Article
Orthopedics
Joon-Kiong Lee, Azlina A. Abbas, Tien-Eang Cheah, Ruslan Nazaruddin Simanjuntak, Sargunan Sockalingam, Sharifah Roohi
Summary: Osteoarthritis (OA) is a significant burden in many populations, with its prevalence expected to rise due to aging and increase in risk factors. Topical NSAIDs are recommended as an early treatment option for managing OA pain, but their use in Malaysia is low and not preferred by prescribers. This consensus recommendation provides guidance for healthcare practitioners on the use of topical NSAIDs in managing OA pain, emphasizing their efficacy, safety, and ease of use. It is recommended to advocate for early use of topical NSAIDs over oral NSAIDs for mild-to-moderate OA pain while involving patients in the decision-making process for optimal outcomes.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Review
Peripheral Vascular Disease
J. David Spence, Tilo Grosser, Garret A. FitzGerald
Summary: Recent studies have questioned the safety of using acetaminophen for pain relief and fever reduction in patients with cardiovascular disease and those taking anticoagulants. The studies suggest that acetaminophen, like most nonsteroidal anti-inflammatory drugs, can increase blood pressure and formulations containing sodium can increase cardiovascular risk. The influence of acetaminophen on coagulation through its effects on vitamin K metabolism is also discussed.
Article
Immunology
Jing Zhang, Hongguang Sheng, Xiaoyi Tang, Panpan Xia, Zhangwang Li, Minxuan Xu, Jianyong Ma, Yunfeng Shen, Peng Yu, Xiao Liu
Summary: According to a post-hoc analysis from the ORCHID trial, the use of non-steroidal anti-inflammatory drugs (NSAIDs) in hospitalized American adult COVID-19 patients is not associated with worse clinical outcomes, including 28-day mortality or hospital discharge. Furthermore, a meta-analysis of 14 studies involving 48,788 COVID-19 patients showed that NSAID use had a survival benefit and decreased the risk of severe COVID-19.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Ophthalmology
Sashwanthi Mohan, Gajendra Chawla, Janani Surya, Rajiv Raman
Summary: This study aimed to compare visual and OCT outcomes in patients with CI-DME who received intravitreal anti-VEGF therapy with and without topical NSAIDs. The results showed no significant differences in visual acuity and OCT thickness between the two groups after 1 year of follow-up.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Oncology
Kate R. Pawloski, Regina Matar, Varadan Sevilimedu, Audree B. Tadros, Laurie J. Kirstein, Hiram S. Cody, Kimberly J. Van Zee, Monica Morrow, Tracy-Ann Moo
Summary: A retrospective study found that NSAIDs are associated with a low risk of hematoma after lumpectomy and SLNB. Discharge with NSAIDs did not increase the risk of hematoma compared to opioid discharge, and NSAIDs should be prescribed as the preferred option.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Review
Pharmacology & Pharmacy
Fatemeh Babaei, Mohammadreza Mirzababaei, Alireza Tavakkoli, Marjan Nassiri-Asl, Hossein Hosseinzadeh
Summary: Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for the treatment of musculoskeletal disorders, pain, and fever. This review explores the antifungal effects of NSAIDs alone or in combination with antifungal drugs in vitro and in vivo. Studies have shown that NSAIDs have antifungal activities against various species of fungi, including inhibiting biofilm formation and yeast-to-hypha conversion. Modulating prostaglandin E2 levels during fungal infection may be a possible mechanism. The combination therapy of NSAIDs and antifungal drugs shows potential as a novel therapeutic strategy in clinical studies, reducing resistance and toxicity.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Orthopedics
Shingo Higa, Ken Nakata, Yusuke Karasawa, Kazuhiro Ohwaki
Summary: The study aimed to investigate the effect of early oral NSAID therapy on the progression of knee osteoarthritis (OA). The results showed that the risk of knee replacement was significantly lower in the NSAID group compared to the APAP group after accounting for potential confounding factors, suggesting a reduced risk of knee replacement in patients with symptomatic knee OA who received early oral NSAID therapy.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Nanoscience & Nanotechnology
Hye Jin Cho, Eunyoung Kang, Seonghoon Kim, D. ChangMo Yang, Joohan Nam, Eunji Jin, Jinhyu Lee, Wonyoung Choe
Summary: In this study, a water-stable Zr-based porphyrinic metal-organic framework (MOF), PCN-224, was used for the targeted adsorption of nonsteroidal anti-inflammatory drugs. The results showed high removal efficiencies for NPX and IBP, but lower efficiency for SMX. The strong interaction between the carboxylic acid functional groups in drugs and the open metal sites of PCN-224 was found to be responsible for the high adsorption capacity.
