Article
Biology
So-Jung Jin, Youngju Song, Hong Shik Park, Kye Won Park, SeungGwan Lee, Hee Kang
Summary: This study reveals that harmine can effectively modulate the inflammatory response in macrophages by regulating the activity of NF-kappa B, JNK, and STAT1. It shows potential therapeutic significance in the treatment of infectious inflammation.
Article
Biochemistry & Molecular Biology
Yikong Lin, Yunyun Li, Xinyi Li, Xinhua Liu, Xiaolin Wang, Min Yu, Yizhun Zhu, Meirong Du
Summary: SCM-198, a synthetic form of leonurine, has been found to possess anti-inflammatory effects and inhibit endometrial inflammation by suppressing the LPS-JNK-cJUN/cFOS-TLR4-NF-kappa B signaling pathway. In vivo studies in a mouse model showed that SCM-198 could be effective in preventing and treating endometritis, whether administered pre-treatment or post-treatment via vaginal or intraperitoneal administration.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Chemistry, Medicinal
Xianjing Zheng, Haimei Liu, Maoqiang Ma, Jianbo Ji, Faliang Zhu, Longru Sun
Summary: This study confirmed the anti-thrombotic activity of phenolic acids from Salvia miltiorrhiza f. alba roots and demonstrated that salvianolic acid B and lithospermic acid significantly decrease the risk of thrombosis by regulating the NF-kappa B/JNK/p38 MAPK signaling pathway in response to TNF-alpha.
ARCHIVES OF PHARMACAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Abuyaseer Abusaliya, Pritam Bhagwan Bhosale, Hun Hwan Kim, Sang Eun Ha, Min Yeong Park, Se Hyo Jeong, Preethi Vetrivel, Joon-Suk Park, Gon Sup Kim
Summary: In this study, it was found that prunetinoside (PUG), a plant-based compound, possesses anti-inflammatory effects on mouse macrophage cells. PUG decreased the expression of inflammatory mediators and reduced the activation of phosphorylated signaling pathways. By blocking the NF-κB pathway and activating JNK, PUG could be a potential therapeutic compound for inflammatory-related conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Hee-Yun Kim, Ho-Geun Kang, Yu-Jin Choi, Hyung-Min Kim, Hyun-Ja Jeong
Summary: One of the factors contributing to hyperinflammation in COVID-19 is the cytokine storm, which is caused by mast cells increasing inflammatory cytokine levels. Caudatin, an active compound derived from Cynanchum auriculatum, has been found to suppress the inflammatory response signaling in human mast cell line, HMC-1 cells, by inhibiting specific signaling molecules.
FOOD SCIENCE AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Medicinal
Dandan Guo, Qianqian Wang, Aifang Li, Shuxuan Li, Baiyan Wang, Yalan Li, Juan Yuan, Tao Guo, Shuying Feng
Summary: This study found that liquiritin could significantly inhibit the progression of psoriasis and alleviate skin inflammation. Liquiritin exhibited suppressive effects on the proliferation of HaCaT keratinocytes and reduced the expression of inflammatory cytokines. In animal experiments, liquiritin also reduced the accumulation of Th17 cells and DCs.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Chunji Ma, Xiujing Hao, Liyang Gao, Yongyu Wang, Juan Shi, Haixia Luo, Min Li
Summary: We established a cell model of M. pneumoniae-infected macrophages to investigate the role and functional mechanisms of extracellular vesicles (EVs) as intercellular messengers. We found that EVs derived from infected macrophages were pure and had a diameter of 30-200 nm. These EVs were taken up by uninfected macrophages and induced the production of inflammatory cytokines through the NF-κB and MAPK signaling pathways. Furthermore, the expression of inflammatory cytokines induced by EVs relied on the TLR2-NF-κB/JNK signaling pathway. These findings provide insights into the persistent inflammatory response and cell-to-cell immune modulation during M. pneumoniae infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Hematology
Erica M. Sparkenbaugh, Michael W. Henderson, Megan Miller-Awe, Christina Abrams, Anton Ilich, Fatima Trebak, Nirupama Ramadas, Shantel Vital, Dillon Bohinc, Kara L. Bane, Chunsheng Chen, Margi Patel, Michael Wallisch, Thomas Renne, Andras Gruber, Brian Cooley, David Gailani, Malgorzata Kasztan, Gregory M. Vercellotti, John D. Belcher, Felicity E. Gavins, Evi X. Stavrou, Nigel S. Key, Rafal Pawlinski
Summary: A hypercoagulable state, chronic inflammation, and increased risk of venous thrombosis and stroke are observed in patients with sickle cell disease (SCD). Activation of coagulation factor XII (FXII) and the contact pathway is increased in SCD, leading to enhanced thrombin generation and systemic inflammation. Inhibition of FXII effectively reduces experimental thromboinflammation and vascular complications in a mouse model of SCD, suggesting that it may provide a safe approach for interfering with inflammation, thrombotic complications, and vaso-occlusion in patients with SCD.
