Article
Food Science & Technology
Tomas Merono, Gregorio Peron, Giorgio Gargari, Raul Gonzalez-Dominguez, Antonio Minarro, Esteban Vegas-Lozano, Nicole Hidalgo-Liberona, Cristian Del Bo, Stefano Bernardi, Paul Antony Kroon, Barbara Carrieri, Antonio Cherubini, Patrizia Riso, Simone Guglielmetti, Cristina Andres-Lacueva
Summary: A polyphenol-rich diet can reduce intestinal permeability in older adults. Participants categorized according to urolithin metabotypes (UMs) exhibited different responses in the improvement of intestinal permeability after the diet. UMs identified as metabotype B showed higher improvement in intestinal permeability and exhibited changes in fatty acid metabolism, the kynurenine pathway of tryptophan catabolism, and microbial metabolization of phenolic acids. These findings are important for tailoring personalized nutrition interventions.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Agriculture, Multidisciplinary
Carlos E. Iglesias-Aguirre, Rocio Garcia-Villalba, David Beltran, Maria Dolores Frutos-Lison, Juan C. Espin, Francisco A. Tomas-Barberan, Maria V. Selma
Summary: We discovered a new bacterium in the feces of a healthy woman that can produce urolithins A and B as well as intermediate metabolites. Additionally, we developed co-culture systems that reproduced the production of urolithins upon fermentation of UM-A and UM-B. This finding demonstrates the potential of these urolithin-producing bacteria for use as probiotics and in the production of bioactive urolithins for various applications.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Food Science & Technology
Chen Wang, Junying Bai, Botao Wang, Leilei Yu, Fengwei Tian, Jianxin Zhao, Hao Zhang, Huayi Suo, Wei Chen, Qixiao Zhai
Summary: The prebiotic stachyose, extracted from plants, has been found to alleviate intestinal inflammation by regulating gut microbiota. Its administration can restore body weight, protect against colonic tissue damage, reduce pro-inflammatory cytokines levels, and reverse histological abnormalities in ulcerative colitis mice. Furthermore, stachyose can restore disturbed intestinal bacteria and alter serum metabolites against inflammatory responses in colitis mice. These findings provide a strong foundation for future studies on the protective role of stachyose in maintaining intestinal homeostasis.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Agriculture, Multidisciplinary
Wenyan Xian, Shiying Yang, Yu Deng, Yuzhe Yang, Chunlian Chen, Wu Li, Ruili Yang
Summary: This study reported the distribution of urolithin metabotypes in Chinese youth and found differences in richness and diversity of gut microbiota among the three metabotypes. The abundance of Gordonibacter and presence of Akkermansia varied significantly among different metabotypes. Correlation analysis showed associations between urolithin types and gut microbiota at the genus level. Further research is needed to explore the mechanisms and health implications of these metabotypes.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Rocio Guizar-Heredia, Lilia G. Noriega, Ana Leonor Rivera, Osbaldo Resendis-Antonio, Martha Guevara-Cruz, Nimbe Torres, Armando R. Tovar
Summary: A prolonged and elevated postprandial glucose response (PPGR) is a key factor in the development of metabolic syndrome and type 2 diabetes, and can be prevented through dietary interventions. However, dietary recommendations alone have not always been successful in preventing alterations in PPGR, as it is also influenced by genetics, body composition, gut microbiota, and other factors. Recent advancements in continuous glucose monitoring and machine learning have made it possible to predict the effects of different dietary foods on PPGRs, allowing for personalized dietary recommendations. Additional components such as nutrigenomics, nutrigenetics, and metabolomics can further enhance the predictive algorithms. This review summarizes the evidence and future prospects of personalized nutrition in preventing PPGR and improving metabolic diseases.
ARCHIVES OF MEDICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Weijun Cui, Xinling Song, Xueping Li, Le Jia, Chen Zhang
Summary: A low molecular weight polysaccharides, HEP-1, was isolated and characterized from the fruiting body of Hericium erinaceus. HEP-1 showed potential effects against T2DM-induced imbalance of glucose and lipid metabolism by activating the IRS/PI3K/AKT signaling pathway and inhibiting fatty acid synthesis via the AMPK/SREBP-1c signaling pathways. Moreover, HEP-1 promoted the production of beneficial bacteria in the gut and increased beneficial metabolites in the liver, thus resisting the occurrence of T2DM through the gut-liver axis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Medicine, Research & Experimental
Cheng Li
Summary: Human responses to the same diets vary due to complex diet-host-microbiota interactions. Recent advances show that quantifying this interaction could lead to personalized nutrition strategies for improving individual health. The gut microbiome, compared to host related factors, can be easily modulated by dietary exposures and plays a crucial role in human health. However, limitations in processing and analyzing 'big-data' on the human microbiome hinder the translation of diet-host-microbiota interactions into tools for personalized health improvement. This review aims to summarize recent advances in understanding diet-host-microbiota interactions to aid in the development of personalized nutrition strategies.
