Article
Orthopedics
Young-Woo Chung, Hong-Yeol Yang, Sung-Ju Kang, Eun-Kyoo Song, Jong-Keun Seon
Summary: Allogeneic hUCB-MSC implantation combined with HTO for medial knee osteoarthritis was safe and showed signs of cartilage status improvement. Further randomized controlled studies with a control group are necessary to determine the real effectiveness and indications of this new combined procedure for patients with osteoarthritis.
INTERNATIONAL ORTHOPAEDICS
(2021)
Article
Cell & Tissue Engineering
Kylie Crompton, Iona Novak, Michael Fahey, Nadia Badawi, Katherine J. Lee, Francoise Mechinaud-Heloury, Priya Edwards, Paul Colditz, Trisha Soosay Raj, Janet Hough, Xiaofang Wang, Simon Paget, Kuang-Chih Hsiao, Peter Anderson, Dinah Reddihough
Summary: This study investigated the safety and preliminary efficacy of sibling cord blood cell infusion in children with cerebral palsy. The findings suggest that sibling cord blood cell infusion is relatively safe for children with cerebral palsy when conducted in appropriate facilities, but the improvement in motor function and upper extremity skills is limited.
Article
Cell & Tissue Engineering
Jessica M. Sun, Laura E. Case, Mohamad A. Mikati, Joan M. Jasien, Colleen McLaughlin, Barbara Waters-Pick, Gordon Worley, Jesse Troy, Joanne Kurtzberg
Summary: Studies suggest that appropriately dosed allogeneic sibling HLA-matched umbilical cord blood infusion has the potential to improve motor function in young children with cerebral palsy. This treatment is well tolerated and shows no adverse events related to the infusion.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Article
Clinical Neurology
Morteza Zarrabi, Masood Ghahvechi Akbari, Man Amanat, Anahita Majmaa, Ali Reza Moaiedi, Hadi Montazerlotfelahi, Masoumeh Nouri, Amir Ali Hamidieh, Reza Shervin Badv, Hossein Karimi, Ali Rabbani, Ali Mohebbi, Shahram Rahimi-Dehgolan, Rosa Rahimi, Ensieh Dehghan, Massoud Vosough, Saeed Abroun, Farhad Mahvelati Shamsabadi, Ali Reza Tavasoli, Houman Alizadeh, Neda Pak, Gholam Reza Zamani, Mahmoud Mohammadi, Mohsen Javadzadeh, Mohammad Ghofrani, Seyed Hossein Hassanpour, Morteza Heidari, Mohammad Mehdi Taghdiri, Mohamad Javad Mohseni, Zahra Noparast, Safdar Masoomi, Mehrdad Goudarzi, Masood Mohamadpour, Razieh Shodjaee, Solaleh Samimi, Monireh Mohammad, Mona Gholami, Nahid Vafaei, Leyli Koochakzadeh, Amir Valizadeh, Reza Azizi Malamiri, Mahmoud Reza Ashrafi
Summary: This study showed that intrathecal injection of UCB-MNCs is safe and effective in children with cerebral palsy, improving their motor function and quality of life.
Article
Cell & Tissue Engineering
Tian-Kuo Lee, Cheng-You Lu, Sheng-Tzung Tsai, Pao-Hui Tseng, Yu-Chen Lin, Shinn-Zong Lin, Jonas C. Wang, Chih-Yang Huang, Tsung-Lang Chiu
Summary: This study reported the complete recovery of a 46-year-old male patient with hemiplegia due to ischemic stroke after receiving allogeneic umbilical cord blood cell therapy. The patient did not experience serious adverse events or GVHD during the 12-month study period and showed improvement in NIHSS, Berg Balance Scale, and Barthel index scores.
CELL TRANSPLANTATION
(2021)
Review
Cell & Tissue Engineering
Madison C. B. Paton, Donna A. Wall, Ngaire Elwood, Kuang-Yueh Chiang, Genevieve Cowie, Iona Novak, Megan Finch-Edmondson
Summary: Allogeneic umbilical cord blood (UCB) infusion for the treatment of neurological conditions appears to be safe based on a systematic review of 10 studies, with no reported serious adverse events definitely or probably related to the infusion. Variability between studies was noted, but overall safety concerns seem to be minimal even with variable HLA matching or no immunosuppression.
