Article
Oncology
Xueliang Gao, Yubao Wang, Caroline F. Ribeiro, Cherubin Manokaran, Hyeyoun Chang, Thanh Von, Silvia Rodrigues, Onur Cizmecioglu, Shidong Jia, Manav Korpal, Joshua M. Korn, Zhigang Wang, Fabienne Schmit, Lan Jiang, Raymond Pagliarini, Yi Yang, Isha Sethi, Sabina Signoretti, Guo-Cheng Yuan, Massimo Loda, Jean J. Zhao, Thomas M. Roberts
Summary: Research findings suggest that blocking p110 beta can slow down the progression of castration-resistant prostate cancer and reduce tumor growth. Combining p110 beta with other inhibitors shows potential for treating CRPC.
MOLECULAR CANCER RESEARCH
(2022)
Article
Oncology
Debashis Sarker, Nancy A. Dawson, Ana M. Aparicio, Tanya B. Dorff, Allan J. Pantuck, Ulka N. Vaishampayan, Lynn Henson, Lakshmi Vasist, Sumita Roy-Ghanta, Michele Gorczyca, Whitney York, Gopinath Ganji, Jerry Tolson, Johann S. de Bono
Summary: The study investigated the combination of enzalutamide and the PI3K beta inhibitor GSK2636771 in patients with PTEN-deficient mCRPC. Results demonstrated acceptable safety and tolerability of the drug combination, but limited antitumor activity was observed.
CLINICAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Jingyuan Li, Jianyu Wang, Dan Xie, Qin Pei, Xue Wan, H. Rosie Xing, Ting Ye
Summary: This study established a clinically relevant model for recognizing lung cancer stem cells and investigated the roles of PI3K/AKT and MAPK/ERK pathways in lung cancer through bioinformatic analysis. Experimentally, it was confirmed that the PI3K/AKT pathway promotes proliferation in lung adenocarcinoma cells, while the MAPK/ERK pathway regulates the proliferation of lung cancer stem cells. These findings highlight the distinct and synergistic roles of oncogenic signaling pathways and stem cell signaling pathways in regulating lung cancer stem cell self-renewal.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Oncology
Xiang-Yu Meng, Hui-Zhi Zhang, Yi-Yue Ren, Ke-Jie Wang, Jun-Feng Chen, Rui Su, Jun-Hui Jiang, Ping Wang, Qi Ma
Summary: PNN was found to be upregulated in prostate cancer tissues and play a crucial role in promoting cell growth, invasion, and migration through the activation of CREB. The effects of PNN on prostate cancer cells were mediated by the PI3K/AKT and ERK/MAPK pathways, indicating that PNN could be a potential therapeutic target for prostate cancer treatment.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Zhizhu Zhang, Ann Richmond, Chi Yan
Summary: Hyperactivation of PI3K/AKT/mTOR and MAPK/MEK/ERK signaling pathways is common in various cancers, and targeting these pathways may enhance the response to immune checkpoint inhibitors (ICIs) as a strategy to overcome resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Vincenza Conteduca, Alessandra Mosca, Nicole Brighi, Ugo de Giorgi, Pasquale Rescigno
Summary: Prostate cancer is a common cancer in men and patients may develop metastatic disease after radical treatments. Prognostic biomarkers are urgently needed to define patients' risk of cancer-related death.
Article
Biochemistry & Molecular Biology
Polash Kumar Biswas, Yeonjoo Kwak, Aram Kim, Jaekwon Seok, Hee Jeong Kwak, Moonjung Lee, Ahmed Abdal Dayem, Kwonwoo Song, Jae-Yong Park, Kyoung Sik Park, Hyun Jin Shin, Ssang-Goo Cho
Summary: This study investigated the role of TTYH3 in bladder cancer and found that high expression of TTYH3 was associated with poor prognosis in bladder cancer patients. Knockdown of TTYH3 in bladder cancer cells resulted in significantly reduced cell proliferation, sphere formation, migration, and invasion, possibly through the downregulation of FGFR1 phosphorylation and subsequent inhibition of the H-Ras/A-Raf/MEK/ERK signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Wang Chen, Linjie Zhu, Long Wang, Jing Zeng, Min Wen, Xiyan Xu, LiLe Zou, Feihong Huang, Qianqian Huang, Dalian Qin, Qibing Mei, Jing Yang, Qiaozhi Wang, Jianming Wu
Summary: This study found that the aqueous extracts of Cibotii rhizoma (AECRs) can promote megakaryopoiesis and thrombopoiesis through activating the PI3K/AKT, MEK/ERK, and JAK2/STAT3 signaling pathways, which has the potential to treat radiation-induced thrombocytopenia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Claudia Mosillo, Maria Letizia Calandrella, Claudia Caserta, Serena Macrini, Annalisa Guida, Grazia Sirgiovanni, Sergio Bracarda
Summary: This review summarizes and discusses new therapeutic approaches for metastatic castration-resistant prostate cancer, including the prognostic and predictive role of molecular alterations, investigation techniques, and potential clinical implications. Despite the approval of several drugs, metastatic castration-resistant prostate cancer remains a lethal disease.