Article
Biochemical Research Methods
Belen Callejon-Leblic, Marta Selma-Royo, Maria Carmen Collado, Jose Luis Gomez-Ariza, Nieves Abril, Tamara Garcia-Barrera
Summary: In this study, the interaction between selenium intake, gut microbiota, and metabolites was investigated. Significant differences in gut metabolites were observed in mice after selenium supplementation, indicating the important effect of selenium on microbiota metabolism. The correlation analysis revealed associations between metabolites and gut bacterial profiles, with a higher abundance of Lactobacillus spp. associated with specific metabolite levels.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Microbiology
Armin Rashidi, Maryam Ebadi, Tauseef Ur Rehman, Heba Elhusseini, Harika Nalluri, Thomas Kaiser, Shernan G. Holtan, Alexander Khoruts, Daniel J. Weisdorf, Christopher Staley
Summary: Our study found that despite heavy and sustained antibiotic pressure, microbial communities within the same patient remained more similar to each other than to those from other patients. We identified 6 taxa within the pre-treatment microbiota that predicted the extent of antibiotic-induced perturbations. Our results suggest that specific species in the pre-treatment microbiota play a key role in determining personalized microbiota responses to antibiotics in humans, which could lead to precision interventions to prevent antibiotic-induced dysbiosis and its adverse clinical consequences.
Article
Clinical Neurology
Yu Kong, Zhongyun Chen, Xuedan Feng, Ya Zuo, Jing Zhang
Summary: This study evaluated the changes in gut microbiota and metabolites in patients with sporadic Creutzfeldt-Jakob disease (sCJD) and found significant differences compared to healthy controls. Certain bacteria taxa were increased in sCJD patients, while metabolites related to phenylpropanoid biosynthesis showed a prominent decrease. Additionally, metabolites involved in linoleic acid metabolism and steroid hormone biosynthesis were associated with disease severity. These findings provide new insights into the relationship between gut microbiota, metabolites, and sCJD, and suggest potential biomarkers for disease evaluation.
JOURNAL OF NEUROLOGY
(2023)
Article
Microbiology
Qi Zhao, Jian-Feng Huang, Yan Cheng, Man-Yun Dai, Wei-Feng Zhu, Xiu-Wei Yang, Frank J. Gonzalez, Fei Li
Summary: This study found that alterations in gut microbiota are linked to testicular dysfunction through disruption of polyamine metabolism. The diversity and dynamics of the gut microbiota may be considered as a therapeutic option to prevent male infertility.
Article
Cardiac & Cardiovascular Systems
Huanan Shi, Bojun Zhang, Taylor Abo-Hamzy, James W. Nelson, Chandra Shekar R. Ambati, Joseph F. Petrosino, Robert M. Jr Jr Bryan, David J. Durgan
Summary: Recent studies have shown that intermittent fasting can alter the gut microbiota and reduce blood pressure, while identifying microbial influenced metabolites as potential mediators in the regulation of host blood pressure.
CIRCULATION RESEARCH
(2021)
Article
Nutrition & Dietetics
Jessica M. Moon, Peter Finnegan, Richard A. Stecker, Hanna Lee, Kayla M. Ratliff, Ralf Jager, Martin Purpura, Carolyn M. Slupsky, Maria L. Marco, Craig J. Wissent, Jason Theodosakis, Chad M. Kerksick
Summary: Glucosamine supplementation can improve gastrointestinal function, reduce stomach bloating, slightly decrease constipation and hard stools, as well as induce changes in fecal microbiota and metabolome.
Article
Biochemistry & Molecular Biology
Carlos J. Garcia, Vit Kosek, David Beltran, Francisco A. Tomas-Barberan, Jana Hajslova
Summary: This study evaluated the diversity of microbially conjugated bile acids (MCBAs) produced by the gut microbiota through a metabolomics approach. The results showed that the gut microbiota can produce various MCBAs and re-conjugate hydroxyls on the sterol backbone as well as generate esters at the C24 acyl site of bile acids.
