Article
Oncology
Hyeong In Ha, Eun-Gyeong Lee, Jiwon Lim, So-Youn Jung, Yoon Jung Chang, Young-Joo Won, Myong Cheol Lim
Summary: The incidence of secondary primary POFT cancer after breast cancer increased in Korea between 1999 and 2017. Second primary POFT cancer patients were diagnosed at older ages and had more serous histology.
CANCER RESEARCH AND TREATMENT
(2021)
Article
Obstetrics & Gynecology
Yasin Durmus, Esra Isci Bostanci, Ayse Sinem Duru Coteli, Mehmet Unsal, Fulya Kayikcioglu, Nurettin Boran
Summary: The study demonstrates that involvement of diaphragm muscle is associated with higher risk of thorax recurrences and worse survival outcomes in patients with stage 3B and 3C ovarian-tubal-peritoneal epithelial cancers, suggesting the need for careful consideration when selecting adjuvant treatments.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2021)
Article
Oncology
Hyeong In Ha, Eun Young Park, Kyung Jin Eoh, Yeon Jee Lee, Sang-Soo Seo, Sokbom Kang, Sang-Yoon Park, Myong Cheol Lim
Summary: This study investigated the clinical significance of the ovarian cancer cluster region (OCCR) in BRCA1 and BRCA2 genes. The results showed that patients with BRCA1 pathogenic variants (PVs) in the OCCR region had shorter progression-free survival (PFS) compared to those outside the OCCR. This trend was more pronounced in the platinum-sensitive subgroup. However, no significant differences were found in overall survival (OS) between patients with BRCA1/2 PVs, regardless of the variant location.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Reproductive Biology
Sigit Purbadi, Tricia Dewi Anggraeni, Angelina Vitria
Summary: This study evaluated the benefit of routine surgical staging for patients with clinical early-stage EOC. The results suggest that routine peritoneal biopsies may not be advantageous for these patients, as further research with a larger cohort is needed to obtain more information.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Neurosciences
Xandra Pereiro, Sandra Beriain, Lara Rodriguez, David Roiz-Valle, Noelia Ruzafa, Elena Vecino
Summary: This study analyzed the Muller glial cells of the largest adult mammal in the world - the whale, providing insights into their characteristics in the retina. The results showed that whale Muller cells have a high proliferation rate and stable karyotype, and exhibit distinct expression patterns compared to other Muller cells.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Obstetrics & Gynecology
J. A. Taylor, M. Burnell, A. Ryan, C. Karpinskyj, J. K. Kalsi, H. Taylor, S. Apostolidou, A. Sharma, R. Manchanda, R. Woolas, S. Campbell, M. Parmar, N. Singh, I. J. Jacobs, U. Menon, A. Gentry-Maharaj
Summary: This prospective cohort study investigated the association between hysterectomy and ovarian/tubal cancer, and found that hysterectomy is not associated with alteration of the risk of invasive epithelial ovarian and tubal cancer.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Oncology
Aditi Bhatt, Olivier Glehen, Oliver Zivanovic, Donal Brennan, Cedric Nadeau, Willemien Van Driel, Naoual Bakrin
Summary: This study presents the results of an international consensus on HIPEC regimens for EOC, providing indications and suitable regimens for treatment. It also identifies areas for future research and offers recommendations for perioperative care.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
M. T. Faber, T. A. Horsbol, L. Baandrup, S. O. Dalton, S. K. Kjaer
Summary: Ovarian/tubal cancer survival showed significant improvements over time for all histological types except mucinous tumors. There was an increase in relative survival and corresponding decrease in excess mortality for all categories of socioeconomic status except for women with localized disease in the lowest income group. The impact of histology and socioeconomic status on all-cause mortality depended on time since diagnosis.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
Stefano Greggi, Francesca Falcone, Giovanni D. Aletti, Marco Cascella, Francesca Bifulco, Nicoletta Colombo, Sandro Pignata
Summary: This survey reveals that only half of the centers have satisfactory surgical management and adherence to ERAS recommendations is at least sufficient. The results show that the higher the ESGO-QIs score, the stronger the adherence to ERAS recommendations, highlighting the correlations between case volume, appropriate perioperative management, and surgical quality.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
Jung Hwan Yoon, Byung Joon Choi, Suk Woo Nam, Won Sang Park
Summary: This study found that exosomes derived from gastric cancer cells can affect the fate of surrounding gastric epithelial cells. Gastric cancer exosomes promote cell survival and proliferation while inhibiting cellular senescence and apoptosis. The exosomes also regulate the expression of telomere-related genes, heat-shock genes, and hedgehog genes.
