Article
Cardiac & Cardiovascular Systems
Xiujuan Xia, Linfang Zhang, Hao Wu, Feng Chen, Xuanyou Liu, Huifang Xu, Yuqi Cui, Qiang Zhu, Meifang Wang, Hong Hao, De-Pei Li, William P. Fay, Luis A. Martinez-Lemus, Michael A. Hill, Canxia Xu, Zhenguo Liu
Summary: This study found that CagA(+) H. pylori effectively colonizes gastric mucosa and impairs endothelial function, leading to increased atherosclerosis through exosomes-mediated ROS formation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Nutrition & Dietetics
Suhn Hyung Kim, Hyeyoung Kim
Summary: Helicobacter pylori infection promotes gastric carcinogenesis by increasing oxidative stress, inflammation, and dysregulation of cell survival and proliferation of gastric epithelial cells. Astaxanthin exhibits antioxidant and anticancer effects by modulating aberrant signaling pathways that lead to dysregulation of cell death and proliferation. Astaxanthin significantly reversed H. pylori-induced transcriptional alterations of key mediators involved in the Wnt/beta-catenin signaling pathway, suggesting its potential as a therapeutic agent to counter-regulate proliferation-associated gene expression changes induced by H. pylori.
Article
Biochemistry & Molecular Biology
Adrian L. Gajewski, Mateusz Gawrysiak, Agnieszka Krupa, Tomasz Rechcinski, Maciej Chalubinski, Weronika Gonciarz, Magdalena Chmiela
Summary: The gastric pathogen Helicobacter pylori has been found to influence the development of coronary heart disease (CHD) by inducing reactive oxygen species (ROS) and transforming cholesterol into 7-ketocholesterol (7-kCh). This study examined the effects of H. pylori components, in the presence of 7-kCh and acetylsalicylic acid (ASA), on gastric epithelial cells and vascular endothelial cells. The results showed that ASA and 7-kCh, especially in conjunction with H. pylori components, increased ROS levels, apoptosis, cell disintegration, activation of STAT3, and elevation of IL-8. AGS cells were unable to undergo wound healing. The findings suggest that the ROS response to H. pylori components may be enhanced by 7-kCh and ASA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Suji Bae, Joo Weon Lim, Hyeyoung Kim
Summary: This research demonstrates that beta-carotene inhibits MMP-10 expression and cell invasion induced by H. pylori by increasing PPAR-gamma-mediated catalase expression and reducing ROS levels in infected cells, thereby exerting an inhibitory effect on MAPK-mediated processes.
Article
Cell Biology
Hiromi Kurokawa, Atsushi Taninaka, Hidemi Shigekawa, Hirofumi Matsui
Summary: Dabigatran is a novel oral anticoagulant that inhibits thrombins, but its use may increase the risk of gastrointestinal bleeding. Research has shown that its main component, dabigatran etexilate, exhibits cytotoxicity that can be inhibited by ascorbic acid. These cytotoxic effects are likely mediated via mitROS production.
Article
Oncology
Jieun Woo, Joo Weon Lim, Hyeyoung Kim
Summary: This study revealed that Helicobacter pylori increases the expression levels of integrin alpha 5 in gastric cancer cells and promotes cell adhesion and migration. Astaxanthin (ASX) effectively inhibits this process by decreasing ROS levels and suppressing JAK1/STAT3 activation, thereby reducing integrin alpha 5 expression and cell adhesion and migration.
MOLECULAR MEDICINE REPORTS
(2023)
Article
Nutrition & Dietetics
Jimin Lee, Joo Weon Lim, Hyeyoung Kim
Summary: Helicobacter pylori infection increases MMP expression and cell invasion, while astaxanthin inhibits MMP expression and cell invasion by suppressing the PI3K/AKT/mTOR signaling pathway.
