Review
Chemistry, Multidisciplinary
Jingbo Qin, Ningqiang Gong, Zhihuan Liao, Shouwen Zhang, Peter Timashev, Shuaidong Huo, Xing-Jie Liang
Summary: This review summarizes the state of the art of design and construction of nanosystems used for mitochondria-targeted delivery in cancer treatment. It discusses the use of nanotechnology through various pathways such as energy metabolism interference, ROS regulation, mitochondrial protein targeting, mtDNA interference, mitophagy inducing, and combination therapy. Finally, it provides an overview of the major challenges and future prospects in this field.
Review
Medicine, Research & Experimental
Mehrdad Hashemi, Rezvaneh Aparviz, Marzie Beickzade, Mahshid Deldar Abad Paskeh, Simin Khorsand Kheirabad, Zeinab Khazaei Koohpar, Amir Moravej, Hossein Dehghani, Hamidreza Saebfar, Mohammad Arad Zandieh, Shokooh Salimimoghadam, Mohsen Rashidi, Afshin Taheriazam, Maliheh Entezari, Saeed Samarghandian
Summary: This review explores the potential applications of small interfering RNA (siRNA) and short hairpin RNA (shRNA) in the treatment of gastric cancer. It highlights the ability of siRNA to reduce the proliferation and invasion of gastric cancer cells and induce chemosensitivity. However, the unmodified siRNA faces challenges in translational potential. The role of nanostructures in facilitating siRNA delivery to gastric cancer cells and suppressing tumor progression is emphasized. The translation of these findings into clinical trials holds promise for advancing the treatment of gastric cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Chemistry, Multidisciplinary
Ragini Singh, Santosh Kumar
Summary: This review discusses the recent advancements of carbon nanotubes (CNTs) in cancer diagnosis and therapy, including various sensing strategies and treatment techniques. It also emphasizes the importance of ensuring the safety of CNTs for biomedical applications.
Review
Oncology
Zhi Wei Tay, Prashant Chandrasekharan, Benjamin D. Fellows, Irati Rodrigo Arrizabalaga, Elaine Yu, Malini Olivo, Steven M. Conolly
Summary: Magnetic Particle Imaging (MPI) is an emerging imaging technique that provides direct imaging of superparamagnetic iron oxide nanoparticles, showing great potential in cancer diagnosis and therapy monitoring. Different from MRI, MPI offers ideal image contrast with zero background tissue signal, enabling clear visualization of cancer. MPI enhances therapeutic precision and accuracy through magnetic means, contributing to the advancement of cancer imaging and guided therapy.
Article
Materials Science, Biomaterials
Shuangling Wang, Jie Lv, Yu Pang, Shuyang Hu, Yulong Lin, Meng Li
Summary: A multifunctional nanoplatform integrating chemotherapy, chemodynamic therapy (CDT), and photoactivation of TRPV1 channels has been established for specific cancer therapy. The nanoplatform displays an enhanced anticancer effect both in vitro and in vivo.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Biochemistry & Molecular Biology
Elena Bellotti, Maria Grazia Cascone, Niccoletta Barbani, Daniela Rossin, Raffaella Rastaldo, Claudia Giachino, Caterina Cristallini
Summary: Chemotherapeutics are commonly used for cancer treatment, but often have off-target effects on healthy cells. Gene therapy is becoming a trend in oncotherapy, aiming to safely deliver genetic material to target cells using non-viral carriers. Using terpolymer-based nanocapsules decorated with folic acid for active targeting shows potential for more effective cancer therapies.
