Article
Oncology
Olivia K. Provance, Eric S. Geanes, Asona J. Lui, Anuradha Roy, Sean M. Holloran, Sumedha Gunewardena, Christy R. Hagan, Scott Weir, Joan Lewis-Wambi
Summary: Overexpression of IFITM1 in TNBC promotes tumor progression, but targeting IFITM1 can inhibit cell proliferation and invasion through the NF-kappa B signaling pathway. Parthenolide, identified as an NF kappa B inhibitor, shows potential as a cytotoxic agent for TNBC treatment.
Article
Biochemistry & Molecular Biology
Yue Yang, Yuanyuan Lu, Chunhua Zhang, Qianqian Guo, Wenzhou Zhang, Ting Wang, Zhuolu Xia, Jing Liu, Xiangyu Cheng, Tao Xi, Feng Jiang, Lufeng Zheng
Summary: In this study, three compounds CPUL119, CPUL129, and CPUL149 were identified to inhibit the stemness of breast cancer cells by triggering ferroptosis.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Brock Humphries, Zhishan Wang, Chengfeng Yang
Summary: Recent advances in understanding breast cancer have highlighted the key role of CSCs in progression and recurrence, with miRNAs playing a crucial role in regulating CSC characteristics. MiRNAs have the potential to serve as biomarkers and clinical therapeutics for breast cancer by targeting signaling pathways associated with CSCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Nadia Flores-Huerta, Macrina B. Silva-Cazares, Lourdes A. Arriaga-Pizano, Jessica L. Prieto-Chavez, Cesar Lopez-Camarillo
Summary: Breast cancer stem cells (bCSC), as a small subset of tumor cells with self-renewal properties and tumorigenic characteristics, play a key role in the development of breast cancer. Studies have shown that non-coding RNAs such as lncRNAs and miRNAs play important roles in regulating the stemness of bCSC.
Article
Biochemistry & Molecular Biology
Hai Liu, Hai Qin, Yi Zhou, Yin Yuan, Yichen Liu, Ying Chen, Yue Yang, Haiwei Ni, Tao Xi, Lufeng Zheng
Summary: HET0016 can attenuate the stemness of breast cancer cells by targeting CYP4Z1, reducing the expression of CSC markers and stem cell functions, as well as suppressing tumor-initiating and metastatic abilities.
MOLECULAR CARCINOGENESIS
(2021)
Article
Biochemistry & Molecular Biology
Yiqiu Liu, Chengjun Zhu, Lin Tang, Qin Chen, Nan Guan, Kun Xu, Xiaoxiang Guan
Summary: Our study using multiple databases found that MYC expression varies in different subtypes of breast cancer, particularly in TNBC. As a transcription factor, MYC not only participates in rewiring cancer signaling pathways like estrogen, WNT, NOTCH, but also interacts with cancer stem cells. This suggests that MYC plays an important role in breast cancer development and its amplification can serve as a predictor of diagnosis and prognosis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Rui Zhang, Mengxue Dong, Juchuanli Tu, Fengkai Li, Qiaodan Deng, Jiahui Xu, Xueyan He, Jiajun Ding, Jie Xia, Dandan Sheng, Zhaoxia Chang, Wei Ma, Haonan Dong, Yi Zhang, Lixing Zhang, Lu Zhang, Suling Liu
Summary: Our previous studies have shown that CCL20 contributes to tumor progression and chemoresistance by regulating breast cancer stem cell self-renewal. This study demonstrates that CCL20 also affects breast cancer progression by remodeling the tumor microenvironment, particularly through the enrichment of PMN-MDSCs. The interaction between PMN-MDSCs and BCSCs in CCL20(high)-expressing breast cancer can be targeted for therapeutic intervention.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Medicine, Research & Experimental
Liantao Guo, Faminzi Li, Hanqing Liu, Deguang Kong, Chuang Chen, Shengrong Sun
Summary: Our study investigates the role and mechanism of SIX1 upregulation in breast cancer carcinogenesis. We found that SIX1 expression varies among different subtypes of breast cancer and that it upregulates breast cancer grading and lymph node metastasis. Additionally, SIX1 participates in the rewiring of several cancer signaling pathways and interacts with cancer stem cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Environmental Sciences
Hai Qin, Yi Zhou, Hai Liu, Yaqin Yuan, Qianqian Guo, Manqin Yuan, Tao Xi, Yujie Zhang
Summary: CYP4Z1 acts as a promoter of cancer stem cells, while 1-Benzy has the potential to suppress breast cancer stemness and metastasis by inhibiting CSC marker expression.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xinrui Zhao, Xinglong Liu, Songling Hu, Yan Pan, Jianghong Zhang, Guomei Tai, Chunlin Shao
