Article
Endocrinology & Metabolism
Benjamin C. T. Field, Yue A. Ruan, Kinga Varnai, Jim Davies, Robert E. J. Ryder, Rajiv Gandhi, Sophie Harris, Dinesh Nagi, Dipesh Patel, Punith H. Kempegowda, Sarah G. Wild, Emma Wilmot, Kamlesh Khunti, Rustam Rea, Parth Narendran
Summary: This study investigated the characteristics of people hospitalized with COVID-19 and diabetic ketoacidosis (DKA) or hyperosmolar hyperglycaemic state (HHS), and identified risk factors for mortality and intensive care admission. The study found that DKA had a higher mortality rate and a lower proportion of non-White ethnicity compared to HHS. Previous insulin therapy was strongly associated with survival in type 2 diabetes-associated DKA.
DIABETES OBESITY & METABOLISM
(2023)
Review
Medicine, General & Internal
Esraa Mamdouh Hassan, Hisham Mushtaq, Esraa Elaraby Mahmoud, Sherley Chhibber, Shoaib Saleem, Ahmed Issa, Jain Nitesh, Abbas B. Jama, Anwar Khedr, Sydney Boike, Mikael Mir, Noura Attallah, Salim Surani, Syed A. Khan
Summary: Diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemia state (HHS) are two life-threatening metabolic complications of diabetes, and reaching a consensus on their diagnostic criteria and treatment has been challenging. The overlap between these two conditions adds an additional hurdle. Timely diagnosis and treatment based on a complete evaluation are crucial, but large-scale studies are lacking.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Environmental Sciences
Keitaro Miyamura, Nobutoshi Nawa, Hisaaki Nishimura, Kiyohide Fushimi, Takeo Fujiwara
Summary: This study aims to investigate the impact of heat exposure on hospitalization for diabetic ketoacidosis, hyperosmolar hyperglycemic state, and hypoglycemia. The results show that heat exposure is associated with an increased risk of hospitalization for these hyperglycemic emergencies.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Kyosuke Takahashi, Norimichi Uenishi, Masamitsu Sanui, Shigehiko Uchino, Naoki Yonezawa, Tetsuhiro Takei, Norihiro Nishioka, Hirotada Kobayashi, Shunichi Otaka, Kotaro Yamamoto, Hideto Yasuda, Shintaro Kosaka, Hidehiko Tokunaga, Naoki Fujiwara, Takashiro Kondo, Tomoki Ishida, Takayuki Komatsu, Koji Endo, Taiki Moriyama, Takayoshi Oyasu, Mineji Hayakawa, Atsumi Hoshino, Tasuku Matsuyama, Yuki Miyamoto, Akihiro Yanagisawa, Tadamasa Wakabayashi, Takeshi Ueda, Tetsuya Komuro, Toshiro Sugimoto, Alan Kawarai Lefor
Summary: This multicenter retrospective cohort study in Japan investigated the clinical profiles and outcomes of patients with diabetic ketoacidosis (DKA) and hyperglycemic hyperosmolar syndrome (HHS). The study found that the mortality rate of DKA patients was similar to previous studies, while the mortality rate of HHS patients was lower. There was variation in ICU admission rates among different hospitals, and no significant association was found between the severity of DKA and mortality.
ACTA DIABETOLOGICA
(2023)
Article
Endocrinology & Metabolism
Eric S. S. Kilpatrick, Alexandra E. E. Butler, Linda Ostlundh, Stephen L. L. Atkin, David B. B. Sacks
Summary: The measurement of blood ketones has become an important tool in diagnosing and managing diabetic ketoacidosis. However, there is still disparity among guidelines on when and how to use this test, and several issues, such as inconsistent measurement methods and lack of evidence for cutoff values, remain to be addressed.
Article
Endocrinology & Metabolism
Maheswaran Dhanasekaran, Sneha Mohan, Dana Erickson, Pankaj Shah, Linda Szymanski, Vella Adrian, Aoife M. Egan
Summary: This study evaluated the occurrence of diabetic ketoacidosis (DKA) in pregnant women at our hospital and identified the associated clinical risk factors. The study found that DKA was associated with a high rate of maternofetal morbidity and fetal loss. Maternal social stressors and suboptimal glycemic control were commonly found. Prenatal education strategies for women with diabetes mellitus should prioritize the prevention of DKA.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Wenjing Zhang, Jiexiu Chen, Juan Bi, Nan Ding, Xin Chen, Zhuo Wang, Yang Jiao
Summary: This study conducted a systematic review to recognize the rare adverse event of combined diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS) associated with immune checkpoint inhibitors (ICIs). The study identified clinical features and outcomes of patients with ICIs-combined DKA-HHS, emphasizing the need for healthcare professionals and patients to be aware of the differences in treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Carly Yim, Nassrein Hussein, Terra Arnason
Summary: An elderly woman with metastatic breast cancer developed hyperglycaemic hyperosmolar state (HHS) following chemotherapy with capecitabine. Treatment involved acutely managing HHS and adjusting insulin regimen, emphasizing the importance of blood glucose monitoring during chemotherapy.
