Article
Immunology
Ainsley Lockhart, Aubrey Reed, Tiago Rezende de Castro, Calvin Herman, Maria Cecilia Campos Canesso, Daniel Mucida
Summary: The intestinal immune system must tolerate food antigens to avoid allergy, a process requiring CD4(+) T cells. Combining antigenically defined diets with gnotobiotic models, the study shows that both food and microbiota have distinct effects on the profile and T cell receptor repertoire of intestinal CD4(+) T cells. The response of CD4(+) T cells to food is disrupted by inflammatory challenge, but protection against food allergy is associated with Treg clonal expansion and decreased proinflammatory gene expression.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Immunology
Linglin Fu, Wanglei Lin, Chong Wang, Yanbo Wang
Summary: In this study, a 3-dimensional intestinal cell model was established to mimic the intestinal mucosal immune system, showing more significant and specific allergic responses compared to conventional cell models and mouse models. This model is of great importance for food allergy investigations.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Alejandro J. Brenes, Maud Vandereyken, Olivia J. James, Harriet Watt, Jens Hukelmann, Laura Spinelli, Dina Dikovskaya, Angus Lamond, Mahima Swamy
Summary: Studies have shown that induced T-IEL and natural T-IEL subsets exhibit differences in their proteomes and metabolic pathways, indicating a significant impact of the gut environment on T-IEL phenotypes. Features such as the skewing of the cell surface repertoire, energy barrier, and high cholesterol levels in T-IEL help maintain their homeostasis and function.
Article
Fisheries
Nathalie Meijerink, Daphne A. van Haarlem, Francisca C. Velkers, Arjan J. Stegeman, Victor P. M. G. Rutten, Christine A. Jansen
Summary: This study characterized various NK subsets in the intestines of broiler chickens, with differences observed between organs rather than over time. Targeting these intestinal NK subsets may be a strategy to improve immune-mediated resistance in broiler chickens.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Immunology
Hans Van der Weken, Raquel Sanz Garcia, Niek N. Sanders, Eric Cox, Bert Devriendt
Summary: Although oral vaccination is optimal for inducing intestinal immunity, challenges remain due to the gastrointestinal environment and poor uptake of vaccine antigens. Targeting molecules to aminopeptidase N on intestinal epithelial cells may improve uptake and delivery to the gut immune system, showing promise for the development of oral vaccines against gut pathogens.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Allergy
Martin Klein, Barbara Misme-Aucouturier, Marie-Aude Cheminant, Marion De Carvalho, Marie Wauters, Olivier Tranquet, Antoine Magnan, Gregory Bouchaud
Summary: The study investigated the therapeutic potential of expanding Tregs with an IL-2/IL-2 antibody complex in allergies. Results showed that the complex treatment significantly reduced allergic symptoms, specific IgE production, and tissue damage while modulating innate lymphoid cells. The IL-2/anti-IL-2 complex offers new hope for reestablishing immune tolerance in patients with allergies.
Article
Oncology
Meghan E. Sise, Qiyu Wang, Harish Seethapathy, Daiana Moreno, Destiny Harden, R. Neal Smith, Ivy A. Rosales, Robert B. Colvin, Sarah Chute, Lynn D. Cornell, Sandra M. Herrmann, Riley Fadden, Ryan J. Sullivan, Nancy J. Yang, Sara Barmettler, Sophia Wells, Shruti Gupta, Alexandra-Chloe Villani, Kerry L. Reynolds, Jocelyn Farmer
Summary: Non-invasive biomarkers such as elevated sIL-2R level and flow cytometric markers of B and T cell dysregulation may aid in the diagnosis of immune checkpoint inhibitor-associated acute tubulointerstitial nephritis (ICI-nephritis).
