Article
Biochemistry & Molecular Biology
Balaji Kyathegowdanadoddi Srinivas, Madhu Chakkere Shivamadhu, Shankar Jayarama
Summary: This study aimed to purify lectin from the sap of Musa acuminate pseudostem and investigate its apoptotic and angiogenic mechanisms in both in-vitro and in-vivo models. The findings suggest that the lectin possesses significant anticancer potential by inducing apoptosis and suppressing neoangiogenesis in cancer cells and animal models.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Dominika Dakowicz, Monika Zajkowska, Barbara Mroczko
Summary: Colorectal cancer is the second most common cause of cancer death globally. Both genetic and protein factors are involved in its pathogenesis. Researchers are exploring new diagnostic tools and potential therapeutic drugs, particularly VEGF family members related to blood vessel formation, which play a crucial role in colorectal cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Karn Wijarnpreecha, Fang Li, Yang Xiang, Xun Xu, Cong Zhu, Vahed Maroufy, Qing Wang, Wei Tao, Yifang Dang, Huy Anh Pham, Yujia Zhou, Jianfu Li, Xinyuan Zhang, Hua Xu, C. Burcin Taner, Liu Yang, Cui Tao
Summary: Previous studies have shown an association between nonselective beta-blockers (NSBBs) and a lower risk of hepatocellular carcinoma (HCC) in cirrhotic patients. This retrospective cohort study utilizing the Cerner Health Facts database in the United States from 2000 to 2017 found that NSBBs, including carvedilol, were significantly associated with a decreased risk of HCC in patients with cirrhosis regardless of complications status. Future randomized-controlled studies should further investigate which NSBB would be the best option to prevent HCC in cirrhosis.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Biochemistry & Molecular Biology
Peace Mabeta, Vanessa Steenkamp
Summary: The VEGF/VEGFR axis plays a crucial role in angiogenesis and tumor vascularization. Current therapies targeting VEGF and its receptors have shown limited effectiveness and undesirable off-target effects. Recent studies have identified VEGF splice variants that modulate angiogenesis, and their expression is regulated by cues within the tumor microenvironment. These variants challenge the established norm of VEGF signaling and their aberrant expression has been observed in several cancers, highlighting the need for further research on their role in cancer and their impact on antiangiogenic therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Donghwa Kim, Sang Won Choi, Jihee Cho, Jae-Hui Been, Kyoungsun Choi, Wenzhe Jiang, Jaeho Han, Jedo Oh, Changmin Park, Soongyu Choi, Songyi Seo, Koung Li Kim, Wonhee Suh, Sang Kook Lee, Sanghee Kim
Summary: Diabetic retinopathy is a leading cause of blindness associated with excessive angiogenesis. Researchers have developed a novel antiangiogenesis agent by modifying the structure of wondonin marine natural products, resulting in improved bioactivity and selectivity. This compound, 31, shows potential as a lead for developing small-molecule drugs to treat diabetic retinopathy and to uncover new mechanisms of angiogenesis.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Avner Adini, Irit Adini, Etty Grad, Yuval Tal, Haim D. Danenberg, Peter M. Kang, Benjamin D. Matthews, Robert J. D'Amato
Summary: Myocardial infarction (MI) remains a leading cause of death in the western world, with current interventions being limited due to comorbidities or lack of resources. Non-invasive approaches to enhance angiogenesis in ischemic tissues have been ineffective in humans, prompting researchers to develop PR1P, a VEGF binding peptide that improves heart function post-MI in rodents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Domenico Ribatti, Antonio Giovanni Solimando, Francesco Pezzella
Summary: Several anti-angiogenic drugs are approved for cancer treatment, but resistance and adverse effects may occur. Combining multiple anti-angiogenic molecules or using them in combination with other treatment regimens is indicated as alternative therapeutic strategies to overcome resistance. Comprehensive omics profiling is crucial for increasing clinical benefits and overcoming resistance to anti-angiogenic therapies.
Review
Chemistry, Medicinal
Anurag Mathur, Abha Meena, Suaib Luqman
Summary: Monoterpenoids, a subclass of terpenoids, have been extensively studied for their antitumor properties, including antiproliferative, apoptotic, antiangiogenic, and antimetastatic effects. This review focuses on the effects of specific monoterpenoids on metastasis and relevant signaling pathways. Monoterpenoids exhibit complexity as natural products that regulate metastatic proteins through various signaling pathways. However, limited clinical trials hinder the drug usage of monoterpenoids in preventing cancer metastasis.
