Review
Medicine, General & Internal
Anna Malgorzata Kucharska, Ewelina Witkowska-Sedek, Malgorzata Ruminska, Beata Pyrzak
Summary: This paper presents literature data describing changes in thyroid function related to rhGH therapy and provides a current explanation of the mechanisms involved in this phenomenon, emphasizing the importance of changes in central and peripheral regulation during treatment.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Zhongli Chen, A. S. Elise van der Sman, Stefan Groeneweg, Linda Johanna de Rooij, W. Edward Visser, Robin P. Peeters, Marcel E. Meima
Summary: Using pharmacological inhibitors, this study identified that MCT10 and LATs play a major role in T3 uptake in BeWo cells. T4 uptake appears to be independent of known TH transporters, suggesting the presence of alternative transporter(s) that are currently unknown.
Review
Oncology
Laure Benoit, Olivier Mir, Francois Vialard, Paul Berveiller
Summary: This study reviewed data on the use of anti-cancer treatments in pregnant women and the transplacental transfer of drugs, aiming to guide clinicians in choosing the best treatment options and providing balanced information to pregnant patients. The occurrence of cancer during pregnancy is increasing, requiring careful consideration of the benefit-risk ratio for both mother and fetus during treatment.
Article
Endocrinology & Metabolism
Emily S. Barrett, Tomomi Workman, Marnie F. Hazlehurst, Sophie Kauderer, Christine Loftus, Kurunthachalam Kannan, Morgan Robinson, Alicia K. Smith, Roger Smith, Qi Zhao, Kaja Z. LeWinn, Sheela Sathyanarayana, Nicole R. Bush
Summary: In this study, modest evidence of association was found between OH-PAHs, particularly 2-OH-PHEN, and pCRH levels. The associations tended to be stronger in early pregnancy. Further research is needed to confirm these findings and investigate alternative mechanisms linking PAHs and timing of birth.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Luis Felipe Falla Zuniga, Yhoiss Smiht Munoz, Maria Carolina Pustovrh
Summary: Thyroid hormones are crucial for fetal development, with complex regulatory mechanisms in the placenta. Their passage from maternal to fetal circulation is modulated by transporters, enzymes, and carrier proteins, impacting placental development. Abnormal TH levels can lead to pregnancy complications and fetal damage.
MOLECULAR REPRODUCTION AND DEVELOPMENT
(2022)
Article
Chemistry, Multidisciplinary
Leonardo Pinto, Priya Bapat, Fernanda de Lima Moreira, Angelika Lubetsky, Ricardo de Carvalho Cavalli, Howard Berger, Vera Lucia Lanchote, Gideon Koren
Summary: The study found a low extent of placental transfer of fexofenadine enantiomers with limited fetal exposure, regardless of the presence of the P-gp inhibitor fluoxetine. The ex vivo placental perfusion model accurately predicted the in vivo placental transfer of fexofenadine enantiomers with similar values for both enantiomers.
PHARMACEUTICAL RESEARCH
(2021)
Article
Nutrition & Dietetics
Synnove Naess, Maria W. Markhus, Tor A. Strand, Marian Kjellevold, Lisbeth Dahl, Ann-Elin M. Stokland, Bjorn G. Nedrebo, Inger Aakre
Summary: The study indicates that pregnant and postpartum women have mild-to-moderate iodine deficiency, and low iodine intake is associated with thyroid dysfunction. Initiating and continuing the use of iodine-containing supplements before pregnancy can help maintain better thyroid function.
JOURNAL OF NUTRITION
(2021)
Article
Endocrinology & Metabolism
Zhongli Chen, Robin P. Peeters, Selmar Leeuwenburgh, Michelle Broekhuizen, Rugina I. Neuman, Emilie Hitzerd, Lunbo Tan, Rutchanna M. S. Jongejan, Yolanda B. de Rijke, Irwin K. M. Reiss, A. H. Jan Danser, W. Edward Visser, Marcel E. Meima
Summary: Fetal development relies heavily on thyroid hormone. The transfer of thyroid hormone from mother to fetus is essential for fetal hormone availability, particularly in the early stages of pregnancy. However, the mechanisms of TH transfer across the placenta are not well understood. This study investigated the transport processes of TH across human placentas using an ex vivo perfusion system.
Article
Nutrition & Dietetics
Carla A. Lopes, Susana Prazeres, Jose Martinez-de-Oliveira, Edward Limbert, Manuel C. Lemos
Summary: Iodine deficiency is a common issue in pregnant women, and supplementation can improve iodine status, although it may not reach the recommended levels in iodine-deficient regions.
