Article
Environmental Sciences
Kaniz Fatima Binte Hossain, Md Mostafizur Rahman, Md Tajuddin Sikder, Toshiyuki Hosokawa, Takeshi Saito, Masaaki Kurasaki
Summary: This study investigated the protective role of selenium (Se) against inorganic mercury (iHg) toxicity in PC12 cells. Results showed that Se co-treatment inhibited intrinsic apoptosis and oxidative stress induced by iHg through various mechanisms, suggesting that excessive ROS generation plays a critical role in iHg-induced oxidative stress and Se has potential in attenuating iHg cytotoxicity via its antioxidant properties.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Pharmacology & Pharmacy
Aijing Bi, Zhen Guo, Guocui Yang, Youfang Huang, Zhimin Yin, Lan Luo
Summary: The highly toxic environmental pollutant cadmium (Cd) can lead to the occurrence and development of multiple neurological diseases. Gamma-glutamylcysteine (gamma-GC) has been found to inhibit Cd-induced apoptosis in PC12 cells by reducing oxidative stress and inhibiting the activation of MAPK and PI3K/Akt signaling pathways. This suggests that gamma-GC could potentially be used as a protective agent against Cd neurotoxicity.
Article
Pharmacology & Pharmacy
Yan Tang, Ya Hou, Yong Zeng, Yao Hu, Yi Zhang, Xiaobo Wang, Xianli Meng
Summary: Salidroside alleviates hypoxic injury in PC12 cells by inhibiting oxidative stress, anti-apoptosis, and enhancing mitochondrial energy synthesis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hironao Nakayama, Masako Nakahara, Erina Matsugi, Midori Soda, Tomoka Hattori, Koki Hara, Ayuki Usami, Chiaki Kusumoto, Shigeki Higashiyama, Kiyoyuki Kitaichi
Summary: Ferulic acid has antioxidant and anti-apoptotic effects in PC12 cells, protecting neurons from damage by inhibiting apoptosis and reducing reactive oxygen species production. It regulates protein phosphorylation, apoptosis-related proteins, and microRNA expression to mitigate oxidative stress induced by H2O2 in rat pheochromocytoma cells.
Article
Biochemistry & Molecular Biology
Mersedeh Shayan, Soghra Mehri, Bibi Marjan Razavi, Hossein Hosseinzadeh
Summary: This study demonstrates that minocycline can protect cells against cadmium-induced oxidative stress and apoptotic cell death, and exhibits antioxidant and anti-apoptotic activity.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Medicine, Research & Experimental
Danni Xie, Ting Deng, Zhenwei Zhai, Tao Qin, Caiyou Song, Ying Xu, Tao Sun
Summary: The characteristics of Alzheimer's disease include irreversible memory loss and progressive cognitive decline. Oxidative stress is considered to be a significant factor contributing to brain diseases such as Alzheimer's. Chinese herbal medicine, specifically Moschus, has antioxidant and antiapoptotic effects and has been used for treating various brain-related conditions. This study aims to evaluate the potential neuroprotective effects of Moschus on hydrogen peroxide-induced cellular injury.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Neurosciences
Kexin Wang, Xinyue Zhang, Miaosi Zhang, Xin Li, Jiao Xie, Suwen Liu, Qun Huang, Jilite Wang, Qingbin Guo, Hao Wang
Summary: Traditional Chinese medicines with hyperoside such as Acanthopanax senticosus and Crataegus pinnatifida have demonstrated anti-oxidative stress properties. Hyperoside, the main component of antioxidant herbs, may delay the onset of neurodegenerative diseases. This study investigated the therapeutic mechanism of hyperoside as a natural antioxidant against Alzheimer's disease in Caenorhabditis elegans and PC12 cells, showing its ability to reduce reactive oxygen species levels and neurotoxicity induced by A beta 42.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Reyhaneh Ahmadian, Mahmoud Reza Heidari, Bibi Marjan Razavi, Hossein Hosseinzadeh
