a cancer cell four times more readily than non-targeting nanoparticles. Inside the cell, the nanoconstruct conducts a double DNA attack from a DNA intercalating drug doxorubicin and radiation-enhancing gold nanoparticles achieving 2.5 fold higher DNA double strand breakage in the cancer genome. An overall 4.0 or 2.7-fold increase in cancer cell killing was achieved compared to the free drug without or with X-ray irradiation and a significant reduction in nonspecific toxicity to folate receptor-negative cells demonstrated the unique advantage of a nanomedicine approach to future chemotherapy and radiotherapy.
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