Interdisciplinary challenges and promising theranostic effects of nanoscience in Alzheimer's disease

Toxicity Evaluations of Superparamagnetic Iron Oxide Nanoparticles: Cell “Vision” versus Physicochemical Properties of Nanoparticles

(2011) Morteza Mahmoudi et al.   ACS Nano

Inhibition of Amyloid Peptide Fibrillation by Inorganic Nanoparticles: Functional Similarities with Proteins

(2011) Seong Il Yoo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

What the halted phase III γ-secretase inhibitor trial may (or may not) be telling us

(2011) Nina F. Schor   ANNALS OF NEUROLOGY

Alzheimer's Disease: Redox Dysregulation As a Common Denominator for Diverse Pathogenic Mechanisms

(2011) Rommy von Bernhardi et al.   ANTIOXIDANTS & REDOX SIGNALING

Acceleration and inhibition of amyloid-β fibril formation by peptide-conjugated fluorescent-maghemite nanoparticles

(2011) Hadas Skaat et al.   JOURNAL OF NANOPARTICLE RESEARCH

Convergent pathogenic pathways in Alzheimer's and Huntington's diseases: shared targets for drug development

(2011) Dagmar E. Ehrnhoefer et al.   NATURE REVIEWS DRUG DISCOVERY

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

A randomized, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease

(2011) M. Sano et al.   NEUROLOGY

Aβ Peptide Fibrillar Architectures Controlled by Conformational Constraints of the Monomer

(2011) Kristoffer Brännström et al.   PLoS One

Dual Effect of Amino Modified Polystyrene Nanoparticles on Amyloid β Protein Fibrillation

(2010) Celia Cabaleiro-Lago et al.   ACS Chemical Neuroscience

Zinc in Postmortem Body Tissues and Fluids

(2010) Teresa Lech et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Non-steroidal anti-inflammatory drugs may modulate the protease activity of Candida albicans

(2010) Alessandra P. Carvalho et al.   MICROBIAL PATHOGENESIS

Biomarkers for Alzheimer's disease: academic, industry and regulatory perspectives

(2010) Harald Hampel et al.   NATURE REVIEWS DRUG DISCOVERY

Alzheimer's disease: strategies for disease modification

(2010) Martin Citron   NATURE REVIEWS DRUG DISCOVERY

Novel mechanism of increased Ca2+ release following oxidative stress in neuronal cells involves type 2 inositol-1,4,5-trisphosphate receptors

(2010) S. Kaja et al.   NEUROSCIENCE

Endothelin-Converting Enzyme-2 Is Increased in Alzheimer’s Disease and Up-Regulated by Aβ

(2009) Jennifer C. Palmer et al.   AMERICAN JOURNAL OF PATHOLOGY

Redox Modulation of Ca2+ Signaling in Human Endothelial and Smooth Muscle Cells in Pre-Eclampsia

(2009) Joern R. Steinert et al.   ANTIOXIDANTS & REDOX SIGNALING

Surface Plasmon Resonance Binding Kinetics of Alzheimer’s Disease Amyloid β Peptide-Capturing and Plaque-Binding Monoclonal Antibodies

(2009) Muthu Ramakrishnan et al.   BIOCHEMISTRY

Inhibition of beta 1–40 amyloid fibrillation with N-acetyl-l-cysteine capped quantum dots

(2009) Lehui Xiao et al.   BIOMATERIALS

Human Serum Albumin Inhibits Aβ Fibrillization through a “Monomer-Competitor” Mechanism

(2009) Julijana Milojevic et al.   BIOPHYSICAL JOURNAL

Anesthesia, Calcium Homeostasis and Alzheimers Disease

(2009) Huafeng Wei et al.   Current Alzheimer Research

Effect of Nanoparticles on Protein Folding and Fibrillogenesis

(2009) Li Fei et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

α-Synuclein modulation of Ca2+signaling in human neuroblastoma (SH-SY5Y) cells

(2009) Nishani T. Hettiarachchi et al.   JOURNAL OF NEUROCHEMISTRY

Alzheimer's disease

(2009) Lennart Mucke   NATURE

Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

(2009) Alan H Nagahara et al.   NATURE MEDICINE

Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies

(2009) Kurt R. Brunden et al.   NATURE REVIEWS DRUG DISCOVERY

Allosteric Modulation of PS1/γ-Secretase Conformation Correlates with Amyloid β42/40 Ratio

