Review
Biochemistry & Molecular Biology
Hui Wang, Tian Tian, Jinhua Zhang
Summary: Colorectal cancer (CRC) is a highly prevalent and lethal malignant tumor in the digestive system. Tumor-associated macrophages (TAMs) play a crucial role in various mechanisms of CRC progression, such as promoting tumor proliferation, invasion, angiogenesis, and immunosuppression, although their exact role is still debated in clinical evidence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Ping Zeng, Xujun Zhang, Tianxin Xiang, Zongxin Ling, Chenhong Lin, Hongyan Diao
Summary: This study comprehensively analyzed the expression and oncogenic features of SPP1 in cancers using the TCGA database, revealing that SPP1 is highly expressed in most cancers and is associated with tumor prognosis, immune invasion, tumor microenvironment, and immunotherapy. Functional analysis identified the terms and pathways related to SPP1. Further experiments validated the oncogenic features of SPP1.
Article
Genetics & Heredity
Weichang Yang, Zhouhua Li, Wenjun Wang, Juan Wu, Jinbo Li, Xiaotian Huang, Xinyi Zhang, Xiaoqun Ye
Summary: This study found that VM-related genes are associated with the prognosis and immune landscape of lung adenocarcinoma (LUAD) patients. A VM score was developed and a predictive model was constructed to evaluate the prognosis and immune landscape of LUAD patients.
FRONTIERS IN GENETICS
(2023)
Article
Oncology
Hanna Elomaa, Maarit Ahtiainen, Sara A. Vaeyrynen, Shuji Ogino, Jonathan A. Nowak, Mai Chan Lau, Olli Helminen, Erkki-Ville Wirta, Toni T. Seppaelae, Jan Boehm, Jukka-Pekka Mecklin, Teijo Kuopio, Juha P. Vaeyrynen
Summary: The expression patterns and prognostic significance of PD-L1 and PD-1 in the colorectal cancer microenvironment are inadequately characterised. This study found that PD-L1(+) macrophages and PD-1(+) T cells were associated with better clinical outcomes in colorectal cancer patients. These findings enhance the understanding of immune checkpoints in the tumor microenvironment and could contribute to the development of improved immunotherapies.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Xing Zhang, Longkun Yang, Ying Deng, Zhicong Huang, Hao Huang, Yuying Wu, Baochang He, Fulan Hu
Summary: This study used single-cell RNA sequencing and bulk RNA sequencing data to select diagnosis and prognosis biomarkers for colorectal cancer (CRC). Epithelium-specific genes with differential expression between intestinal lesions and normal mucosa throughout the adenoma-carcinoma sequence were identified in the scRNA-seq data. Diagnostic and prognostic biomarkers were then selected based on genes that are shared between adenoma and CRC epithelium-specific clusters in the bulk RNA-seq dataset.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Pharmacology & Pharmacy
Aranka Brockmueller, Anna-Lena Mueller, Parviz Shayan, Mehdi Shakibaei
Summary: The role of beta 1-integrin receptors in the anti-invasive and anti-metastatic effect of resveratrol was investigated using two CRC cell lines and multicellular, pro-inflammatory 3D-alginate TME cultures. Resveratrol dose-dependently suppressed migration-promoting adhesion adapter protein paxillin and enhanced the expression of E-cadherin, accompanied by changes in CRC cell invasion.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Hongrong Wu, Haoyang He, Jiexiong Huang, Chuan Wang, Yuejiao Dong, Ruilin Lin, Zhuofeng Cheng, Qiancheng Qiu, LiangLi Hong
Summary: This study investigated the clinical significance of transferrin receptor protein 1 (TFRC) in lower-grade glioma (LGG) and its association with tumor immunity. The results showed that TFRC was highly expressed in many tumors and was associated with poor prognosis in LGG. TFRC expression was also correlated with tumor immune microenvironment, tumor mutational burden, m6a modification, and ferroptosis in LGG. Additionally, TFRC was associated with immune-related pathways and immune checkpoints in LGG.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Immunology