Review
Cell & Tissue Engineering
Gabriela Sanchez-Petitto, Katayoun Rezvani, May Daher, Hind Rafei, Partow Kebriaei, Elizabeth J. Shpall, Amanda Olson
Summary: Umbilical cord blood transplantation is an attractive alternative source of hematopoietic stem cells, with unique immune tolerance and engraftment kinetics. It has a lower risk of GvHD and comparable clinical outcomes to bone marrow transplantation. However, limitations in cell numbers and delayed engraftment pose challenges for its wider application. Research is being conducted to address these limitations and explore the potential of cord blood in treating various disorders.
STEM CELLS TRANSLATIONAL MEDICINE
(2023)
Article
Cell & Tissue Engineering
Juan Wei, Yufei Zhang, Chunyan Chen, Xiaoyue Feng, Zhao Yang, Jing Feng, Qiong Jiang, Jinjin Fu, Ji Xuan, Hong Gao, Lianming Liao, Fangyu Wang
Summary: The study evaluated the effectiveness and safety of allogeneic umbilical cord-derived mesenchymal stem cells (TH-SC01) for complex perianal fistula in patients with Crohn's disease. A single-arm clinical trial was conducted, and adult patients with complex treatment-refractory perianal fistulas were enrolled and received a single intralesional injection of 120 million TH-SC01 cells. The results showed that local injection of TH-SC01 cells might be an effective and safe treatment for complex treatment-refractory perianal fistulas after conventional and/or biological treatments fail.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Clinical Neurology
Vladimir A. Smirnov, Sergey M. Radaev, Yana Morozova, Sergey Ryabov, Mikhail Ya Yadgarov, Sergey A. Bazanovich, Ivan S. Lvov, Alexander E. Talypov, Andrew A. Grin'
Summary: This study aimed to evaluate the safety and efficacy of systemic administration of allogeneic unrelated human umbilical cord blood mononuclear cells in patients with acute severe spinal cord contusion. The results showed that this treatment method was safe and effective in promoting motor function restoration.
WORLD NEUROSURGERY
(2022)
Article
Cell & Tissue Engineering
Byoungwoo Cha, Hyunseok Kwak, Ji In Bang, Su Jin Jang, Mi Ri Suh, Jee In Choi, MinYoung Kim
Summary: This prospective clinical trial evaluated the efficacy and safety of umbilical cord blood therapy for pediatric patients with global developmental delay (GDD) or intellectual disability (ID). The results showed that the therapy had positive effects on cognitive and motor development, as well as daily living and language abilities of the patients, with no significant adverse effects.
STEM CELLS AND DEVELOPMENT
(2023)
Article
Cell Biology
Pei Tian, Andrew Elefanty, Edouard G. Stanley, Jennifer C. Durnall, Lachlan H. Thompson, Ngaire J. Elwood
Summary: Clinical-grade induced pluripotent stem cells (iPSCs) can be efficiently created using small volumes of thawed cord blood from public cord blood banks. This study presents a protocol that involves ex-vivo expansion and reprogramming of erythroid progenitor cells derived from cord blood, resulting in iPSC lines that are tested for pluripotency, genomic integrity, and stability.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biophysics
Stephanie Vairy, Isabelle Louis, Marie-France Vachon, Johanne Richer, Pierre Teira, Sonia Cellot, Edith Villeneuve, Elie Haddad, Michel Duval, Henrique Bittencourt
Summary: Intrabone cord blood transplantation (IB UCBT) is safe and well-tolerated in children with malignant and non-malignant hematologic diseases, providing faster hematologic recovery compared to traditional IV UCBT. A clinical trial showed a 6-year event-free survival rate of 66.7% and an overall survival rate of 80% with IB UCBT.
BONE MARROW TRANSPLANTATION
(2021)
Review
Biology
Hany Elmariah, Claudio G. Brunstein, Nelli Bejanyan
Summary: Allogeneic HCT is the only potential curative therapy for hematologic diseases, but patients are profoundly immunocompromised initially. Immune reconstitution after HCT, especially with alternative donors like haploidentical and umbilical cord blood, can improve access to treatment. Despite challenges, interventions such as antimicrobial prophylaxis and graft manipulation are available to mitigate risks during the immunocompromised period.
