Article
Nutrition & Dietetics
Isabel Galvez, Maria Carmen Navarro, Leticia Martin-Cordero, Eduardo Otero, Maria Dolores Hinchado, Eduardo Ortega
Summary: Obesity is associated with low-grade inflammation and increased susceptibility to viral infections, such as COVID-19. Macrophage immunometabolism and metabolic flexibility play a crucial role in this context. Strategies for regulating inflammatory responses while preserving innate defenses are important in obesity and inflammatory diseases. However, the effectiveness of dietary interventions in reducing inflammation, especially in adipose tissue, is still controversial and requires further research.
Review
Immunology
Conor De Barra, Donal O'Shea, Andrew E. Hogan
Summary: Natural killer (NK) cells play a critical role in protecting the body against infection and cancer by targeting infected or transformed cells and initiating immune responses. They also have a role in tissue homeostasis, including adipose tissue, where they control macrophage polarization and regulate stressed adipocyte fate. Obesity is associated with immune dysregulation, including defects in peripheral and adipose tissue NK cells, leading to increased rates of cancer and susceptibility to severe infections. This review summarizes the literature on NK cells in obesity, discussing the consequences, mechanisms, and therapeutic interventions.
CLINICAL IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Xinbo Zhang, Jeffrey G. McDonald, Binod Aryal, Alberto Canfran-Duque, Emily L. Goldberg, Elisa Araldi, Wen Ding, Yuhua Fan, Bonne M. Thompson, Abhishek K. Singh, Qian Li, George Tellides, Jose Ordovas-Montanes, Rolando Garcia Milian, Vishwa Deep Dixit, Elina Ikonen, Yajaira Suarez, Carlos Fernandez-Hernando
Summary: Desmosterol, the most abundant cholesterol biosynthetic intermediate in human coronary artery lesions, plays an essential role during atherogenesis by integrating with macrophage cholesterol metabolism and inflammatory activation to dampen inflammation and protect from disease progression.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Gastroenterology & Hepatology
Olivier Govaere, Sine Kragh Petersen, Nuria Martinez-Lopez, Jasper Wouters, Matthias Van Haele, Rosellina M. Mancina, Oveis Jamialahmadi, Orsolya Bilkei-Gorzo, Pierre Bel Lassen, Rebecca Darlay, Julien Peltier, Jeremy M. Palmer, Ramy Younes, Dina Tiniakos, Guruprasad P. Aithal, Michael Allison, Michele Vacca, Melker Goransson, Rolando Berlinguer-Palmini, James E. Clark, Michael J. Drinnan, Hannele Yki-Jarvinen, Jean-Francois Dufour, Mattias Ekstedt, Sven Francque, Salvatore Petta, Elisabetta Bugianesi, Jorn M. Schattenberg, Christopher P. Day, Heather J. Cordell, Baki Topal, Karine Clement, Stefano Romeo, Vlad Ratziu, Tania Roskams, Ann K. Daly, Quentin M. Anstee, Matthias Trost, Anetta Hartlova
Summary: MSR1 plays a critical role in the pathogenesis of obesity-associated NAFLD by regulating lipid uptake and accumulation, influencing hepatic inflammation and metabolic disorder, and could be a potential therapeutic target for the treatment of NAFLD.
JOURNAL OF HEPATOLOGY
(2022)
Article
Engineering, Biomedical
Sahil Inamdar, Abhirami P. Suresh, Joslyn L. Mangal, Nathan D. Ng, Alison Sundem, Hoda Shokrollahzadeh Behbahani, Thomas E. Rubino Jr, Jordan R. Yaron, Taravat Khodaei, Matthew Green, Marion Curtis, Abhinav P. Acharya
Summary: This study suggests that controlled release of succinate using polyethylene succinate microparticles (PES MPs) in the tumor microenvironment can modulate macrophage responses, reduce tumor volume, and activate pro-inflammatory adaptive immune responses.
