期刊
NUTRIENTS
卷 2, 期 5, 页码 532-550出版社
MDPI
DOI: 10.3390/nu2050532
关键词
vitamin A-deficient; quail embryo; retinoic acid; gene regulation; heart morphogenesis
资金
- NIH
- USDA
- Michigan Agricultural Experiment Station
Vitamin A insufficiency has profound adverse effects on embryonic development. Major advances in understanding the role of vitamin A in vertebrate heart formation have been made since the discovery that the vitamin A active form, all-trans-retinoic acid, regulates many genes, including developmental genes. Among the experimental models used, the vitamin A-deficient avian embryo has been an important tool to study the function of vitamin A during early heart formation. A cluster of retinoic acid-regulated developmental genes have been identified that participate in building the heart. In the absence of retinoic acid the embryonic heart develops abnormally leading to embryolethality.
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