Article
Reproductive Biology
Janna Hinderer, Julia Luedeke, Lisa Riege, Alexander Bartel, Barbara Kohn, Elisabeth Mueller, Sebastian P. Arlt
Summary: This study aimed to assess the influence of the cycle stage and pregnancy on hormone concentrations in female dogs by measuring TSH, fT4, tT4, and P4 levels. The results showed significant differences in hormone concentrations between sampling times, but no differences between pregnant and non-pregnant animals. The observed patterns of hormone concentration changes during pregnancy are similar to findings in humans, indicating potential effects on fetal thyroid function. The peak TSH concentrations during lactation suggest a higher demand for thyroid hormones during this phase. Therefore, the cycle stage should be considered when evaluating thyroid function in bitches.
Article
Biochemistry & Molecular Biology
Elijah C. Reische, Tuija Mannisto, Alexandra Purdue-Smithe, Kurunthachalam Kannan, Un-Jung Kim, Eila Suvanto, Helja-Marja Surcel, Mika Gissler, James L. Mills
Summary: The study conducted in Finland found no significant relationship between iodine levels and the risk of preeclampsia, reassuring given the high prevalence of iodine deficiency in pregnancy.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Rossella Cannarella, Marco Musmeci, Vincenzo Garofalo, Tiziana A. Timpanaro, Guido Leone, Manuela Caruso, Paolo E. Maltese, Rosita A. Condorelli, Sandro La Vignera, Aldo E. Calogero
Summary: This study describes the clinical features of two unrelated patients with resistance to thyroid hormones. One patient carries a novel mutation and shows related symptoms, while the other has additional issues after childbirth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Reproductive Biology
Esteban Salazar-Petres, Daniela Pereira Carvalho, Jorge Lopez-Tello, Amanda Nancy Sferruzzi-Perri
Summary: In normal mouse pregnancy, placental structure, function, and mitochondrial phenotype respond differently to the growth of female and male fetuses. This study may provide design references for sex-specific therapies for placental insufficiency and fetal growth abnormalities, which could benefit the offspring throughout their lives.
BIOLOGY OF REPRODUCTION
(2022)
Article
Environmental Sciences
Xuan Li, Tao Yu, Muxin Zhai, Yongyuan Wu, Baojing Zhao, Cancan Duan, Huiru Cheng, Han Li, Zhaolian Wei, Yuanyuan Yang, Zhen Yu
Summary: This study found that cadmium exposure reduces placental angiogenesis in preeclampsia by decreasing the expression of PLGF and VEGF and increasing the expression of sFlt1. Cadmium exposure also decreases the expression of thyroid hormone receptor alpha and Dio2. These results suggest that cadmium exposure impairs placental angiogenesis in preeclampsia by disturbing thyroid hormone receptor signaling.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Nutrition & Dietetics
Alexandra C. Purdue-Smithe, Tuija Mannisto, Elijah Reische, Kurunthachalam Kannan, Un-Jung Kim, Eila Suvanto, Helja-Marja Surcel, Mika Gissler, James L. Mills
Summary: In a prospective study in Finland, maternal iodine status was not associated with risk of stillbirth in a mild to moderately iodine-deficient population. Thyroglobulin (Tg) and thyroid-stimulating hormone (TSH) levels were also not linked to stillbirth risk. Despite iodine deficiency being prevalent in developed countries, no significant associations were found between serum iodide, TSH, Tg, and stillbirth risk.
MATERNAL AND CHILD NUTRITION
(2021)
Review
Nutrition & Dietetics
Neha Sharma, Oliver C. Watkins, Anne H. Y. Chu, W. Cutfield, Keith M. Godfrey, Hannah E. J. Yong, Shiao-Yng Chan
Summary: The incidence of preterm birth is increasing globally, and myo-inositol supplementation may have a positive impact on reducing this risk. However, the molecular mechanisms by which myo-inositol affects preterm labor remain unclear. This paper presents hypotheses on the role of uteroplacental myo-inositol in human parturition and explores potential molecular mechanisms through which myo-inositol may inhibit preterm labor onset.
