Article
Biology
Sophie M. Morgani, Jakob J. Metzger, Jennifer Nichols, Eric D. Siggia, Anna-Katerina Hadjantonakis
Article
Biology
Claire S. Simon, Lu Zhang, Tao Wu, Weibin Cai, Nestor Saiz, Sonja Nowotschin, Chen-Leng Cai, Anna-Katerina Hadjantonakis
Article
Biology
Sergio Menchero, Isabel Rollan, Antonio Lopez-Izquierdo, Maria Jose Andreu, Julio Sainz de Aja, Minjung Kang, Javier Adan, Rui Benedito, Teresa Rayon, Anna-Katerina Hadjantonakis, Miguel Manzanares
Review
Developmental Biology
Sonja Nowotschin, Anna-Katerina Hadjantonakis, Kyra Campbell
Article
Biology
Nestor Saiz, Laura Mora-Bitria, Shahadat Rahman, Hannah George, Jeremy P. Herder, Jordi Garcia-Ojalvo, Anna-Katerina Hadjantonakis
Review
Biology
Nestor Saiz, Anna-Katerina Hadjantonakis
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2020)
Biographical-Item
Cell Biology
Ruth M. Arkell, Sally L. Dunwoodie, Anna-Katerina Hadjantonakis, Elizabeth J. Robertson
NATURE CELL BIOLOGY
(2021)
Article
Biology
Sophie M. Morgani, Jie Su, Jennifer Nichols, Joan Massague, Anna-Katerina Hadjantonakis
Summary: Rreb1 is essential for mouse embryonic development, and its loss leads to various defects and embryonic lethality.Understanding the function of Rreb1 in development may provide insights into its role in diseases involving loss of epithelial integrity.
Article
Biology
Sophie M. Morgani, Anna-Katerina Hadjantonakis
Summary: Research reveals that early PGCs in mouse embryos exhibit lower BMP and MAPK responses compared to neighboring cells, while showing similar responses to WNT, indicating distinct signaling regulatory mechanisms between germline and soma cells. Additionally, canonical BMP signaling is not autonomously required for directing PGC-like differentiation.
Article
Biochemistry & Molecular Biology
Abderhman Abuhashem, Vidur Garg, Anna-Katerina Hadjantonakis
Summary: The coordinated regulation of transcriptional networks is crucial for cellular identity and developmental progression. Pol II pausing, a prevalent mechanism for controlling and synchronizing transcription, regulates the productive elongation step of transcription in response to various signaling pathways. Recent advances in understanding the molecular basis and function of Pol II pausing in organismal development highlight the potential of combining genomics approaches and perturbation systems to further expand our knowledge in this field.
Review
Biology
Sayali Chowdhary, Anna-Katerina Hadjantonakis
Summary: The blastocyst is a significant stage in mammalian embryo development, consisting of three cell lineages formed through binary cell fate specification. During this stage, cells differentiate and mature as the embryo implants into the maternal uterus.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Biology
Alexandre Francou, Kathryn Anderson, Anna-Katerina Hadjantonakis
Summary: Epithelial-to-mesenchymal transition (EMT) is a process in which epithelial cells transform into mesenchymal phenotypes and gain the ability to migrate. This phenomenon is crucial in gastrulation, a highly conserved developmental process. The ingress of epiblast cells at the primitive streak is asynchronous and involves the contraction of apical surfaces through shrinkage of apical junctions. An analysis of apical proteins revealed the enrichment of actomyosin network and Crumbs2 complexes, which may regulate the asynchronous shrinkage of cell junctions. Loss of function experiments demonstrated that Crumbs2 is required for myosin II localization and activity at apical junctions, suggesting its role in actomyosin anisotropy.
Article
Cell Biology
Abderhman Abuhashem, Alexandra G. Chivu, Yixin Zhao, Edward J. Rice, Adam Siepel, Charles G. Danko, Anna-Katerina Hadjantonakis
Summary: This study reveals that RNA Pol II pausing plays a critical role in the pluripotency continuum of mouse embryos. The researchers show that in the absence of NELF, pluripotent stem cells fail to balance the levels of induced and repressed genes and enhancers. Additionally, they find an increase in chromatin-associated NELF during the transition from the naive to later pluripotent states.
GENES & DEVELOPMENT
(2022)
Article
Biochemical Research Methods
Abderhman Abuhashem, Anna-Katerina Hadjantonakis
Summary: This article provides a step-by-step protocol for generating genetically engineered mouse models with a degradation tag, enabling the control of degradation of endogenous proteins, which is crucial for studying protein function.
Review
Developmental Biology
Sophie Morgani, Jennifer Nichols, Anna-Katerina Hadjantonakis
BMC DEVELOPMENTAL BIOLOGY
(2017)