Article
Cell Biology
Natsuko Tanabe, Keiko Tomita, Soichiro Manaka, Risa Ichikawa, Tadahiro Takayama, Takayuki Kawato, Misae Ono, Yuma Masai, Akihisa Utsu, Naoto Suzuki, Shuichi Sato
Summary: The aim of this study was to investigate the effects of AGEs on inflammatory mediators in MC3T3-E1 cells and the underlying molecular mechanisms. Co-stimulation with AGEs and LPS resulted in increased expression of COX2, IL-1a, S100A9, and the production of PGE(2). These effects were inhibited by the PLC inhibitor, U73122. Co-stimulation also led to increased nuclear translocation of NF-κB, which was inhibited by U73122. Additionally, co-stimulation induced the expression of p-PLCΙ and p-JNK, which was suppressed by U73122.
Article
Microbiology
Yangyang Xu, Honglei Wang, Xuan Zhang, Xiaojie Zheng, Yingqi Zhu, Haige Han, Wen-hai Feng
Summary: Highly pathogenic PRRSV infection enhances IL-6 production and expression through activation of JNK and NF-κB signaling pathways. TAK-1 plays a crucial role in the activation of JNK and NF-κB pathways following HP-PRRSV infection, indicating the dependence of IL-6 expression on AP-1 and NF-κB activation.
VETERINARY MICROBIOLOGY
(2021)
Article
Plant Sciences
Xu Sun, Yongqiu Zheng, Yaqing Tian, Qixiang Xu, Shuochuan Liu, Huahua Li, Kunming Cheng, Jianan Yuan, Huaimin Liu, Peng Zhu
Summary: This study found that Astragalus polysaccharide (APS), the major active ingredient in Huangqi, can effectively alleviate alcohol-induced hepatic fibrosis by inhibiting the activation of PTRF and the TLR4/JNK/NF-κB/MyD88 pathway. This provides a scientific explanation for the anti-hepatic fibrosis activity of APS and presents a promising therapeutic approach for treating hepatic fibrosis.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Immunology
Rong Hu, Libo Chen, Xiaolong Chen, Zhong Xie, Chao Xia, Yong Chen
Summary: Aloperine has been shown to inhibit osteoclast activity and formation mediated by RANKL, indicating its potential as a new drug for the prevention and treatment of postmenopausal osteoporosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Guangxia Yang, Kai Wang, Hua Song, Rujie Zhu, Shuai Ding, Hui Yang, Jian Sun, Xin Wen, Lingyun Sun
Summary: This study investigated the effect of celastrol on osteoarthritis (OA) and identified the mechanisms involved. The results showed that celastrol delayed cartilage damage, reduced osteophyte formation and bone resorption in an OA rat model. In vitro experiments also demonstrated that celastrol suppressed the production of inflammatory factors and inhibited matrix degradation. Furthermore, celastrol inhibited the TLR2/NF-kappa B signaling pathway. These findings suggest that celastrol could be a potential therapy for OA by targeting this signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Li Wang, Yu-fang Yang, Long Chen, Zhu-qing He, Dian-yong Bi, Lei Zhang, Yan-wu Xu, Jian-cheng He