Summary: Radiotherapy is a conventional treatment method for breast cancer, but radioresistance affects the prognosis negatively. This study found that the GDF15 gene is related to poor prognosis in breast cancer patients after radiotherapy. Breast cancer cells with acquired radioresistance showed high expression of GDF15 and enhanced properties of epithelial-to-mesenchymal transition (EMT) and stemness. Knockdown of GDF15 sensitized radioresistant cells to irradiation and inhibited their EMT and stemness properties. GDF15 may serve as a prognosis-related biomarker and a potential therapeutic target for breast cancer radiotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Su-Lim Kim, Hack Sun Choi, Dong-Sun Lee
Summary: The BRD4/nuclear PD-L1/RelB axis plays an essential role in breast CSC formation. Nuclear PD-L1 regulates RelB, and the RelB/p65 complex induces IL6 and breast CSC formation. Targeting nuclear PD-L1 represents a potential and novel tool for immunotherapies of intractable BC.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Multidisciplinary Sciences
Jiaqiang Dong, Jiong Li, Yang Li, Zhikun Ma, Yongxin Yu, Cun-Yu Wang
Summary: The study reveals that super-enhancers play a critical role in the transcription of cancer stemness genes and pro-metastatic genes, effectively inhibiting CSC self-renewal and eliminating CSCs, providing a potential therapy for HNSCC.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Fan Xu, Jiali Wang, Shuman Zhen, Yuqing Duan, Qingshan Li, Lihua Liu
Summary: The stemness characteristic of breast cancer is important for cancer recurrence and metastasis. This study found that C1ql4 is highly expressed in breast cancer tissues and cell lines, and its high expression is significantly correlated with malignancy. Mechanistically, C1ql4 promotes breast cancer cell stemness and EMT through the PI3K/AKT/NF-kB signaling pathway. Therefore, C1ql4 might be a potential target for breast cancer treatment.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Runtian Wang, Kun Xu, Qin Chen, Qin Hu, Jian Zhang, Xiaoxiang Guan
Summary: This study found a positive correlation between c-Myc and breast cancer stem cell (BCSC) phenotype, as well as a link between c-Myc and copper-induced cell toxicity. Transcriptomics data also showed that pro-tumoral cuproptosis biomarkers were enriched in MYC-targets and positively correlated with cancer stemness.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Xupeng Bai, Jie Ni, Julia Beretov, Shanping Wang, Xingli Dong, Peter Graham, Yong Li
Summary: The study shows that THOC2 and THOC5 are upregulated in radioresistant TNBC cells, promoting stem-like properties and radioresistance. Silencing THOC2 or THOC5 expression decreases protein expression of SOX2 and NANOG, depletes stem-like properties, and causes radiosensitization in TNBC cells. Depletion of THOC2 or THOC5 blocks xenograft tumorigenesis and growth of radioresistant TNBC in vivo, suggesting potential therapeutic strategies against relapsed TNBC.
Review
Oncology
Francesco Perri, Giuseppina Della Vittoria Scarpati, Monica Pontone, Maria Luisa Marciano, Alessandro Ottaiano, Marco Cascella, Francesco Sabbatino, Agostino Guida, Mariachiara Santorsola, Piera Maiolino, Ernesta Cavalcanti, Giulia Togo, Franco Ionna, Francesco Caponigro
Summary: Metabolic reprogramming is a common phenomenon in various solid tumors, including head and neck cancers. Analyzing the genetic and biological mechanisms of metabolic reprogramming in squamous cell carcinomas of the head and neck can provide potential therapeutic strategies to counteract it.
Article
Oncology
Sjoerd P. F. T. Nota, David O. Osei-Hwedieh, David L. L. Drum, Xinhui Wang, Francesco Sabbatino, Soldano Ferrone, Joseph H. Schwab
Summary: This study assessed the expression of CSPG4 in human chondrosarcoma and the effectiveness of CSPG4-specific CAR T cells in killing chondrosarcoma cells in vitro. The results showed medium to high expression of CSPG4 in conventional chondrosarcoma and demonstrated the effectiveness of CSPG4-targeted CAR T cells in killing CSPG4-positive chondrosarcoma tumors.