Article
Oncology
Edmond M. Kwan, Chao Dai, Heidi Fettke, Christine Hauser, Maria M. Docanto, Patricia Bukczynska, Nicole Ng, Siavash Foroughi, Lisa-Jane K. Graham, Kate Mahon, Winston Tan, Xiaohong Wang, Zhixin Zhao, Tiantian Zheng, Kemin Zhou, Jianjun Yu, Pan Du, Lisa G. Horvath, Shidong Jia, Manish Kohli, Arun A. Azad
Summary: CNVs in the PTEN-PI3K-AKT pathway were readily detected using a novel cfDNA assay in mCRPC patients, with high prevalence of PTEN loss and PIK3CA gain. Additional PTEN-PI3K-AKT pathway aberrations were found in one fifth of PTEN-neutral cases, and concurrent CNVs in the PTEN-PI3K-AKT and AR pathways predicted poor survival outcomes, suggesting potential benefits of dual AR/Akt inhibition in precision treatment for mCRPC.
JCO PRECISION ONCOLOGY
(2021)
Article
Oncology
Xun Shangguan, Zehua Ma, Minghao Yu, Jie Ding, Wei Xue, Jun Qi
Summary: This study reveals a dependence on SQLE-mediated cholesterol metabolism in castration-resistant prostate cancer with PTEN and p53 deficiency, providing insights for new therapeutic strategies.
Article
Cell Biology
Zhen-Yuan Zheng, Man-Yu Chu, Wan Lin, Ya-Qi Zheng, Xiu-E Xu, Yang Chen, Lian-Di Liao, Zhi-Yong Wu, Shao-Hong Wang, En-Min Li, Li-Yan Xu
Summary: In esophageal squamous cell carcinoma (ESCC), the MAPK signaling pathway is highly activated and associated with poor prognosis. Inhibiting MAPK leads to rapid activation of the STAT3 pathway. Combination therapy targeting both MAPK and STAT3 may be an effective strategy for ESCC treatment.
CELL DEATH & DISEASE
(2022)
Article
Genetics & Heredity
Fan Bao, Su An, Yang Yang, Tian-Rui Xu
Summary: SODD is overexpressed in lung tissues and promotes the development and progression of lung cancer by regulating the PI3K/PDK1/AKT and RAF/MEK/ERK signaling pathways.
Article
Biochemistry & Molecular Biology
Sumit Siddharth, Panjamurthy Kuppusamy, Qitong Wu, Arumugam Nagalingam, Neeraj K. Saxena, Dipali Sharma
Summary: Hepatocellular carcinoma (HCC) is a malignant tumor with increasing incidence and mortality rates, and there is a lack of effective therapeutic options for advanced HCC. This study found that the combination of low-dose sorafenib and non-toxic dose of metformin can effectively inhibit the growth and migration potential of HCC cells, enhance the efficacy of sorafenib, and inhibit the MAPK/ERK/Stat3 signaling pathway. The results of in vivo studies also supported these findings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Sara J. Hamis, Yury Kapelyukh, Aileen McLaren, Colin J. Henderson, C. Roland Wolf, Mark A. J. Chaplain
Summary: The study developed a mechanistic mathematical model to describe the synergistic action of dabrafenib and trametinib on ERK activity in BRAFV600E-mutant melanoma cells, elucidating the molecular mechanism underlying vertical inhibition of the BRAF-MEK-ERK cascade.