Summary: Compound Dihuang Granule (CDG) is used in traditional Chinese medicine to treat Parkinson's disease (PD) by suppressing the JNK/AP-1 signaling pathway and thus inhibiting apoptosis in the nigrostriatal pathway, alleviating PD symptoms.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cell Biology
Jing Zhang, Yu-Jing Wu, Xiao-Xi Hu, Wei Wei
Summary: Lck and nuclear factor-kappa B play crucial roles in the development and progression of autoimmune diseases and malignancies, and understanding their signaling pathways may lead to the identification of new therapeutic targets and approaches.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Genetics & Heredity
Yongbo Yu, Wei Liu, Min Chen, Yang Yang, Yeran Yang, Enyu Hong, Jie Lu, Jun Zheng, Xin Ni, Yongli Guo, Jie Zhang
MOLECULAR GENETICS & GENOMIC MEDICINE
(2020)
Article
Biology
Yaqiong Jin, Jin Shi, Huanmin Wang, Jie Lu, Chenghao Chen, Yongbo Yu, Yaru Wang, Yeran Yang, Dong Ren, Qi Zeng, Xin Ni, Yongli Guo
Summary: The study found that the DDX1 gene polymorphism rs72780850 is associated with an increased risk of NB, especially in aggressive cases. This association may be due to the regulation of DDX1 gene expression affecting tumor risk. Additionally, the molecular mechanism of the rs72780850 polymorphism leading to increased NB risk may be related to the binding affinity of the MAX transcription factor.
SCIENCE CHINA-LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yongbo Yu, Feng Chen, Yaqiong Jin, Yeran Yang, Shengcai Wang, Jie Zhang, Chenghao Chen, Qi Zeng, Wei Han, Huanmin Wang, Yongli Guo, Xin Ni
ACTA BIOCHIMICA POLONICA
(2020)
Article
Pediatrics
Shengcai Wang, Lin Mei, Yanzhen Li, Xuexi Zhang, Jie Zhang, Wentong Ge, Yongli Guo, Yongbo Yu, Guoli Wang, Tianlu Mei, Qiaoyin Liu, Nian Sun, Yuzhu He, Xiaodan Li, Yuwei Liu, Jun Tai, Xin Ni
Summary: This study found that gastroscopy under local anesthesia has high sensitivity and accuracy in diagnosing congenital pyriform sinus fistula, especially for patients with inflammation subsiding for more than 4 weeks.
FRONTIERS IN PEDIATRICS
(2021)
Article
Pediatrics
Yongbo Yu, Shengcai Wang, Xuexi Zhang, Shuai Xu, Yanzhen Li, Qiaoyin Liu, Yeran Yang, Nian Sun, Yuanhu Liu, Jie Zhang, Yongli Guo, Xin Ni
Summary: This study demonstrates that TPO and AOX1 are significantly downregulated in pediatric PTC, with decreased levels of TPO and AOX1 proteins in blood plasma. These proteins show satisfactory predictive performance in plasma and low levels are associated with poor survival in patients with PTC. The findings suggest that TPO and AOX1 could serve as novel biomarkers for the diagnosis and prognosis of pediatric PTC.
TRANSLATIONAL PEDIATRICS
(2021)
Article
Genetics & Heredity
Yeran Yang, Jiwei Chen, Hong Qin, Yaqiong Jin, Li Zhang, Shen Yang, Huanmin Wang, Libing Fu, Enyu Hong, Yongbo Yu, Jie Lu, Yan Chang, Xin Ni, Min Xu, Tieliu Shi, Yongli Guo
Summary: The study identified a novel germline compound heterozygous mutation of the BRCA2 gene associated with familial PNTs, potentially promoting carcinogenesis by disrupting the DNA damage and response signal pathway.
