期刊
NEUROSCIENCE BULLETIN
卷 26, 期 4, 页码 297-303出版社
SPRINGER
DOI: 10.1007/s12264-010-0329-1
关键词
chronic unpredictable mild stress; hypothalamo-pituitary-adrenal axis; corticotropin-releasing hormone; amygdala; paraventricular nucleus
Objective Corticotropin-releasing hormone (CRH) plays an important role in neuroendocrine, autonomic and behavioral responses to stressors. In the present study, the effect of chronic unpredictable mild stress (CUMS) on CRH neurons was investigated in rat brain. Methods The rats were exposed to one of the stressors each day for 21 d. Immunostaining was performed to detect the CRH-positive neurons in the paraventricular nucleus (PVN) of the hypothalamus and in amygdala. Results After the stress protocol, the animals showed a reduction in body weight gain as well as reduced sucrose preference and locomotor activity. Interestingly, the CRH neurons in both PVN and central nucleus of the amygdala (CeA) were stimulated by CUMS. The densities of CRH-containing neurons in both PVN and CeA were significantly higher than those in control group. Conclusion The CRH systems in PVN and CeA may both contribute to depression-like behaviors during CUMS.
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