Article
Oncology
Baoyi Zhang, Kevin Yao, Emily Zhou, Lanjing Zhang, Chao Cheng
Summary: Colorectal cancer is the third leading cause of cancer-related death in the United States, with 15% of cases associated with microsatellite instability. A distinct subtype of MSS colorectal cancer with Chr20q amplification (MSS-A) was found to have better recurrence-free survival compared to MSS patients without this alteration (MSS-N), suggesting potential for individualized therapeutic treatment based on this stratification.
Article
Pathology
Satsuki Kishikawa, Takuo Hayashi, Tsuyoshi Saito, Kazuya Takamochi, Shinji Kohsaka, Kei Sano, Noriko Sasahara, Keita Sasa, Taisei Kurihara, Kieko Hara, Yoshiyuki Suehara, Fumiyuki Takahashi, Kenji Suzuki, Takashi Yao
Summary: This study evaluated the clinicopathological, immunohistochemical, and molecular characteristics of 70 cases of invasive mucinous adenocarcinoma (IMA) of the lung, revealing a significant association between diffuse expression of MUC6 and KRAS-wild-type tumors, smaller tumor size, and female patients. Patients with tumors exhibiting diffuse MUC6 expression had significantly favorable outcomes, suggesting a distinct clinicopathological subset characterized by wild-type KRAS and possibly less aggressive clinical course.
Article
Oncology
Bin-Jin Hwang, Li-Chung Tsao, Chaitanya R. Acharya, Timothy Trotter, Pankaj Agarwal, Junping Wei, Tao Wang, Xiao-Yi Yang, Gangjun Lei, Takuya Osada, Herbert Kim Lyerly, Michael A. Morse, Zachary Conrad Hartman
Summary: This study demonstrates that the suppression of innate immune gene expression in tumor cells is a major factor contributing to the insensitivity of colorectal cancer to immune checkpoint inhibitor treatment. By reintroducing the suppressed gene MAVS, the study found that it can stimulate both local and systemic immune responses against the tumor and enhance the efficacy of anti-tumor immunotherapy when combined with PD-L1 inhibitors.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Genetics & Heredity
Hua-chuan Zheng, Hang Xue, Cong-yu Zhang, Rui Zhang, Kai-hang Shi
Summary: BTG1 expression is associated with clinicopathological characteristics and prognosis in various cancers, and it may serve as a potential marker for carcinogenesis, progression, and prognosis.
FRONTIERS IN GENETICS
(2022)
Article
Medicine, General & Internal
Sen Zhang, Na Li, Yonghua Yang, Yan Li, Chenshi Lin, Guoquan Fu, Jun Cai
Summary: The study found that high expression of CKAP2 may serve as a marker of poor prognosis in lung adenocarcinoma, and it is not associated with EGFR mutation and ALK rearrangement.
Article
Biochemistry & Molecular Biology
Eirini Martinou, Carla Moller-Levet, Dimitrios Karamanis, Izhar Bagwan, Angeliki M. Angelidi
Summary: HOXB9 plays an important role in colorectal cancer, promoting disease progression and affecting overall survival. In vitro experiments showed that HOXB9 overexpression increased cell proliferation and upregulated the expression of genes related to epithelial-mesenchymal transition. In patients with colorectal liver metastases, high expression of HOXB9 was associated with worse overall survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Zoltan Herold, Magdolna Dank, Magdolna Herold, Peter Nagy, Klara Rosta, Aniko Somogyi
Summary: This study focused on the combined effects of CgA(+) and paraneoplastic thrombocytosis on CRC patient survival, proposing a new subtype of CRC characterized by CgA(+) and distinct pathophysiologies.
