Article
Pharmacology & Pharmacy
Heng Yang, Wanqi Lan, Wu Liu, Tingtao Chen, Yanhua Tang
Summary: Our study demonstrates that dapagliflozin significantly accelerates blood flow recovery and reduces limb necrosis in a mouse model of hindlimb ischemia. This effect is mediated through enhanced angiogenesis, reduced muscle fibrosis, and induction of macrophage phenotypic shift from M1 to M2 and decreased expression of inflammatory factors. Dapagliflozin may exert these effects partially through modulation of the NF-κB signaling pathway. Furthermore, dapagliflozin enhances endothelial cell proliferation, migration, and tube formation in vitro.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Cell Biology
Peinan Tu, Qian Xu, Xianming Zhou, Nicolas Villa-Roel, Sandeep Kumar, Nianguo Dong, Hanjoong Jo, Caiwen Ou, Zhiyong Lin
Summary: This study revealed the important role of cellular communication network factor 3 (CCN3) in the regulation of aortic valve calcification. Knockout of CCN3 in mice led to aggravated valve calcification and cardiac dysfunction. Further experiments showed that CCN3 regulates bone morphogenic protein 2 (BMP2) production and secretion in macrophages, which inhibits valvular calcification.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Oncology
Han Guan, Likai Mao, Jinfeng Wang, Sheng Wang, Shuai Yang, Hongliang Wu, Wenyan Sun, Zhijun Chen, Ming Chen
Summary: This study found that exosome-mediated RNF157 mRNA from prostate cancer cells promotes M2 polarization of macrophages by destabilizing HDAC1, thereby accelerating prostate cancer tumor progression.
FRONTIERS IN ONCOLOGY
(2022)
Article
Engineering, Biomedical
Lei Chen, Zhiyong Li, Yongtai Zheng, Fei Zhou, Jingling Zhao, Qiyi Zhai, Zhaoqiang Zhang, Tianrun Liu, Yongming Chen, Shaohai Qi
Summary: This study integrates porcine dermal extracellular matrix (dECM) into 3D-printed dermal analogues (PDA) to prevent scar contraction. The PDA with a micron-scale spatial structure exhibits excellent biocompatibility and is able to reduce scar contraction and improve cosmetic outcomes of split thickness skin grafts (STSG). It induces early neovascularization and a type-2-like immune response, suggesting its potential for clinical application in reducing scar contraction.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Hongtao Xu, Yanlun Zhu, Allen Wei-Ting Hsiao, Jiankun Xu, Wenxue Tong, Liang Chang, Xuerao Zhang, Yi-Fan Chen, Jie Li, Wei Chen, Yingze Zhang, Hon Fai Chan, Chien-Wei Lee
Summary: The use of MSC-EVs boosted with bioactive glasses (EVB) shows great potential in treating tendon injuries by promoting angiogenesis and enhancing anti-inflammatory responses of M2 macrophages. EVB can significantly improve the biomechanical properties and promote functional regeneration of the repaired tendon.