Article
Biochemistry & Molecular Biology
Deqian Kong, Yue Liu, Li Li, Huajun Wang, Ke Li, Guangying Zheng
Summary: This study confirmed that the targeting of GPX4 by astaxanthin (ATX) could inhibit ferroptosis, improve oxidative stress, and alleviate damage to human lens epithelial cells (LECs), suggesting a promising therapeutic approach for age-related cataract.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Immunology
Linfang Zhang, Xiujuan Xia, Hao Wu, Xuanyou Liu, Qiang Zhu, Meifang Wang, Hong Hao, Yuqi Cui, De-Pei Li, Shi-You Chen, Luis A. Martinez-Lemus, Michael A. Hill, Canxia Xu, Zhenguo Liu
Summary: H. pylori infection impairs endothelial function in male mice through exosome-mediated ROS formation, while female mice show no change in endothelial function. This effect is achieved by increasing ROS production in the blood vessels.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Emily Taillieu, Chloe De Witte, Heiko De Schepper, Wouter Van Moerkercke, Sophie Rutten, Stijn Michiels, Yuna Arnst, Sofie De Bruyckere, Sven Francque, Frauke van Aert, Christophe George, Emma Callewaert, Tiene Callewaert, Glenn Vanneste, Erik Vanderstraeten, Nina Van Heddegem, Margaux Vansteelant, Koen Chiers, Freddy Haesebrouck, Christophe Van Steenkiste
Summary: This study reveals that gastric non-Helicobacter pylori Helicobacter (NHPH) species naturally associated with animals are linked with gastric disease in human patients. The findings suggest that routine PCR testing for zoonotic gastric NHPHs should be conducted on patients with gastric complaints to diagnose potential pathogens.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Jiayin Yu, Zhihao Guo, Jiachang Yan, Changxin Bu, Chang Peng, Cuie Li, Rui Mao, Jian Zhang, Zhi Wang, Shi Chen, Meicun Yao, Zhiyong Xie, Chuan Yang, Yi Yan Yang, Peiyan Yuan, Xin Ding
Summary: This study reports a pH-responsive ROS nanogenerator composed of an acid-responsive metal polyphenol network (MPN) shell and a mesoporous metal-organic nanostructure core (Fe-HMME). The nanogenerators generate more ROS singlet oxygen than HMME under ultrasonication, fueled by oxygen generated through Fenton/Fenton-like reactions in the infection microenvironment. They show high therapeutic efficacy in killing multidrug-resistant H. pylori and removing biofilm, with negligible side effects on the normal gut microbiota. These self-enhanced ROS nanogenerators have great potential for H. pylori infection treatment.
Review
Biochemistry & Molecular Biology
Ting-Yu Lin, Wen-Hsi Lan, Ya-Fang Chiu, Chun-Lung Feng, Cheng-Hsun Chiu, Chia-Jung Kuo, Chih-Ho Lai
Summary: This review discusses the potential of using statins to antagonize cholesterol synthesis as an ideal strategy for reducing the occurrence of H. pylori-related gastric cancer, and summarizes several clinical studies on the association between statin therapy and the development of gastric cancer.
Article
Biotechnology & Applied Microbiology
Jinglei Liu, Fangxu Zhang, Zheming Zhang, Chunning Zheng
Summary: This study found that Everolimus has a pharmacological role in protecting gastric epithelial cells from H.pylori-induced damage. It achieves this by reducing oxidative stress and inhibiting inflammatory response, as well as inhibiting the attachment of monocytes to epithelial cells.
Article
Cell Biology
Olga Sokolova, Gunter Maubach, Michael Naumann
Summary: Helicobacter pylori infection induces a strong inflammatory response in gastric mucosa and alters epithelial integrity and function. The activation of NF-κB transcription factors, specifically by the bacterial heptose metabolites, triggers this innate immune response. Our study reveals that the activation of ALPK1-dependent TIFA in H. pylori-infected gastric epithelial cells is followed by TIFA degradation, which is inhibited by proteasomal and lysosomal inhibitors. TRAF2, TRAF6, TAK1, or NEMO are not involved in TIFA degradation, and H. pylori promotes the interaction of TIFA with protein adaptors involved in lysosomal trafficking.
EUROPEAN JOURNAL OF CELL BIOLOGY
(2023)
Editorial Material
Microbiology
Agustina Taglialegna
Summary: In this study, Sharafutdinov et al. report the identification of a single nucleotide polymorphism in the gene encoding the HtrA protease of Helicobacter pylori that is linked to gastric cancer.
NATURE REVIEWS MICROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Suyun Choi, Hyeyoung Kim
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Chemistry, Medicinal
Suhn Hyung Kim, Hyeyoung Kim
Article
Biochemistry & Molecular Biology
Jaeeun Lee, Joo Weon Lim, Hyeyoung Kim
Summary: Excessive alcohol intake leads to the accumulation of fatty acid ethyl esters in the pancreas, causing pancreatic cell injury and alcoholic pancreatitis. Lycopene inhibits NADPH oxidase-mediated ROS production, preventing damage induced by ethanol and fatty acids in pancreatic cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Suji Bae, Joo Weon Lim, Hyeyoung Kim
Summary: This research demonstrates that beta-carotene inhibits MMP-10 expression and cell invasion induced by H. pylori by increasing PPAR-gamma-mediated catalase expression and reducing ROS levels in infected cells, thereby exerting an inhibitory effect on MAPK-mediated processes.
Article
Cell Biology
Min Seung Kwak, Joo Weon Lim, Hyeyoung Kim
Summary: Obesity increases the incidence of acute pancreatitis and induces the adipocytokine resistin, which in turn aggravates the expression of the proinflammatory mediator IL-6. Astaxanthin (ASX) has been found to inhibit IL-6 expression by reducing calcium overload and oxidative stress caused by resistin in pancreatic acinar cells.
