Article
Cell Biology
Sharmila Ahmad, Markus Hodal Drag, Suraya Mohamad Salleh, Zexi Cai, Mette Olaf Nielsen
Summary: By constructing gene coexpression networks, our study found that perirenal adipose tissue (PER) exhibited changes in cell cycle regulation, gene expression, transmembrane transport, and metabolic processes in response to prenatal malnutrition, while subcutaneous adipose tissue (SUB) in males showed alterations in adenosine diphosphate metabolism and development. PER was identified as the primary target of prenatal malnutrition, while SUB played a minor role. These sex-specific modules were associated with prenatal nutrition and adipocyte size distribution patterns.
PHYSIOLOGICAL GENOMICS
(2023)
Article
Biotechnology & Applied Microbiology
Sharmila Ahmad, Markus Hodal Drag, Suraya Mohamad Salleh, Zexi Cai, Mette Olaf Nielsen
Summary: Early or postnatal malnutrition can impact gene expression in adipose tissues differently, with significant differences observed in perirenal adipose tissue. Mismatched pre- and postnatal feeding leads to long-term programming of adipose tissue remodeling and immunity-related pathways, with implications for metabolic dysfunctions.
Article
Medicine, Research & Experimental
Yu -Shan Chang, Shun-Yun Hou, Shang-Shiuan Yu, Shin-Yu Tsai, Ying-Yi Chen, Li-Jin Hsu, Pei-Jane Tsai, Hui-Kuan Lin, Chyi-Her Lin, Yau-Sheng Tsai
Summary: The study found that postnatal short-term exposure to dexamethasone (Dex) impaired mitochondrial function and autophagy flux in brown adipose tissue (BAT) in neonatal rats. It was also found that preterm infants had higher diurnal temperature variation during systemic corticosteroid treatment.
Review
Endocrinology & Metabolism
Safaa H. Hammoud, Ibrahim AlZaim, Yusra Al-Dhaheri, Ali H. Eid, Ahmed F. El-Yazbi
Summary: Healthy adipose tissue is crucial for human wellbeing, contributing to energy balance and internal organ insulation, and playing a role in synthesizing and secreting adipokines affecting glucose and lipid balance. Inflammation induced by obesity in adipose tissue is linked to insulin resistance, metabolic syndrome, type 2 diabetes, as well as cardiovascular diseases, while alterations in perirenal adipose tissue have implications for renal and cardiovascular function. This suggests potential avenues for future pharmacological therapies targeting adipose tissue immunometabolism in the treatment of chronic kidney disease and cardiovascular disorders.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hideyuki Okuma, Kentaro Mori, Suguru Nakamura, Tetsuo Sekine, Yoshihiro Ogawa, Kyoichiro Tsuchiya
Summary: SGLT2 inhibitor ipragliflozin (Ipra) reduces urinary albumin excretion and glomerular hypertrophy in high-fat diet (HFD)-fed mice. The expansion of perirenal fat (PRAT) induced by Ipra may play an important role in improving diabetic nephropathy (DN) in HFD-fed mice by reducing leptin levels and inhibiting glomerular endothelial cells (GECs) proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Adriana Grigoras, Raluca Anca Balan, Irina-Draga Caruntu, Simona Eliza Giusca, Ludmila Lozneanu, Roxana Elena Avadanei, Andreea Rusu, Laura Adriana Riscanu, Cornelia Amalinei
Summary: Perirenal adipose tissue (PRAT) as a component of visceral adipose tissue, plays an important role in maintaining cardiovascular system and kidney balance. PRAT is a complex microenvironment consisting of various adipocytes, nerve endings, and inflammatory cells. It may also be involved in hypertension, obesity, chronic renal diseases, and tumor progression.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemical Research Methods
Joanna Lazniewska, Jack R. T. Darby, Stacey L. Holman, Alexandra Sorvina, Sally E. Plush, Massimiliano Massi, Doug A. Brooks, Janna L. Morrison
Summary: The study utilized two sheep models of IUGR to determine the metabolic effects of growth restriction on foetal perirenal adipose tissue. The results showed that PAT of IUGR foetuses exhibited higher metabolic activity and adaptive changes, which may be protective in response to the insult of IUGR.