Article
Multidisciplinary Sciences
Chul-min Lee, Joong Sub Choi, Mimi Kim, Bo-Kyeong Kang, Jaeman Bae, Won Moo Lee, Un Suk Jung, Jeong Min Eom, Yeon Kyoung Kim, Jin Young Kim
Summary: This study aimed to evaluate the ability of CT imaging to differentiate between peritoneal carcinomatosis of advanced epithelial ovarian cancer (AEOC) and tuberculosis (TB) peritonitis. The results showed that there were different CT imaging features between the two diseases, with changes in the fallopian tubes and peritoneal micronodules being independent parameters associated with TB peritonitis. Combining these two imaging parameters can effectively differentiate TB peritonitis from peritoneal carcinomatosis.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Miklos Acs, Zoltan Herold, Attila Marcell Szasz, Max Mayr, Sebastian Haeusler, Pompiliu Piso
Summary: The main treatment for advanced ovarian, fallopian tube, and primary peritoneal carcinoma is cytoreductive surgery and platinum-containing chemotherapy. Intraperitoneal chemotherapy with or without hyperthermia has been developed to improve survival. However, current studies are mostly retrospective and nonrandomized, making patient selection heterogeneous. This study reports the experience of a single center in using cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy in patients with advanced epithelial carcinoma. The study shows that multimodal therapy is feasible with acceptable morbidity and mortality. Prolongation of hyperthermic intraperitoneal chemotherapy provides survival benefits regardless of previous chemotherapy.
Article
Oncology
Anna Darelius, Bjorg Kristjansdottir, Pernilla Dahm-Kahler, Annika Strandell
Summary: The study found that salpingectomy is associated with a reduced risk of EOC Type II, while hysterectomy is associated with a reduced risk of both EOC Type I and Type II. Tubal ligation also shows a trend towards reduced risk, although without statistical significance.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Review
Oncology
Shuangshuang Mei, Xing Chen, Kai Wang, Yuxin Chen
Summary: Ovarian cancer is a common gynecological malignancy with high morbidity and mortality. Peritoneal metastasis is common in ovarian cancer, involving large amounts of ascites. The mechanism behind this is still unclear.
CANCER CELL INTERNATIONAL
(2023)
Article
Oncology
Sarah Brunty, Lauren Clower, Brenda Mitchell, Taylor Fleshman, Nadim Bou Zgheib, Nalini Santanam
Summary: Ovarian cancer ranks as the 4th leading cause of cancer death in women, with a significant proportion of cases linked to endometriosis. Studies suggest that peritoneal fluid from women with endometriosis can induce transformative changes in ovarian cells, promoting the progression from endometriosis to ovarian cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Pamela M. J. McLaughlin, Maximilian Klar, Tibor A. Zwimpfer, Gilles Dutilh, Marcus Vetter, Christian Marth, Andreas du Bois, Carmen Schade-Brittinger, Alexander Reuss, Claudine Bommer, Christian Kurzeder, Viola Heinzelmann-Schwarz
Summary: This randomized phase III trial aims to identify a population of EOC patients who can benefit from the effectiveness of letrozole with little expected toxicity, thereby improving overall quality of life. The study involves 540 patients across clinical centers in Switzerland, Germany, and Austria and will collect follow-up data for up to 10 years. The goal is to prove the efficacy of letrozole in the maintenance setting for ovarian cancer.