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Naveen K. Mehta, Martin Pfluegler, Kristan Meetze, Bochong Li, Isabelle Sindel, Fabian Vogt, Melanie Marklin, Jonas S. Heitmann, Joseph Kauer, Lukas Osburg, Latifa Zekri, Hans-Joerg Buehring, Stefanie Mueller, Sebastian Hoerner, Patrick A. Baeuerle, Jennifer S. Michaelson, Gundram Jung, Helmut R. Salih
Summary: Immunotherapeutic strategies using CAR-T cells and bsAbs have achieved remarkable clinical success in lymphoid malignancies but not in acute myeloid leukemia (AML). This study developed a bsAb, CLN-049, targeting FLT3 and demonstrated its favorable efficacy and safety profile in preclinical models, indicating its potential as a treatment option for AML.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Khalid W. Kalim, Jun-Qi Yang, Mark Wunderlich, Vishnu Modur, Phuong Nguyen, Yuan Li, Ting Wen, Ashley Kuenzi Davis, Ravinder Verma, Qing Richard Lu, Anil G. Jegga, Yi Zheng, Fukun Guo
Summary: Targeting Cdc42 in Treg cells has shown promising therapeutic potential in cancer immunotherapy, by enhancing antitumor T-cell immunity without triggering autoimmune reactions. This approach involves inducing Treg cell instability through Cdc42 targeting, leading to improved immune responses against tumors.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Karen J. Froning, Arlene Sereno, Flora Huang, Stephen J. Demarest
Summary: T cell receptor (TCR) therapeutics have the unique ability to recognize intracellular antigens on virus-infected or cancerous cells. In this study, recombinant TCR/anti-CD3 bifunctionals directed towards NY-ESO-1 or MAGE-A3 were generated with various molecular formats. The results showed that the potency of inducing redirected lysis activity against tumors was highly restricted to small, tandem binding formats with an rTCR/antiCD3 Fab, while molecules with IgG-like or IgG-Fc structures displayed poor activity.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Sandhya Sharma, Mae Woods, Naren U. Mehta, Tim Sauer, Kathan S. Parikh, Michael Schmuck-Henneresse, Huimin Zhang, Birju Mehta, Malcolm K. Brenner, Helen E. Heslop, Cliona M. Rooney
Summary: This study found that depleting naive T cells before extracting antigen-specific T cells from patients can enhance their expansion, antigen specificity, and therapeutic potency. By using CD45RA-depleted PBMCs, EBV-specific T cells were successfully generated and applied in clinical trials for lymphoma and viral infections.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Aakash P. Desai, Farhad Kosari, Maria Disselhorst, Jun Yin, Alireza Agahi, Tobias Peikert, Julia Udell, Sarah H. Johnson, James Smadbeck, Stephen Murphy, Giannoula Karagouga, Alexa McCune, Janet Schaefer-Klein, Mitesh J. Borad, John Cheville, George Vasmatzis, Paul Baas, Aaron Mansfield
Summary: Two unique TCR clusters associated with survival were identified in patients with pleural mesothelioma treated with ICI. These clusters may provide insights for antigen discovery and the design of adoptive T cell therapies.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Hyun J. Jang, Christine Caron, Calvin K. Lee, Lu Wang, Burhan Jama, Jack D. Bui, Gerald P. Morris
Summary: The discovery that 16% of T cells naturally co-express two T-cell receptor (TCR) clonotypes prompts the examination of the role of dual TCR cells in immune functions. Using TCR alpha-reporter transgenic mice, the study tested the role of dual TCR cells in antitumor immune responses and found that they had a selective advantage in tumor responses. Dual TCR cells demonstrated an advantage in recognition of B16F10-derived neoantigens, suggesting their potential in antitumor immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Immunology
Rosina Lopez-Fandino, Elena Molina, Daniel Lozano-Ojalvo
Summary: The gastrointestinal tract has to balance nutritional needs and prevent the entry of harmful substances. It adjusts absorptive and defending functions by sensing environmental changes and activating adaptive mechanisms. Homeostatic processes at barrier sites protect from adverse reactions to food and maintain intestinal stability with the help of microbiota and dietary antigens.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Wenbin Zhou, Muxin Yu, Hong Pan, Wen Qiu, Hui Wang, Mengjia Qian, Nan Che, Kai Zhang, Xinrui Mao, Li Li, Ruoxi Wang, Hui Xie, Lijun Ling, Yi Zhao, Xiaoan Liu, Cong Wang, Qiang Ding, Shui Wang
Summary: Microwave ablation (MWA) has shown a high complete ablation rate for early-stage breast cancer and induced a shift in the Th1/Th2 balance towards Th1, along with stimulating antitumor immune response. This suggests that MWA may not only be a promising local therapy for breast cancer but also trigger antitumor immunity, offering new avenues for treatment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
