Article
Chemistry, Organic
Imran Kazi, Anuradha Nandy, Raji Selvam, Govindasamy Sekar
Summary: An efficient method for transition metal-free halogen bond-assisted regioselective C-H arylation of 2-phenylimidazo-[1,2-a]pyridines under visible-light condition has been developed. The halogen bond between an aryl halide and base (KOBu)-Bu-t initiates an electron transfer process and generates an aryl radical, which catalyzes its coupling with 2-phenylimidazo-[1,2-a]pyridines to give arylated products in good yield. This methodology has been successfully utilized to synthesize antileishmanial agents.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Han Yu, Lin Ma, Kenji Wada, Ryohsuke Kurihara, Qi Feng, Shinobu Uemura, Kyosuke Isoda
Summary: This study successfully synthesized tertiary and secondary amines from aqueous ammonia and benzylic alcohols using a titania-supported iridium catalyst. The catalytic system showed good tolerance to atmospheric conditions and could efficiently produce the desired product within a short period. The activity of the catalyst was strongly influenced by the crystal structure of the titania supports for iridium catalysts.
Article
Chemistry, Organic
Mohd Khalid Zaheer, Narendra Kumar Vaishanv, Awadhesh Kumar, Sameer Mishra, Ruchir Kant, Kishor Mohanan
Summary: An efficient a-arylation of a-fluoro- a-nitrosulfonylmethanes using diaryliodonium salts is reported. A wide range of a-fluoronitrosulfonylmethane substrates smoothly underwent a-arylation to obtain adducts with fully substituted fluorocarbon centers in good to excellent yields. The protocol was also found to be applicable for the a-arylation of a-cyano- a-fluorosulfonylmethane derivatives, yielding valuable cyano building blocks.
SYNTHESIS-STUTTGART
(2023)
Article
Chemistry, Applied
Xiaobin Tan, Wenfang Xiong, Baiyao Zhu, Hongjian Liu, Wanqing Wu, Huanfeng Jiang
Summary: Introducing the primary amino group into aromatic ring is a crucial task in organic chemistry, especially in the field of pharmaceuticals and agrochemicals. In this study, we present a photoinduced direct C-H amination of arenes with ammonia using site-selective C-H thianthrenation, which leads to excellent regioselectivity. The reaction conditions are mild and a wide range of functional groups, such as sensitive -Cl, -Br, and -OH groups, can be tolerated, which is challenging in conventional approaches. Moreover, the synthetic utility of our amination protocol has been demonstrated through late-stage modification and gram-scale synthesis of complex drug-like molecules.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Chemistry, Physical
Kayaramkodath C. Ranjeesh, Sukhjot Kaur, Abdul K. Mohammed, Safa Gaber, Divyani Gupta, Khaled Badawy, Mohamed Aslam, Nirpendra Singh, Tina Skorjanc, Matjaz Finsgar, Jesus Raya, Tharamani C. Nagaiah, Dinesh Shetty
Summary: This study reports a covalent organic framework catalyst with in-situ proton filter ability, which can effectively control proton supply and enhance N2 flux for efficient nitrogen reduction reaction. The feasibility of the catalyst is further validated through molecular dynamics simulations and control experiments. These findings signify a paradigm shift in engineering high-performance NRR electrocatalysts and contribute to more feasible green NH3 production.
