Article
Radiology, Nuclear Medicine & Medical Imaging
Doerthe Brueggmann, Matthias Grimstein, Christine Solbach, Doris Klingelhoefer, Michael H. K. Bendels, Jenny Jaque, David A. Groneberg
Summary: This study analyzed the global research output of mammography, highlighting the leading role of the United States in this field and showcasing the exceptional research activity of countries like Sweden. The research demonstrates strong international collaborative efforts and reveals distinct differences in comparison to other biomedical research landscapes.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Jianyi Zhang, Roberto Bolli, Daniel J. Garry, Eduardo Marban, Philippe Menasche, Wolfram-Hubertus Zimmermann, Timothy J. Kamp, Joseph C. Wu, Victor J. Dzau
Summary: This paper provides an update on the recent preclinical and clinical trials using cell therapy and engineered heart tissues for postinfarction left ventricular remodeling and heart failure. The authors discuss novel approaches for cardiac remuscularization through activating proliferative mechanisms or direct reprogramming, aiming to facilitate the translation of discoveries in regenerative myocardial therapies to the clinic.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Ron Waksman, Mohit Pahuja, Sean van Diepen, Alastair G. Proudfoot, David Morrow, Ernest Spitzer, Graham Nichol, Myron L. Weisfeldt, Mauro Moscucci, Patrick R. Lawler, Alexandre Mebazaa, Eddy Fan, Neal W. Dickert, Marc Samsky, Robert Kormos, Ileana L. Pina, Bram Zuckerman, Andrew Farb, John S. Sapirstein, Charles Simonton, Nick E. J. West, Abdulla A. Damluji, Ian C. Gilchrist, Uwe Zeymer, Holger Thiele, Donald E. Cutlip, Mitchell Krucoff, William T. Abraham
Summary: This article discusses the establishment and objectives of the Shock Academic Research Consortium, which aims to develop practical consensus definitions to evaluate the efficacy and safety of mechanical circulatory support devices in clinical trials for cardiogenic shock patients.
Article
Cardiac & Cardiovascular Systems
Ming Xu, Fupeng Yang, Bin Shen, Jiamei Wang, Wenhao Niu, Hui Chen, Na Li, Wei Chen, Qinqin Wang, Zhiqing He, Ru Ding
Summary: This study analyzed the research on acute myocardial infarction (AMI) in women using bibliometric methods. It was found that the United States published the most articles in international research on this topic over the past 20 years and participated in international cooperation frequently. Harvard University and the University of Toronto were the primary research institutions, and Circulation was the most cited journal with significant academic impact. The research hotspots and trends included risk factors, disease, prognosis, mortality, criteria, and algorithms. The study of AMI in women is flourishing, and the research on criteria and algorithms deserves great attention in the future.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Medicine, General & Internal
Akash Goyal, Tony Schibler, Brooke Alhanti, Karen L. Hannan, Christopher B. Granger, Michael A. Blazing, Renato D. Lopes, John H. Alexander, Eric D. Peterson, Sunil Rao, Jennifer B. Green, Matthew T. Roe, Tyrus Rorick, Lisa G. Berdan, Craig Reist, Kenneth W. Mahaffey, Robert A. Harrington, Robert M. Califf, Manesh R. Patel, Adrian F. Hernandez, W. Schuyler Jones
Summary: This study evaluated the start-up time of cardiovascular RCTs in North America and found a median start-up time of about 9 months overall, but less than 4 months for top-performing sites. The findings suggest that using central IRBs may improve RCT efficiency.
Article
Medicine, General & Internal
Uwe Zeymer, Anne Freund, Matthias Hochadel, Petr Ostadal, Jan Belohlavek, Richard Rokyta, Steffen Massberg, Stefan Brunner, Enzo Luesebrink, Marcus Flather, David Adlam, Kris Bogaerts, Amerjeet Banning, Manel Sabate, Ibrahim Akin, Alexander Jobs, Steffen Schneider, Steffen Desch, Holger Thiele
Summary: An individual patient-based meta-analysis found that early use of VA-ECMO did not reduce the 30-day death rate in patients with infarct-related cardiogenic shock. Furthermore, there was an increased risk of major bleeding and vascular complications associated with VA-ECMO. Therefore, careful consideration of the indication for VA-ECMO is necessary in this setting.