Article
Oncology
Dian-Dian Liu, Wei-Cong Hong, Kun-Yin Qiu, Xin-Yu Li, Yong Liu, Li-Wen Zhu, Wei-Xin Lai, Han- Chen, Hua-Qing Yang, Lu-Hong Xu, Jian-Pei Fang
Summary: CAR-T cell therapy is an effective treatment for relapsed and refractory acute lymphoblastic leukemia (R/R ALL). CAR-T cells derived from healthy donors have better antitumor efficacy than those derived from patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lelia Bertoni, Sandrine Jacquet-Guibon, Thomas Branly, Melanie Desance, Florence Legendre, Martine Melin, Pascaline Rivory, Daniel-Jean Hartmann, Amandine Schmutz, Jean-Marie Denoix, Magali Demoor, Fabrice Audigie, Philippe Galera
Summary: This study evaluated the efficacy of allogeneic bone-marrow derived mesenchymal stem cells compared to umbilical cord blood derived MSCs in limiting the progression of OA-associated changes in horses. Results showed a significant reduction in OA-related changes with bone-marrow derived MSCs, suggesting promising therapeutic potential for OA in horses. Further research is needed to validate these results and discover innovative strategies for optimizing the therapeutic benefits of these cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell & Tissue Engineering
Tongbiao Zhao, Zhen-ning Zhang, Peter D. Westenskow, Dilyana Todorova, Zheng Hu, Tongxiang Lin, Zhili Rong, Jinchul Kim, Jingjin He, Meiyan Wang, Dennis O. Clegg, Yong-guang Yang, Kun Zhang, Martin Friedlander, Yang Xu
Article
Chemistry, Applied
Qiuping Ye, Xinyi Jin, Xinliang Zhu, Tongxiang Lin, Zhilong Hao, Qian Yang
JOURNAL OF OLEO SCIENCE
(2015)
Review
Cell & Tissue Engineering
Tongxiang Lin, Shouhai Wu
STEM CELLS INTERNATIONAL
(2015)
Review
Biochemistry & Molecular Biology
Xiaowei Jin, Tongxiang Lin, Yang Xu
CURRENT MOLECULAR PHARMACOLOGY
(2016)
Review
Biotechnology & Applied Microbiology
Qingxi Zhang, Wanling Chen, Sheng Tan, Tongxiang Lin
HUMAN GENE THERAPY
(2017)
Article
Medicine, General & Internal
Wanxin Wen, Hongxia Gao, Nini Kang, Aili Lu, Caiwen Qian, Yuanqi Zhao
Review
Cell & Tissue Engineering
Tongxiang Lin, Yi Lin
STEM CELL RESEARCH & THERAPY
(2017)
Correction
Multidisciplinary Sciences
Yuanqi Zhao, Min Zhao, Xiaomin Li, Xiancong Ma, Qinghao Zheng, Xiaosheng Chen, Yinwing Lin, Yefeng Cai
Article
Integrative & Complementary Medicine
RenRong Wei, Jing OuYang, WeiXian Lin, TongXiang Lin
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2018)
Article
Integrative & Complementary Medicine
Renrong Wei, Cuiping Rong, Qingfeng Xie, Shouhai Wu, Yuchao Feng, Ruihua Wang, Zhenhui Dai, Tongxiang Lin
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2019)
Article
Integrative & Complementary Medicine
Changlin Zhang, Yingdi Liao, Lingling Liu, Yifan Sun, Shaoqin Lin, Jiaying Lan, Hui Mao, Haoxuan Chen, Yuanqi Zhao
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2020)
Article
Medicine, General & Internal
Haoyou Xu, Lijun Qiao, Supeng Fang, Zhanneng Ren, Guangliang Wu, Yu Zheng, Biying Yang, Yuanqi Zhao
Summary: This meta-analysis study found no significant association between alcohol intake and risk of multiple sclerosis. However, it did find that beer intake may increase the risk of multiple sclerosis. Further research is needed to verify this conclusion.
SAO PAULO MEDICAL JOURNAL
(2022)
Letter
Clinical Neurology
Weijun Zhang, Qin Huang, Zhengzheng Xuan, Shibiao Wu, Yuanqi Zhao, Haoyou Xu
JOURNAL OF CLINICAL NEUROLOGY
(2020)