NUTRITION RESEARCH REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Xiyao Liu, Huijia Fu, Li Wen, Fangyu Zhu, Yue Wu, Zhi Chen, Richard Saffery, Chang Chen, Hongbo Qi, Chao Tong, Philip N. Baker, Mark D. Kilby
Summary: Single intrauterine fetal death (sIUFD) in monochorionic diamniotic (MCDA) twin pregnancy is associated with metabolic changes in the surviving co-twin. Metabolomic profiling reveals distinctive metabolic signatures in placental tissue and cord plasma, with some metabolites correlated with fetal growth.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Medicine, General & Internal
Lan Zhang, Hongli Liu, Shuai Huang, Chao Tong, Zhigang Wang, Hongbo Qi, Philip N. Baker, Mark D. Kilby
Summary: This study evaluated alterations in fetal Doppler parameters before and after radiofrequency ablation surgery for twin reversed arterial perfusion sequence (TRAPs). The findings suggest that pump fetuses after surgery, with a gestational age of 20 weeks or more, may experience increased middle cerebral artery peak systolic velocity (MCA-PSV) and middle cerebral artery pulsatility index (MCA-PI), indicating the need for early intervention.
FRONTIERS IN MEDICINE
(2022)
Article
Pediatrics
Sisi Li, Yuhan Qiu, Xi Yuan, Qin Zhang, Mark D. Kilby, Richard Saffery, Philip N. Baker, Li Wen, Chao Tong, Hongbo Qi
Summary: This study investigates the impact of gestational weight gain (GWG) on the body mass index-for-age z score (BAZ) and obesity risk among twin offspring. The results show that total GWG is positively correlated with offspring birthweight and BAZ at 6, 12, and 24 months. Excessive total GWG is related to an increased relative risk of large for gestational age (LGA) and overweight at 6 and 12 months. Only the second trimester gestational weight gain rate (GWGR) is positively correlated with birthweight, and is associated with an increased risk of LGA and overweight at 12 months.
FRONTIERS IN PEDIATRICS
(2022)
Article
Hematology
Vanja Karamatic Crew, Louise A. Tilley, Timothy J. Satchwell, Samah A. AlSubhi, Benjamin Jones, Frances A. Spring, Piers J. Walser, Catarina Martins Freire, Nicoletta Murciano, Maria Giustina Rotordam, Svenja J. Woestmann, Marwa Hamed, Reem Alradwan, Mouza AlKhrousey, Ian Skidmore, Sarah Lewis, Shimon Hussain, Jane Jackson, Tom Latham, Mark D. Kiloy, William Lester, Nadine Becker, Markus Rapedius, Ashley M. Toye, Nicole M. Thornton
Article
Cell Biology
Ping Xu, Yangxi Zheng, Jiujiang Liao, Mingyu Hu, Yike Yang, Baozhen Zhang, Mark D. Kilby, Huijia Fu, Yamin Liu, Fumei Zhang, Liling Xiong, Xiyao Liu, Huili Jin, Yue Wu, Jiayu Huang, Tingli Han, Li Wen, Rufei Gao, Yong Fu, Xiujun Fan, Hongbo Qi, Philip N. Baker, Chao Tong
Summary: Pre-eclampsia (PE) is a metabolic disorder of the placenta that is caused by defective invasion of trophoblasts. This study investigated the role of AMPK in PE development and found that AMPK activation exacerbates PE manifestations but reduces cell death in the placenta. AMPK activation promotes glucose metabolism and glycogen deposition, enhancing cell viability but compromising trophoblast invasion. In contrast, ablation of AMPK leads to decreased glycogen deposition and structural malformation in the placenta. These findings highlight the importance of balancing invasiveness and viability in trophoblasts for proper placental function.
CELL PROLIFERATION
(2023)
Article
Obstetrics & Gynecology
Isabelle Greatholder, Emma Tomlinson, Jack Wilkinson, Lucy E. Higgins, Mark D. Kilby, Alexander E. P. Heazell
Summary: This study aimed to explore the feasibility of an observational study to identify modifiable factors associated with adverse neonatal outcomes in twin pregnancies. The results showed that twin pregnancies have different frequencies of exposures compared to singleton pregnancies, highlighting the need for twin-specific studies to identify modifiable factors and develop preventative strategies for morbidity and mortality in twin pregnancies.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Obstetrics & Gynecology
Shiao-Yng Chan, Sheila J. Barton, See Ling Loy, Hsin Fang Chang, Philip Titcombe, Jui-Tsung Wong, Marilou Ebreo, Judith Ong, Karen ML. Tan, Heidi Nield, Sarah El -Heis, Timothy Kenealy, Yap-Seng Chong, Philip N. Baker, Wayne S. Cutfield, Keith M. Godfrey
Summary: This study examined the impact of a combined myo-inositol, probiotics, and micronutrient nutritional supplement on time-to-natural-conception and clinical pregnancy rates. The results showed that there was no significant difference in time-to-natural-conception and clinical pregnancy rates within a year between women receiving the supplement and those in the control group. Overweight women had a longer time-to-conception, but the supplement may shorten their time-to-conception to that comparable to nonoverweight/nonobese women.
