Article
Polymer Science
Maria Herrero-Herrero, Jose Antonio Gomez-Tejedor, Ana Valles-Lluch
Summary: Tailored membranes with a fiber diameter of 1.8 μm were electrospun from PLGA and PCLGA solutions by adjusting electrospinning and polymer solution parameters. PCLGA, with its amorphous morphology, required the addition of a salt to increase conductivity for successful electrospinning, presenting notable difficulties due to its structure. Interestingly, PCLGA, with a higher glycolic acid molar fraction, could be successfully electrospun, a feat not previously reported.
Article
Chemistry, Physical
Morteza Bazgir, Wei Zhang, Ximu Zhang, Jacobo Elies, Morvarid Saeinasab, Phil Coates, Mansour Youseffi, Farshid Sefat
Summary: The study evaluated the characteristics and degradation effects of PLGA- and PCL-based nanofibrous scaffolds, finding that longer electrospinning times resulted in stronger mechanical properties and maintained fiber structure. Both PCL and PLGA scaffolds demonstrated adequate degradation over time, with slight increase in fiber diameter and substantial decrease in pore size and porosity percentage. This experiment suggests promise for PCL and PLGA in tissue engineering and regenerative medicine applications.
Article
Chemistry, Physical
Dongxue Han, Reem Ghubayra, Rhett Dacy Carpenter-Thompson, Tifeng Jiao, Bingbing Li
Summary: The crystallization behavior of electrospun PCL/PLGA blend fibers was studied, and it was found that the choice of solvent and the PCL concentration significantly affected the crystallization mechanism and morphology. Thicker fibers showed microscopic phase separation while thinner fibers exhibited failure and fracture after solvent wash. Solvent vapor annealing experiments revealed the PCL lamellar network in thicker fibers and the PCL shish-kebab in thinner fibers.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Biotechnology & Applied Microbiology
Sanaz Behtaj, Fereshteh Karamali, Elahe Masaeli, Yuri G. Anissimov, Maksym Rybachuk
Summary: This study investigates the impact of different polyester-based biopolymer materials blended with PCL on the attachment and proliferation of RPCs, revealing that PGS/PCL scaffolds promote RPC attachment and proliferation more favorably compared to other blends, showing potential for future clinical therapy for retinal degenerative disorders.
BIOCHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Yiye Lu, Geoffrey W. Coates
Summary: Poly(lactic-co-glycolic acid) (PLGA) is widely used in various biomedical applications due to its biodegradability and biocompatibility. This study successfully developed a method to synthesize syndioenriched, alternating PLGA from racemic methyl-glycolide (rac-MeG), and confirmed the high degree of alternation of the comonomer sequence and moderate syndiotacticity within the polymer backbone stereoconfiguration through NMR investigations.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Yiye Lu, Geoffrey W. Coates
Summary: Poly(lactic-co-glycolic acid) (PLGA) is a biodegradable and biocompatible polymer used in biomedical applications. This study presents a method for synthesizing syndioenriched, alternating PLGA from racemic methyl-glycolide with the use of an optimized racemic aluminum catalyst. The resulting material has a high degree of alternation in copolymer sequence and moderate syndiotacticity, and is amorphous, making it suitable for drug complexation.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Review
Biotechnology & Applied Microbiology
Bruno Godinho, Nuno Gama, Artur Ferreira
Summary: Poly(glycerol sebacate) (PGS) is a biodegradable elastomer attracting attention in tissue engineering. New synthesis methods have been reported to reduce time and energy, and adjust properties for specific applications. This review compiles 20+ years of reports and proposes alternatives for faster production of PGS structures with desired properties.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Polymer Science
Hong Wang, Yanwei Zhang, Yaru Liu, Yi Ren, Jianhong Wang, Baolong Niu, Wenfeng Li
Summary: This paper focuses on the development of targeted drug delivery systems for cancer therapy. HA-SS-PLGA copolymer was used to form reduction-sensitive amphiphilic micelles, which actively targeted tumor cells and inhibited cancer cell proliferation. This research provides a promising drug carrier for cancer therapy.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Polymer Science
Wanich Limwanich, Puttinan Meepowpan, Montira Sriyai, Tawan Chaiwon, Winita Punyodom
Summary: Biodegradable poly(epsilon-caprolactone) (PCL) was successfully synthesized through a green polymerization process without heavy metal catalyst and toxic solvent. L-Lactic (LLA) and glycolic acids (GA) were used as initiators, producing PCL with different molecular weights in the absence of water. Non-isothermal DSC analysis showed that GA had higher reactivity than LLA in epsilon-CL ROP, and proposed the polymerization mechanism initiated by LLA and GA.