FRONTIERS IN ONCOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Federica Monaco, Sergio Coluccia, Arturo Cuomo, Davide Nocerino, Daniela Schiavo, Gilda Pasta, Francesca Bifulco, Pasquale Buonanno, Vittorio Riccio, Marianna Leonardi, Francesco Perri, Alessandro Ottaiano, Francesco Sabbatino, Alessandro Vittori, Marco Cascella
Summary: This bibliometric study analyzed the utilization of percutaneous electrical nerve stimulation (PENS) for pain treatment. The study found that while there is an increasing trend in the number of publications on this topic and the publication of articles in high impact factor journals, there is a need for stronger scientific collaborations between researchers and institutions from different countries.
APPLIED SCIENCES-BASEL
(2023)
Article
Medicine, General & Internal
Alessandro Ottaiano, Mariachiara Santorsola, Francesco Perri, Vincenza Granata, Marco Cascella, Francesco Sabbatino, Guglielmo Nasti
Summary: This study compared the different treatment sequences of TAS-102 first or regorafenib first in patients with metastatic colorectal cancer. The results showed a significant difference in overall survival, with a median survival of 4.5 months for the TR sequence and 3.0 months for the RT sequence.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Luigi Liguori, Giovanna Polcaro, Annunziata Nigro, Valeria Conti, Carmine Sellitto, Francesco Perri, Alessandro Ottaiano, Marco Cascella, Pio Zeppa, Alessandro Caputo, Stefano Pepe, Francesco Sabbatino
Summary: Advancement in sequencing technologies has led to the development of targeted therapies for cancer treatment. However, the long-term control of cancer progression remains challenging due to the development of resistance. Bispecific antibodies (bsAbs), which target multiple components involved in cancer pathways simultaneously, have emerged as a potential solution to overcome off-target resistance. This review provides an overview of the classification, design, mechanisms of action, and clinical evidence of bsAbs for the treatment of solid malignancies.
Article
Medicine, General & Internal
Alessandro Ottaiano, Mariachiara Santorsola, Luisa Circelli, Francesco Perri, Marco Cascella, Francesco Sabbatino, Maurizio Capuozzo, Vincenza Granata, Silvia Zappavigna, Angela Lombardi, Marianna Scrima, Nadia Petrillo, Monica Ianniello, Marika Casillo, Oreste Gualillo, Guglielmo Nasti, Michele Caraglia, Giovanni Savarese
Summary: This study examines the impact of hypertension, type 2 diabetes, weight, and p53 mutations on the prognosis of metastatic colorectal cancer patients. Patients were diagnosed with type 2 diabetes according to ADA criteria and classified hypertension based on ACC/AHA guidelines. Overall survival analysis showed that diabetic patients had lower disease control rates and that the concurrent presence of type 2 diabetes, BMI, and hypertension was an independent prognostic factor. P53 mutations were found to be associated with BMI and had a negative impact on prognosis, suggesting a complex relationship between metabolism and cancer occurrence.
FRONTIERS IN MEDICINE
(2023)
Review
Oncology
Francesco Perri, Francesco Sabbatino, Alessandro Ottaiano, Roberta Fusco, Michele Caraglia, Marco Cascella, Francesco Longo, Rosalia Anna Rega, Giovanni Salzano, Monica Pontone, Maria Luisa Marciano, Arianna Piccirillo, Massimo Montano, Morena Fasano, Fortunato Ciardiello, Giuseppina Della Vittoria Scarpati, Franco Ionna
Summary: Epstein Barr virus (EBV) is implicated in the development of both solid and hematologic malignancies, particularly nasopharyngeal carcinomas (NPCs). Viral proteins produced during the latent phase of EBV in epithelial cells can induce or promote carcinogenesis and can be targeted by immunotherapy strategies. The use of check-point inhibitors has shown promising results in treating EBV-associated carcinomas.
Review
Oncology
Alessandro Ottaiano, Mariachiara Santorsola, Luisa Circelli, Anna Maria Trotta, Francesco Izzo, Francesco Perri, Marco Cascella, Francesco Sabbatino, Vincenza Granata, Marco Correra, Luca Tarotto, Salvatore Stilo, Francesco Fiore, Nicola Martucci, Antonello La Rocca, Carmine Picone, Paolo Muto, Valentina Borzillo, Andrea Belli, Renato Patrone, Edoardo Mercadante, Fabiana Tatangelo, Gerardo Ferrara, Annabella Di Mauro, Giosue Scognamiglio, Massimiliano Berretta, Maurizio Capuozzo, Angela Lombardi, Jerome Galon, Oreste Gualillo, Ugo Pace, Paolo Delrio, Giovanni Savarese, Stefania Scala, Guglielmo Nasti, Michele Caraglia
Summary: Oligometastatic disease is a condition in which cancer spreads to only a few distant sites, and it is associated with a more favorable prognosis compared to polymetastatic disease. Recent studies have identified specific molecular and genetic features that underlie the oligometastatic phenotype, suggesting the potential for personalized therapies. This scoping review highlights new clinical, biological, and methodological challenges in understanding and treating oligometastatic disease.