BRITISH JOURNAL OF CANCER
(2021)
Article
Oncology
Matthew Ramotar, Melvin L. K. Chua, Hong Truong, Ali Hosni, Melania Pintilie, Elai Davicioni, Neil E. Fleshner, Adam P. Dicker, Robert G. Bristow, Hansen H. He, Theo van der Kwast, Robert B. Den, Alejandro Berlin
Summary: The presence of intraductal carcinoma and cribriform architecture, along with the Decipher genomic classifier, have prognostic value in post-prostatectomy radiotherapy for prostate cancer patients. Patients with IDC/CA have a higher risk of relapse, while GC scores can predict biochemical relapse and metastasis rates.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2022)
Meeting Abstract
Oncology
Jen Hoogenes, Rodney H. Breau, Bimal Bhindi, Ricardo A. Rendon, Simon Tanguay, Antonio Finelli, Alan So, Luke Lavallee, Frederic Pouliot, Jean-Baptiste Lattouf, Lucas W. Dean, Darrel E. Drachenberg, Lori Wood, Naveen S. Basappa, Daniel Yick, Chin Heng, Aaron Richard Hansen, Denis Soulieres, Georg A. Bjarnason, Ranjeeta Mallick, Anil Kapoor
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Luke Lavallee, Chris Morash, Fred Saad, Steven Yip, Anil Kapoor, Michael Paul Kolinsky, Frederic Pouliot, Elie Antebi, Darrel Drachenberg, Cristiano Ferrario, Geoffrey Gotto, Robert James Hamilton, Jenny J. Ko, Krista Noonan, Alan So, Shawn Malone, Anousheh Zardan, Kim N. Chi, Sebastien J. Hotte, Tamim Niazi
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Aly-Khan A. Lalani, Anand Swaminath, Gregory Russell Pond, Scott Carlyle Morgan, Arun Azad, William Chu, Eric Winquist, Anil Kapoor, Michael Bonert, Jonathan L. Bramson, Michael G. Surette, Christina M. Canil, Shankar Siva, Georg A. Bjarnason, Mark Norman Levine, Jim Wright, Sebastien J. Hotte
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Matthew Scott Ernst, Vishal Navani, J. Connor Wells, Frede Donskov, Naveen S. Basappa, Chris Labaki, Sumanta K. Pal, Luis A. Meza, Lori Wood, D. Scott Ernst, Bernadett Szabados, Rana R. Mckay, Francis Parnis, Cristina Suarez, Takeshi Yuasa, Anil Kapoor, Ajjai Shivaram Alva, Georg A. Bjarnason, Toni K. Choueiri, Daniel Yick Chin Heng
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Austin Kalirai, Isaiah Joy, Sunita Ghosh, Christian K. Kollmannsberger, Aaron Richard Hansen, Myuran Thana, Jeffrey Graham, Daniel Yick Chin Heng, Vincent Castonguay, Georg A. Bjarnason, Rodney H. Breau, Anil Kapoor, Frederic Pouliot, Lori Wood, Naveen S. Basappa
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Xiaozeng Lin, Yan Gu, Yingying Su, Ying Dong, Pierre Major, Anil Kapoor, Damu Tang
Summary: This study discovered four novel multigene sets that can accurately predict the relapse and fatality risk of adrenocortical carcinoma (ACC). These sets are associated with critical ACC factors and mesenchymal stem cells, advancing our understanding of ACC and providing potential improvements in ACC management.
Article
Medicine, General & Internal
Vishal Navani, Matthew Ernst, J. Connor Wells, Takeshi Yuasa, Kosuke Takemura, Frede Donskov, Naveen S. Basappa, Andrew Schmidt, Sumanta K. Pal, Luis Meza, Lori A. Wood, D. Scott Ernst, Bernadett Szabados, Thomas Powles, Rana R. McKay, Andrew Weickhardt, Cristina Suarez, Anil Kapoor, Jae Lyun Lee, Toni K. Choueiri, Daniel Y. C. Heng
Summary: This study found that treatment with IOVE therapy was associated with a significantly increased likelihood of objective imaging response compared to IOIO therapy. The presence of lung metastases, receipt of cytoreductive nephrectomy, and favorable IMDC risk were associated with an increased likelihood of experiencing objective imaging response.