ADVANCED ENERGY MATERIALS
(2023)
Article
Chemistry, Applied
Erika Linde, Shobhan Mondal, Berit Olofsson
Summary: Our group has developed new methods for the synthesis of diaryliodonium salts, which are versatile reagents in organic synthesis and materials chemistry. We have identified limitations in the existing protocols for synthesizing different types of diaryliodonium salts. In this update, we discuss the challenges related to the stability and reactivity of the reagents and propose strategies to overcome these limitations.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Chemistry, Organic
Simone Grosso, Marcelina Mlynczak, Gwilherm Evano, Olivier Riant
Summary: An efficient and unprecedented cross-coupling reaction between acylzirconocenes and diaryliodonium tetrafluoroborates is reported. This method utilizes acylzirconocenes, readily prepared starting materials, and a low pressure of in situ generated carbon monoxide to synthesize a variety of alkyl-aryl-ketones under simple copper cyanide catalysis, without the need for additional ligands.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Gabriella Kervefors, Leonard Kersting, Berit Olofsson
Summary: A transition metal-free approach using unsymmetric diaryliodonium salts with anisyl ligands has been developed for the N-arylation of amino acid derivatives, achieving high chemoselectivity and yields. This method is applicable for transferring electron deficient, electron rich, and sterically hindered aryl groups, and a cyclic diaryliodonium salt was successfully employed. The N-arylated products were obtained with retained enantiomeric excess.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Inorganic & Nuclear
Jing Jiang, Xinzhi Wang, Yao Tian, Li Tian, Lunhong Ai
Summary: Robust multifunctional substrates in heterogeneous catalysts are highly demanded to effectively stabilize active-metal centers and improve catalytic performances. In this study, a porous quasi-metal-organic framework (quasi-NiCo-MOF) is introduced as a smart substrate to spatially confine bimetallic NiCo-phosphide nanoparticles. A controllable thermal transformation strategy is demonstrated for deli-gandation and phosphorization of the parent NiCo-MOF. The resulting P-NiCo-MOF can efficiently activate and dissociate AB and H2O molecules, delivering a high hydrogen generation rate.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Zhiyuan Bao, Chao Chen
Summary: An efficient method for the synthesis of multi-substituted cyclic imides was developed using cyanoesters and diaryliodonium salts. This method involves a cascade of N-arylation-acylation and rearrangement reactions, producing the desired heterocycles in high yields. The method has a broad substrate scope, excellent functional group compatibility, and can be extended to fused cyclic imides.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Organic
Hui-cheng Cheng, Lichao Zhou, Xuming Zhou, Jiao-li Ma, Penghu Guo, Yang Zhang, Hong-bing Ji
Summary: An efficient methodology for synthesizing N-arylamides via copper-catalyzed amidation of diaryliodonium salts with nitriles has been developed, yielding a series of N-arylated amides in moderate to good yields. This provides an alternative route for the synthesis of various N-arylamides, with a proposed mechanism based on control experiments presented.
TETRAHEDRON LETTERS
(2021)
Article
Chemistry, Organic
Yu-Ming Yang, Wei Yan, Han-Wei Hu, Yimin Luo, Zhen-Yu Tang, Zhuangzhu Luo
Summary: This method involves the green and efficient visible-light induced functionalization of anilines under mild conditions, using non-toxic diacetyl as the photosensitizer and acetylating reagent, and water as the solvent. It provides a valuable approach in organic synthesis with environmentally friendly conditions, simple operation, wide substrate scope, and functional group tolerance.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Wan-Lei Yu, Zi-Gang Ren, Wei Ma, Haixue Zheng, Wangsuo Wu, Peng-Fei Xu
Summary: In this study, an oxidant-free dehydrogenative amination of alkenes was achieved through synergistic photoredox and cobalt catalysis, resulting in the synthesis of a wide range of five-membered N-heterocycles with excellent atom-economy.
Article
Multidisciplinary Sciences
Jae Bin Lee, Gun Ha Kim, Ji Hwan Jeon, Seo Yeong Jeong, Soochan Lee, Jaehyun Park, Doyoung Lee, Youngkook Kwon, Jeong Kon Seo, Joong-Hyun Chun, Seok Ju Kang, Wonyoung Choe, Jan-Uwe Rohde, Sung You Hong
Summary: The authors present a transition-metal-free, radical relay pi-extension approach to produce N-doped polycyclic aromatic compounds directly from simple azines and cyclic iodonium salts. This method offers a solution to the limitation of low reactivity in unactivated azines.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Organic
P. Veeraraghavan Ramachandran, Shivani Choudhary
Summary: Monotrifluoroacetoxyborane-amines are efficient reagents for the one-pot, tandem reductive amination/alkylation-cycloamidation of keto or amino acids to achieve the synthesis of 5-aryl or 5-methyl pyrrolidin-2-ones and 6-aryl or 6-methyl piperidin-2-ones.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Geography, Physical