PHYTOTHERAPY RESEARCH
(2023)
Article
Oncology
Yunlong Yang, Yihai Cao
Summary: Metastasis, the leading cause of cancer-associated mortality, is still poorly understood. Both blood and lymphatic vasculatures play crucial roles in distal metastasis, with VEGF being a key angiogenic factor. Anti-VEGF drugs have been widely used in clinical treatment of various cancers, but their impact on cancer metastasis and systemic disease is largely unknown.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Integrative & Complementary Medicine
Rong Han, Yun Sun, Ruoting Ma, Dexi Wang, Jianan Sun, Shengjun Zhao, Haiying Zhang
Summary: Ferula akitschkensis volatile oil (FAVO) inhibits tumor growth and angiogenesis by suppressing the HIF-2α/VEGF signaling pathway.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Oncology
Cheng-Hsien Chen, Fei-Ting Hsu, Wei-Lung Chen, Jiann-Hwa Chen
Summary: The combination therapy of regorafenib and magnolol synergistically inhibited hepatocellular carcinoma growth by enhancing apoptotic induction, suppressing the expression of VEGF-A and MCL-1, and inhibiting metastasis.
Article
Oncology
Wafaa S. Ramadan, Saleh Alkarim, Mohammed Moulay, Ghadeer Alrefeai, Fatma Alkudsy, Khalid Rehman Hakeem, Ashwaq Iskander
Summary: The challenges in treating hepatocellular carcinoma (HCC) are largely due to drug resistance or relapse, which is attributed to the presence of hepatic cancer stem cells (HCSCs). In this study, the therapeutic effect of ellagic acid (EA) on HCC and the reaction of the HCC microenvironment and HCSCs to EA therapy were evaluated.
Article
Cell Biology
Yingming Jiang, Jintuan Huang, Zhenze Huang, Weiyao Li, Rongchang Tan, Tuoyang Li, Zijian Chen, Xiaocheng Tang, Yandong Zhao, Jun Qiu, Chujun Li, Hao Chen, Zuli Yang
Summary: This study found that ADAMTS12 plays a role in promoting tumor development and angiogenic activity in gastric cancer. High expression of ADAMTS12 is associated with chemoresistance and worse overall survival outcomes.
CELLULAR SIGNALLING
(2023)
Article
Oncology
Longhai Li, Kai Jiang, Dongpeng Li, Dongxiao Li, Zitong Fan, Guosheng Dai, Sheng Tu, Xiangyu Liu, Guangyou Wei
Summary: The study finds that high expression of CXCL7 is correlated with VEGF expression and poor prognosis in CRC patients. The combined expression of CXCL7 and VEGF can better predict patients' survival time.
FRONTIERS IN ONCOLOGY
(2021)
Review
Medicine, General & Internal
Klaudia Katarzyna Brogowska, Monika Zajkowska, Barbara Mroczko
Summary: Breast cancer is the most common and lethal malignancy in women. Its development is influenced by factors such as age, genetic mutations, and body weight. Currently, there is a lack of sensitive and specific screening tests, but researchers are exploring new diagnostic biomarkers. The VEGF family of proteins and their receptors play a significant role in the pathogenesis of breast cancer and could potentially be used as diagnostic biomarkers and therapeutic targets.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Psychology, Multidisciplinary
Sicheng Xiong, Yi Xu, Bin Zhang, Lihui Zhu, Jianhui Xie
Summary: This study identified three patterns of restrained eating in adolescents and found that these patterns were associated with interpersonal factors such as parental monitoring, deviant peer affiliation, and peer relationships. The results can inform targeted prevention and intervention strategies.
CURRENT PSYCHOLOGY
(2023)
Article
Engineering, Electrical & Electronic
Liping Zhu, Bingyao Wang, Yihan Yan, Shuang Guo, Gangyi Tian
Summary: With the rapid increase in the number of automobiles, traffic accidents are becoming more frequent. This paper proposes three new traffic flow features and extracts them using residual analysis, quadratic discrimination, and multi-resolution wavelet analysis for traffic anomaly detection. Experimental results show that accident identification based on the proposed features is more effective, providing an alternative approach for further applications and studies.
SIGNAL IMAGE AND VIDEO PROCESSING
(2023)
Article
Engineering, Mechanical
Ling Lan, Yue-lan Di, Hai-dou Wang, Yan-fei Huang, Li-na Zhu, Xu-hang Li
Summary: Micro/nanostructures are fabricated on the surface of stainless steel via laser etching, and a superhydrophobic coating with silver nanoparticles is prepared using polydopamine. The effect of soaking time on the reduction of nano-Ag, surface wettability, and antibacterial properties is investigated.