Article
Oncology
Hao Jiang, Wen Deng, Ke Zhu, Zhenhao Zeng, Bing Hu, Zhengtao Zhou, An Xie, Cheng Zhang, Bin Fu, Xiaochen Zhou, Gongxian Wang
Summary: The study revealed that LINC00467 was upregulated in prostate cancer, and its inhibition suppressed the growth, migration, and invasion of PC cells, leading to a suppression of tumor growth. Furthermore, LINC00467 was primarily localized in the cytoplasm, promoting prostate cancer progression through the miR-494-3p/STAT3 axis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Zhihui Wu, Juan Zhou, Fangwei Chen, Jing Yu, Hui Li, Qingfeng Li, Wencan Li
Summary: In this study, it was found that 13-methyl-palmatrubine (13MP) can suppress TAM-mediated NSCLC progression by transforming the polarization of TAMs from M2 to M1, as well as inhibit the proliferation, invasion, and angiogenesis of NSCLC cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Fang Yu, Tao Bai
Summary: This study revealed that Sevoflurane enhances macrophage M2 polarization and the metastatic potential of prostate cancer cells, resulting in increased lung metastasis. Mechanistically, Sevoflurane upregulates the expression of IL-6, which subsequently enhances HO-1 expression. In vivo experiments confirmed that Sevoflurane promotes macrophage M2 polarization and lung metastasis through the IL-6/HO-1 pathway. These findings highlight the importance of Sevoflurane in prostate cancer metastasis and suggest that the IL-6/HO-1 pathway could be a potential target for preventing lung metastasis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tur-Fu Huang, Shih-Wei Wang, Yu-Wei Lai, Shih-Chia Liu, Yu-Jen Chen, Thomas Y. Hsueh, Chih-Chung Lin, Chun-Hsuan Lin, Ching-Hu Chung
Summary: The compound 4-acetylantroquinonol B (4AAQB) has shown inhibitory effects on cancer growth and angiogenesis, making it a potential candidate for prostate cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Chih-Hsing Hung, Hua-Yu Hsu, Hsin-Ying Clair Chiou, Mei-Lan Tsai, Huey-Ling You, Yu-Chih Lin, Wei-Ting Liao, Yi-Ching Lin
Summary: Arsenic can promote macrophage polarization to M2 type, resulting in the epithelial-mesenchymal transition of lung epithelial cells. This study found that arsenic induces repolarization of M1 macrophages to M2 macrophages through the autophagy/mitophagy pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Peace Mabeta, Vanessa Steenkamp
Summary: The VEGF/VEGFR axis plays a crucial role in angiogenesis and tumor vascularization. Current therapies targeting VEGF and its receptors have shown limited effectiveness and undesirable off-target effects. Recent studies have identified VEGF splice variants that modulate angiogenesis, and their expression is regulated by cues within the tumor microenvironment. These variants challenge the established norm of VEGF signaling and their aberrant expression has been observed in several cancers, highlighting the need for further research on their role in cancer and their impact on antiangiogenic therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Yuanyuan Cui, Xiaomei Jiang, Maozhu Yang, Yinglin Yuan, Zili Zhou, Xiang Gao, Guiqing Jia, Lvzhou Cao, Danni Li, Yanshuang Zhao, Xin Zhang, Gaoping Zhao
Summary: Cardiovascular disease remains the leading cause of death and morbidity worldwide. In this study, a metabolism reshaped surface was engineered to reduce inflammatory responses and promote rapid endothelial recovery. By using specific linkers and functional molecules, the system not only inhibited platelets and fibrinogen, but also improved immunometabolism and anti-inflammatory functions, leading to better clinical outcomes of vascular implants.
MATERIALS TODAY BIO
(2023)
Article
Oncology
Xinyun Han, Junxian Hu, Wenbo Zhao, Hongwei Lu, Jingjin Dai, Qingyi He
Summary: WKYMVm can induce the polarization of macrophages to M2 phenotype and enhance their production of PDGF-BB. It also promotes angiogenesis and has the potential to be a promising alternative strategy for angiogenesis in bone repair.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Oncology
Ming Xiao, Qi Bian, Yimin Lao, Jing Yi, Xueqing Sun, Xuxu Sun, Jie Yang
Summary: Deletion of SUMO-specific protease 3 in macrophages promotes polarization towards the M2 subtype and accelerates breast cancer malignancy. The deficiency of SENP3 leads to increased SUMOylation of Akt1, resulting in hyper-phosphorylation and activation of Akt1, thus facilitating M2 polarization and tumor progression.
MOLECULAR ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Huai-Ching Tai, Shih-Wei Wang, Sanskruti Swain, Liang-Wei Lin, Hsiao-Chi Tsai, Shan-Chi Liu, Hsi-Chin Wu, Jeng-Hung Guo, Chun-Lin Liu, Yu-Wei Lai, Tien-Huang Lin, Shun-Fa Yang, Chih-Hsin Tang
Summary: Melatonin has been found to inhibit the migratory and invasive abilities of osteoblastic prostate cancer cells by targeting kinases and transcriptional activity, suggesting its potential as a therapeutic option for treating osteoblastic bone lesions in prostate cancer.