Virginia L. Harvey, Victoria M. Egerton, Andrew T. Chamberlain, Phillip L. Manning, William I. Sellers, Michael Buckley
Article
Anatomy & Morphology
Fernanda Bribiesca-Contreras, Ben Parslew, William Sellers
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2019)
Article
Biology
Robert J. Brocklehurst, Sabine Moritz, Jonathan Codd, William Sellers, Elizabeth L. Brainerd
JOURNAL OF EXPERIMENTAL BIOLOGY
(2019)
Review
Biology
Robert J. Brocklehurst, Emma R. Schachner, Jonathan R. Codd, William I. Sellers
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2020)
Article
Multidisciplinary Sciences
Savannah Elizabeth Cobb, William Sellers
Article
Multidisciplinary Sciences
Thomas A. Puschel, Jordi Marce-Nogue, Andrew T. Chamberlain, Alaster Yoxall, William Sellers
SCIENTIFIC REPORTS
(2020)
Article
Geosciences, Multidisciplinary
Thomas A. Puschel, Jordi Marce-Nogue, Justin Gladman, Biren A. Patel, Sergio Almecija, William I. Sellers
FRONTIERS IN EARTH SCIENCE
(2020)
Article
Biochemistry & Molecular Biology
William Sellers, Kayleigh A. R. Rose, Dane A. Crossley, Jonathan R. Codd
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2020)
Article
Biology
Ilan M. Ruhr, Kayleigh A. R. Rose, William I. Sellers, Dane A. Crossley, Jonathan R. Codd
Summary: In this study, it was found that younger turtles in Chelydra serpentina flip over faster than older individuals, and they self-right with lower biomechanical costs. This may be due to the relatively longer neck of younger turtles and their faster and less costly self-righting, which help overcome the risks of inversion.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Article
Ornithology
Fernanda Bribiesca-Contreras, Ben Parslew, William I. Sellers
Summary: This study investigated the functional morphology of the forelimb musculature in 18 species of aquatic birds, revealing that muscle architecture and function differ among different species. Total wing muscle mass scaled isometrically to body mass, while fascicle length scaled to muscle mass. The distribution of mass in the wing muscles of aquatic birds seemed to be related to flight and foraging style.
JOURNAL OF ORNITHOLOGY
(2021)
Article
Anatomy & Morphology
Kayleigh A. R. Rose, Peter G. Tickle, Ruth M. Elsey, William I. Sellers, Dane A. Crossley, Jonathan R. Codd
Summary: The study reveals that the respiratory muscles of juvenile American alligators have different functional specializations, with expiratory muscles having greater force-generating capacity and inspiratory muscles adapted for larger working range and contraction velocity. As crocodilians grow in size, their breathing mechanics change, and the specialization of the diaphragm and compliance of the body wall may contribute to low-cost breathing.
JOURNAL OF ANATOMY
(2021)
Article
Multidisciplinary Sciences
Samuel J. Coatham, William Sellers, Thomas A. Puschel
Summary: The study assessed the effectiveness of using convex hull BSP estimation in a variety of extant mammals for potential application with extinct species. By comparing BSPs calculated from soft tissue segments with those estimated using convex hulls, consistent predictive relationships were found, enabling confidence in future volumetric reconstruction and biomechanical analyses.
ROYAL SOCIETY OPEN SCIENCE
(2021)
Article
Multidisciplinary Sciences
Heather E. Ewart, Peter G. Tickle, William I. Sellers, Markus Lambertz, Dane A. Crossley, Jonathan R. Codd
Summary: This study found that self-righting in terrestrial Mediterranean spur-thighed tortoise is relatively metabolically expensive, costing about two times the mass-specific power required for walking. Rapid limb and head movements facilitate successful righting, but the constraint of breathing while being upside down also contributes to a significant metabolic cost. Therefore, these animals should choose environments or behaviors that reduce the risk of becoming inverted.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Adam van Casteren, Jonathan R. Codd, Kornelius Kupczik, Guy Plasqui, William Sellers, Amanda G. Henry
Summary: Chewing different items can result in varying metabolic costs, and chewing by human subjects represents a measurable energy sink. Chewing tasteless and odorless gum increases metabolic rate, with energy expenditure increasing with gum stiffness and requiring greater muscle recruitment. This adds an previously unexplored energetic dimension to the interpretation of hominin dentofacial fossils.
Article
Anatomy & Morphology
Lilian Anderson, Charlotte Brassey, Stuart Pond, Karl Bates, William Irvin Sellers
Summary: A reversion to secondary quadrupedality has occurred at least four separate times within Dinosauria, with faculative quadrupedality proposed as an important transitional step. This study focuses on Scutellosaurus, reconstructing its functional anatomy and creating a locomotor simulation. The results show that while quadrupedal gaits were physically possible, they did not outperform bipedal gaits in any tested metric.
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2023)