Article
Chemistry, Multidisciplinary
Rong Wang, Xiaojie Sun, Lanlan Chen, Wenbin Liang
Summary: In this study, biodegradable blends of PGA and PBAT with in situ compatibilization using MDI were prepared. The addition of PBAT was found to increase the complex viscosity and storage modulus of the blends, leading to improved compatibility and impact strength. The morphology of the dispersed phase evolved from spherical structure to in situ microfiber, enhancing interfacial adhesion and improving toughness.
Article
Polymer Science
Dongyong Sha, Zihan Wu, Jingjing Zhang, Yifan Ma, Zhaogang Yang, Yuan Yuan
Summary: In the past decade, PGS has gained significant attention in various biomedical fields due to its superior elasticity, biocompatibility, and biodegradability. To meet the increasing demands, different modification strategies and construction methods have been developed to expand the properties of PGS. Currently, PGS has been applied in areas such as hard tissue engineering, soft tissue engineering, drug delivery, and device design.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Qin Chang, Dong Jing, Xie Beibei, Wang Hongkun, Zhang Na, Zhao Chunhua, Qiao Congde, Liu Mingxia, Yang Xiaodeng, Li Tianduo
Summary: Poly(lactic-co-glycolic acid)(PLGA) with different molecular weights and LA/GA molar ratio was prepared and characterized in this study. The results demonstrated that PLGA(3.2) film with an LA/GA molar ratio of 52/48 is a promising curcumin carrier.
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
(2023)
Article
Pharmacology & Pharmacy
Seung-No Hong, Minjae Kim, Jin-A Park, Minji Kang, Hyunkyung Cha, Sohyun Park, Joon Kon Kim, Jinyoung Pac, Yuju Seo, Sungwhan Kim, Minju Kim, Dae Woo Kim, Yan Lee
Summary: This study designed dexamethasone-loaded poly(lactic-co-glycolic acid) microparticles with bone-specific binding affinity for the treatment of sinus surgery-induced osteitis in chronic rhinosinusitis (CRS). The microparticles released the encapsulated dexamethasone in a sustained manner on the exposed bone after the surgical wound in the nasal cavity. The results showed that the microparticles had higher binding affinity and inhibited the formation of undesirable new woven bone. Therefore, this localized corticoid delivery method has the potential to treat CRS-related osteitis with minimal side effects.
Article
Polymer Science
Yuanyuan Dou, Han Wu, Li Zhang, Zhenbo Ning, Ni Jiang, Zhihua Gan
Summary: Three types of spherulitic morphologies, including conventional ring-banded spherulites, special spherulites with a curve-like morphology, and composite spherulites, were found in PCL-b-PA6-b-PCL due to the wide crystallization temperature range of chemically jointed PA6 blocks. The formation conditions, internal factors, and lamellar orientation and assembly of different spherulites were studied in detail. The appearance of unusual spherulitic morphology may result from different internal stress induced by chemically jointed PA6 blocks under diverse crystallization conditions.