Article
Clinical Neurology
Barry Ting Sheen Kweh, Terence Tan, Andrew Morokoff
Summary: This report presented the first case of RCVS likely induced by a combination of factors including HHS, cyclophosphamide chemotherapy, non-Hodgkin's lymphoma, pancytopenia, and previous blood transfusions. The clinical presentation in this case suggested that HHS was the crucial inciting factor. This case highlights the need for a high index of suspicion for RCVS, given its dynamic and transient clinical and radiological features.
JOURNAL OF CLINICAL NEUROSCIENCE
(2021)
Article
Endocrinology & Metabolism
Matteo Monami, Alessia Scatena, Cesare Miranda, Luca Monge, Alessandro De Cassai, Antonio Volpe, Rodolfo Tramonta, Gerardo Medea, Corrado Bordieri, Marco Falcone, Laura Stefanon, Andrea Bernetti, Cristina Cappella, Mauro Gargiulo, Valentina Lorenzoni, Germano Scevola, Eugenio Stabile, Benedetta Ragghianti, Giovanni Antonio Silverii, Roberto da Ros, Marco Meloni, Laura Giurato, Giuseppe Murdolo, Eleonora Bianchini, Francesco Gaggia, Carlotta Gauna, Francesco Romeo, Matteo Apicella, Michele Mantuano, Luigi Uccioli, Cristiana Vermigli
Summary: The Italian Society of Diabetology and other scientific societies are developing the first Italian guidelines for the treatment of diabetic foot syndrome (DFS), covering diagnosis, treatment, prevention, and organization management.
ACTA DIABETOLOGICA
(2023)
Review
Medicine, General & Internal
Leonid Barski, Evgeny Golbets, Alan Jotkowitz, Dan Schwarzfuchs
Summary: Diabetic ketoacidosis is a life-threatening emergency in diabetes patients, and its management is still controversial. Different society guidelines have inconsistencies and certain treatment aspects are not precise enough. Special patient factors and comorbidities should receive more attention, but guidelines often lack recommendations for specific conditions.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Medicine, General & Internal
Bashar Khiatah, Amanda Frugoli, Deborah Carlson
Summary: The medical community aims to provide evidence-based guidelines for disease treatment, but sometimes unique physiology requires personalized care. Failure to recognize patient outliers and adjust treatment can be life-threatening. This paper discusses a clinical caveat for treating hypokalemia in DKA patients.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Endocrinology & Metabolism
Mohsen S. Eledrisi, Haifaa Alkabbani, Malk Aboawon, Aya Ali, Imad Alabdulrazzak, Maab Elhaj, Ashraf Ahmed, Hazim Alqahwachi, Joanne Daghfal, Salem A. Beshyah, Rayaz A. Malik
Summary: This study assessed the clinical characteristics and outcomes of patients hospitalized with DKA. The results showed a significant increase in inpatient mortality among T2DM patients in Qatar's government hospitals, which was associated with older age and admission to the intensive care unit.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Endocrinology & Metabolism
Zhichao He, Kakei Lam, Wenxia Zhao, Shan Yang, Yu Li, Jiayao Mo, Siyuan Gao, Dan Liang, Kaifeng Qiu, Min Huang, Junyan Wu
Summary: The study aims to investigate the main characteristics and association between euglycemic diabetic ketoacidosis (euDKA)/diabetic ketoacidosis (DKA) and sodium-dependent glucose transporters 2 inhibitors (SGLT-2i) using the FDA adverse event reporting system (FAERS). Post-marketing data analysis found that SGLT-2i was significantly associated with higher reporting of euDKA/DKA compared to other hypoglycemia agents. Male patients predominated in euDKA cases, while female patients predominated in DKA cases. Most patients discontinued SGLT-2i treatment after euDKA/DKA, with some experiencing symptomatic remission and a small percentage showing no remission.
ACTA DIABETOLOGICA
(2023)
Article
Emergency Medicine
Jennifer L. Trainor, Nicole S. Glaser, Leah Tzimenatos, Michael J. Stoner, Kathleen M. Brown, Julie K. McManemy, Jeffrey E. Schunk, Kimberly S. Quayle, Lise E. Nigrovic, Arleta Rewers, Sage R. Myers, Jonathan E. Bennett, Maria Y. Kwok, Cody S. Olsen, T. Charles Casper, Simona Ghetti, Nathan Kuppermann
Summary: The study aimed to characterize the degree of dehydration in children with DKA and identify factors associated with dehydration severity. Results showed that most children had mild-to-moderate dehydration. Biochemical measures were more closely associated with dehydration severity than clinical assessments, but neither were sufficiently predictive for rehydration practice.
ANNALS OF EMERGENCY MEDICINE
(2023)