Editorial Material
Multidisciplinary Sciences
Zenghui Xie, Fugui Xie, Limin Zhu, Xin-Jun Liu
Summary: Robotization, miniaturization, and portability are the new development trends in milling equipment for large-scale complex structures. The robotic mobile and mirror milling technology has made remarkable progress in practical production.
NATIONAL SCIENCE REVIEW
(2023)
Article
Cell Biology
Ya-Lan Wei, Yu-Qing Lei, Zhou-Jie Ye, Xu-Dong Zhuang, Li-Ping Zhu, Xin-Rui Wang, Hua Cao
Summary: Bepridil, a commonly used medication for arrhythmia and heart failure, has been found to have toxic effects on rat myocardial cells and zebrafish embryos. The treatment with bepridil resulted in calcium overload, morphological abnormalities, and developmental abnormalities. RNA-seq analysis provided insights into the gene expression profiles and metabolic responses. This study evaluates the use of antiarrhythmic agents in prenatal heart patients.
CELL AND TISSUE RESEARCH
(2023)
Article
Engineering, Environmental
Wei Li, Wei-Liang Jin, Hong-Xin Jiang, Rui Wang, Hao Jia, Jing-Qi Liu, An-Na Tang, Li-Na Zhu, De-Ming Kong
Summary: In this study, a MF@COF composite material was successfully prepared and applied for sample treatment in non-targeted food safety analysis and oil/water separation, showing highly hierarchical pores, strong hydrophobicity, ultralight weight, robust stability, good mechanical elasticity, and processability. Experimental results demonstrated that this composite material can achieve complete removal of chemical hazards from fat-rich foods in 30 seconds, as well as effective separation of oil/water systems.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Manufacturing
Zi-Hui Zhu, Peng Huang, Suet To, Li-Min Zhu, Zhiwei Zhu
Summary: A fast-tool-servo-controlled shear-thickening micropolishing method is proposed for removing undesired surface diffraction on diamond-turned microstructured surfaces. The method allows for controllable material removal by adjusting the gap width and achieves improved surface quality.
INTERNATIONAL JOURNAL OF MACHINE TOOLS & MANUFACTURE
(2023)
Article
Computer Science, Artificial Intelligence
Liping Zhu, Zhe Chen, Bingyao Wang, Gangyi Tian, Laihu Ji
Summary: 3D object detection typically uses point clouds as input, which are converted into voxels using voxel-based methods. However, the presence of background points in the raw point cloud and the random sampling during voxel partition diminish the performance of the detection system. In this work, we propose a plug-to-play module that includes a shape-aware filter and a semantic-ranked sampler to effectively remove background points and enhance voxel feature expression. Our method achieves faster inference speed and higher detection accuracy compared to state-of-the-art methods, as demonstrated by experiments on the KITTI car detection benchmark.
NEURAL COMPUTING & APPLICATIONS
(2023)
Article
Metallurgy & Metallurgical Engineering
Hao-tian Zhu, Hai-rui Guo, Qi-jing Zheng, Chun-yan Guan, Li-ping Zhu, Hai-bin LI, Jin-yu Yang
Summary: Ho3+ and Yb3+ co-doped La7P3O18 up-conversion phosphors were prepared via high-temperature solid-state process. The samples showed a mixture of monoclinic structure La7P3O18 crystals and minor LaPO4 crystals according to XRD analysis. UV-Vis DRS results revealed that La7P3O18 crystal was an indirect semiconductor with an optical band gap of 4.10 eV. Upon excitation at 980 nm, the Ho3+ and Yb3+ co-doped La7P3O18 phosphors exhibited characteristic blue (486 nm), green (550 nm), and red (661 nm) luminescence peaks of Ho3+ ions. The 661 nm peak dominated the up-conversion luminescence spectra. The intensity of up-conversion luminescence initially increased and then decreased with the increase of Ho3+ and Yb3+ doping content. Concentration quenching may occur at Ho3+ and Yb3+ doping contents of 1 at.% and 10 at.%, respectively, through an electric quadrupole-electric quadrupole interaction process. The pumping power dependence of luminescence indicated a two-photon absorption process for the excitation of green and red emissions. The color coordinates of the Ho3+ and Yb3+ co-doped La7P3O18 crystals were located in the orange-red region.