FERTILITY AND STERILITY
(2023)
Article
Biotechnology & Applied Microbiology
Xi Yuan, Jiayu Huang, Li Wen, Boris Novakovic, Mark D. Kilby, Chao Tong, Hongbo Qi, Richard Saffery, Philip N. Baker
Summary: Despite being genetically identical, monozygotic (MZ) twins can have discordant congenital heart disease (CHD) due to in utero environmental factors. This study identified epigenetic variations in cord blood of discordant MZ twins that are associated with CHD. The results revealed specific DNA methylation variations that are biomarkers and potential targets for intervention in CHD.
Article
Nutrition & Dietetics
Jun S. Lai, Marjorelee T. Colega, Keith M. Godfrey, Kok Hian Tan, Fabian Yap, Yap Seng Chong, Yung Seng Lee, Johan G. Eriksson, Shiao-Yng Chan, Mary F. F. Chong
Summary: Adopting a healthy diet during and after pregnancy is important for women's cardiometabolic health. Changes in diet quality from pregnancy to 6 years postpregnancy were related to cardiometabolic markers 8 years postpregnancy in a study of 652 women. Improving or preventing a decline in diet quality postpregnancy may improve lipid profile and insulin resistance.
Article
Pediatrics
Li Wen, Huijia Fu, Richard Saffery, Chao Tong, Yamin Liu, Mark D. Kilby, Hongbo Qi, Philip N. Baker
Summary: This study measured the concentrations of adiponectin and leptin in the cord blood of monochorionic twins with selective intrauterine growth restriction (IUGR). The findings showed that cord blood adiponectin concentrations were negatively associated with IUGR, while cord blood leptin concentrations were significantly lower in IUGR twins. Furthermore, adiponectin was negatively associated with height increments in the first 6 months, and leptin was inversely associated with weight and height increments in the first 6 months, as well as weight and height at 6 and 24 months. These results indicate the influence of adiponectin and leptin in cord blood on IUGR and childhood growth trajectories.
Article
Nutrition & Dietetics
Jun S. Lai, Keith M. Godfrey, Choon Nam Ong, Kok Hian Tan, Fabian Yap, Yap Seng Chong, Jerry K. Y. Chan, Shiao-Yng Chan, Mary F. -F. Chong
Summary: This study examined the associations between perinatal plasma carotenoids and E vitamers concentrations and glycemia, insulin resistance, and gestational and type 2 diabetes mellitus in GUSTO women. The findings suggest that higher concentrations of alpha- and beta-carotene and lutein may be beneficial for gestational fasting glycemia, while higher concentrations of vitamin E may increase gestational and post-pregnancy glycemia.
Article
Health Care Sciences & Services
V. Vien Lee, Smrithi Vijayakumar, Wei Ying Ng, Ni Yin Lau, Qiao Ying Leong, Delicia Shu Qin Ooi, Lin Lin Su, Yung Seng Lee, Shiao-Yng Chan, Agata Blasiak, Dean Ho
Summary: This study aimed to understand the needs and expectations of women before, during and after pregnancy for digital health interventions (DHIs) in order to inform and optimize future DHI developments. Through interviews and thematic analysis, personalization and localization of DHIs emerged as key concepts, with corresponding themes and subthemes identified.
NPJ DIGITAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Eamon Fitzgerald, Mojun Shen, Hannah Ee Juen Yong, Zihan Wang, Irina Pokhvisneva, Sachin Patel, Nicholas O'Toole, Shiao-Yng Chan, Yap Seng Chong, Helen Chen, Peter D. Gluckman, Jerry Chan, Patrick Kia Ming Lee, Michael J. Meaney
Summary: Pathological placental inflammation might increase the risk of future health problems. This study finds that genes associated with the homeostatic function of Hofbauer cells, a placenta-specific macrophage, are associated with protection against adult cardiovascular and depressive disorders.
NATURE COMMUNICATIONS
(2023)
Article
Nutrition & Dietetics
Soo Min Han, Fang Huang, Jose G. B. Derraik, Mark H. Vickers, Surabhi Devaraj, Karine Redeuil, Esther Campos-Gimenez, Wei Wei Pang, Keith M. Godfrey, Shiao-Yng Chan, Sagar K. Thakkar, Wayne S. Cutfield
Summary: Maternal supplementation with vitamin D before and during pregnancy can increase the concentration of vitamin D in breast milk, but does not affect the concentration of B vitamins. The concentration of vitamin D3 in breast milk gradually increases during early lactation, while the concentrations of B vitamins have peaks at different time points.
CLINICAL NUTRITION
(2023)