Article
Dentistry, Oral Surgery & Medicine
Feifei Xue, Hongjie Feng, Tianxiao Wang, Guanying Feng, Nan Ni, Ruixia Wang, Hua Yuan
Summary: This study found that hsa_circ_0000264 is upregulated in head and neck squamous cell carcinoma (HNSCC) and promotes HNSCC progression by upregulating the expression of high mobility group AT-hook 2 (HMGA2) through sponging hsa-let-7b-5p. hsa_circ_0000264 may serve as a potential target for HNSCC treatment.
Article
Biology
Vennila Ponnusamy, Richard T. H. Ip, Moumin A. E. K. Mohamed, Paul Clarke, Eva Wozniak, Charles Mein, Leslie Schwendimann, Akif Barlas, Philippa Chisholm, Ela Chakkarapani, Adina T. Michael-Titus, Pierre Gressens, Ping K. Yip, Divyen K. Shah
Summary: Ponnusamy et al identified let-7b-5p as an elevated microRNA in neonates with moderate to severe encephalopathy using next generation sequencing of dried blood spots. They demonstrated that let-7b-5p exerts its effects through the Hippo-YAP pathway in cell culture and murine models of perinatal brain injury, indicating the need for validation in larger neonate cohorts to confirm its role as a biomarker for neonatal encephalopathy.
COMMUNICATIONS BIOLOGY
(2021)
Article
Cell Biology
Ling Li, Xiujuan Zhang, Yanni Lin, Xinxin Ren, Tian Xie, Jing Lin, Shumeng Wu, Qinong Ye
Summary: This study found that microRNA-let-7b-5p (let-7b-5p) represses the expression of Hexokinase 2 (HK2) by targeting its 3'-untranslated region. By suppressing HK2-mediated aerobic glycolysis, let-7b-5p restricts breast tumor growth and metastasis. In patients with breast cancer, let-7b-5p expression is significantly downregulated and is negatively correlated with HK2 expression. These findings suggest that the let-7b-5p/HK2 axis plays a key role in aerobic glycolysis as well as breast tumor proliferation and metastasis, and targeting this axis is a potential therapeutic strategy for breast cancer.
CELL DEATH DISCOVERY
(2023)
Article
Cell Biology
Ming Xiu, Xia Huan, Yang Ou, Sha Ying, Jianmeng Wang
Summary: The study investigated the cellular behavior and characteristics of IGF-1/IGF-1R in intestinal cells, revealing that IGF-1 can internalize into the cytoplasm and transport into the cell nuclei. It was found that IGF-1R undergoes clathrin-mediated endocytosis and enters into Rab-5-positive endosomes before being transported to the cell nuclei along microtubules, promoting cell proliferation.
CELL PROLIFERATION
(2021)
Article
Dentistry, Oral Surgery & Medicine
Hong Zhang, Zhenhua Wang, Zhongti Zhang
Summary: This study investigated the role and mechanism of a abnormally expressed circular RNA (hsa_circ_0009128) in oral squamous cell carcinoma (OSCC) progression. The results showed that hsa_circ_0009128 was upregulated in OSCC tissues and cell lines, and correlated with advanced TNM stage and lymph node metastasis. Knockdown of hsa_circ_0009128 inhibited cell proliferation and migration, and decreased EMT in OSCC cells. These findings suggest that hsa_circ_0009128 may play an important role in the malignant progression of OSCC by targeting MMP9 to activate EMT.
Article
Oncology
Teeranut Asavasupreechar, Ryoko Saito-Koyama, Yasuhiro Miki, Keiichi Tamai, Jiro Abe, Chihiro Inoue, Ikuro Sato, Viroj Boonyaratanakornkit, Hironobu Sasano
Summary: This study revealed that the presence of progesterone receptor (PR) and PR isoform B (PRB) is correlated with better clinical outcomes in breast cancer and non-small cell lung cancer (NSCLC). The microRNA let-7b can inhibit cell proliferation by inducing PR and PRB expression in breast cancer cell lines. The let-7b-E2F1 interaction was found to be responsible for the inhibition of PRB in breast cancer cells.