Article
Public, Environmental & Occupational Health
Cristina Cano Garcia, Nancy Nimer, Mattia Luca Piccinelli, Stefano Tappero, Andrea Panunzio, Francesco Barletta, Reha-Baris Incesu, Zhe Tian, Fred Saad, Anil Kapoor, Alberto Briganti, Carlo Terrone, Shahrokh F. Shariat, Derya Tilki, Alessandro Antonelli, Ottavio De Cobelli, Luis A. Kluth, Andreas Becker, Felix K. H. Chun, Pierre I. Karakiewicz
Summary: The purpose of this study was to compare the five-year overall survival (OS) between clear cell metastatic renal cell carcinoma (ccmRCC) patients and age-and sex-matched population-based controls, with a focus on race/ethnicity. Using the Surveillance, Epidemiology and End Results database, ccmRCC patients of different racial/ethnic backgrounds were identified. The study found that African Americans had the greatest OS difference compared to the controls, followed by Hispanics, Caucasians, and Asians/Pacific Islanders. Multivariable Cox regression analysis showed that African Americans had the highest hazard ratio for death.
ANNALS OF EPIDEMIOLOGY
(2023)
Article
Oncology
Xiaozeng Lin, Ying Dong, Yan Gu, Anil Kapoor, Jingyi Peng, Yingying Su, Fengxiang Wei, Yanjun Wang, Chengzhi Yang, Armaan Gill, Sandra Vega Neira, Damu Tang
Summary: Breast cancer is the leading cause of cancer deaths in women and there is a need for improvement in risk estimation and effective therapies. In our research, we found that taxifolin inhibits breast cancer by increasing the expression of 36 genes. These genes effectively predict death probability in breast cancer patients, and aggressive breast cancers are associated with increases in the 1q21.3 DNA region. Taxifolin can induce the expression of tumor suppressor genes in this region, providing a novel mechanism for suppressing breast cancer. This study advances our understanding of breast cancer risk estimation and treatment.
Article
Medicine, General & Internal
Amanjot Sidhu, Nabeeha Khan, Cameron Phillips, Juan Briones, Anil Kapoor, Pawel Zalewski, Neil E. Fleshner, Edward Chow, Urban Emmenegger
Summary: In this study, we found that approximately 20% of patients with metastatic castration-resistant prostate cancer (mCRPC) experience PSA flares induced by Ra223 treatment, and these flares are not closely associated with patient outcomes. Although only a few patients had PSA decreases greater than 30% after the flare, the overall survival was comparable to patients with PSA responses or non-responses.
JOURNAL OF CLINICAL MEDICINE
(2023)
Meeting Abstract
Oncology
M. J. Dubec, J. Gaffney, A. Datta, D. L. Buckley, R. Little, A. Clough, C. Hague, M. Berks, S. Cheung, A. Salah, C. L. Eccles, R. G. Bristow, D. Higgins, J. H. Naish, J. Matthews, M. van Herk, G. J. Parker, A. Choudhury, J. P. O'Connor, A. McPartlin
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
Harry C. Brastianos, Jure Murgic, Adriana Salcedo, Melvin L. K. Chua, Alice Meng, Michael Fraser, Michael Brundage, Neil E. Fleshner, Theodorus van der Kwast, Robert G. Bristow, Paul C. Boutros, Alejandro Berlin
Summary: We investigated the impact of tumor heterogeneity on the accuracy of DNA-based biomarkers in predicting early relapse after prostatectomy. We found that the biomarkers maintained their predictive accuracy, suggesting that spatial heterogeneity may not hinder biomarker performance.
EUROPEAN UROLOGY ONCOLOGY
(2022)
Meeting Abstract
Urology & Nephrology
A. Pecoraro, S. Knipper, C. Palumbo, G. Rosiello, S. Luzzago, M. Deuker, Z. Tian, S. F. Shariat, F. Saad, A. Briganti, A. Kapoor, S. De Cillis, A. Piana, F. Piramide, M. Sica, D. Amparore, E. Checcucci, M. Manfredi, C. Fiori, F. Porpiglia, P. Karakiewicz
Meeting Abstract
Urology & Nephrology
J. Chin, U. Metser, K. Zukotynski, V Mak, D. Langer, P. Maccrostie, A. Finelli, A. Kapoor, L. Lavallee, L. Klotz, M. Hagerty, C. Hildebrand, G. Bauman