ACS APPLIED NANO MATERIALS
(2023)
Review
Agriculture, Multidisciplinary
Lawrence Mzukisi Madikizela, Tarryn Lee Botha, Ilunga Kamika, Titus Alfred M. Msagati
Summary: This article provides a critical review of the plant uptake, translocation, and toxic effects of pharmaceuticals in contaminated environments, including the presence of metabolites of these drugs in plants. The use of constructed wetlands with plants for remediation is also discussed. Factors influencing the plant uptake and translocation of pharmaceuticals are examined, and future research directions are suggested.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Andrew Y. Hwang, Steven M. Smith
Summary: Prescription NSAID use among patients with CVD has declined from 1988 to 2016, primarily due to reduced COX-2-selective inhibitor use. Nonetheless, the prevalence of prescription NSAIDs has persisted among a subset of high-risk CVD populations.
Review
Hematology
Yi Zheng, Nan Zhang, Gary Tse, Guangping Li, Gregory Y. H. Lip, Tong Liu
Summary: The concomitant use of oral anticoagulants (OACs) and nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with an increased risk of bleeding. Taking vitamin K antagonist (VKAs) or direct OACs (DOACs) concurrently with NSAIDs increases the risk of any bleeding and gastrointestinal bleeding. However, DOACs show a lower risk of bleeding compared to VKAs when considering other confounding factors. The combined use of VKAs and nonselective NSAIDs or rivaroxaban and NSAIDs increases the risk of bleeding.
THROMBOSIS RESEARCH
(2023)
Review
Orthopedics
Nelson F. Athow, Patrick M. Morgan, Gregory A. Brown
Summary: The study found that hip and/or knee osteoarthritis is associated with an increased risk of cardiovascular disease morbidity and mortality, but did not show a link between nonselective NSAID use and cardiovascular risk. Factors such as the use of walking aids and walking difficulties may increase cardiac risk.
JOURNAL OF ARTHROPLASTY
(2023)
Article
Chemistry, Multidisciplinary
Deqing Lin, Xiaoning Xu, Lin Chen, Lei Chen, Mengyun Deng, Jinrun Chen, Zhibin Ren, Lei Lei, Jiaqing Wang, Jie Deng, Xingyi Li
Summary: A facile method for converting carboxylate-containing indomethacin into a cyclooxygenase-2 selective inhibitor via the amidation of an unnatural peptide sequence is reported. The resulting indomethacin amides have high selectivity for COX-2 and can self-assemble into a supramolecular hydrogel for boosting anti-inflammatory efficacy.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Analytical
Ruijuan Zheng, Yingchen Yang, Chang Yang, Yan Xia
Summary: A core-shell material (UiO@TapbTp) has been developed for detecting nonsteroidal anti-inflammatory drugs by MALDI-TOF MS, showing improved enrichment ability and matrix performance. Pre-enrichment under optimized conditions significantly reduces the detection limits of drugs, with good recoveries in complex samples like saliva and environmental water.
Article
Oncology
Bofei Li, Ka Shing Cheung, Ian Yu-Hong Wong, Wai Keung Leung, Simon Law
Summary: The study found that nonaspirin nonsteroidal anti-inflammatory drugs (NA-NSAIDs) did not reduce the risk of gastric cancer in patients who underwent Helicobacter pylori eradication, suggesting that the chemopreventive effect of NA-NSAIDs observed in prior studies may have been confounded by immortal time bias.