Article
Medicine, Research & Experimental
Yang Zheng, Jiahui Wang, Jiaru Wang, Ruizhu Jiang, Tiejian Zhao
Summary: This study investigated the effects of curcumol on liver fibrosis in mice through analysis of gut microbiota and serum metabolomics. The results revealed the relationship between gut microbiota and metabolites in the process of liver fibrosis. Curcumol was found to improve pathological changes in liver tissue and inhibit liver inflammation. Furthermore, it was found to alter the abundances of certain gut bacteria and regulate arachidonic acid metabolism, suggesting its potential antihepatic fibrosis effect.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Nutrition & Dietetics
James P. Wirth, Fatmata Sesay, Joshua Mbai, Sundus Ibrahim Ali, William E. S. Donkor, Bradley A. Woodruff, Zahra Pilane, Kheyriya Mohamed Mohamud, Ahmed Muse, Hamda Omar Yussuf, Warsame Said Mohamed, Rosmarie Veraguth, Serge Rezzi, Thomas N. Williams, Abdullahi Muse Mohamoud, Farhan Mohamed Mohamud, Melanie Galvin, Fabian Rohner, Yvonne Katambo, Nicolai Petry
Summary: Limited data on anaemia and iron deficiency in Somalia were addressed by a 2019 micronutrient survey, which found high prevalence rates in children and women. Iron deficiency was identified as the main risk factor for anaemia, contributing to a substantial portion of the cases. Enhancing food assistance and micronutrient-specific programmes are recommended to tackle the anaemia and iron deficiency issues in Somalia.
MATERNAL AND CHILD NUTRITION
(2022)
Article
Nutrition & Dietetics
Mette M. Berger, Alan Shenkin, Anna Schweinlin, Karin Amrein, Marc Augsburger, Hans-Konrad Biesalski, Stephan C. Bischoff, Michael P. Casaer, Kursat Gundogan, Hanna-Liis Lepp, Angelique M. E. de Man, Giovanna Muscogiuri, Magdalena Pietka, Loris Pironi, Serge Rezzi, Cristina Cuerda
Summary: This guideline aims to provide information for daily clinical nutrition practice regarding assessment, monitoring, and prescription of micronutrients (MNs), and proposes a consensus terminology to reduce confusion.
CLINICAL NUTRITION
(2022)
Article
Critical Care Medicine
Lucile Equey, Philipp K. A. Agyeman, Rosemarie Veraguth, Serge Rezzi, Luregn J. Schlapbach, Eric Giannoni
Summary: This study investigated the levels of ascorbic acid (VitC) and thiamine (VitB1) in newborns and children with blood culture-proven sepsis, and found that low and deficient levels of these vitamins were frequently observed. Age, systemic inflammation, and vitamin supplementation were associated with vitamin levels during sepsis.
PEDIATRIC CRITICAL CARE MEDICINE
(2022)
Article
Nutrition & Dietetics
Pollyanna Patriota, Serge Rezzi, Idris Guessous, Pedro Marques-Vidal
Summary: This population-based prospective cohort study found no association between vitamin D levels and changes in weight and waist circumference at 5- and 10-year follow-up.
Review
Public, Environmental & Occupational Health
Konstantinos Mantantzis, Vanessa Campos, Christian Darimont, Francois-Pierre Martin
Summary: Sleep is crucial for health and wellbeing, and is associated with circadian metabolic and physiological changes. Diet and glucose regulation play significant roles in sleep quality. Improving sleep through dietary changes can lead to positive impacts on health, wellbeing, and overall quality of life.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Nutrition & Dietetics
Francois-Pierre Martin, Hanne L. P. Tytgat, Helle Krogh Pedersen, Deborah Moine, Aron C. Eklund, Bernard Berger, Norbert Sprenger
Summary: Human milk oligosaccharides (HMOs) in breast milk, specifically 2-HMO (2'fucosyllactose, lacto-N-neotetraose), have been found to reduce the risk of lower respiratory tract infections (LRTIs) in infants. This study aimed to further investigate the molecular pathways linking 2-HMO formula feeding and LRTI mitigation. The researchers found that 2-HMO formula feeding increased gamma-glutamylation and N-acetylation of amino acids, while decreasing inflammatory signaling lipids. Additionally, specific Bifidobacterium and Bacteroides species were implicated in these metabolic changes. These findings contribute to our understanding of infant gut and microbiome metabolism and how it may impact immune competence.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Pollyanna Patriota, Serge Rezzi, Idris Guessous, Pedro Marques-Vidal
Summary: This study conducted in Switzerland assessed the association between 25-hydroxyvitamin D and long-term weight change. The findings suggest a limited correlation between genetically determined vitamin D levels and weight gain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Pollyanna Patriota, Serge Rezzi, Idris Guessous, Pedro Marques-Vidal
Summary: Several studies have shown an inverse association between serum levels of vitamin D and obesity. This study aimed to investigate the associations between vitamin D levels and various anthropometric markers and adipokines. The results revealed a negative correlation between vitamin D levels and most anthropometric markers, and a positive correlation with adiponectin levels in women. Total body fat was found to be the strongest marker associated with decreased vitamin D levels.
