Article
Cell Biology
Jianyang Xiang, Wahafu Alafate, Wei Wu, Yichang Wang, Xiaodong Li, Wanfu Xie, Xiaobin Bai, Ruichun Li, Maode Wang, Jia Wang
Summary: NEK2 is significantly upregulated in glioblastoma (GBM) and higher expression of NEK2 is associated with poor prognosis. Knockdown of NEK2 attenuates proliferation, migration, invasion, and tumorigenesis of GBM, while overexpression of NEK2 promotes GBM progression. NEK2 is positively related to the NF-kappa B signaling pathway in GBM.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Yichang Wang, Gang Bao, Miao Zhang, Jianyang Xiang, Haoyu Zhou, Alafate Wahafu, Wei Wu, Xudong Ma, Longwei Huo, Xiaobin Bai, Wanfu Xie, Peijun Liu, Maode Wang
Summary: Glioblastoma (GBM) is a deadly brain tumor with limited treatment options. This study reveals that CRB2 is up-regulated in GBM and is associated with poor prognosis. It also shows a link between CRB2 and the NF-kappa B signaling pathway, suggesting that CRB2 could be a potential therapeutic target for GBM.
EXPERIMENTAL CELL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Jennifer K. Matsui, Haley K. Perlow, Alex R. Ritter, Rituraj Upadhyay, Raju R. Raval, Evan M. Thomas, Sasha J. Beyer, Clement Pillainayagam, Justin Goranovich, Shirley Ong, Pierre Giglio, Joshua D. Palmer
Summary: This review discusses the treatment modalities for glioblastoma, the mechanisms of radioresistance, and promising radiosensitizers. Small molecules and immunotherapy agents used in conjunction with radiotherapy have been studied in clinical trials. Recent preclinical studies regarding radiosensitizers for glioblastoma are also discussed.
Article
Oncology
Bin Hu, Xiumei Ma, Renhua Huang, Zheng Wu, Jun Lu, Yuntao Guo, Jianmin Tang, Chunhui Ma, Jun Ma, Lei Zhang, Yongrui Bai
Summary: This study identified that mutations in SMAD3 and SMAD4 genes can impact the response of pancreatic cancer to radiotherapy. Mutations in SMAD3 enhance radioresistance in PDAC cells, while mutations in SMAD4 have the opposite effect. These findings suggest that mutations in SMAD3 and SMAD4 could serve as potential biomarkers for radiotherapy in pancreatic cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Genetics & Heredity
Song Zeng, He Zhang, Di Zhang, Xiaopeng Hu, Liming Song
Summary: The expression of FDX1 is significantly downregulated in ccRCC, and patients with higher FDX1 expression have better prognosis. FDX1 could serve as a potential novel prognostic biomarker for ccRCC patients with good predictive power.
Article
Oncology
Hyunkoo Kang, Sungmin Lee, Kyeongmin Kim, Jaewan Jeon, Seok-Gu Kang, HyeSook Youn, Hae Yu Kim, BuHyun Youn
Summary: Research shows that radioresistant GBM cells enhance stemness and glycolytic activity through the Spy1-CLIP3 axis. Glimepiride, in combination with radiotherapy, disrupts stem cell maintenance and suppresses glycolytic activity by restoring CLIP3 function, leading to reduced tumor growth and improved survival in a GBM orthotopic xenograft mouse model.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Review
Biology
Francesco Pasqualetti, Mario Miniati, Alessandra Gonnelli, Giovanni Gadducci, Noemi Giannini, Laura Palagini, Maricia Mancino, Taiusha Fuentes, Fabiola Paiar
Summary: Glioblastoma is highly resistant to radiotherapy. Cancer stem cells play an important role in the growth and resistance of GB. The radiosensitivity of stem cells and biomarkers of stemness are crucial in this field.