ENDOCRINE-RELATED CANCER
(2023)
Article
Environmental Sciences
Li-hua Dong, Jing-jing Huang, Peng Zu, Jing Liu, Xue Gao, Jian-wei Du, Yu-fu Li
Summary: The study revealed that circKDM4C is downregulated in AML patients, and overexpression of circKDM4C in AML cell lines can inhibit proliferation, migration, invasion, and promote ferroptosis. CircKDM4C acts as a sponge of hsa-let-7b-5p to regulate P53 expression in AML. CircKDM4C is negatively correlated with hsa-let-7b-5p, but positively correlated with P53 in AML patients.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Oncology
Ling Mao, Xiaoweng Wu, Zhengpeng Gong, Ming Yu, Zhi Huang
Summary: The study revealed that PDIA6 is upregulated in OSCC tissues and its overexpression promotes aerobic glycolysis and the progression of oral squamous cell carcinoma.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Cell Biology
Jie Gao, Ying Meng, Xin Ge, Chen-Xing Hou, Qing-Hai Zhu, Yi-Zhou Wang, Li-Fan Sun, Chen-Xing Wang, Huai-Qi Li, Tianzhu Zhang, Jin-Hai Ye
Summary: This study revealed the expression and function of SATB2 in oral squamous cell carcinoma, showing that high expression of SATB2 is associated with poor prognosis. Overexpression of SATB2 promotes proliferation, migration, invasion, and tumor growth of OSCC cells, and NOX4 is identified as a downstream target of SATB2. This suggests that SATB2 may play a key role in OSCC tumorigenesis and could be a potential target for future therapeutic development.
CELLULAR SIGNALLING
(2021)
Article
Biotechnology & Applied Microbiology
Yixiu Yu, Jiamei Niu, Xingwei Zhang, Xue Wang, Hongquan Song, Yingqun Liu, Xiaohui Jiao, Fuyang Chen
Summary: This study identifies HOTAIRM1 as a significantly upregulated lncRNA in OSCC that is strongly associated with unfavorable prognosis. Bioinformatics analyses demonstrate that HOTAIRM1 is closely related to tumor stage, overall survival, genome instability, tumor cell stemness, tumor microenvironment, and immunocyte infiltration. Functional experiments confirm that HOTAIRM1 knockdown inhibits proliferation of OSCC cells and affects cell cycle regulation. In vivo experiments show that knocking down HOTAIRM1 inhibits tumor growth. Overall, HOTAIRM1 could serve as a potential prognostic biomarker and therapeutic target for OSCC.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Shen Zheng, Ran Wu, Yunlong Deng, Qiang Zhang
Summary: Dysregulation of mitochondrial calcium uniporter (MCU) plays a carcinogenic role in several cancers, including oral squamous cell carcinoma (OSCC). The study aimed to investigate the role of MCU in OSCC and its regulatory relationship with dihydroartemisinin (DHA). The results showed that MCU and its complex members were overexpressed in OSCC and DHA treatment suppressed MCU expression. MCU overexpression reversed the inhibitory effects of DHA on other proteins. Knockdown of MCU or DHA treatment suppressed proliferation and migration of OSCC cells.
Article
Biotechnology & Applied Microbiology
Ying Lou, Liuyang Ren, Lu Wang
Summary: In this study, the role of a novel circRNA, circ_0049396, and its underlying mechanism in oral squamous cell carcinoma (OSCC) were investigated. The findings showed that circ_0049396 overexpression inhibited the malignant behavior of OSCC cells by regulating the miR-663b/ENDOU axis. Based on these results, circ_0049396 could be a potential therapeutic agent for OSCC.