Summary: This study investigated the protective effects of alpha-mangostin against neurotoxicity induced by arsenic and cadmium. The results demonstrated that alpha-mangostin could reduce the toxic effects of arsenic and cadmium on PC12 cells, and decrease oxidative stress and apoptosis.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Mersedeh Shayan, Soghra Mehri, Bibi Marjan Razavi, Hossein Hosseinzadeh
Summary: Arsenic is a naturally occurring metalloid that can cause acute and chronic toxicity in humans. Neurotoxicity is a serious manifestation of arsenic toxicity. This study found that minocycline, an antimicrobial agent with antioxidant properties and the ability to cross the blood-brain barrier, can significantly attenuate arsenic-induced neurotoxicity by reducing oxidative stress and apoptosis. These findings suggest that minocycline could be a promising treatment for arsenic toxicity.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Integrative & Complementary Medicine
Linlin Jing, Rongmin Gao, Jie Zhang, Dongmei Zhang, Jin Shao, Zhengping Jia, Huiping Ma
Summary: Norwogonin attenuates hypoxia-induced injury in PC12 cells by scavenging ROS, maintaining the activities of antioxidant enzymes, and inhibiting mitochondrial apoptosis pathway.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2021)
Article
Biochemistry & Molecular Biology
Yanli Tan, Hong Cheng, Cheng Su, Pan Chen, Xiaobo Yang
Summary: This study found that exposure to manganese sulfate (MnSO4) can affect neurological effects in PC12 cells through the PI3K/Akt signaling pathway, leading to decreased antioxidant enzyme activity and increased cell apoptosis. Additionally, the PI3K/Akt signaling pathway plays a crucial role in mediating manganese-induced neurotoxicity.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Food Science & Technology
Luchen Wang, Lingmin Song, Juan Ma, Huimei Wang, Yingzhi Li, Danfei Huang
Summary: Alcohol has toxic effects on various organs, including the brain. Microglia cells in the brain may play a role in alcohol intoxication. This study demonstrated that alcohol alters autophagy levels or promotes apoptosis in microglia cells, providing insights into the mechanisms of alcohol neurotoxicity. The findings of this study may increase public awareness of alcohol's negative effects and contribute to the development of novel treatment approaches for alcoholism.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Liqing Yin, Yongzhu Zhang, Fidelis Azi, Mekonen Tekliye, Jianzhong Zhou, Xiaoli Liu, Mingsheng Dong, Xiudong Xia
Summary: The fermented tofu by Actinomucor elegans showed higher phenolic content and antioxidant activity, and provided neuroprotective effects on hypoxia-injured PC12 cells. It reduced cell death, inhibited oxidative stress, regulated apoptosis-related proteins, and modulated cell cycle proteins to enhance cell survival. Additionally, the fermented tofu activated autophagy as a potential mechanism for cell protection against hypoxic damage.
Article
Cell Biology
Jihe Kang, Yidian Wang, Xudong Guo, Xuegang He, Wenzhao Liu, Haiwei Chen, Zhaoheng Wang, Aixin Lin, Xuewen Kang
Summary: In this in vitro study, N-acetylserotonin (NAS) demonstrated neuroprotective effects by inhibiting oxidative stress and apoptosis in PC12 cells. NAS was found to enhance antioxidant enzyme activity, decrease reactive oxygen species (ROS) levels, and activate the PI3K/AKT signaling pathway, resulting in reduced cell apoptosis and oxidative damage.
Article
Biochemistry & Molecular Biology
Wei Chen, Hua Zhang, Guishan Liu, Ji Kang, Biao Wang, Jilite Wang, Jing Li, Hao Wang
Summary: This study showed that lutein has a protective effect against oxidative damage and apoptosis in PC12 cells induced by MGO. The underlying mechanism involves the regulation of the PI3K/Akt signaling pathway. These findings suggest that lutein has potential for the prevention of diabetic-related neurodegenerative diseases.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)