Review
Agriculture, Multidisciplinary
Pauline Duffuler, Khushwant S. Bhullar, Stepheny C. de Campos Zani, Jianping Wu
Summary: Food-derived bioactive peptides and protein hydrolysates have gained attention as diet-based strategies for preventing and mitigating chronic diseases, but their clinical translation is limited by a lack of understanding of their mechanisms of action and pharmacokinetics. Commercialization is also hindered by limited information on efficacy, safety, bitter taste, and cost-effective production methods.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Cardiac & Cardiovascular Systems
Yifei Wang, Lijun Guo, Zhibo Zhang, Shuangqing Fu, Pingping Huang, Anzhu Wang, Mi Liu, Xiaochang Ma
Summary: Myocardial ischemia/reperfusion injury (MIRI) refers to the severe damage that occurs in previously ischemic myocardium after a brief interruption of blood supply followed by restoration of blood flow. MIRI has become a major challenge affecting the effectiveness of cardiovascular surgery. Research on MIRI has shown significant progress, focusing on understanding the disease mechanisms and exploring cardioprotective strategies.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Mario Gaudino, Antonino Di Franco, Cristiano Spadaccio, Mohamed Rahouma, N. Bryce Robinson, Michelle Demetres, Stephen Fremes, Torsten Doenst
Summary: This study investigates the association between spontaneous myocardial infarction (SMI) reduction and survival benefit in coronary artery bypass (CABG) compared with percutaneous interventions (PCI). The results show that CABG is associated with a lower incidence of SMI and higher survival rate compared to PCI.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Cell & Tissue Engineering
Armin Attar, Fateme Bahmanzadegan Jahromi, Shahin Kavousi, Ahmad Monabati, Asma Kazemi
Summary: Research on the role of mesenchymal stem cells (MSCs) in increasing ejection fraction (LVEF) after acute myocardial infarction (AMI) has sparked some controversy. This study found that transplantation of MSCs after AMI significantly increases LVEF, with a more pronounced effect if done within the first week after the heart attack. Further studies are needed to investigate long-term clinical outcomes such as heart failure and cardiovascular mortality.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Immunology
Wenjian Nian, Zijian Huang, Cong Fu
Summary: The high prevalence of heart failure following myocardial infarction (MI) has been a challenging issue. MI triggers strong non-infectious inflammation, and the infiltration of various immune cells and changes in the local inflammatory microenvironment play a vital role in ventricular remodeling. Therefore, targeting the immune system to improve the prognosis of MI has gained interest; however, previous immune-targeted therapies have not shown significant success in clinical trials. This review focuses on the role and potential therapeutic targets of different immune cells, particularly monocytes/macrophages and neutrophils, in ventricular remodeling after MI, highlighting the importance and potential of immunomodulatory therapies for MI. Additionally, the reasons for the failure of previous immunomodulatory treatments and the issues that need to be addressed are analyzed, along with the prospects and strategies of using immune cells to drive novel immunomodulatory therapies, aiming to advance the development of immunomodulatory treatments through providing evidence and new insights.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Lejla Medzikovic, Tara Azem, Wasila Sun, Parmis Rejali, Leana Esdin, Shadie Rahman, Ateyeh Dehghanitafti, Laila Aryan, Mansoureh Eghbali
Summary: Mortality from myocardial infarction (MI) has declined due to improved treatment methods, but outcomes of MI with subsequent reperfusion therapy are generally poorer for women compared with men. Further investigation is needed to understand the sex-based differences in disease pathophysiology and treatment response, and develop sex-specific therapeutic methods against myocardial ischemia-reperfusion injury (IRI). This literature review summarizes current knowledge on sex differences in the pathophysiological mechanisms of myocardial IRI, as well as sex differences in the pharmacokinetics, pharmacodynamics, and pharmacogenetics of drugs used to limit myocardial IRI.
Review
Medicine, General & Internal
Kevin Emery Boczar, Sheojung Shin, Kathryn A. Bezzina, Aishwarya Geejo, Alexander Liam Pearson, Saba Shahab, Christophe A. Fehlmann, Sarah Visintini, Rob Beanlands, George A. Wells
Summary: This systematic review aims to compare the efficacy of anti-inflammatory agents on cardiovascular outcomes in patients with known cardiovascular disease. Randomized controlled trials will be included in the analysis, and network meta-analysis will be conducted to compare treatment effects. Quality assessment will also be performed.
