Article
Psychiatry
Masakazu Hatano, Hiroyuki Kamei, Ippei Takeuchi, Kazuhiko Gomi, Takashi Sakakibara, Shogo Hotta, Satoru Esumi, Kiyotaka Tsubouchi, Yoshihito Shimizu, Shigeki Yamada
Summary: This study aimed to evaluate the impact of a delay in initiating clozapine treatment on long-term outcomes. The results showed that early initiation of treatment can reduce the risk of treatment failure, rehospitalization, and discontinuation of antipsychotic medication.
Article
Pharmacology & Pharmacy
Farhana Islam, Xiaoyu Men, Kazunari Yoshida, Clement C. Zai, Daniel J. Mueller
Summary: Pharmacogenetics research has shown that genetic factors influence the efficacy and tolerability of antipsychotic treatment, with the most robust findings related to associations between polymorphisms in CYP2D6 and exposure and response to specific antipsychotics. Product labels and guidelines have provided dosing recommendations based on CYP2D6 metabolizer phenotypes.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Endocrinology & Metabolism
Helene Speyer, Casper Westergaard, Nikolai Albert, Mette Karlsen, Anne Emilie Sturup, Merete Nordentoft, Jesper Krogh
Summary: The study found that reducing dosage, discontinuing medication, or switching to a partial agonist can lead to a small but significant weight loss of around 1.5 kg. The overall weight change from pre to post intervention was a reduction of 1.13 kg.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Psychiatry
Yaoyao Sun, Yuyanan Zhang, Zhe Lu, Hao Yan, Liangkun Guo, Yundan Liao, Tianlan Lu, Lifang Wang, Jun Li, Wenqiang Li, Yongfeng Yang, Hao Yu, Luxian Lv, Dai Zhang, Wenjian Bi, Weihua Yue
Summary: This study aimed to evaluate the changes in schizophrenia symptoms under different antipsychotic treatments by analyzing data from a multicenter clinical trial. The results identified central and bridge symptoms in the networks that changed over time. Acute antipsychotic treatment altered the network structure, and responsive patients showed lower global strength after treatment compared to resistant patients. The central and bridge symptoms remained prominent across different antipsychotics.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Immunology
Shao-rui Hao, Yuan-yue Zhou, Xue Zhang, Hai-yin Jiang
Summary: This study explored the changes in the gut bacterial microbiome in AP-exposed children with obesity. The findings showed that AP users, regardless of their body mass index, had decreased microbial richness and diversity compared to the control group. The AP-exposed children also had differences in microbial functions.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Psychiatry
Miguel Castillo Sanchez, Mireia Fabregas Escurriola, Maria Isabel Fernandez Sanmartin, Iryna Solntseva, Daniel Berge Baquero, Alberto Goday Arno
Summary: A study conducted in Spain found that individuals with schizophrenia (SZ) or under treatment with antipsychotic drugs (TAD) have a higher risk of cardiovascular disease and cardiovascular mortality. The differences between SZ and TAD groups in terms of mortality and disease incidence indicate that the risk of cardiovascular disease in SZ may be independent of TAD.
PSYCHIATRY RESEARCH
(2021)
Review
Endocrinology & Metabolism
Aaron Bezzina, Lee Ashton, Trent Watson, Carole L. James
Summary: Workplaces are important settings for implementing wellness programs to address overweight and obesity in men. Existing workplace programs targeting weight outcomes in men have shown overall success in weight reduction. However, further research is needed to develop more randomized controlled trials, long-term follow-up, and programs exclusively for men.
Review
Environmental Sciences
Cheng-Yang Hu, Xiao-Jing Yang, Si-Yu Gui, Kun Ding, Kai Huang, Yuan Fang, Zheng-Xuan Jiang, Xiu-Jun Zhang
Summary: The study found a potential positive association between residential greenness and several birth outcomes. However, further research is needed to replicate these findings and explore their implications in more detail, given the moderate to high between-study heterogeneity.
ENVIRONMENTAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Jacqueline A. Wilkinson, Alexander S. Harrison, Patrick Doherty
Summary: The study found that various characteristics of obese patients before cardiac rehabilitation predict different degrees of weight loss, with factors such as smoking cessation, diabetes, history of cardiac surgery, low fitness levels having a negative impact on weight loss, while higher initial weight, older age, and employment status contributing to increased weight loss.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Psychiatry
Ashok Malla, Srividya N. Iyer, Ridha Joober, Thara Rangaswamy, Padmavati Ramachandran, Norbert Schmitz, Aarati Taksal, Greeshma Mohan, Howard C. Margolese
Summary: This study investigated the impact of supervised antipsychotic medication discontinuation on clinical and functional outcomes in first-episode psychosis in two different cultural environments. The results showed that certain cultural environments and patient characteristics may facilitate supervised discontinuation of antipsychotic medication following treatment of a first-episode psychosis without negative consequences.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2022)
Article
Oncology
Yun Jiang, Madilyn Mason, Youmin Cho, Ankita Chittiprolu, Xingyu Zhang, Karen Harden, Yang Gong, Marcelline R. Harris, Debra L. Barton
Summary: Older adults with cancer have lower tolerance to oral chemotherapy drug capecitabine compared to younger adults, experiencing different side effects. While dose reductions and interruptions are more common in older adults, age may not be an independent factor in treatment changes, with other socio-demographic and clinical factors potentially playing a more important role.
Article
Psychiatry
Seung Eun Lee, Nam Young Lee, Se Hyun Kim, Kyoung-Ah Kim, Yong Sik Kim
Summary: Liraglutide 3.0 mg significantly reduces body weight in obese patients treated with antipsychotic drugs without affecting psychiatric conditions. However, some patients may experience mild nausea as a side effect, and half of the patients lost more than 5% of body weight after 16 weeks of treatment.
PSYCHIATRY RESEARCH
(2021)
Review
Behavioral Sciences
James S. Brown
Summary: This review examines the history of antipsychotics in cancer treatment, discusses which drugs may be effective in treating different types of cancers, and describes the molecular mechanisms through which antipsychotics may inhibit cancer.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Psychiatry
Ye Yang, Peng Xie, Yujun Long, Jing Huang, Jingmei Xiao, Jingping Zhao, Weihua Yue, Renrong Wu
Summary: This study found that previous exposure to antipsychotic drugs, particularly high-metabolic-risk antipsychotics, is associated with metabolic disturbances induced by current antipsychotic medication. Specifically, the use of high-metabolic-risk antipsychotics is associated with an increased risk of LDL-C levels.
Article
Neurosciences
Jaehyun Kim, Tae Hyon Ha, Kiwon Kim, Eun-Mi Lee, Hyekyeong Kim, Doh Kwan Kim, Hong-Hee Won, Matthew Lewis, Hyewon Lee, Woojae Myung
Summary: The study found that the use of atypical antipsychotic drugs in elderly individuals with depressive disorders is associated with a significantly higher risk of subsequent dementia. Risperidone showed the highest risk for dementia among atypical antipsychotics. Healthcare professionals should be aware of this potential long-term risk when prescribing these medications.
JOURNAL OF ALZHEIMERS DISEASE
(2021)