JOURNAL OF PINEAL RESEARCH
(2022)
Article
Chemistry, Medicinal
Safwan Safwan, Shih-Wei Wang, George Hsiao, Sui-Wen Hsiao, Su-Jung Hsu, Tzong-Huei Lee, Ching-Kuo Lee
Summary: In this study, eight trichothecenes and one cyclonerane were isolated and identified from the solid-state fermentation of Trichoderma brevicompactum NTU439 isolated from the marine alga Mastophora rosea. Compound 8 showed promising cytotoxic activity against multiple cancer cell lines, and other compounds also exhibited certain biological activities.
Article
Cell Biology
Chang-Yu Song, Sunny Li-Yun Chang, Chih-Yang Lin, Chun-Hao Tsai, Shang-Yu Yang, Yi-Chin Fong, Yu-Wen Huang, Shih-Wei Wang, Wei-Cheng Chen, Chih-Hsin Tang
Summary: New treatments for chondrosarcoma are crucial due to its poor prognosis, and factors like PDGF and visfatin play significant roles in tumor development and angiogenesis. Research has shown that visfatin promotes chondrosarcoma angiogenesis by modulating miR-1264 expression, potentially offering a new therapeutic approach for the treatment of chondrosarcoma.
Article
Chemistry, Multidisciplinary
Shu-Rong Chen, Shih-Wei Wang, Ching-Yeu Chen, Tzu-Yi Ke, Jue-Jun Lin, Tsong-Long Hwang, Yi-Ting Huang, Yu-Ching Huang, Yuan-Bin Cheng
Summary: Sixteen azaphilone derivatives, including four new compounds, were isolated from the algae-derived fungus Penicillium sclerotiorum. These compounds showed anti-angiogenic effects on human endothelial progenitor cells. The structure-activity relationships (SAR) for the anti-angiogenic effects of these azaphilones were deduced.
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN
(2023)
Article
Biochemistry & Molecular Biology
Sheng-Yen Hsiao, Chih-Hsin Tang, Po-Chun Chen, Tien-Huang Lin, Chia-Chia Chao
Summary: Melatonin exhibits antitumor activities against bladder cancer by inhibiting the epithelial-mesenchymal transition process and autophagy of bladder cancer cells. Melatonin treatment also slightly prolongs the survival of tumor-bearing mice.
Article
Pharmacology & Pharmacy
Sunny Li-Yun Chang, Chiang-Wen Lee, Chen-Yu Yang, Zih-Chan Lin, Kuo-Ti Peng, Shih-Chia Liu, Shih-Wei Wang, Hsiao-Chi Tsai, Yi-Chin Fong, Chao-Yang Lai, Yuan-Li Huang, Chun-Hao Tsai, Chih-Yuan Ko, Ju-Fang Liu, Chih-Hsin Tang
Summary: Despite low survival rates of metastatic osteosarcoma (OS) with surgery and chemotherapy, new therapeutic approaches are needed. Epigenetic changes like histone H3 methylation play crucial roles in various cancers including OS, although the underlying mechanisms are unclear. Treating OS cells with the histone lysine demethylase inhibitor IOX-1 increased histone H3 methylation, suppressed migration and invasion, reversed epithelial-to-mesenchymal transition, and reduced stemness properties.
BIOCHEMICAL PHARMACOLOGY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Chih-Hsin Tang
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Tzu-Yi Ke, Shih-Wei Wang, Shu-Rong Chen, Dong-Ming Huang, Yun-Sheng Lin, Tsong-Long Hwang, Wen-Chun Sun, Yuan-Bin Cheng
Summary: Four new alkaloids and three new polyacetylenes were isolated from Hippobroma longiflora. The structures of the compounds were determined using mass and NMR spectroscopic data, as well as X-ray and ECD analyses. The compounds exhibited weak antiangiogenic activity against human endothelial progenitor cells.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Cell Biology
Liang-Wei Lin, Shih-Wei Wang, Wei-Chien Huang, Thanh Kieu Huynh, Chao-Yang Lai, Chih-Yuan Ko, Yi-Chin Fong, Jie-Jen Lee, Shun-Fa Yang, Chih-Hsin Tang
Summary: Neovascular age-related macular degeneration (AMD) is a disease characterized by abnormal blood vessel growth in the retina, leading to severe vision loss. The presence of certain markers in the retinas of AMD patients suggests a contribution of endothelial progenitor cells (EPCs) in this pathogenesis. This study explores the potential of melatonin, a hormone produced in the retina, to inhibit EPC angiogenesis in neovascular AMD. The results demonstrate that melatonin can effectively inhibit the formation of EPC blood vessels and shows promise as a potential treatment for neovascular AMD.