Review
Cardiac & Cardiovascular Systems
Xintian Shou, Yumeng Wang, Chenglin Duan, Guozhen Yuan, Namin Wei, Yihan Yang, Yuanhui Hu
Summary: Patients with T2DM are more prone to CVD, and GLP1RA is a glucose-lowering drug with cardiovascular benefits. Through bibliometric analysis, this study identified the research hotspots and frontiers in the cardiovascular research of GLP1RA, including five hotspots and two frontiers.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Toshiyuki Nishikido, Kausik K. Ray
Summary: LDL cholesterol plays a key role in atherosclerosis progression, and statin therapy is recommended for reducing LDL-C levels and cardiovascular disease risk. For patients unable to achieve sufficient LDL-C reduction with statins or are statin-intolerant, PCSK9 inhibitors are an alternative treatment that significantly reduces LDL-C levels and cardiovascular risk.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Hematology
Stephan Binneboessel, Raphael Romano Bruno, Bernhard Wernly, Maryna Masyuk, Hans Flaatten, Jesper Fjolner, Georg Wolff, Malte Kelm, Michael Beil, Sigal Sviri, Wojciech Szczeklik, Susannah Leaver, Dylan W. De Lange, Bertrand Guidet, Christian Jung
Summary: This study investigated the impact of cytokine absorption on mortality in elderly critically ill patients with COVID-19 and renal failure admitted to intensive care units. The results showed that short-term mortality rates were higher in patients treated with cytokine absorption, but mortality was associated with disease severity rather than cytokine absorption in a multivariate analysis.
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
(2023)
Article
Critical Care Medicine
Christian Jung, Bertrand Guidet, Hans Flaatten
INTENSIVE CARE MEDICINE
(2023)
Article
Medical Informatics
Michael Beil, P. Vernon van Heerden, Dylan W. de Lange, Wojciech Szczeklik, Susannah Leaver, Bertrand Guidet, Hans Flaatten, Christian Jung, Sigal Sviri, Leo Joskowicz
Summary: This study used the framework of information theory to evaluate the uncertainty in decision-making about life-sustaining treatment (LST) in the intensive care unit (ICU). The results showed that information about the severity of the acute illness was the most important, while age, gender, and geriatric characteristics contributed to a lesser degree. This suggests that there is still a gap in fully understanding decision-making about LST and further research is needed.
BMC MEDICAL INFORMATICS AND DECISION MAKING
(2023)
Article
Hematology
Stephan Binneboessel, Maryna Masyuk, Kerstin Piayda, Raphael Romano Bruno, Bernhard Wernly, Peter Jirak, Georg Wolff, Norbert Gerdes, Philipp Heinrich Baldia, Malte Kelm, Fabian Nienhaus, Alexander Lang, Holger Winkels, Gerd Geerling, Rainer Guthoff, Sema Kaya, Gerald Flossmann, Thomas Riemer, Michael Baertschi, Christian Jung
Summary: This study aims to investigate the effect of weightlessness on retinal microcirculation and explore its relationship with the development of SANS.
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
(2023)
Article
Medicine, General & Internal
Robert Uzel, Richard Rezar, Raphael Romano Bruno, Sarah Wernly, Christian Jung, Georg Delle Karth, Christian Datz, Friedrich Hoppichler, Bernhard Wernly
Summary: Frailty was evaluated as a predictor of outcome in patients with moderate to severe secondary mitral regurgitation. The study found that frailty was associated with a higher risk of adverse outcomes and outperformed EuroSCORE2 in predicting the combined endpoint. Therefore, routine assessment of frailty should be carried out in patients with heart failure to guide clinical decision making.
WIENER KLINISCHE WOCHENSCHRIFT
(2023)
Article
Medicine, General & Internal
Richard Rezar, Behrooz Mamandipoor, Clemens Seelmaier, Christian Jung, Michael Lichtenauer, Uta C. C. Hoppe, Reinhard Kaufmann, Venet Osmani, Bernhard Wernly
Summary: Severe hyperlactatemia (>10mmol/L) or impaired lactate metabolism are associated with increased mortality. A study analyzed the maximum lactate concentration on day 1 of 10,724 septic patients and categorized them into three groups based on lactate levels. Findings showed that severe hyperlactatemia was linked to high mortality rates, especially if it persists beyond 24 hours. The results suggest that severe hyperlactatemia, along with clinical parameters, could be used to determine treatment limits.