Article
Immunology
Bo Qiu, Yang Sun, Wei Nie, Qi Yang, Xiangjun Guo
Summary: The expression of FBXW7 is decreased in oral squamous cell carcinoma (OSCC) tissues and has diagnostic value. Overexpression of FBXW7 inhibits OSCC cell proliferation and promotes autophagy. Similar results are observed in a mouse model.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Jun Liang, Jingang Liu, Zhaoming Deng, Zhigang Liu, Lizhong Liang
Summary: DLX6 is overexpressed in oral cancer tissues and is associated with advanced tumor stage and poor prognosis. DLX6 promotes proliferation and inhibits cell apoptosis in oral cancer cells. The EGFR-CCND1 pathway may be a potential mechanism involved in the regulatory axis.
Article
Oncology
Zixian Huang, Xi Rui, Chen Yi, Yongju Chen, Rui Chen, Yancan Liang, Yan Wang, Weicheng Yao, Xiaoding Xu, Zhiquan Huang
Summary: This study identified LCN2 as a potential target for the treatment of OSCC. Inhibition of LCN2 expression effectively inhibited OSCC proliferation and metastasis by inhibiting EGFR phosphorylation and downstream signaling activation. LCN2 enhances the recycling of EGFR, activating the EGFR-MEK-ERK cascade. Inhibition of LCN2 significantly inhibited EGFR activation, leading to significant inhibition of tumor growth and metastasis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Review
Oncology
Anna Myriam Perrone, Gloria Ravegnini, Stefano Miglietta, Lisa Argnani, Martina Ferioli, Eugenia De Crescenzo, Marco Tesei, Marco Di Stanislao, Giulia Girolimetti, Giuseppe Gasparre, Anna Maria Porcelli, Francesca De Terlizzi, Claudio Zamagni, Alessio Giuseppe Morganti, Pierandrea De Iaco
Summary: Electrochemotherapy (ECT) is an emerging treatment for solid tumors that involves maximizing the action of specific cytotoxic drugs through the tumor-directed delivery of non-ablative electrical pulses. Despite mainly being recommended for palliative care, ECT has the potential to improve patient outcomes by preventing or delaying tumor progression. Additionally, the efficacy of different drugs in ECT, such as cisplatin and bleomycin, should be compared through systematic literature reviews to explore the possibilities of overcoming chemoresistance and improving local control.
Article
Oncology
Anna Myriam Perrone, Martina Ferioli, Lisa Argnani, Francesca De Terlizzi, Cecilia Pirovano, Piero Covarelli, Giulia Dondi, Marco Tesei, Eugenia De Crescenzo, Gloria Ravegnini, Andrea Galuppi, Alessio G. Morganti, Pierandrea De Iaco
Summary: A multicenter prospective observational study found that palliative electrochemotherapy (ECT) can improve quality of life in patients with vulvar cancer (VC), with better results in patients with good clinical response, smaller lesions, and lesions located in the anterior part.
Article
Cell Biology
Irene Soffritti, Maria D'Accolti, Gloria Ravegnini, Maria-Cristina Arcangeletti, Clara Maccari, Flora De Conto, Adriana Calderaro, Elisabetta Caselli
Summary: Viral infections, particularly by HCMV and HHV-6, may play a role in the onset and progression of systemic sclerosis by modulating miRNA expression and causing cell fibrosis, potentially serving as biomarkers for SSc diagnosis, assessment of disease progression, and antifibrotic therapies.
Review
Medicine, General & Internal
Antonio De Leo, Donatella Santini, Claudio Ceccarelli, Giacomo Santandrea, Andrea Palicelli, Giorgia Acquaviva, Federico Chiarucci, Francesca Rosini, Gloria Ravegnini, Annalisa Pession, Daniela Turchetti, Claudio Zamagni, Anna Myriam Perrone, Pierandrea De Iaco, Giovanni Tallini, Dario de Biase
Summary: Ovarian carcinomas are a heterogeneous group of neoplasms with different types and characteristics. The WHO classifies them into five distinct types, each with unique molecular features. Advances in molecular pathology have improved our understanding of ovarian carcinomas and can guide personalized clinical decisions.