Tian-mei Zeng, Yu-fei Pan, Zhen-gang Yuan, Dong-sheng Chen, Yun-jie Song, Yong Gao
Summary: This study found that the tumor microenvironment and immune-related gene expression profile play a crucial role in the outcome of immune checkpoint inhibitor-combined chemotherapy in advanced intrahepatic cholangiocarcinoma. Researchers identified an immune-related RNA signature that predicts the clinical response, which could serve as a potential biomarker for immune-chemotherapy in the future.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yiming Ma, Lei Zhan, Jun Yang, Jingdong Zhang
Summary: SLC11A1 plays a crucial role in the tumor microenvironment of colorectal cancer and may serve as a potential biomarker for poor prognosis and immunotherapy efficacy in CRC.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Aranka Brockmueller, Constanze Buhrmann, Parviz Shayan, Mehdi Shakibaei
Summary: This study demonstrates a negative reciprocal crosstalk between p53 and Sirt-1, and high concentrations of resveratrol can induce apoptosis in colorectal cancer cells by modulating the expression of these two proteins.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Shengqiang Zhang, Hongyan Zhang, Huawei Li, Jida Guo, Jun Wang, Linyou Zhang
Summary: This study found that GNPNAT1 is highly expressed in lung adenocarcinoma (LUAD) tumor tissues compared to normal tissues and is associated with poor prognosis. Co-expressed genes mainly participate in chromosome segregation, RNA metabolism, and RNA transport. GNPNAT1 plays a role in cell cycle transition and the development of certain cancers.
Article
Immunology
Guanghao Li, Yongheng Liu, Yanting Zhang, Yao Xu, Jin Zhang, Xianfu Wei, Zhongmin Zhang, Chao Zhang, Jinyan Feng, Qiang Li, Guowen Wang
Summary: This study explores the prognostic value of ferroptosis-related lncRNAs in HCC patients. A novel signature consisting of five ferroptosis-related lncRNAs is established and shown to have a high clinical application value in predicting overall survival. The findings suggest that this signature could serve as an efficient indicator for predicting prognosis and guiding treatment in HCC patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Aranka Brockmueller, Sosmitha Girisa, Ajaikumar B. B. Kunnumakkara, Mehdi Shakibaei
Summary: Resveratrol can enhance the sensitivity of colorectal cancer cells to 5-FU by regulating the beta 1-integrin/HIF-1α signaling axis, leading to suppression of cancer cell growth and invasion, inhibition of inflammation and cancer stem cell production. These findings highlight the potential application of resveratrol in the treatment of colorectal cancer by overcoming chemoresistance to 5-FU.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Xiaogang Zhou, Yu Liu, Jing Xiang, Yuntao Wang, Qiqian Wang, Jianling Xia, Yunfei Chen, Yifeng Bai
Summary: In the treatment of COAD patients with immune checkpoint inhibitors, IL-1 signaling mutation status is associated with a better prognosis and longer overall survival. The IL-1-MT group exhibits higher levels of immune cell infiltration and immunogenicity, with significantly upregulated expression of immune-related genes and checkpoint molecules.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Aranka Brockmueller, Parviz Shayan, Mehdi Shakibaei
Summary: This study found that resveratrol can exert its suppressive actions on tumor microenvironment (TME)-induced tumorigenesis in colorectal cancer (CRC) cells through the beta 1-integrin receptor. Resveratrol altered the distribution pattern and expression of beta 1-integrin on the surface of CRC cells in TME, leading to decreased cell proliferation and viability, and increased apoptosis. Inhibition of beta 1-integrin or interruption of downstream signaling pathway attenuated the anti-tumor effects of resveratrol. The results highlight the important role of beta 1-integrins as signal carriers for resveratrol in CRC cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)