期刊
ONCOTARGET
卷 5, 期 21, 页码 10222-10236出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.2655
关键词
HER3; NEDD4; Biomarkers; Monoclonal antibodies; Molecular therapeutics
资金
- Janssen RD, LLC
- Texas Emerging Technology Fund
- Welch Foundation [AU0042]
ERBB3/HER3 is emerging as a molecular target for various cancers. HER3 is overexpressed and activated in a number of cancer types under the conditions of acquired resistance to other HER family therapeutic interventions such as tyrosine kinase inhibitors and antibody therapies. Regulation of the HER3 expression and signaling involves numerous HER3 interacting proteins. These proteins include PI3K, Shc, and E3 ubiquitin ligases NEDD4 and Nrdp1. Furthermore, recent identification of a number of HER3 oncogenic mutations in colon and gastric cancers elucidate the role of HER3 in cancer development. Despite the strong evidence regarding the role of HER3 in cancer, the current understanding of the regulation of HER3 expression and activation requires additional research. Moreover, the lack of biomarkers for HER3-driven cancer poses a big challenge for the clinical development of HER3 targeting antibodies. Therefore, a better understanding of HER3 regulation should improve the strategies to therapeutically target HER3 for cancer therapy.
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