Article
Engineering, Biomedical
Sahil Inamdar, Tina Tylek, Abhirami Thumsi, Abhirami P. Suresh, Madhan Mohan Chandra Sekhar Jaggarapu, Michelle Halim, Shivani Mantri, Arezoo Esrafili, Nathan D. Ng, Elizabeth Schmitzer, Kelly Lintecum, Camila de Avila, John D. Fryer, Ying Xu, Kara L. Spiller, Abhinav P. Acharya
Summary: In this study, microparticles based on polymerization of alpha-ketoglutarate were developed to modulate macrophage phenotype. These microparticles encapsulated and released spermine, which induced a complex and non-typical phenotypic profile in bone marrow-derived macrophages. The results suggest that spermine encapsulated microparticles have potential applications in inflammation-associated diseases.
Article
Immunology
Adrian Povo-Retana, Marco Farinas, Rodrigo Landauro-Vera, Marina Mojena, Carlota Alvarez-Lucena, Miguel A. Fernandez-Moreno, Antonio Castrillo, Juan Vladimir de la Rosa Medina, Sergio Sanchez-Garcia, Carles Foguet, Francesc Mas, Silvia Marin, Marta Cascante, Lisardo Bosca
Summary: In recent years, the relationship between cell bioenergetics and immune cell function has attracted attention, leading to the emergence of immunometabolism research. This study focuses on the metabolic changes in macrophages induced by two DNA-binding agents with anti-tumor activity. The results reveal that these agents activate human macrophages towards a pro-inflammatory phenotype by inducing specific metabolic rewiring, providing insights for designing targeted therapeutic interventions in cancer treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Roland Baumgartner, Felipe B. Casagrande, Randi B. Mikkelsen, Martin Berg, Konstantinos A. Polyzos, Maria J. Forteza, Aastha Arora, Thue W. Schwartz, Siv A. Hjorth, Daniel F. J. Ketelhuth
Summary: Studies on G-protein-coupled receptor-35 (GPR35) suggest that its expression does not directly impact macrophage activation, vascular inflammation, and the development of atherosclerosis, as indicated by experiments on GPR35KO and WT chimeric mice.
Article
Multidisciplinary Sciences
Xanthe A. M. H. van Dierendonck, Frank Vrieling, Lisa Smeehuijzen, Lei Deng, Joline P. Boogaard, Cresci-Anne Croes, Lieve Temmerman, Suzan Wetzels, Erik Biessen, Sander Kersten, Rinke Stienstra
Summary: In response to inflammatory activation by pathogens, macrophages accumulate triglycerides to suppress lipolysis, thereby attenuating the inflammatory response. This finding is important for understanding the mechanisms of macrophage inflammatory response and the treatment of related diseases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Immunology
Li Ning, Shishi Zou, Wang Bo, Huiqing Lin
Summary: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are life-threatening conditions with complex molecular mechanisms and high mortality rates. In recent years, the field of immunometabolism has made significant progress in understanding the interaction between intracellular metabolism and immune function. Evidence has shown the important roles of immunometabolism in inflammatory response and ALI. Different immune cells undergo metabolic reprogramming and epigenetic changes during ALI, which not only provide energy and biosynthetic precursors, but also regulate inflammation and immunity. However, there are variations in the features and roles of metabolic reprogramming in different immune cells. This article outlines the impact of adverse factors on immunometabolism in different immune cell types during ALI, highlights key proteins associated with energy expenditure and metabolic reprogramming, and discusses potential therapeutic targets and challenges in immunometabolism against ALI.
CLINICAL IMMUNOLOGY
(2023)
Article
Engineering, Biomedical
Lianne C. Shanley, Olwyn R. Mahon, Sinead A. O'Rourke, Nuno G. B. Neto, Michael G. Monaghan, Daniel J. Kelly, Aisling Dunne
Summary: Recent studies have shown that immune cells undergo metabolic reprogramming upon activation, and exploiting this process has therapeutic potential. This study demonstrates for the first time that the size of hydroxyapatite particles can impact macrophage metabolism, with micron-sized particles promoting a pro-inflammatory phenotype through glycolysis. This highlights immunometabolism as a targetable aspect of the immune response for therapeutic benefit and informs intelligent biomaterial design.