Review
Endocrinology & Metabolism
Cecilia Catellani, Gloria Ravegnini, Chiara Sartori, Sabrina Angelini, Maria E. Street
Summary: Growth hormone and the insulin-like growth factor system play crucial roles in cell proliferation, differentiation, apoptosis, and angiogenesis, while miRNAs and lncRNAs regulate gene expression and have been linked to diseases such as cancer.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
Federica D'Amico, Anna Myriam Perrone, Simone Rampelli, Sara Coluccelli, Monica Barone, Gloria Ravegnini, Marco Fabbrini, Patrizia Brigidi, Pierandrea De Iaco, Silvia Turroni
Summary: This pilot study on the trajectory of gut microbiota in patients with epithelial ovarian cancer undergoing chemotherapy found distinct changes in the microbiota of platinum-resistant patients, potentially linked to therapeutic failure. In contrast, platinum-sensitive patients showed more diverse and stable microbiota, which may be beneficial for treatment.
Review
Oncology
Gloria Ravegnini, Francesca Gorini, Eugenia De Crescenzo, Antonio De Leo, Dario De Biase, Marco Di Stanislao, Patrizia Hrelia, Sabrina Angelini, Pierandrea De Iaco, Anna Myriam Perrone
Summary: Endometrial cancer is the most common gynecological cancer with challenging diagnostic and prognostic features. miRNAs play an important role in EC but there is currently lack of consensus in studies. Future research needs to explore more diagnostic and prognostic biomarkers and address the challenges in the current classification schemes.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Review
Oncology
Giulia Dondi, Eleonora Porcu, Alessandra De Palma, Giuseppe Damiano, Eugenia De Crescenzo, Linda Cipriani, Maria Dirodi, Gloria Ravegnini, Antonio De Leo, Margherita Nannini, Martina Ferioli, Alessio G. Morganti, Maria Abbondanza Pantaleo, Pierandrea De Iaco, Anna Myriam Perrone
Summary: Uterine sarcomas, rare cancers sometimes diagnosed in women of childbearing age, may be treated using fertility-sparing treatments in selected early stage cases. The outcomes of such treatments are influenced by the histology of the tumor, with leiomyosarcoma showing the worst prognosis and highest death rate among the subtypes mentioned in the systematic review.
Article
Oncology
Gloria Ravegnini, Antonio De Leo, Camelia Coada, Francesca Gorini, Dario de Biase, Claudio Ceccarelli, Giulia Dondi, Marco Tesei, Eugenia De Crescenzo, Donatella Santini, Angelo Gianluca Corradini, Giovanni Tallini, Patrizia Hrelia, Pierandrea De Iaco, Sabrina Angelini, Anna Myriam Perrone
Summary: The study found that miR-499a-3p and miR-499a-5p were overexpressed in CTNNB1 mutant EC patients, while NSMP patients with low miR-499a-5p expression had longer overall survival. Combining CTNNB1 status and miR-499a-5p levels allows better stratification of NSMP patients and may promote personalized treatment in intermediate-risk patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Maria A. Pantaleo, Milena Urbini, Angela Schipani, Margherita Nannini, Valentina Indio, Antonio De Leo, Bruno Vincenzi, Antonella Brunello, Giovanni Grignani, Mariaelena Casagrande, Elena Fumagalli, Elena Conca, Maristella Saponara, Elisa Gruppioni, Annalisa Altimari, Dario De Biase, Giovanni Tallini, Gloria Ravegnini, Daniela Turchetti, Marco Seri, Andrea Ardizzoni, Paola Secchiero, Annalisa Astolfi
Summary: Germline SDHA variants are highly prevalent in SDHA-deficient GIST, and the disease may occur in older adults as well. Genetic testing and surveillance should be conducted for SDHA mutation carriers and their relatives.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Camelia Alexandra Coada, Giulia Dondi, Gloria Ravegnini, Antonio De Leo, Donatella Santini, Eugenia De Crescenzo, Marco Tesei, Alessandro Bovicelli, Susanna Giunchi, Ada Dormi, Marco Di Stanislao, Alessio G. Morganti, Dario De Biase, Pierandrea De Iaco, Anna Myriam Perrone
Summary: Endometrial cancer is the most common gynecological malignancy. Risk stratification should be based on the integration of histologic, clinical, and molecular parameters.