FRONTIERS IN GENETICS
(2021)
Article
Pathology
Meng Zhang, Yongbo Yu, Xiaoxing Guan, Xingfeng Yao, Chao Jia, Enyu Hong, Yongli Guo, Lejian He
Summary: This study describes four cases of sclerosing epithelioid fibrosarcoma (SEF) in children with unique genetic characteristics. The tumors were located in the deep soft tissue and exhibited prominent sclerotic hyalinized stroma and monomorphic epithelioid cells. Genetic analysis revealed translocation between EWSR1 and CREB3L1, as well as amplification of fusion parts, indicating the presence of a unique molecular variant of SEF.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Immunology
Ping Chu, Yan Chang, Xuan Zhang, Shujing Han, Yaqiong Jin, Yongbo Yu, Yeran Yang, Guoshuang Feng, Xinyu Wang, Ying Shen, Xin Ni, Yongli Guo, Jie Lu
Summary: Pediatric extrapulmonary tuberculosis (EPTB) in China has not been well studied in terms of clinical characteristics and economic burden. This multicenter study aimed to investigate and summarize the situation of EPTB in pediatric patients. The results showed differences between EPTB, pulmonary TB (PTB), and combined TB in terms of hospitalization frequency, length of stay, discharge against medical advice, mortality, low birth weight, diagnosis at the first visit, and hospitalization plan situation. EPTB and combined TB had higher financial burdens compared to PTB.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Oncology
Xiangjun Liu, Mengmiao Pei, Yongbo Yu, Xiaolin Wang, Jingang Gui
Summary: The tumor metastasis in high-risk neuroblastoma patients is a significant problem that affects patient survival. This study utilized comprehensive bioinformatics analysis to identify LPAR1 as a potential target for the treatment of neuroblastoma. The decreased expression of LPAR1 in neuroblastoma cells and the migration-inhibitory effects of LPA-LPAR1 axis suggest that LPAR1 may be a promising target for future neuroblastoma treatment.
Article
Pathology
Meng Zhang, Xingfeng Yao, Xiaoxing Guan, Chao Jia, Ruqian Zhang, Huanmin Wang, Yongli Guo, Xin Ni, Yongbo Yu, Lejian He
Summary: Clear cell sarcoma of the kidney (CCSK) is often associated with TP53 deletion, which is related to adverse clinical outcomes. A study analyzed 39 CCSK patients and found that 87.18% of patients had BCOR internal tandem duplication (ITD), 2.56% had YWHAE rearrangement, and 2.56% had BCOR-CCNB3 gene fusion. Furthermore, 25.64% of patients had TP53 aberration, and patients with both BCOR ITD and TP53 deletion had the poorest prognosis.
Article
Biochemical Research Methods
Chiyi Jiang, Yeran Yang, Sidou He, Zhixia Yue, Tianyu Xing, Ping Chu, Wenfa Yang, Hui Chen, Xiaoxi Zhao, Yongbo Yu, Xuan Zhang, Yan Su, Yongli Guo, Xiaoli Ma
Summary: This study evaluated the important role of BPTF in bone marrow (BM) in predicting the progression of neuroblastoma (NB). It was found that BPTF is an independent risk factor for predicting NB progression. The BPTF inhibitor AU1 is expected to become a new targeted drug for NB therapy, revealing previously unknown mechanisms of BPTF in NB cell proliferation and metastasis through TFAP4 and PI3K/AKT pathways.
BIOLOGICAL PROCEDURES ONLINE
(2023)
Article
Oncology
Xuan Zhang, Shijia Zhan, Xiaoxing Guan, Yanli Zhang, Jie Lu, Yongbo Yu, Yaqiong Jin, Yeran Yang, Ping Chu, Enyu Hong, Hui Yang, Huimin Ren, Di Geng, Yadi Wang, Pingping Zhou, Yongli Guo, Yan Chang
Summary: High-risk neuroblastoma (HR-NB) is an aggressive childhood cancer with a low survival rate. MYCN amplification is a critical factor in these tumors, but there are no approved treatments targeting MYCN. The identification of new molecular targets and therapeutic strategies is urgently needed.