Article
Engineering, Environmental
Weishuo Chen, Channa Zhong, Shuangcheng Li, Die Wen, Dongdong Zhou, Jun Shao, Shuiliang Chen, Haoqing Hou, Sheng Xiang
Summary: The blends of poly(D-lactic acid) and poly(L-lactic acid) (PDLA/PLLA) exhibit higher crystallization rate and mechanical strength than individual PDLA or PLLA due to the formation of stereocomplex crystals (SC). SC serves as an effective nucleating agent for PLA homochiral crystals (HC). However, the morphology of SC in asymmetric blends and its effect on the crystallization behavior of HC remains unclear. In this study, PDLA/PLLA blends with different weight ratios were prepared using different methods to obtain SC with different morphologies. The results showed that SC morphology influenced the formation of HC, with fibrous and banded SC inhibiting HC formation, spherical SC enhancing HC formation, and network structure SC significantly accelerating the crystallization rate of HC.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2023)
Article
Ophthalmology
Eduardo A. Novais, Mehreen Adhi, Eric M. Moult, Ricardo N. Louzada, Emily D. Cole, Lennart Husvogt, Byungkun Lee, Sabin Dang, Caio V. S. Regatieri, Andre J. Witkin, Caroline R. Baumal, Joachim Hornegger, Vijaysekhar Jayaraman, James G. Fujimoto, Jay S. Duker, Nadia K. Waheed
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2016)
Article
Ophthalmology
Hermelino O. Neto, Caio V. Regatieri, Mario J. Nobrega, Cristina Muccioli, Antonio M. Casella, Rafael E. Andrade, Mauricio Maia, Vinicius Kniggendorf, Magno Ferreira, Andre C. Branco, Rubens Belfort
OPHTHALMIC SURGERY LASERS & IMAGING RETINA
(2017)
Editorial Material
Ophthalmology
Eduardo M. Rocha, Monica Alves, Joao Marcello Furtado, Caio Regatieri
ARQUIVOS BRASILEIROS DE OFTALMOLOGIA
(2018)
Article
Ophthalmology
Claes H. Dohlman, Fabiano Cade, Caio V. Regatieri, Chengxin Zhou, Fengyang Lei, Alja Crnej, Mona Harissi-Dagher, Marie-Claude Robert, George N. Papaliodis, Dongfeng Chen, James V. Aquavella, Esen K. Akpek, Anthony J. Aldave, Kimberly C. Sippel, Donald J. D'Amico, Jan G. Dohlman, Per Fagerholm, Liqiang Wang, Lucy Q. Shen, Miguel Gonzalez-Andrades, James Chodosh, Kenneth R. Kenyon, C. Stephen Foster, Roberto Pineda, Samir Melki, Kathryn A. Colby, Joseph B. Ciolino, Demetrios G. Vavvas, Shigeru Kinoshita, Reza Dana, Eleftherios I. Paschalis
Editorial Material
Ophthalmology
Dante Akira Kondo Kuroiwa, Lucas Zago Ribeiro, Caio Vinicius Saito Regatieri
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Editorial Material
Ophthalmology
Lucas Zago Ribeiro, Dante Akira Kondo Kuroiwa, Caio Vinicius Saito Regatieri
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Editorial Material
Medicine, General & Internal
Rafael Andre da Silva, Luiz Philipe de Souza Ferreira, Vinicius Moraes de Paiva Roda, Jose Maria Soares Junior, Manuel de Jesus Simoes, Caio Vinicius Saito Regatieri
Article
Health Care Sciences & Services
Fernando Korn Malerbi, Luis Filipe Nakayama, Robyn Gayle Dychiao, Lucas Zago Ribeiro, Cleva Villanueva, Leo Anthony Celi, Caio Vinicius Regatieri
Summary: Artificial Intelligence (AI) is a significant milestone in the digital transformation of health care. However, the education and training in health care often lack digital competencies. To ensure safe and effective AI implementation, health care professionals need to acquire knowledge of machine learning, data evaluation, workflow integration, bias control, and human-machine interaction. They should also understand the legal and ethical aspects of digital health care and the impact of AI adoption. Overcoming barriers to promote electronic health literacy requires partnerships among developers, professional societies, and academia, incorporating specialists from different backgrounds.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Review
Medicine, General & Internal
Luis Filipe Nakayama, Lucas Zago Ribeiro, Frederico Novaes, Isabele Ayumi Miyawaki, Andresa Emy Miyawaki, Juliana Angelica Estevao de Oliveira, Talita Oliveira, Fernando Korn Malerbi, Caio Vinicius Saito Regatieri, Leo Anthony Celi, Paolo S. Silva
Summary: This study compares AI systems applied in DR teleophthalmology screening and addresses the fairness initiatives and challenges for implementation. The review included nine articles published between 2004 and 2020, and identified four telemedicine systems that perform quality assessment, image preprocessing, and pathological screening. However, none of the algorithms assessed data and post-deployment biases, and there was a lack of representation from low-income countries.
