Review
Biochemistry & Molecular Biology
Hyeji Jeon, Su Min Seo, Tae Wan Kim, Jaesung Ryu, Hyejeong Kong, Si Hyeong Jang, Yong Soo Jang, Kwang Seock Kim, Jae Hoon Kim, Seongho Ryu, Seob Jeon
Summary: The aim of this study was to develop a new diagnostic biomarker for identifying specific serum exosomal miRNAs in epithelial ovarian cancer (EOC) and investigate the target gene of the miRNA to understand the molecular mechanisms involved. The results showed that miRNA-1290 was significantly overexpressed in serum exosomes and tissues of EOC patients compared to those with benign ovarian neoplasms. Furthermore, the study suggested that serum exosomal miR-1290 could be considered as a potential biomarker for differentiating EOC from benign ovarian neoplasms, and SOCS4 might be a potential target gene of miR-1290 in EOC.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Oncology
Yuan-Yuan Liu, Ren-Feng Zhao, Chao Liu, Jie Zhou, Liu Yang, Li Li
Summary: This study identified differentially expressed microRNAs associated with platinum resistance in ovarian cancer patients through analysis of a gene expression database and experimental validation, and explored their feasibility as biomarkers.
FRONTIERS IN ONCOLOGY
(2022)
Review
Cell Biology
Boya Peng, Poh Ying Theng, Minh T. N. Le
Summary: miR-125b, a key miRNA in cancer pathogenesis, is deregulated in various types of cancer and plays important roles in tumourigenesis and cancer progression. Its potential as a diagnostic and prognostic biomarker, as well as a therapeutic tool against cancer, is supported by emerging evidence on its essential functions.
CELL PROLIFERATION
(2021)
Review
Biochemistry & Molecular Biology
Malgorzata Guz, Witold Jeleniewicz, Marek Cybulski
Summary: In recent years, the roles of non-coding RNAs (ncRNAs), particularly miRNAs, in cancer have been widely recognized. Aberrant expression of miRNAs is associated with various stages of cancer development, making them potential biomarkers and therapeutic targets. MiRNAs show promising applications in cancer diagnosis, prediction, and response to therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Vivek Kumar, Archana Pandey, Arisha Arora, Priyanka Gautam, Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan
Summary: This study aimed to evaluate the therapeutic and diagnostic potential of microRNA (miRNA) in the management of epithelial ovarian cancer (EOC). Expression analysis and functional enrichment revealed the association of miRNA with the disease and involvement of target genes in cancer progression pathways. miRNA-205 and miRNA-34a were found to be significantly downregulated and upregulated, respectively, in EOC, and showed significant negative correlation with their target genes. The combined miRNA-target gene panel exhibited higher diagnostic value in predicting the risk of EOC.
DNA AND CELL BIOLOGY
(2023)
Article
Reproductive Biology
Paul Jank, Jonas Leichsenring, Svenja Kolb, Inga Hoffmann, Philip Bischoff, Catarina Alisa Kunze, Mihnea P. P. Dragomir, Moritz Gleitsmann, Moritz Jesinghaus, Wolfgang D. D. Schmitt, Hagen Kulbe, Christine Sers, Albrecht Stenzinger, Jalid Sehouli, Ioana Elena Braicu, Christina Westhoff, David Horst, Carsten Denkert, Stefan Groeschel, Eliane T. T. Taube
Summary: This study investigated the prognostic significance of EVI1 and PARP1 protein expression in high-grade serous ovarian cancer (HGSOC) patients. The results showed that high expression of both proteins was associated with improved prognosis.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yu-Jen Chen, Chia-Tien Hsu, Shang-Feng Tsai, Cheng-Hsu Chen