Article
Biochemistry & Molecular Biology
Yu-Hsiang Chang, Yuan-Li Huang, Hsiao-Chi Tsai, An-Chen Chang, Chih-Yuan Ko, Yi-Chin Fong, Chih-Hsin Tang
Summary: This study aims to investigate the role of miRNAs in CCL2-mediated MMP expression and cell motility in human osteosarcoma. The results demonstrate a positive correlation between CCL2 or MMP-3 levels and osteosarcoma metastasis, and stimulation of osteosarcoma cells with CCL2 enhances migration and invasion abilities. Additionally, CCL2 enhances MMP-3-dependent cell motility by inhibiting miR-3659 synthesis.
Article
Chemistry, Multidisciplinary
Cong-Min Peng, Shih-Wei Wang, Yi-Lin Hwang, Wen-Chun Sun, Li-Pin Chiu, Yi-Ting Liu, Yu-Wei Lai, Hsueh-Yun Lee
Summary: The in situ CuI-mediated cyclization methodology was used to synthesize benzimidazoles with different substitution manner. Structure-activity relationship (SAR) study confirmed the significance of the 5,6,7-trimethoxybenzimidazole moiety. Representative derivatives exhibited potent antiproliferative activity against A549, HCT-116, and PC-3 cells, as well as inhibition of tubulin polymerization. Compound 10 showed the most promising activity with an IC50 value of 0.07 μM against cancer cell growth and 0.26 μM against tubulin polymerization.
Article
Cell Biology
Po- Liu, Ya-Jing Jiang, An-Chen Chang, Chang-Lun Huang, Yi-Chin Fong, Jeng-Hung Guo, Chun-Lin Liu, Shih-Wei Wang, Ju-Fang Liu, Sunny Li-Yu Chang, Chih-Hsin Tang
Summary: Lung cancer is common and metastatic lung cancer has a low survival rate. Lymphangiogenesis plays a crucial role in the development and metastasis of lung cancer. The adipokine angiopoietin-like protein 2 (ANGPTL2) is involved in tumor progression and metastasis, but its role in lung cancer is unknown. Analysis of data from multiple sources revealed a correlation between high levels of ANGPTL2 expression and disease progression and lymph node metastasis in lung cancer. ANGPTL2 promotes lymphatic endothelial cell tube formation and migration through integrin alpha 5 beta 1, p38, and nuclear factor (NF)-KB signaling. In vivo studies showed that overexpression of ANGPTL2 enhances tumor growth and lymphangiogenesis. Therefore, ANGPTL2 is a potential therapeutic target for treating lung cancer.
Article
Biochemistry & Molecular Biology
Jui-Chieh Chen, Hsun-Chang Shih, Chih-Yang Lin, Jeng-Hung Guo, Cheng Huang, Hsiu-Chen Huang, Zhi-Yong Chong, Chih-Hsin Tang
Summary: Chondrosarcoma, the second most common bone cancer, is difficult to treat surgically when it is high-grade and metastatic. Doxorubicin (Dox) is commonly used in chemotherapy, but drug resistance hampers its effectiveness. This study found that the apelin (APLN) pathway is highly activated in Dox-resistant cells and in high-grade chondrosarcoma tissues. Inhibition of the APLN axis has shown therapeutic benefits in other cancers, and this study suggests that targeting APLN may improve the treatment of chondrosarcoma by overcoming drug resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Ho-Cheng Wu, Lung-Lin Shiu, Shih-Wei Wang, Chia-Ying Huang, Tzong-Huei Lee, Ping-Jyun Sung, Yueh-Hsiung Kuo
Summary: This study investigated the chemical profiles and anti-lymphangiogenic activity of Juniperus chinensis var. tsukusiensis, a type of Taiwan juniper. Several new compounds were successfully isolated and evaluated for their anti-lymphangiogenic effects in human lymphatic endothelial cells. The results showed that one compound, totarolone, displayed the most potent anti-lymphangiogenic activity. These findings suggest the promising potential of Juniperus chinensis var. tsukusiensis in developing therapeutics targeting tumor lymphangiogenesis.