期刊
SCIENCE SIGNALING
卷 8, 期 363, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/scisignal.aaa6769
关键词
-
资金
- Canadian Institutes of Health Research
Piezo proteins-a family of mammalian cation-selective ion channels that respond to mechanical stretch-are molecular mediators of biological processes, including vascular tone, hearing, touch, and pain. In this issue of Science Signaling, Rohacs and colleagues demonstrate that activation of the heat-sensitive transient receptor potential vanilloid 1 (TRPV1), another cation channel, inhibits Piezo channels through a calcium-induced depletion of phosphoinositides. This regulation could contribute to the cellular mechanisms by which the TRPV1 activator capsaicin mitigates mechanical hypersensitivity.
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