ANNALS OF MEDICINE
(2023)
Article
Health Care Sciences & Services
Luis Filipe Nakayama, William Warr Binotti, Naira Link Woite, Chrystinne Oliveira Fernandes, Pia Gabrielle Alfonso, Leo Anthony Celi, Caio Vinicius Regatieri
Summary: The COVID-19 pandemic has increased the use of digital solutions in medical care in Brazil, but internet access remains a challenge, particularly in rural areas. This study provides an overview of the digital divide in the country, identifies the challenges and opportunities for digital health care implementation, and highlights the need to address the divide to ensure equitable access to digital health care.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Ophthalmology
Luis Filipe Nakayama, Lucas Zago Ribeiro, Juliana Angelica Estevao de Oliveira, Joao Carlos Ramos Goncalves de Matos, William Greig Mitchell, Fernando Korn Malerbi, Leo Anthony Celi, Caio Vinicius Saito Regatieri
Summary: The purpose of this study is to evaluate and compare normative databases of different OCT machines, analyzing patient demographic, contrast inclusion and exclusion criteria, diversity index, and statistical approach. The study found that Avanti OCT has the largest normative database, Spectralis has the largest proportionate representation of White patients, Cirrus has the largest proportionate representation of Asian patients, and Triton has the largest proportionate representation of Black patients. Regression models were used for statistical analysis in all databases. Avanti dataset has the highest diversity index in terms of race, followed by Cirrus, Triton, and Spectralis.
INTERNATIONAL JOURNAL OF RETINA AND VITREOUS
(2023)
Article
Endocrinology & Metabolism
Juliana Angelica Estevao de Oliveira, Luis Filipe Nakayama, Lucas Zago Ribeiro, Talita Virginia Fernandes de Oliveira, Stefano Neto Jai Hyun Choi, Edgar Menezes Neto, Viviane Santos Cardoso, Sergio Atala Dib, Gustavo Barreto Melo, Caio Vinicius Saito Regatieri, Fernando Korn Malerbi
Summary: This study compared the performance of a handheld fundus camera (Eyer) and standard tabletop fundus cameras for diabetic retinopathy and macular edema screening. The results showed that the handheld retinal camera performed comparably to standard tabletop cameras, demonstrating high agreement and reliability. The portability and low costs of the handheld camera make it a promising tool for increasing coverage of diabetic retinopathy screening programs, especially in low-income countries. This study contributes important evidence to the early diagnosis and treatment of diabetic retinopathy.
ACTA DIABETOLOGICA
(2023)
Article
Medicine, General & Internal
Mauro Gobira, Luis Filipe Nakayama, Rodrigo Moreira, Eric Andrade, Caio Vinicius Saito Regatieri, Rubens Belfort Jr
Summary: The performance of ChatGPT-4.0 in answering the 2022 Brazilian National Examination for Medical Degree Revalidation was evaluated in this study. The results showed satisfactory performance overall, but the model had lower accuracy on subjective questions and public healthcare themes.
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
(2023)
Article
Ophthalmology
Juliana Prazeres, Luiz Filipe Lucatto, Adriano Ferreira, Nilva Moraes, Josefina A. P. Braga, Luiz H. Lima, Caio Regatieri, Mauricio Maia
Summary: This study used EDI-OCT to measure the thickness of the macular choroid in asymptomatic pediatric patients with SCD. The results showed that the choroidal thickness in the macular area was significantly thinner compared to control eyes.
INTERNATIONAL JOURNAL OF RETINA AND VITREOUS
(2022)
Letter
Ophthalmology
Fernando Korn Malerbi, Caio Vinicius Regatieri, Joao Roberto de Sa, Paulo Henrique Morales, Michel Eid Farah, Sergio Atala Dib
ACTA OPHTHALMOLOGICA
(2018)