期刊
MATERIALS
卷 5, 期 12, 页码 2658-2680出版社
MDPI
DOI: 10.3390/ma5122658
关键词
lipid bilayer membranes; silicon oxide; mica; titanium dioxide; atomic force microscope; fluorescence microscope; single molecule tracking; surface hydrophilicity; anomalous diffusion; phase separation
类别
资金
- MEXT/JSPS KAKENHI [21015027, 21107530, 21685004, 23685003]
- MEXT/JST, Japan
- Grants-in-Aid for Scientific Research [23685003, 21685004, 21107530, 21015027] Funding Source: KAKEN
Supported lipid bilayers are artificial lipid bilayer membranes existing at the interface between solid substrates and aqueous solution. Surface structures and properties of the solid substrates affect the formation process, fluidity, two-dimensional structure and chemical activity of supported lipid bilayers, through the 1-2 nm thick water layer between the substrate and bilayer membrane. Even on SiO2/Si and mica surfaces, which are flat and biologically inert, and most widely used as the substrates for the supported lipid bilayers, cause differences in the structure and properties of the supported membranes. In this review, I summarize several examples of the effects of substrate structures and properties on an atomic and nanometer scales on the solid-supported lipid bilayers, including our recent reports.
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