Review
Pharmacology & Pharmacy
Sumera Khizar, Eslam Elkalla, Nadia Zine, Nicole Jaffrezic-Renault, Abdelhamid Errachid, Abdelhamid Elaissari
Summary: Cancer, with its high mortality rates, requires new therapeutic possibilities with enhanced benefits. Magnetic nanoparticles have shown substantial progress in cancer treatment, employing chemo-, immuno-, gene-, and radiotherapy along with hyperthermia.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Review
Biotechnology & Applied Microbiology
Yajing Sun, Qingshan Yang, Xue Xia, Xiaozhe Li, Weimin Ruan, Meng Zheng, Yan Zou, Bingyang Shi
Summary: Researchers are focusing on developing polymeric nanoparticles targeted at mitochondria to enhance the efficiency of cancer therapy.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Engineering, Biomedical
Quazi T. H. Shubhra, Kai Guo, Yixuan Liu, Md Razzak, Md Serajum Manir, A. K. M. Moshiul Alam
Summary: This study describes the development of a smart drug delivery system for multimodal synergistic cancer therapy, utilizing chemo-photothermal-starvation approaches to improve drug release and cellular uptake as well as achieve a synergistic therapeutic effect for cancer treatment.
ACTA BIOMATERIALIA
(2021)
Article
Oncology
Sibi Raj, Sartaj Khurana, Ramesh Choudhari, Kavindra Kumar Kesari, Mohammad Amjad Kamal, Neha Garg, Janne Ruokolainen, Bhudev C. Das, Dhruv Kumar
Summary: Nanotechnology offers a promising approach for cancer diagnosis and treatment, providing specific and efficient drug delivery to target tissues while minimizing side effects. Various types of nanocarriers are being studied for potential use in cancer therapy.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Manshi Patel, Arati Prabhu
Summary: In recent years, fusion technology platforms that combine various treatments such as photodynamic therapy, photothermal therapy, and hyperthermia have emerged as safe and effective strategies for cancer treatment. These therapies use metal and magnetic nanoparticles to produce reactive oxygen species or heat, providing a potential solution for tumor treatment. The integration of light, heat, magnetism, and traditional treatments for precise interventions against cancer is considered a future trend in cancer therapeutics.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Medicine, Research & Experimental
Qian Zhou, Wensheng Chen, Zhenzhen Fan, Zhipeng Chen, Jinxia Liang, Guandi Zeng, Lu Liu, Wanting Liu, Tong Yang, Xin Cao, Biao Yu, Meng Xu, Ye-Guang Chen, Liang Chen
Summary: In this study, MYOCD was identified as a clinically relevant tumor suppressor gene in lung cancer patients, showing a potent inhibitory effect on lung cancer stem cells. NSCLC cells deficient of MYOCD were found to be particularly sensitive to TGFBR kinase inhibitor, and a synergistic effect was observed when combining TGFBRi with stemness inhibitor to treat MYOCD deficient lung cancers.
Article
Biophysics
Su-Hyun Kwon, Hasan Al Faruque, Hyeonwoo Kee, Eunjoo Kim, Sukho Park
Summary: The study introduces an exosome-based hybrid nanostructure with improved targeting ability and therapeutic efficacy against colorectal cancer. By utilizing exosomes as a carrier and adding a tumor-targeting ligand, the structure exhibits enhanced targeting performance. Through in vitro and in vivo experiments, it was found that the structure could induce increased apoptosis and effectively inhibit tumor growth.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Oncology
Anas Ahmad, Summya Rashid, Anis Ahmad Chaudhary, Abdullah S. Alawam, Mohammad Ibrahim Alghonaim, Syed Shadab Raza, Rehan Khan
Summary: Cancer is a complex disease with significant global impact. Nanotechnology offers potential solutions to the limitations of current cancer therapies by improving drug delivery and targeting transcription factors. This review summarizes various nanoformulations and nanomaterials designed to target transcription factors involved in carcinogenesis, tumor growth, and metastasis, highlighting the impact of nanotechnology in cancer management.
SEMINARS IN CANCER BIOLOGY
(2023)
Article
Engineering, Biomedical
Pengfei Zhao, Yan Han, Holly Nguyen, Eva Corey, Xiaohu Gao
Summary: A simple yet effective cancer treatment method involves repurposing clinically approved magnetic nanoparticles and utilizing static parallel magnetic fields for intracellular nanoparticle self-assembly, leading to targeted cell death while preserving other cells and organs intact. This approach opens up a new avenue for cancer treatment by utilizing nanosciences and nanoparticle design principles accumulated over the past decades.
ADVANCED HEALTHCARE MATERIALS
(2022)