SCIENTIFIC REPORTS
(2022)
Article
Nutrition & Dietetics
Barbara Walther, Dominik Guggisberg, Rene Badertscher, Lotti Egger, Reto Portmann, Sebastien Dubois, Max Haldimann, Katrin Kopf-Bolanz, Peter Rhyn, Otmar Zoller, Rosmarie Veraguth, Serge Rezzi
Summary: The decline in liquid milk consumption in Western countries has been compensated by the increased consumption of processed dairy products and the introduction of new plant-based beverages. However, these plant-based drinks are not real alternatives to milk in terms of nutrient composition and protein quality. Completely replacing milk with plant-based drinks without adjusting the overall diet can lead to deficiencies of certain important nutrients in the long term.
FRONTIERS IN NUTRITION
(2022)
Article
Pediatrics
Pollyanna Patriota, Sylvie Borloz, Inge Ruiz, Therese Bouthors, Serge Rezzi, Pedro Marques-Vidal, Michael Hauschild
Summary: This study aimed to assess the prevalence of hypovitaminosis D and its associations with cardiovascular risk factors in adolescents with obesity. The results showed that almost 9 out of 10 adolescents with obesity in the study cohort had hypovitaminosis D, but it did not seem to be associated with a higher cardiovascular risk profile.
Article
Nutrition & Dietetics
Antoine Equey, Mette M. Berger, Semira Gonseth-Nussle, Marc Augsburger, Serge Rezzi, Andrew C. C. Hodgson, Sandrine Estoppey, Giuseppe Pantaleo, Celine Pellaton, Maiwenn Perrais, Sebastien Lenglet, Valentin Rousson, Valerie D'Acremont, Murielle Bochud
Summary: Low plasma zinc levels are associated with higher anti-SARS-CoV-2 IgG and IgA seropositivity in the Swiss population, suggesting that adequate zinc status may play an important role in protecting against COVID-19 infection.
CLINICAL NUTRITION
(2023)
Article
Chemistry, Multidisciplinary
Rafael V. M. Freire, Linda Hong, Miroslav Peterek, Stephane Canarelli, Serge Rezzi, Stefan Salentinig
Summary: Functional food emulsions enriched in health-promoting nutrients, such as buriti oil, have been studied for their effects on cardiometabolic health. This study investigates the colloid transformations of whey-stabilized buriti oil-in-water emulsions during simulated digestion. It is found that the oil phase transforms into highly ordered structures during simulated intestinal digestion under compromised bile conditions, and the digestion process can be modulated by adding vitamin E to the oil.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Claire L. K. Boulange, Helle K. Pedersen, Francois-Pierre Martin, Lea Siegwald, Albert Palleja C. Caro, Aron C. Eklund, Wei Jia, Huizhen Zhang, Bernard Berger, Norbert G. Sprenger, Ralf G. Heine, CINNAMON Study Investigator Grp
Summary: Cow's milk protein allergy (CMPA) is a common food allergy in infants and young children. A study was conducted on non-breastfed infants with CMPA to assess the effects of a whey-based extensively hydrolyzed formula (EHF) supplemented with 2'-fucosyllactose (2'-FL) and lacto-N-neotetraose (LNnT) on the fecal microbiome and metabolome. The supplementation of human milk oligosaccharides (HMO) enriched bifidobacteria in the gut microbiome and delayed the shift of the microbiome composition towards an adult-like pattern. HMO supplementation partially corrected the dysbiosis commonly observed in infants with CMPA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Pollyanna Patriota, Idris Guessous, Serge Rezzi, Pedro Marques-Vidal
Summary: This prospective population-based study found that vitamin D levels were inversely associated with cardiovascular disease (CVD) events, but not with CVD or overall mortality.
Meeting Abstract
Gastroenterology & Hepatology
Shiying Zhang, Xochitl Morgan, Belgin Dogan, Francois-Pierre J. Martin, Suzy Strickler, Akihiko Oka, Jeremy Herzog, Bo Liu, Scot E. Dowd, Curtis Huttenhower, Matthieu Pichaud, Esra Dogan, Randy Longman, Rhonda Yantiss, Lukas A. Mueller, Ellen J. Scherl, R. Balfour Sartor, Kenneth W. Simpson
