Review
Immunology
Minghui Wang, Hu Zhang, Jiling Liang, Jielun Huang, Ning Chen
Summary: Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by the formation of neurofibrillary tangles and senile plaques. Neuroinflammation, specifically the long-term activation of pro-inflammatory microglia and NLRP3 inflammasomes, plays a crucial role in the development and progression of AD. Exercise has been found to ameliorate AD by regulating the immune response and promoting neurogenesis in the hippocampus.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Neurosciences
Dominic I. Javonillo, Kristine M. Tran, Jimmy Phan, Edna Hingco, Enikoe A. Kramar, Celia da Cunha, Stefania Forner, Shimako Kawauchi, Giedre Milinkeviciute, Angela Gomez-Arboledas, Jonathan Neumann, Crystal E. Banh, Michelle Huynh, Dina P. Matheos, Narges Rezaie, Joshua A. Alcantara, Ali Mortazavi, Marcelo A. Wood, Andrea J. Tenner, Grant R. MacGregor, Kim N. Green, Frank M. LaFerla
Summary: Animal models are important for studying disease mechanisms and potential treatments, but the availability of numerous animal models presents challenges for Alzheimer's disease (AD) researchers. In this study, the 3xTg-AD mouse model was analyzed to understand the specific pathologies that develop at different ages and to comment on changes since its development 20 years ago. The study also compared the 3xTg-AD model with the 5xFAD model and found that plasma NfL is influenced by plaque burden. The results are freely available for researchers and demonstrate the usefulness of a standardized characterization pipeline for investigating and comparing different AD models.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Chemistry, Medicinal
Kundlik Gadhave, Deepak Kumar, Vladimir N. Uversky, Rajanish Giri
Summary: The exact molecular mechanisms associated with Alzheimer's disease remain a mystery, making the utilization of signaling pathways as potential drug targets limited. It is necessary to find correlations and cross-talk between these pathways and establish different therapeutic targets for a better understanding of the biological events responsible for AD-related neurodegeneration. Consideration should be given to the central role of autophagy in AD and its interplay with other pathways as the finest therapeutic strategy.
MEDICINAL RESEARCH REVIEWS
(2021)
Article
Neurosciences
Kelly Ceyzeriat, Benjamin B. Tournier, Philippe Millet, Giovanna Dipasquale, Nikolaos Koutsouvelis, Giovanni B. Frisoni, Valentina Garibotto, Thomas Zilli
Summary: This study found that low-dose radiation therapy (LD-RT) reduced amyloid load and possibly neuroinflammation markers in early-stage Alzheimer's disease, but did not impact tauopathy.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neurosciences
Amanda Ferreira Neves, Christian Camargo, Courtney Premer, Joshua M. Hare, Bernard S. Baumel, Milena Pinto
Summary: The study demonstrates that the timing and frequency of MSC injections can impact various aspects of AD-like neuropathology in the 3xTg-AD mouse model. Single-dose MSC injections in young mice reduced neuroinflammation, while multiple doses affected beta-secretase cleavage and tau phosphorylation. Multiple-dose MSC injections also showed differing effects on tau phosphorylation at different sites in young and old mice.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Clinical Neurology
Emily J. Koller, Kristen R. Ibanez, Quan Vo, Karen N. McFarland, Elsa Gonzalez De la Cruz, Lillian Zobel, Tristan Williams, Guilian Xu, Daniel Ryu, Preya Patel, Benoit Giasson, Stefan Prokop, Paramita Chakrabarty
Summary: The study reveals that different tau mutations exhibit varying degrees of synergy with A beta depending on the presence of cerebral deposits.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2022)
Article
Geriatrics & Gerontology
Ida Mohebpour, Michael Malek-Ahmadi, Thomas Virden, Angela Breitmeyer, Marwan N. Sabbagh, Briana Auman, Christine M. Belden, Parichita Choudhury, Autumn Arch, Kathryn Davis, Carol Cline, Naudia Moorley, Alireza Atri, Geidy Serrano, Thomas G. Beach
Summary: This study validated the correlation between the Alzheimer's Questionnaire (AQ) and AD-associated neuritic plaque (NP) and neurofibrillary tangle (NFT) pathology, showing that AQ is highly accurate and reliable for clinicians screening for AD-related cognitive impairment.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jessica Dennison, Armando Mendez, Angela Szeto, Ines Lohse, Claes Wahlestedt, Claude-Henry Volmar
Summary: This study investigated the effects of a histone deacetylase inhibitor, chidamide, on male and female mice in an AD model. The results showed that chidamide treatment significantly improved glucose tolerance and increased expression of glucose transporters in the brains of male mice. Furthermore, the expression of genes involved in the neuroinflammatory pathway and amyloid processing pathway showed different patterns between male and female mice after chidamide treatment.