JOURNAL OF BIOPHOTONICS
(2021)
Article
Biochemistry & Molecular Biology
Elena Vega-Martin, Daniel Gonzalez-Moreno, Marta Sanz-Gomez, Ana Karen Guzman-Aguayo, Francisco Javier Manzano-Lista, Angela Schulz, Isabel Aranguez, Reinhold Kreutz, Maria S. Fernandez-Alfonso
Summary: This study found that diabetes induction leads to a proinflammatory and profibrotic environment in the perirenal adipose tissue of rats, which may be associated with the progression of kidney damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
So Young Chun, Jun Nyung Lee, Yun-Sok Ha, Bo Hyun Yoon, Eun Hye Lee, Bo Mi Kim, Haejung Gil, Man-Hoon Han, Woo Seok Oh, Tae Gyun Kwon, Tae-Hwan Kim, Bum Soo Kim
Summary: Human adipose tissue, particularly perirenal fat tissue, is a valuable source of extracellular matrix (ECM) for regenerative medicine. By optimizing the extraction process and comparing different methods, it has been shown that fine homogenization and drying with acetone followed by decellularization with Triton X-100 can yield high-quality ECM with potential applications in tissue engineering and regenerative medicine.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Pilar Fernandez-Mateos, Pilar Cano-Barquilla, Vanesa Jimenez-Ortega, Leire Virto, Juliana Perez-Miguelsanz, Ana I. Esquifino
Summary: Increased adiposity is associated with oxidative stress, inflammation, and metabolic disorders. Melatonin has been shown to prevent the negative effects of obesity on neuroendocrine and inflammatory parameters related to oxidative stress. This study examines the effects of a high-fat diet (HFD) on the gene expression of redox balance enzymes in subcutaneous (SAT) and perirenal (PRAT) adipose tissue of male Wistar rats and the potential preventive role of melatonin. The results indicate that HFD disrupts the normal gene expression patterns of redox enzymes in both SAT and PRAT, with PRAT being more susceptible to oxidative stress induced by obesity. However, melatonin administration along with HFD partially prevents the changes in gene expression of redox enzymes in both SAT and PRAT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
So Young Chun, Yun-Sok Ha, Bo Hyun Yoon, Eun Hye Lee, Bo Mi Kim, Haejung Gil, Man-Hoon Han, Tae Gyun Kwon, Bum Soo Kim, Jun Nyung Lee
Summary: This study found that acetone treatment of human perirenal adipose tissue can achieve optimal delipidation efficiency and ECM extraction, with lower DNA content and the highest residual collagen concentration.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2022)
Article
Agriculture, Dairy & Animal Science
Siyuan Wang, Jie Liu, Weiming Zhao, Guofu Wang, Shuxin Gao
Summary: This study examined the differences between BF and PF in Angus and Simmental cattle, revealing that BF has smaller cell area but greater lipid deposition ability. RNA-seq identified a large number of genes, indicating that genes related to fat metabolism were highly expressed in four tissues, and DEGs differed significantly between Angus and Simmental cattle.
ANIMAL BIOTECHNOLOGY
(2021)
Review
Medicine, General & Internal
Eun Hye Lee, So Young Chun, Jun Nyung Lee, Jae-Wook Chung, Bo Hyun Yoon, Hyun Tae Kim, Tae Gyun Kwon, Yun-Sok Ha, Bum Soo Kim
Summary: Perirenal adipose tissue, obtained from healthy donors during a kidney transplant, is now recognized to have a direct effect on metabolic diseases due to its characteristics like a large number of brown adipose cells and high energy consumption efficiency. Despite these advantages, all perirenal adipose tissue from healthy donors is currently being incinerated as medical waste. This review discusses the potential clinical application of brown adipocytes and beige cells in perirenal adipose tissue.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Ming Jiang, Menghuan Li, Cuiying Liu, Lei Jing, Qiong Huang, Tingting Wu, Xiangqing Kong, Jing Liu
Summary: This study conducted on Chinese adults found a positive independent relationship between perirenal fat volume (PrFV) and serum uric acid (SUA) levels, suggesting that perirenal fat may be a potential risk factor for elevated SUA levels.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Veterinary Sciences
Le Zhao, Haili Yang, Xingchun Li, Yumei Zhou, Taolu Liu, Yongju Zhao
Summary: This study evaluated candidate reference genes for the early whiting mechanism of goat brown adipose tissue (BAT) and identified the most stable reference genes. These findings contribute to further understanding the molecular mechanisms underlying BAT whiting in goats and provide important reference genes for research in this field.
FRONTIERS IN VETERINARY SCIENCE
(2022)