(2009) Kengo Uemura et al.   PLoS One

A Condensation-Ordering Mechanism in Nanoparticle-Catalyzed Peptide Aggregation

(2009) Stefan Auer et al.   PLoS Computational Biology

Peptide and Protein Mimetics Inhibiting Amyloid β-Peptide Aggregation

(2008) Tsuyoshi Takahashi et al.   ACCOUNTS OF CHEMICAL RESEARCH

Amyloid Activates GSK-3β to Aggravate Neuronal Tauopathy in Bigenic Mice

(2008) Dick Terwel et al.   AMERICAN JOURNAL OF PATHOLOGY

Active and Passive Immunotherapy for Neurodegenerative Disorders

(2008) David L. Brody et al.   Annual Review of Neuroscience

Role of Axonal Transport in Neurodegenerative Diseases

(2008) Kurt J. De Vos et al.   Annual Review of Neuroscience

TiO2 nanoparticles promote β-amyloid fibrillation in vitro

(2008) Wei-hui Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Influence of fluorinated and hydrogenated nanoparticles on the structure and fibrillogenesis of amyloid beta-peptide

(2008) Sandra Rocha et al.   BIOPHYSICAL CHEMISTRY

Brain cholinergic impairment in liver failure

(2008) M.-S. Garcia-Ayllon et al.   BRAIN

The Brain Injury Biomarker VLP-1 Is Increased in the Cerebrospinal Fluid of Alzheimer Disease Patients

(2008) J.-M. Lee et al.   CLINICAL CHEMISTRY

Metal complexes as artificial proteases: toward catalytic drugs

(2008) Junghun Suh et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Islet Amyloid in Type 2 Diabetes, and the Toxic Oligomer Hypothesis

(2008) Leena Haataja et al.   ENDOCRINE REVIEWS

Biomarkers for early diagnosis of Alzheimer disease: ‘ALZheimer ASsociated gene’- a new blood biomarker?

(2008) Kurt A. Jellinger et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Anisotropic Assembly of Ag Nanoprisms

(2008) Yeonjoo Bae et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inhibition of Amyloid β Protein Fibrillation by Polymeric Nanoparticles

(2008) Celia Cabaleiro-Lago et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: a randomised, double-blind, placebo-controlled study

(2008) Rachelle S Doody et al.   LANCET

Protein-nanoparticle interactions

(2008) Iseult Lynch et al.   Nano Today

Nanomaterials at work in biomedical research

(2008) Younan Xia   NATURE MATERIALS

Biosensing with plasmonic nanosensors

(2008) Jeffrey N. Anker et al.   NATURE MATERIALS

CSF biomarker levels in early and late onset Alzheimer's disease

(2008) Femke H. Bouwman et al.   NEUROBIOLOGY OF AGING

Matrix metalloproteinase 3 haplotypes and plasma amyloid beta levels: The Rotterdam Study

(2008) Christiane Reitz et al.   NEUROBIOLOGY OF AGING

Efficient Inhibition of the Alzheimer's Disease  -Secretase by Membrane Targeting

(2008) L. Rajendran et al.   SCIENCE

Photothermal ablation of amyloid aggregates by gold nanoparticles

(2007) Robert C. Triulzi et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Modulation of synaptic plasticity and Tau phosphorylation by wild-type and mutant presenilin1

(2007) I. Dewachter et al.   NEUROBIOLOGY OF AGING

Aβ inhibits the proteasome and enhances amyloid and tau accumulation

(2007) Bertrand P. Tseng et al.   NEUROBIOLOGY OF AGING

CSF and MRI markers independently contribute to the diagnosis of Alzheimer's disease

(2007) Niki S.M. Schoonenboom et al.   NEUROBIOLOGY OF AGING

Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers

(2007) Fernanda G. De Felice et al.   NEUROBIOLOGY OF AGING

Degradation of fibrillar forms of Alzheimer's amyloid β-peptide by macrophages

(2007) Amitabha Majumdar et al.   NEUROBIOLOGY OF AGING

Conversion from cognitive health to mild cognitive impairment and Alzheimer's disease: Prediction by plasma amyloid beta 42, medial temporal lobe atrophy and homocysteine

(2006) Imrich Blasko et al.   NEUROBIOLOGY OF AGING