Article
Biochemistry & Molecular Biology
Gloria Ravegnini, Margherita Nannini, Valentina Indio, Cesar Serrano, Francesca Gorini, Annalisa Astolfi, Aldo Di Vito, Fabiana Morroni, Maria Abbondanza Pantaleo, Patrizia Hrelia, Sabrina Angelini
Summary: GISTs with PDGFRA D842V mutation show differential miRNA expression compared to non-D842V mutated GISTs. Differentially expressed miRNAs mainly target genes involved in the immune response pathways. Additionally, the miRNA-mRNA network reveals the indolent behavior of D842V mutated GISTs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Health Care Sciences & Services
Martina Ruscelli, Thais Maloberti, Angelo Gianluca Corradini, Francesca Rosini, Giulia Querzoli, Marco Grillini, Annalisa Altimari, Elisa Gruppioni, Viviana Sanza, Alessia Costantino, Riccardo Ciudino, Matteo Errani, Alessia Papapietro, Sara Coluccelli, Daniela Turchetti, Martina Ferioli, Susanna Giunchi, Giulia Dondi, Marco Tesei, Gloria Ravegnini, Francesca Abbati, Daniela Rubino, Claudio Zamagni, Emanuela D'Angelo, Pierandrea De Iaco, Donatella Santini, Claudio Ceccarelli, Anna Myriam Perrone, Giovanni Tallini, Dario de Biase, Antonio De Leo
Summary: This study aims to evaluate the impact of integrated molecular and pathologic risk stratification in the clinical practice of endometrial carcinoma (EC). It found that molecular classes and risk groups were correlated with disease-free survival. The study supports the prognostic importance of EC molecular classification and the essential role of histopathologic assessment in patients' management.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Oncology
Camelia Alexandra Coada, Miriam Santoro, Vladislav Zybin, Marco Di Stanislao, Giulia Paolani, Cecilia Modolon, Stella Di Costanzo, Lucia Genovesi, Marco Tesei, Antonio De Leo, Gloria Ravegnini, Dario De Biase, Alessio Giuseppe Morganti, Luigi Lovato, Pierandrea De Iaco, Lidia Strigari, Anna Myriam Perrone
Summary: This study investigated the potential of radiomic features extracted from pre-surgical CT scans to predict disease-free survival (DFS) in endometrial cancer (EC) patients. Machine learning models achieved high sensitivities and specificities in both training and test sets, showing promise for predicting EC recurrence.
Review
Oncology
Federica Medici, Stefania Rizzo, Milly Buwenge, Alessandra Arcelli, Martina Ferioli, Gabriella Macchia, Francesco Deodato, Savino Cilla, Pierandrea De Iaco, Anna Myriam Perrone, Silvia Strolin, Lidia Strigari, Gloria Ravegnini, Alberto Bazzocchi, Alessio G. Morganti
Summary: Sarcopenia is a syndrome characterized by age-related loss of skeletal muscle mass and function, worsens radiation-induced toxicity and prognosis, and has a negative impact on the quality of life. Myosteatosis, a pathological infiltration of muscle tissue by adipose tissue, is correlated with prognosis in cancer patients. Sarcopenic obesity, characterized by large fat mass, is independently associated with higher mortality and worse complications compared to sarcopenia alone. Assessment of sarcopenia is commonly done using CT images. Several studies have shown the negative impact of sarcopenia on overall survival in patients undergoing radiation therapy for various tumors. Further research is needed to find ways to prevent and manage sarcopenia during and after radiation therapy in both adult and pediatric patients.