Correction
Chemistry, Medicinal
Yongbo Yu, Junchao Duan, Weijia Geng, Qiuling Li, Lizhen Jiang, Yang Li, Yang Yu, Zhiwei Sun
CHEMICAL RESEARCH IN TOXICOLOGY
(2023)
Article
Pathology
Yongbo Yu, Meng Zhang, Xingfeng Yao, Xiaoxing Guan, Chao Jia, Ping Chu, Ruqian Zhang, Yeran Yang, Yaqiong Jin, Huanmin Wang, Xin Ni, Lejian He, Yongli Guo
Summary: Recently, TERT gene rearrangements have been found in neuroblastoma (NB), but their prevalence in other types of neuroblastic tumours (NTs) is unknown. This study developed a practical method for detecting TERT defects and evaluated their clinical relevance as biomarkers for NT prognosis. The study used fluorescence in situ hybridisation (FISH) to assess TERT genomic status in Chinese children with NTs. TERT rearrangements were identified in 6.0% of NTs overall, and in 12.4% of high-risk patients. TERT rearrangements were associated with aggressive NT subtypes and decreased survival chances.
JOURNAL OF PATHOLOGY CLINICAL RESEARCH
(2023)
Article
Pediatrics
Yeran Yang, Wei Liu, Yaqiong Jin, Min Chen, Jie Lu, Yongbo Yu, Huimin Ren, Shujing Han, Ping Chu, Yongli Guo, Jie Zhang, Xin Ni
Summary: This study identified genetic mutations associated with FBCA in Chinese children, revealing potential pathogenic genes and mutations involved in developmental pathways. The results provide molecular-level support for the branchial theory of FBCA pathogenesis.
PEDIATRIC INVESTIGATION
(2021)
Review
Toxicology
Shahid Yousuf Ganie, Darakhshan Javaid, Younis Ahmad Hajam, Mohd Salim Reshi
Summary: Arsenic toxicity is a complex and pervasive public health problem that affects millions of people worldwide. This review aims to consolidate current knowledge on arsenic toxicity, including its sources, chemical forms, and the pathways through which it affects human health. The study found that arsenic is associated with chronic diseases such as cancer, cardiovascular disorders, and neurotoxicity, and oxidative stress, genotoxicity, and epigenetic modifications play important roles in arsenic-induced cellular damage. Further research is needed to fill gaps in our understanding of arsenic toxicity and inform public health policies aimed at minimizing exposure.
TOXICOLOGY RESEARCH
(2024)
Article
Toxicology
Lu Zhang, Min Li, Dalong Zhang, Shujing Zhang, Li Zhang, Xiaojun Wang, Zhiyong Qian
Summary: With the increasing incidence of neurodevelopmental disorders, it is important to screen and evaluate developmental neurotoxicity (DNT) compounds from a large number of environmental chemicals and understand their mechanisms. This study conducted a DNT qualitative structure-activity relationship (QSAR) study for the first time, and preliminarily illustrated the structural characterization of DNT compounds. Multiple models and methods were used to construct prediction models, resulting in the best model with good predictive ability. By combining different models, both MCC values and application domain values were improved. Additionally, through modeling descriptors analysis and structure alerts (SAs) identification, electronical properties, van der Waals volume-related properties, and S, Cl or P containing substructure were found to be associated with DNT. This study lays a foundation for further DNT prediction of environmental exposures in human and contributes to the understanding of DNT mechanism.
TOXICOLOGY RESEARCH
(2024)
Article
Toxicology
Khushboo Sharma, Satish Koundal, Mandeep Singh, Pooja Chadha, Harvinder Singh Saini
Summary: The unregulated discharge of untreated or partially treated industrial wastewater poses a serious threat to aquatic ecosystems. This study exposed Channa punctata fish to untreated and microbially treated textile industry effluent to analyze their toxicity effects. The results showed that the untreated effluent group had more severe hematological, biochemical, histopathological, and ultrastructural alterations compared to the microbially treated group. This highlights the importance of finding more effective microbial treatments to protect aquatic life and human health.
TOXICOLOGY RESEARCH
(2024)
Article
Toxicology
Chen Gu, Yan Sun, Meiqi Mao, Jinguo Liu, Xiongyao Li, Xiaoping Zhang
Summary: This study investigated the mechanism of lunar dust simulant (CLDS-i) in inducing inflammatory lung injury. The results showed that CLDS-i regulated immune inflammatory cells and activated signaling pathways related to inflammatory diseases, promoting the occurrence and development of inflammatory injury. The study also found that amino acid metabolism imbalance might be related to the activation of the NF-kappa B signaling pathway.
TOXICOLOGY RESEARCH
(2024)