Article
Pathology
Antonio Pinto, Joao Matos, Teresa Pereira, Giovani L. Silva, Saudade Andre
Summary: This study aimed to investigate the relationship between DNA ploidy pattern and molecular subtypes in breast cancer patients and its prognostic impact. The results showed that DNA aneuploidy is significantly associated with disease-free survival and overall survival in Luminal A and Luminal B subtypes.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Oncology
Eriko Katsuta, Abhisha Sawant Dessai, John M. L. Ebos, Li Yan, Toru Ouchi, Kazuaki Takabe
Summary: The phosphorylated histone variant, gamma-H2AX, plays a key role in breast cancer, and its high expression is associated with increased DNA repair, cell proliferation, metastasis, and worse survival.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Medicine, General & Internal
Guhyun Kang, Jung-Soo Pyo, Nae Yu Kim, Dong-Wook Kang
Summary: This study evaluates the clinicopathological significance and prognostic implications of intratumoral budding (ITB) in colorectal cancers (CRCs) through a meta-analysis. The results show that high ITB is significantly correlated with aggressive tumor behaviors and worse prognosis in CRCs. The detection of ITB can be useful for predicting clinicopathologic features and the prognosis of CRC.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Wen-Xiang Li, Jia-Jia Zheng, Gang Zhao, Chen-Tao Lyu, Wei-Qi Lu
Summary: The study revealed that reduced expression of DSCR1 is associated with poor clinicopathologic features and shorter overall survival in CRC patients. Overexpression of DSCR1 isoform 4 led to inhibition of cell cycle and proliferation, as well as induction of senescence in CRC cells. Moreover, DSCR1-4 overexpression suppressed tumor growth and angiogenesis in vivo, highlighting its potential as a critical tumor suppressor in CRC progression.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Vincent Ho, Liping Chung, Kate Wilkinson, Vivienne Lea, Stephanie H. Lim, Askar Abubakar, Weng Ng, Mark Lee, Tara L. Roberts, Wei Chua, Cheok Soon Lee
Summary: The high expression of MRE11 in colorectal cancer is associated with poor prognosis, especially in patients with right-sided primary CRC. This suggests that MRE11 may serve as an independent prognostic marker in this subgroup.
Article
Biochemistry & Molecular Biology
Soo Young Jeong, Jung Han Kim, Jae-Jun Lee, Sung Taek Park, Hyeong Su Kim
Summary: Protein tyrosine kinase 6 (PTK6) plays a crucial role in cell proliferation and differentiation. The expression of PTK6 in tumor is associated with prognosis and clinicopathological features in cancer patients, but the direction of this association depends on the degree of PTK6 expression in non-tumor tissues.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Article
Oncology
Matteo Fassan, Massimo Milione, Giulia Maddalena, Chiara Cremolini, Marta Schirripa, Filippo Pietrantonio, Nicoletta Pella, Emanuela Dell'Aquila, Elisa Sperti, Clizia Zichi, Francesca Bergamo, Marco Volante, Alessandra Boccaccino, Federica Morano, Francesco Cortiula, Giovanna De Maglio, Lorenza Rimassa, Valeria Smiroldo, Lorenzo Calvetti, Giuseppe Aprile, Lisa Salvatore, Daniele Santini, Roberta Salmaso, Giovanni Centonze, Paola Biason, Chiara Borga, Sara Lonardi, Vittorina Zagonel, Angelo P. Dei Tos, Massimo Di Maio, Fotios Loupakis
Summary: Neuroendocrine differentiation in BRAFmt metastatic colorectal cancers is associated with worse prognosis in terms of progression-free survival (PFS) and overall survival (OS). Further studies are needed to investigate the molecular mechanisms underlying the acquisition of neuroendocrine phenotype for potential novel-targeted treatment strategies.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Medicine, General & Internal
Hong Bae Choi, Jung-Soo Pyo, Soomin Son, Kyungdoc Kim, Guhyun Kang
Summary: The study evaluates the diagnostic and prognostic role of CDX2 expression in colorectal cancers (CRCs) through a meta-analysis. The results show that CDX2 expression is associated with clinicopathological characteristics of CRC. CDX2 is highly expressed in adenocarcinoma and lowly expressed in medullary carcinoma. In addition, CDX2 expression is correlated with the presence of BRAF(V600E) mutation. Patients with CDX2 expression have better survival rates.