Summary: Chronic allograft dysfunction (CAD) is a major condition affecting long-term kidney graft survival. In this study, the correlation between plasma miR-21 and the severity of CAD was investigated. RNA sequencing was performed and differentially expressed miRNAs in CAD were identified. MiR-21-5p, miR-20a-5p, and miR-101-3p were found to be associated with the TGF-beta pathway and CAD. These findings may lead to the development of early prediction miRNA biomarkers and therapeutic tools for CAD in the field of kidney transplantation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Rachel E. Crossland, Jean Norden, Sakhila Ghimire, Mateja Kralj Juric, Kim F. Pearce, Clare Lendrem, Matthew Collin, Eva Mischak-Weissinger, Ernst Holler, Hildegard T. Greinix, Anne M. Dickinson
Summary: The study found that miR-155 and miR-146a were upregulated in gastrointestinal and skin tissue samples of aGvHD patients, and their expression levels in serum and urine samples were also associated with the risk of developing aGvHD. These results support the potential of miR-155 and miR-146a as biomarkers for aGvHD, but further investigation is needed to understand their role in generalized inflammation and specific pathophysiology.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Michele Patricia Rode, Adny Henrique Silva, Julia Cisilotto, Daiane Rosolen, Tania Beatriz Creczynski-Pasa
Summary: This study evaluated exosomal miRNAs derived from metastatic prostate cancer cell lines LNCaP and PC-3, identifying 14 candidates for prognostic biomarkers. miR-425-5p was associated with residual tumor, pathological staging, and TP53 status in prostate cancer samples.
CELLULAR SIGNALLING
(2021)
Article
Pharmacology & Pharmacy
Edison Salas-Huenuleo, Andrea Hernandez, Lorena Lobos-Gonzalez, Iva Polakovicova, Francisco Morales-Zavala, Eyleen Araya, Freddy Celis, Carmen Romero, Marcelo J. Kogan
Summary: This study developed a nano-platform that selectively delivered miR-145 to ovarian cancer cells, resulting in reduced cell viability and activation of apoptosis through the disruption of cell membranes, indicating its potential for inhibiting cancer cell growth.
Article
Biochemistry & Molecular Biology
Meyer Elbaz, Julien Faccini, Clemence Laperche, Marie-Helene Grazide, Jean-Bernard Ruidavets, Cecile Vindis
Summary: Circulating miR-223 and miR-186 are promising predictive biomarkers for long-term mortality after MI.
Article
Oncology
Chun-Wen Cheng, Wen-Ling Liao, Po-Ming Chen, Jyh-Cherng Yu, Hui-Ping Shiau, Yi-Hsien Hsieh, Huei-Jane Lee, Yu-Chun Cheng, Pei-Ei Wu, Chen-Yang Shen
Summary: The study demonstrates that miR-139 can suppress invasion and migration of breast cancer stem cells by down-regulating CXCR4/p-Akt signaling, and its reduced expression is associated with worse clinicopathological features in breast cancer patients, suggesting it as a potential therapeutic target for invasive breast cancer.
Review
Biochemistry & Molecular Biology
Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Mohammad Taheri, Mohammad Samadian
Summary: miR-1290, a crucial member of the miRNA family, is involved in regulating the expression of multiple genes and interacting with various molecular pathways and genes, potentially impacting the development of malignancies.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Clinical Neurology
Rukiye Tekdemir, Yavuz Selvi, Kursat Altinbas, Nadir Kocak
Summary: This study found that miRNAs play an important role in the pathogenesis of bipolar disorder and may serve as biomarkers for diagnosis and screening of the disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Multidisciplinary Sciences
Min Liu, Fei Mo, Xiaohan Song, Yun He, Yan Yuan, Jiaoyan Yan, Ye Yang, Jian Huang, Shu Zhang
Summary: The study utilized comprehensive bioinformatics analysis and experimental validation to identify hsa-miR-21-5p as significantly up-regulated in breast cancer tissues, cells, and exosomes. Further investigations confirmed the diagnostic value of plasma exosomal hsa-miR-21-5p in distinguishing healthy individuals from breast cancer patients, with a sensitivity of 86.7% and specificity of 93.3%.