Article
Neurosciences
K. Kohler, F. Salisbury, C. Wessel, J. Wang, S. Sunderam, M. J. Duncan, L. E. Guerriero, L. E. Beechem, B. D. Gillis, A. D. Bachstetter, B. F. O'Hara, M. P. Murphy
Summary: Fragmentation of the sleep-wake rhythm is associated with the risk of developing Alzheimer's disease (AD). Chronic sleep fragmentation increases brain amyloid-beta levels and neuroinflammation. Improving sleep consolidation may be beneficial for slowing the progression of AD.
Review
Biochemistry & Molecular Biology
Ujala Sehar, Priyanka Rawat, Arubala P. Reddy, Jonathan Kopel, P. Hemachandra Reddy
Summary: Alzheimer's disease is a progressive neurodegenerative disease that affects behavior, thinking, and memory in elderly individuals. It can occur in two forms – early onset familial and late-onset sporadic, with genetic mutations and lifestyle/environment factors playing a role in its development. Key pathological changes include the production and accumulation of Aβ and p-tau in affected brain regions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Jessica L. Dennison, Claude-Henry Volmar, Danbing Ke, James Wang, Emilie Gravel, Sabrina Hammond-Vignini, Zuomei Li, James A. Timmons, Ines Lohse, Marshall A. Hayward, Shaun P. Brothers, Claes Wahlestedt
Summary: JOTROL, a novel oral formulation of resveratrol, has higher bioavailability compared to non-formulated resveratrol. It has been found to be effective in the prevention and treatment of AD by regulating AD-related gene expression, inhibiting inflammatory genes, and regulating cytokine levels.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neurosciences
Doris Lambracht-Washington, Min Fu, Linda S. Hynan, Roger N. Rosenberg
Summary: DNA Aβ42 immunization in 3xTg-AD mice showed reduced amyloid and tau pathology, improved nest building activity, and increased survival rate. The upregulated genes involved in inflammatory pathways in AD mice were downregulated after immunization, while the expression of genes related to neuronal pathways were restored to wild-type levels in immunized mice. The complex immune response after DNA Aβ42 immunization suggests a move towards disease prevention beyond the amyloid hypothesis.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Neurosciences
Dawling A. Dionisio-Santos, Berke Karaahmet, Elizabeth K. Belcher, Laura D. Owlett, Lee A. Trojanczyk, John A. Olschowka, M. Kerry O'Banion
Summary: The study found that subcutaneous administration of glatiramer acetate (GA) improved behavioral performance, decreased Aβ plaques, and increased microglia complexity in 3xTg AD mice. There were subtle changes in the microglial transcriptome, with an upregulation of Dcstamp.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Cell Biology
Dayan B. Goodenowe, Vijitha Senanayake
Summary: Reduced cognition in the elderly is associated with low levels of plasmalogens, high levels of amyloid plaques and neurofibrillary tangles. Only PL 18:0/22:6, tangles, and flotillin were independently associated with reduced cognition. High brain levels of PL 18:0/22:6 were predictive of normal cognition, while low levels and high levels of tangles or flotillin were predictive of dementia.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Neurosciences
Jacob M. Basak, Aura Ferreiro, Lucy S. Cohen, Patrick W. Sheehan, Collin J. Nadarajah, Michael F. Kanan, Kimberley V. Sukhum, Gautam Dantas, Erik S. Musiek
Summary: The study reveals that sepsis may exacerbate amyloid plaque deposition and plaque-related inflammation, potentially leading to increased dementia in older sepsis survivors.
NEUROBIOLOGY OF DISEASE
(2021)