Review
Health Care Sciences & Services
Valeria Conti, Graziamaria Corbi, Francesco Sabbatino, Domenico De Pascale, Carmine Sellitto, Berenice Stefanelli, Nicola Bertini, Matteo De Simone, Luigi Liguori, Ilenia Di Paola, Maddalena De Bernardo, Angela Tesse, Nicola Rosa, Pasquale Pagliano, Amelia Filippelli
Summary: Long COVID or post-COVID-19 syndrome (PCS) refers to the development of persistent symptoms and/or complications in patients diagnosed with COVID-19. The pathogenesis and course of this syndrome are influenced by factors such as age, sex/gender, and pre-existing conditions. The lack of precise diagnostic and prognostic biomarkers complicates the clinical management of patients. This review aims to summarize recent evidence on the factors influencing PCS, possible biomarkers, and therapeutic approaches.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Oncology
Alessandro Ottaiano, Mariachiara Santorsola, Luisa Circelli, Monica Ianniello, Marika Casillo, Nadia Petrillo, Francesco Sabbatino, Marco Cascella, Francesco Perri, Maurizio Capuozzo, Vittorio Albino, Vincenza Granata, Francesco Izzo, Annabella Di Mauro, Massimiliano Berretta, Raffaella Ruggiero, Oreste Gualillo, Roberto Sirica, Guglielmo Nasti, Giovanni Savarese
Article
Medicine, General & Internal
Francesco Sabbatino, Pasquale Pagliano, Carmine Sellitto, Berenice Stefanelli, Graziamaria Corbi, Valentina Manzo, Emanuela De Bellis, Luigi Liguori, Francesco Antonio Salzano, Stefano Pepe, Amelia Filippelli, Valeria Conti
Summary: This study investigates the potential of sPD-L1 as a prognostic biomarker for COVID-19. The results suggest that sPD-L1 promotes immune escape in the early phase of COVID-19, but may act to dampen excessive immune responses later. Additionally, there is a correlation between lymphocyte number and length of stay and inflammatory markers.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Alessandro Ottaiano, Francesco Sabbatino, Francesco Perri, Marco Cascella, Roberto Sirica, Renato Patrone, Maurizio Capuozzo, Giovanni Savarese, Monica Ianniello, Nadia Petrillo, Luisa Circelli, Vincenza Granata, Massimiliano Berretta, Mariachiara Santorsola, Guglielmo Nasti
Summary: This review discusses the prognostic significance of the KRAS p.G12C mutation in metastatic colorectal cancer and highlights its potential as a promising therapeutic target. The aim is to increase awareness of the factors that can influence the clinical, prognostic, and therapeutic implications associated with distinct mutations within the same protein.
Article
Biochemistry & Molecular Biology
Luigi Liguori, Angelo Luciano, Giovanna Polcaro, Alessandro Ottaiano, Marco Cascella, Francesco Perri, Stefano Pepe, Francesco Sabbatino
Summary: In patients with metastatic renal cell carcinoma, prior treatment with anti-angiogenic tyrosine kinase inhibitors (TKIs) significantly increases the risk of immune checkpoint inhibitor (ICI)-mediated recurrent thyroid disorder adverse events (TDAEs) without modifying their clinical characteristics.
Review
Biology
Alessandro Ottaiano, Monica Ianniello, Mariachiara Santorsola, Raffaella Ruggiero, Roberto Sirica, Francesco Sabbatino, Francesco Perri, Marco Cascella, Massimiliano Di Marzo, Massimiliano Berretta, Michele Caraglia, Guglielmo Nasti, Giovanni Savarese
Summary: Cancer is a complex disease characterized by aberrant cellular behaviors and genetic variances, leading to tumor heterogeneity. This heterogeneity poses challenges in cancer prognosis and treatment, and understanding and quantifying it is crucial. This review emphasizes the significance of comprehending tumor heterogeneity to raise awareness about this elusive characteristic of cancer.
Article
Biochemistry & Molecular Biology
Nian Jiang, Bowen Xie, Ming Fan, Jian Jian Li
Summary: Although the major cellular energy driving tumor metastasis after anti-cancer radiotherapy is unknown, accumulating evidence suggests that cancer cells can reactivate mitochondrial oxidative respiration to meet the increased cellular fuel demand for repairing and surviving anti-cancer radiation. This dynamic metabolic rewiring may play a key role in cancer therapy resistance and metastasis.