TRANSACTIONS OF NONFERROUS METALS SOCIETY OF CHINA
(2023)
Article
Chemistry, Multidisciplinary
Shengmiao Sun, Bixuan Wang, Molan Qing, Danbi Tian, Ling Jiang, Liying Zhu
Summary: A modified screen-printed electrode based on ZIF-8, Ag NPs, and ErGO was developed for dopamine detection. The synthesized ErGO/Ag-ZIF-8 composites maintained the structure of ZIF-8. The oxidation current of dopamine increased linearly in the range of 0.1-200 mu M with a detection limit of 0.03 mu M (S/N=3). The sensor exhibited good reproducibility and selectivity, and it was successfully applied for dopamine detection in goat serum with satisfactory recovery range.
Article
Automation & Control Systems
Linlin Li, Wei-Wei Huang, Xiangyuan Wang, Yuan-Liu Chen, LiMin Zhu
Summary: This paper proposes a generalized periodic-disturbance observer (PDOB) to address the issue of repetitive disturbances in automation systems, with an application to a non-minimum phase system. The PDOB is combined with a baseline proportional-integral (PI) controller to achieve real-time cross-coupling suppression. Experimental results show significant improvements in tracking performance and no interference with tracking-based control schemes.
IEEE TRANSACTIONS ON AUTOMATION SCIENCE AND ENGINEERING
(2023)
Article
Automation & Control Systems
Yan-Ning Fang, Xiaonan Pu, Suet To, Bernard Hon, Li-Min Zhu, Zhiwei Zhu
Summary: To overcome the limitations of current piezo-actuated triaxial fast tool servos (FTSs), a novel normal-stressed electromagnetic triaxial FTS with a compact structure and high resonant frequency is proposed. It achieves triaxial motions in the range of hundreds of micrometers and utilizes a single armature for decoupled and noncontact driving forces. The prototype of the triaxial FTS shows excellent agreement with the design target in terms of static and dynamic performances. The system is further enhanced with a linear active disturbance rejection control and an iterative learning scheme for fast and accurate trajectory tracking. By fabricating a hexagonal spherical microlens array, the triaxial FTS demonstrates its capability with a high level of spatial accuracy and good surface quality.
IEEE TRANSACTIONS ON INDUSTRIAL ELECTRONICS
(2023)
Article
Engineering, Manufacturing
ZaoZao Chen, JunNan Chen, Zhe Zhang, XinQuan Zhang, LiMin Zhu
Summary: To address the low efficiency and cutting tool interference issues in machining high aspect ratio surfaces or complex microstructures with existing diamond turning techniques, a novel method is proposed by introducing two additional rotational motions into the traditional ultra-precision machine tool. This allows for arbitrary adjustment of the tool posture during the machining process and enables efficient machining of intricate microstructures, such as monolithic microstructural optics, using the side cutting edge. The mechanical system, machining principle, tool path planning, compensation for tool tip offset, fabrication and inspection of a partially overlapping Fresnel lens array, as well as the analysis of measurement data, are presented to validate the successful fabrication of such complex microstructures with high profile accuracy and surface quality.
JOURNAL OF MANUFACTURING PROCESSES
(2023)
Article
Engineering, Electrical & Electronic
Wenze Zhang, Weiwei Huang, Yijun Shen, Yaqi Zhang, Limin Zhu, Yang Zhang
Summary: Five-axis sweep scanning is an emerging surface inspection technology that efficiently detects complex surfaces. Existing methods rely on CAD models, making them unsuitable for measuring deformed surfaces. To address this, an adaptive approach with real-time path planning is proposed, eliminating the need for CAD models. The approach utilizes accurate surface prediction and efficient path planning, confirmed through experiments on complex free-form surfaces.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2023)
Article
Biotechnology & Applied Microbiology
Shengmiao Sun, Bowen Shen, Ling Jiang, Liying Zhu
Summary: This study investigated the potential of Deinococcus wulumuqiensis R12 as a bioadsorbent for Cr(VI) removal. The optimal conditions for maximum Cr removal efficiency were found to be pH 7.0, 24 h contact time, and 7 mg l(-1) initial Cr concentration. Characterization of bacterial cells revealed that Cr was adsorbed to the surface through functional groups. D. wulumuqiensis R12 showed a high adsorption capacity for Cr(VI) and maintained its viability and metabolic activity even in the presence of Cr.
JOURNAL OF APPLIED MICROBIOLOGY
(2023)