MEDIATORS OF INFLAMMATION
(2021)
Article
Biochemistry & Molecular Biology
Jiyeon Choi, Joo Weon Lim, Hyeyoung Kim
Summary: House dust mites are crucial in airway inflammation, activating Toll-like receptor 4 and inducing inflammatory cytokine expression in respiratory epithelial cells. The antioxidant lycopene can inhibit these effects by suppressing TLR4 activation and reducing ROS levels in cells.
Review
Biochemistry & Molecular Biology
Yu Jin Ahn, Hyeyoung Kim
Summary: Lutein, obtained from foods like dark green leafy vegetables and egg yolk, has antioxidant properties and can inhibit inflammatory mediators and signaling pathways, thus preventing the development of inflammatory diseases. This review discusses the anti-inflammatory function of lutein in various organs against diseases such as neurodegenerative disorders, eye diseases, diabetes, osteoporosis, cardiovascular diseases, skin diseases, liver injury, obesity, and colon diseases.
Article
Nutrition & Dietetics
Suhn Hyung Kim, Hyeyoung Kim
Summary: Helicobacter pylori infection promotes gastric carcinogenesis by increasing oxidative stress, inflammation, and dysregulation of cell survival and proliferation of gastric epithelial cells. Astaxanthin exhibits antioxidant and anticancer effects by modulating aberrant signaling pathways that lead to dysregulation of cell death and proliferation. Astaxanthin significantly reversed H. pylori-induced transcriptional alterations of key mediators involved in the Wnt/beta-catenin signaling pathway, suggesting its potential as a therapeutic agent to counter-regulate proliferation-associated gene expression changes induced by H. pylori.
Article
Oncology
Sun Ah Chung, Joo Weon Lim, Hyeyong Kim
Summary: The study demonstrated that DHA inhibits cytokine expression and NF-kappa B activation induced by poly (I:C) or TNF-alpha in PSCs by reducing intracellular and mitochondrial ROS accumulation. Consuming DHA-rich foods may be beneficial in preventing chronic pancreatitis by inhibiting cytokine expression in PSCs.
JOURNAL OF CANCER PREVENTION
(2021)
Article
Nutrition & Dietetics
Hae Sou Kim, Joo Weon Lim, Hyeyoung Kim
Summary: In this study, it was found that Korean red ginseng extract (RGE) suppresses the expression of IL-8 and alleviates mitochondrial dysfunction in H. pylori-infected cells through the activation of Nrf2, induction of SOD-1 and HO-1, and reduction of ROS.
Article
Biochemistry & Molecular Biology
Jaeeun Lee, Joo Weon Lim, Hyeyoung Kim
Summary: Alcohol increases gut permeability, leading to pancreatic damage. Ethanol or LPS treatment increases ROS production. Lycopene inhibits IL-6 expression and reduces ROS levels through the Nrf2 pathway.
Article
Nutrition & Dietetics
Jaeeun Lee, Joo Weon Lim, Hyeyoung Kim
Summary: Oxidative stress induces DNA damage and apoptosis, while astaxanthin protects against oxidative stress-induced damage by preventing Ku protein degradation and suppressing apoptosis. The study found that oxidative stress decreases Ku70/80 expression through the ubiquitin-proteasome pathway, leading to DNA fragmentation and apoptotic cell death. However, astaxanthin inhibits oxidative stress-mediated apoptosis by reducing ROS levels and inhibiting Ku protein degradation. Overall, dietary astaxanthin supplementation or consumption of astaxanthin-rich food may be effective in preventing or delaying oxidative stress-induced cell damage by suppressing Ku protein loss and apoptosis in gastric epithelial cells.
Article
Nutrition & Dietetics
Jimin Lee, Joo Weon Lim, Hyeyoung Kim
Summary: Helicobacter pylori infection increases MMP expression and cell invasion, while astaxanthin inhibits MMP expression and cell invasion by suppressing the PI3K/AKT/mTOR signaling pathway.
Review
Biochemistry & Molecular Biology
Jaeeun Lee, Min-Hyun Kim, Hyeyoung Kim
Summary: A moderate amount of ROS plays an important role in cell signaling and immune response, while excessive production can lead to inflammation and pathological conditions. The gastrointestinal mucosa is continuously exposed to ROS, increasing the risk of GI disorders. AST, a compound with antioxidant and anti-inflammatory properties, has shown protective effects against GI diseases through various mechanisms, including ROS neutralization, enhancement of antioxidant enzyme activity, and suppression of inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
An Jun Lee, Joo Weon Lim, Hyeyoung Kim
Summary: House dust mite (HDM) induces oxidative stress and inflammatory response by releasing chemokines, leading to IL-8 expression. Ascorbic acid reduces ROS production, inhibits MAPKs, NF-κB and AP-1 activation, and reduces IL-8 expression. Consuming ascorbic acid-rich foods may help prevent HDM-induced respiratory inflammation by suppressing oxidative stress-mediated signaling pathways.
JOURNAL OF CANCER PREVENTION
(2021)