Article
Oncology
Andre Fedier, Nadia Maggi, Alessandra Tozzi, Muriel Disler, Ricardo Coelho, Francis Jacob, Viola Heinzelmann-Schwarz
Summary: This study investigated the acquired resistance of ovarian cancer cells to olaparib and its cross-resistance to other chemotherapeutic drugs. The results showed that escalating concentrations of olaparib did not produce acquired resistance or cross-resistance to other drugs. The sensitivity of ovarian cancer cells to olaparib was correlated with their sensitivity to niraparib. Additionally, PARPi-sensitive cells also exhibited cross-sensitivity to non-platinum compounds and drugs not directly interacting with the DNA.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2022)
Article
Oncology
Mahesh Sarki, Chang Ming, Souria Aissaoui, Nicole Burki, Maria Caiata-Zufferey, Tobias Ephraim Erlanger, Rossella Graffeo-Galbiati, Karl Heinimann, Viola Heinzelmann-Schwarz, Christian Monnerat, Nicole Probst-Hensch, Manuela Rabaglio, Ursina Zurrer-Hardi, Pierre Olivier Chappuis, Maria C. Katapodi
Summary: This study provides important information for cascade screening programs for hereditary breast and ovarian cancer and Lynch syndrome. The findings suggest that males are less likely to respond to invitations, particularly for breast and ovarian cancer. The study also found that the intention to invite first-degree relatives is higher, and that the family environment and carrying pathogenic variants predict the intention to invite relatives.
Article
Oncology
Dana M. Chase, Margarita Romeo Marin, Floor Backes, Sileny Han, Whitney Graybill, Mansoor Raza Mirza, Bhavana Pothuri, Giorgia Mangili, David M. O'Malley, Dominique Berton, Lyndsay Willmott, Klaus Baumann, Robert L. Coleman, Tamar Safra, Viola Heinzelmann-Schwarz, Domenica Lorusso, Florian M. Karl, Tatia Woodward, Bradley J. Monk, Antonio Gonzalez-Martin
Summary: This study found that disease progression in ovarian cancer has a negative impact on health-related quality of life (HRQoL). Therefore, prolonging progression-free survival (PFS) is important for preserving HRQoL in patients with OC.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Zoi Diamantopoulou, Francesc Castro-Giner, Fabienne Dominique Schwab, Christiane Foerster, Massimo Saini, Selina Budinjas, Karin Strittmatter, Ilona Krol, Bettina Seifert, Viola Heinzelmann-Schwarz, Christian Kurzeder, Christoph Rochlitz, Marcus Vetter, Walter Paul Weber, Nicola Aceto
Summary: The generation of circulating tumor cells (CTCs) with metastatic ability is concentrated during the rest phase, and CTCs generated during the active phase lack metastatic ability. Mechanistically, the upregulation of mitotic genes during the rest phase enables CTCs' metastasis proficiency. Circadian rhythm hormones such as melatonin, testosterone and glucocorticoids dictate the generation dynamics of CTCs, and insulin promotes tumor cell proliferation in a time-dependent manner.
Article
Cell Biology
Cecile Cumin, Yen-Lin Huang, Charlotte Rossdam, Felix Ruoff, Susana Posada Cespedes, Ching-Yeu Liang, Flavio C. Lombardo, Ricardo Coelho, Natalie Rimmer, Martina Konantz, Monica Nunez Lopez, Shahidul Alam, Alexander Schmidt, Diego Calabrese, Andre Fedier, Tatjana Vlajnic, Mark von Itzstein, Markus Templin, Falk F. R. Buettner, Arun Everest-Dass, Viola Heinzelmann-Schwarz, Francis Jacob
Summary: The molecular repertoire promoting cancer cell plasticity remains partly unknown, but this study proposes that glyco-sphingolipids, specifically globo and ganglio series, play a role in promoting the transition between epithelial and mesenchymal cells. The study found elevated levels of globosides in tumor compartments compared to the ganglioside-rich stroma. It also discovered that the ganglioside-synthesizing enzyme ST8SIA1 was consistently elevated in mesenchymal-like samples, indicating a poor outcome.