WIENER KLINISCHE WOCHENSCHRIFT
(2023)
Article
Medicine, General & Internal
Dragos Andrei Duse, Michael Groene, Nicolas Kramser, Matthias Ortkemper, Christine Quast, Fabian Voss, Nadia Heramvand, Karel Kostev, Malte Kelm, Patrick Horn, Christian Jung, Ralf Erkens
Summary: This study analyzed the initial serum phosphate levels of 488 patients who achieved return of spontaneous circulation (ROSC) after cardiac arrest (CA), and found that phosphate levels higher than 2.7 mmol/L were associated with higher mortality and neurological impairment. These results suggest that phosphate determination may improve the preciseness of overall and neurological prognostication in patients after cardiopulmonary resuscitation (CPR) following ROSC.
Article
Cardiac & Cardiovascular Systems
Verena Veulemans, Nihal Wilde, Hendrik Wienemann, Rik Adrichem, Thijmen W. Hokken, Baravan Al-Kassou, Jasmin Shamekhi, Victor Mauri, Oliver Maier, Christian Jung, Patrick Horn, Matti Adam, Georg Nickenig, Stephan Baldus, Nicolas M. Van Mieghem, Malte Kelm, Alexander Sedaghat, Tobias Zeus
Summary: This study evaluated the impact of different TAVI-guidewires on procedural success and outcomes during transcatheter aortic valve implantation (TAVI). The use of the Lunderquist(TM) guidewire was associated with a higher final implantation depth, but had no significant impact on outcomes such as conduction disturbances and pacemaker need within 30 days.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Medicine, General & Internal
Dragos Andrei Duse, Fabian Voss, Laura Heyng, Georg Wolff, Christine Quast, Daniel Scheiber, Patrick Horn, Malte Kelm, Ralf Westenfeld, Christian Jung, Ralf Erkens
Summary: This study found that phosphate and lactate levels are associated with the benefits of mechanical circulatory support (MCS) in patients with out-of-hospital cardiac arrest (OHCA) and return of spontaneous circulation (ROSC). MCS therapy was found to reduce 30-day mortality in patients with initial phosphate levels above 2.2 mmol/L. Both lactate and phosphate levels showed comparable predictive ability for overall survival.
Article
Emergency Medicine
Janina Dziegielewski, Falko C. Schulte, Christian Jung, Georg Wolff, Oliver Hannappel, Philipp Kuempers, Michael Bernhard, Mark Michael
Summary: This retrospective study analyzed the epidemiology, management, and outcome of critically ill non-traumatic patients admitted to the emergency department (ED). It found that further development of structured care algorithms for these patients is needed.
BMC EMERGENCY MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Robert Uzel, Raphael R. Bruno, Christian Jung, Christian Lang, Hannes Hoi, Martin Gruenbart, Christian Datz, Friedrich Hoppichler, Bernhard Wernly
Summary: This study evaluated the impact of ACE inhibitors and angiotensin receptor blockers (ACE-I/ARB) on elderly patients with moderate-to-severe mitral regurgitation (MR) and mildly reduced to preserved ejection fraction. The results showed that patients treated with ACEI/ARB had a lower risk for the combined endpoint of death and heart failure-related readmission, even after adjustment for risk scores and frailty. Therefore, ACE-I/ARB might be a valuable therapeutic option for conservatively treated patients.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Raphael Romano Bruno, Robert Uezel, Maximilian Spieker, Christian Datz, Daniel Oehler, Florian Boenner, Malte Kelm, Friedrich Hoppichler, Christian Jung, Bernhard Wernly
Summary: This study examines the gender distribution and 1-year prognosis of older patients with pharmacologically treated functional mitral regurgitation (MR). It reveals that female patients have similar rates of heart failure hospitalization and all-cause mortality compared to male patients.
Letter
Rheumatology
Mathias Ausserwinkler, Hans Jorg Neumann, Bernhard Wernly
RHEUMATOLOGY INTERNATIONAL
(2023)
Letter
Critical Care Medicine
Bernhard Wernly, Hans Flaatten, Susannah Leaver, Bertrand Guidet, Christian Jung