Article
Biochemistry & Molecular Biology
Ana Virginia Sanchez-Sanchez, Antonio Garcia-Espana, Pilar Sanchez-Gomez, Jaime Font-de-Mora, Marian Merino, Jose Luis Mullor
Summary: NANOG is a key transcription factor for maintaining pluripotency, with elevated expression levels in various human cancers and a role in tumor metastasis. Studies show that NANOG regulates cancer cell migration through the SDF1/CXCR4 pathway, suggesting a potential therapeutic target for Nanog-dependent tumor progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Imran Khan, Mohammad Hassan Baig, Sadaf Mahfooz, Moniba Rahim, Busra Karacam, Elif Burce Elbasan, Ilya Ulasov, Jae-June Dong, Mustafa Aziz Hatiboglu
Summary: Autophagy plays a crucial role in cellular energy consumption, survival, and defense mechanisms. Its impact on tumorigenesis and resistance mechanisms in glioblastoma remain ambiguous, highlighting the need for understanding the molecular mechanisms and designing improved treatment strategies. Autophagy also holds potential as a molecular target for therapeutic interventions in glioma stem cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Clinical Neurology
Tobias Weiss, Michael Weller
Summary: The recent report in Nature Cancer suggests that glioblastoma can be classified into four functional subgroups based on pathway inference from gene expression data, with a subgroup reliant on oxidative phosphorylation potentially targeted by mitochondrial metabolism inhibitors.
NATURE REVIEWS NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shin Pai, Vijesh Kumar Yadav, Kuang-Tai Kuo, Narpati Wesa Pikatan, Chun-Shu Lin, Ming-Hsien Chien, Wei-Hwa Lee, Michael Hsiao, Shao-Chih Chiu, Chi-Tai Yeh, Jo-Ting Tsai
Summary: High expression of PDK1 is associated with poor prognosis in OSCC, and it is related to glycolytic re-programming and chemo/radioresistance. The study found important associations between PDK1/CD47/LDHA expression in OSCC. The combination of PDK1 inhibitor BX795, cisplatin, and radiotherapy could effectively target OSCC by inhibiting oncogenic and glycolytic signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Lizhi Pang, Madeline Dunterman, Wenjing Xuan, Annette Gonzalez, Yiyun Lin, Wen-Hao Hsu, Fatima Khan, Robert S. Hagan, William A. Muller, Amy B. Heimberger, Peiwen Chen
Summary: It has been found that the clock gene regulates the activity of glioma stem cells and affects the development of glioblastoma. The clock gene directs the expression of OLFML3, which leads to the upregulation of POSTN through HIF1a and subsequently promotes tumor angiogenesis through activation of the TBK1 signaling pathway. Blocking the CLOCK-directed POSTN-TBK1 axis has been shown to inhibit tumor progression and angiogenesis.
Article
Oncology
Amirhosein Kefayat, Alireza Amouheidari, Fatemeh Ghahremani, Zahra Alirezaei
Summary: The study aimed to assess the diagnostic and prognostic values of preoperative stem cell factor (SCF) plasma level in GBM patients. Results showed that the SCF plasma level can serve as a novel diagnostic blood-circulating biomarker for patients with GBM, but is not correlated with tumor volume, PFS, or OS in GBM patients.
Article
Oncology
Nawal Alshahrany, Ayesha Begum, Dorit Siebzehnrubl, Ana Jimenez-Pascual, Florian A. Siebzehnrubl
Summary: Glioblastoma, the most lethal brain cancer in adults, is characterized by heterogeneity, therapy resistance, and infiltration. The fibroblast growth factor receptor 1 (FGFR1) signaling pathway plays a role in therapy resistance and cancer stemness. FGFR1 has been found to be associated with poorer survival and tumor invasion in glioblastoma.
Article
Cell Biology
Marie Geraldine Lacore, Caroline Delmas, Yvan Nicaise, Aline Kowalski-Chauvel, Elizabeth Cohen-Jonathan-Moyal, Catherine Seva
Summary: This study identifies GPM6A and PTPRZ1 as crucial factors in glioblastoma, playing important roles in GBSC invasion, radioresistance, and sphere formation. Blocking the expression of GPM6A or PTPRZ1 reduces GBSC invasion and increases radiosensitivity.