ACTA BIOMATERIALIA
(2023)
Review
Cell Biology
Eloise Ramel, Sebastian Lillo, Boutaina Daher, Marina Fioleau, Thomas Daubon, Maya Saleh
Summary: The study focuses on the metabolic programs of tumor-associated myeloid cells and how the cancerous metabolic environment modulates their functions, impacting anti-tumor immune responses and immune evasion mechanisms.
Review
Immunology
Kenneth K. Y. Ting, Jenny Jongstra-Bilen, Myron I. Cybulsky
Summary: Recent advances in immunometabolism have highlighted the role of metabolites in fine-tuning inflammatory responses in myeloid cells. Competition for cofactors regulates the balance between inflammatory and anti-inflammatory pathways, allowing for precise control of the inflammatory response.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lincon Felipe Lima-Silva, Jennifer Lee, Pedro M. Moraes-Vieira
Summary: Studies have shown that solute carriers play a significant role in regulating macrophage metabolism, affecting mitochondrial activity and intracellular processes, which ultimately impact the functional status of macrophages.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Agriculture, Dairy & Animal Science
Alessandra Sfacteria, Ettore Napoli, Claudia Rifici, Daria Commisso, Giada Giambrone, Giuseppe Mazzullo, Gabriele Marino
Summary: Immunoglobulins released by inflammatory cells in the tumor microenvironment have been implicated in the pathogenesis and progression of human cancer. This study investigates the relationship between immune cells in canine mammary gland tumors and the expression of immunoglobulins. The findings suggest a potential role of immune cells and molecules in the biology of canine mammary gland tumors.
Article
Allergy
Hajar Ali, Collin Brooks, Yu-Chieh Tzeng, Julian Crane, Richard Beasley, Peter Gibson, Philip Pattemore, Thorsten Stanley, Neil Pearce, Jeroen Douwes
Summary: This study found that autonomic nervous system activity is not associated with pathophysiology or inflammatory phenotype in young asthmatics with generally well-controlled asthma. However, enhanced sympathetic nervous system activity can be detected in asthmatics with airway hyperreactivity or who use beta-agonist medication.
Review
Allergy
Ian D. Pavord, Peter J. Barnes, Catherine Lemiere, Peter G. Gibson
Summary: Optimizing asthma diagnosis is crucial for reducing the burden of asthma globally. A compound diagnostic approach and label are now required due to the complexity and heterogeneity of different forms of asthma. By recognizing typical symptoms and abnormal physiology, asthma can be identified, and further features such as eosinophilic or type 2 inflammation can be used to give a compound diagnostic label of eosinophilic asthma, which provides important information about future exacerbation risk and treatment responsiveness. Implementing treatable traits and using targeted assessment allows for a specific treatment plan based on a pragmatic and iterative process. (c) 2022 Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology (J Allergy Clin Immunol Pract 2023;11:1-8)
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Allergy
Vanessa E. Murphy, Annelies L. Robijn, Tommy B. Metcalfe, Thomas K. Wright, Peter G. Gibson, Kirsten McCaffery, Megan E. Jensen
Summary: This study investigated beliefs about medicines in pregnant women with asthma and their association with adherence to inhaled corticosteroids (ICS). The findings showed that ICS users were more likely to perceive that the benefits of medication use outweighed any risks, while non-adherence was not associated with having relatively more concerns about asthma medicines.
Editorial Material
Respiratory System
Peter G. Gibson
Article
Allergy
Lei Liu, Ying Liu, Xin Zhang, Yu Lai Yuan, Zhi Hong Chen, Alan Chen-Yu Hsu, Brian G. Oliver, Min Xie, Ling Qin, Wei Min Li, Dan Liu, Gang Wang, Lisa G. Wood
Summary: This study investigated the relationships between dyslipidemia, asthma phenotypes, and future asthma exacerbations. The results showed that dyslipidemia was associated with airway obstruction, asthma phenotypes, and asthma exacerbations.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Review
Respiratory System
Hayley A. Scott, Shawn H. M. Ng, Rebecca F. McLoughlin, Sarah R. Valkenborghs, Parameswaran Nair, Alexandra C. Brown, Olivia R. Carroll, Jay C. Horvat, Lisa G. Wood
Summary: This review examined the association between obesity and airway/systemic inflammation and adipokine levels in adults with asthma. The results showed that obese asthmatics have a different pattern of inflammation compared to non-obese asthmatics. Further mechanistic studies and investigations into the clinical relevance of this altered inflammatory response are warranted.