Review
Oncology
Tibor A. Zwimpfer, Ori Tal, Franziska Geissler, Ricardo Coelho, Natalie Rimmer, Francis Jacob, Viola Heinzelmann-Schwarz
Summary: High-grade serous ovarian cancers (HGSOCs) arise from the fallopian tube and harbor TP53 gene mutations, while low-grade serous ovarian cancers (LGSOCs) have different features and are considered a distinct subtype. Treatment for LGSOCs is limited due to a lack of separate trial data, but current understanding suggests slow tumor growth and precursors from serous borderline ovarian tumors. Therapeutic decisions are guided by characteristics such as estrogen receptor positivity and specific mutations, leading to maintenance with endocrine treatment or targeted therapies. Ongoing trials are exploring the use of MEK inhibitors in combination with hormonal treatments for LGSOCs.
CANCER TREATMENT REVIEWS
(2023)
Article
Health Care Sciences & Services
Vasiliki Baroutsou, Rodrigo Cerqueira Gonzalez Pena, Reka Schweighoffer, Maria Caiata-Zufferey, Sue Kim, Sharlene Hesse-Biber, Florina M. Ciorba, Gerhard Lauer, Maria Katapodi
Summary: In health care research, patient-reported opinions are crucial for personalized medicine. This study examined the role of sentiment analysis in predicting openness of intrafamilial communication about genetic cancer risk.
JMIR FORMATIVE RESEARCH
(2023)
Article
Engineering, Biomedical
Manuela Estermann, Ricardo Coelho, Francis Jacob, Yen-Lin Huang, Ching-Yeu Liang, Ana Bela Faia-Torres, Dedy Septiadi, Barbara Drasler, Bedia Begum Karakocak, Irini Magdelina Dijkhoff, Alke Petri-Fink, Viola Heinzelmann-Schwarz, Barbara Rothen-Rutishauser
Summary: Reliable and predictive experimental models are urgently needed for studying the metastatic mechanisms of ovarian cancer cells in the omentum. The lack of certain omental cell types that influence cancer cell metastasis hinders the application of current tissue models. This study introduces a 3D multi-cellular human omentum tissue model that mimics the metastatic processes of ovarian cancer cells and allows the study of their interaction with endothelial cells and the effects of chemotherapeutic drugs. This model may serve as a platform for future patient-specific investigations in personalized oncology.
Article
Oncology
Ossia M. Eichhoff, Corinne I. Stoffel, Jan Kasler, Luzia Briker, Patrick Turko, Gergely Karsai, Nina Zila, Verena Paulitschke, Phil F. Cheng, Alexander Leitner, Andrea Bileck, Nicola Zamboni, Anja Irmisch, Zsolt Balazs, Aizhan Tastanova, Susana Pascoal, Pal Johansen, Rebekka Wegmann, Julien Mena, Alaa Othman, Vasanthi S. Viswanathan, Judith Wenzina, Andrea Aloia, Annalisa Saltari, Andreas Dzung, Michael Krauthammer, Stuart L. Schreiber, Thorsten Hornemann, Martin Distel, Berend Snijder, Reinhard Dummer, Mitchell P. Levesque
Summary: The clinical management of NRAS-mutated melanomas is challenging due to resistance that arises through genetic, transcriptional, and metabolic adaptation. However, the adoption of a mesenchymal phenotype with a quiescent metabolic program in NRAS-mutated melanoma cells confers sensitivity to reactive oxygen species (ROS) induction, which can be inhibited by ROS inducers in combination with MAPK pathway inhibitors. The findings suggest that targeting both metabolic reprogramming and MAPK signaling could improve patient treatment in melanoma and other cancers.
Article
Oncology
Tibor A. Zwimpfer, Fabienne D. Schwab, Daniel Steffens, Felix Kaul, Noemi Schmidt, James Geiger, Franziska Geissler, Viola Heinzelmann-Schwarz, Walter P. Weber, Christian Kurzeder
Summary: In this case report, a 37-year-old patient with CALNM in a ipsilateral relapse of breast cancer is described. The use of delayed lymphoscintigraphy and the sentinel procedure aided in accurate staging and treatment. The findings suggest that CALNM without evidence of systemic metastasis should be considered a regional event in recurrent breast cancer, allowing for a curative approach.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Meeting Abstract
Obstetrics & Gynecology
Franziska Geissler, Ricardo Coelho, Zwimpfer Tibor, Andre Fedier, Francis Jacob, Viola Heinzelmann-Schwarz
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)