Article
Nutrition & Dietetics
Lily M. Williams, Bronwyn S. Berthon, Isobel L. Stoodley, Evan J. Williams, Lisa G. Wood
Summary: Medicinal mushroom extracts (MMEs) have immunomodulatory effects on innate immunity. This study examined the influence of MMEs on immune cell responses to inflammatory stimuli in older adults. The extracts showed differential effects on the release of inflammatory and antiviral mediators in vitro.
Article
Nutrition & Dietetics
Erin D. Clarke, Jordan Stanford, Jessica J. A. Ferguson, Lisa G. Wood, Clare E. Collins
Summary: This study investigates the relationship between fatty acids, diet quality scores, and inflammatory markers. The results indicate a positive association between saturated fat and inflammation, while monounsaturated fatty acids, polyunsaturated fatty acids, and the Mediterranean diet are inversely associated with inflammation.
Article
Nutrition & Dietetics
Natalie Gray, Isobel G. Stoodley, Lisa E. Wood, Clare J. Collins, Leanne M. Brown, Kym G. Rae, Kirsty L. Pringle, Tracy Schumacher
Summary: Higher intakes of Omega-3 long-chain polyunsaturated fatty acids are associated with lower rates of preterm birth and preeclampsia. This study analyzed the dietary intake and fractions of LC-PUFAs in Indigenous Australian women during pregnancy. Results showed that a majority of the women met national recommendations for n-3 LC-PUFA intake, but had low levels of ALA in their RBC membranes. Further research is needed to understand the role of fatty acids in preterm birth and preeclampsia.
Review
Respiratory System
Peter G. Gibson, Vanessa M. McDonald, Dennis Thomas
Summary: The landscape of asthma has changed significantly in the last decade with the development of effective medications and inhaler devices. However, the proportion of uncontrolled patients remains high, primarily due to factors such as inappropriate use of medications, disease heterogeneity, and other contributing factors. Inhaled corticosteroids (ICS) with or without long-acting beta agonists (LABA) are currently the mainstay of asthma management. The future of asthma treatment will involve personalized medications and smart inhalers to improve adherence, inhaler technique, and polypharmacy. Precision medicine approaches, such as treatable traits (TTs), aim to identify and manage specific clinically important factors to optimize treatment. Research and validation of TTs in different clinical settings and populations are ongoing. Combination inhaler therapy and the TTs approach are complementary treatment strategies.
Review
Respiratory System
Hayley Lewthwaite, Anthony Byrne, Bruce Brew, Peter G. Gibson
Summary: Long COVID is a new and complex chronic health condition experienced by one in eight adults following acute COVID-19. 'Treatable Traits' is a personalized medicine approach that can address the complexity and heterogeneity of this condition, by identifying and targeting the most prevalent treatable traits associated with long COVID. Current evidence supports exercise training or respiratory muscle training for long COVID treatable traits in the chest and functional limitation clusters, but further high-quality research is needed for other treatable traits.
Editorial Material
Respiratory System
Peter G. Gibson
Review
Nutrition & Dietetics
Isobel L. Stoodley, Lily M. Williams, Lisa G. Wood
Summary: Maintaining muscle mass, strength, and function is crucial for the elderly population. Exercise and dietary protein intake are recommended strategies, with animal proteins being the most studied. However, plant-based proteins have been found to have lower digestibility and incomplete amino acid profiles. This systematic review evaluated the effects of plant-based protein interventions compared to placebo on body composition, strength, and physical function in older adults. The review found that plant-based protein interventions improved muscle mass over time and were comparable to other interventions in terms of effectiveness.
Editorial Material
Allergy
Paola D. Urroz Guerrero, Peter G. Gibson
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Meeting Abstract
Nutrition & Dietetics
S. R. Valkenborghs, L. G. Wood, R. Callister, J. W. Upham, C. L. Grainge, S. Anderson, L. M. Williams, R. F. McLoughlin, E. J. Williams, H. A. Scott
PROCEEDINGS OF THE NUTRITION SOCIETY
(2023)
