Article
Neurosciences
Xiuji Kan, Zeya Yan, Fei Wang, Xinyu Tao, Tao Xue, Zhouqing Chen, Zhong Wang, Gang Chen
Summary: Remote ischemic conditioning (RIC) is a remote, transient, and noninvasive procedure that provides temporary ischemia and reperfusion. This study conducted a comprehensive meta-analysis to evaluate the efficacy and safety of RIC for acute ischemic stroke. The results showed that RIC could reduce stroke recurrence, improve patients' prognosis, and did not cause other adverse events except for relatively benign RIC-related adverse events.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Cardiac & Cardiovascular Systems
Zigang Liu, Yongmei Zhao, Ming Lei, Guancong Zhao, Dongcheng Li, Rong Sun, Xian Liu
Summary: A meta-analysis evaluating the efficacy of remote ischemic preconditioning (RIPC) in preventing acute kidney injury (AKI) after cardiac surgery showed that RIPC significantly reduced the incidence of AKI, particularly for mild-to-moderate cases that did not require renal replacement therapy. The results suggest that RIPC is an effective strategy for AKI prevention after cardiac surgery.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Surgery
Wenfu Zhang, Yingting Wu, Mingwang Zeng, Chao Yang, Zhengang Qiu, Rongrong Liu, Lifeng Wang, Maolin Zhong, Qiaoling Chen, Weidong Liang
Summary: In this systematic review and meta-analysis, the effect of remote ischemic conditioning (RIC) in reducing renal ischemia-reperfusion injury in patients undergoing kidney transplantation or partial nephrectomy was investigated. The results showed that the protective effect of RIC on renal ischemic-reperfusion was weak, and more studies are needed to confirm its nephroprotective effect.
FRONTIERS IN SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Thomas Ravn Lassen, Jesper Just, Marie Vognstoft Hjortbak, Nichlas Riise Jespersen, Katrine Tang Stenz, Tingting Gu, Yan Yan, Junyi Su, Jakob Hansen, Rikke Baek, Malene Moller Jorgensen, Jens Randel Nyengaard, Steen Buus Kristiansen, Kim Ryun Drasbek, Jorgen Kjems, Hans Erik Botker
Summary: The study demonstrates that cardioprotection by RIC may be mediated by circulating EVs that accumulate in the injured myocardium. The EV miRNAs may promote cell survival during reperfusion, suggesting a potential mechanism for the protective effect.
BASIC RESEARCH IN CARDIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Alberto Dominguez-Rodriguez, Pedro Abreu-Gonzalez, Nestor Baez-Ferrer, Russel J. Reiter, Pablo Avanzas, Daniel Hernandez-Vaquero
Summary: This study conducted a systematic review and meta-analysis to assess the efficacy of melatonin as a cardioprotective treatment. The results showed that melatonin-treated patients had higher left ventricular ejection fraction and lower levels of troponin compared to those treated with a placebo, indicating that melatonin administration in humans attenuated heart dysfunction with a favorable effect on the LVEF.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Christopher Lotz, Johannes Herrmann, Quirin Notz, Patrick Meybohm, Franz Kehl
Summary: Mitochondria play a crucial role in myocardial ischemia/reperfusion injury and pharmacological cardiac conditioning, including maintaining cellular function, regulating calcium balance and cell death, participating in aging and mitochondrial regeneration, etc.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Se-Hee Min, Suk Hyung Choe, Won Shik Kim, Soon-Hyun Ahn, Youn Joung Cho
Summary: This study aimed to investigate the role of remote ischemic conditioning (RIC) in head and neck free flap reconstructive surgery. The study found that RIC did not improve tissue oxygenation of the transferred flap, but showed evidence of organ-protective effects in experimental models.
SCIENTIFIC REPORTS
(2022)
Article
Biology
Claudia Penna, Matteo Sorge, Francesca Tullio, Stefano Comita, Saveria Femmino, Mara Brancaccio, Pasquale Pagliaro
Summary: Remote ischemic conditioning is a simple cardioprotective practice that involves brief intermittent ischemia applied to a limb. Keeping the limb warm during intermittent ischemia can enhance the efficacy of remote ischemic conditioning. Using a thermal blanket around the ischemic limb could be a simple and safe approach to test in humans.
Article
Medicine, General & Internal
Quan Guo, Zhenzhou Zhao, Fan Yang, Zhiwen Zhang, Xiaoyu Rao, Jing Cui, Qingbo Shi, Kaiyuan Liu, Kang Zhao, Haiyu Tang, Liang Peng, Cao Ma, Jun Pu, Muwei Li
Summary: This study confirmed the efficacy and safety of a six-month CRIC treatment for patients with CSA, showing improvements in myocardial flow reserve, angina symptoms, and exercise performance.
Review
Anesthesiology
Yu-qin Long, Xiao-mei Feng, Xi-sheng Shan, Qing-cal Chen, Zhengyuan Xia, Fu-hai Ji, Hong Liu, Ke Peng
Summary: This meta-analysis demonstrates that RIPC reduces the incidence of AKI after cardiac surgery. This renoprotective effect of RIPC is mainly evident during volatile only anesthesia, in non-high-risk patients, and when AKIN or KDIGO criteria used for AKI diagnosis.
ANESTHESIA AND ANALGESIA
(2022)
Article
Cell Biology
Martin Donato, Eliana P. Bin, Veronica D'Annunzio, Ricardo J. Gelpi
Summary: Remote ischemic preconditioning (rIPC) can protect the heart from ischemia/reperfusion injury by activating different signaling pathways. Factors such as age, comorbidities, medication, and anesthetic protocol may weaken the subcellular mechanisms of rIPC in patients. Further carefully designed studies are necessary to develop a clearer understanding of the pathways and mechanisms of early and late rIPC.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Cardiac & Cardiovascular Systems
Helmut Raphael Lieder, Andreas Skyschally, Michael Sturek, Gerd Heusch, Petra Kleinbongard
Summary: Ischemic preconditioning (IPC) reduces infarct size through trigger molecule release and activation of STAT3. However, IPC failed to protect Ossabaw minipigs from infarction, while remote ischemic conditioning (RIC) induced the release of cardioprotective triggers and reduced infarct size.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Review
Clinical Neurology
Meng Lu, Yujiao Wang, Xin Yin, Yuanyuan Li, Hongyan Li
Summary: Remote limb ischemic postconditioning (RIPostC) reduces vascular injury and improves cognitive evaluation in patients with ischemic stroke, demonstrating its safe and effective cerebral protective effect.
FRONTIERS IN NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Katharina Feige, Sebastian Roth, Rene M'Pembele, Anna Galow, Sarah Koenig, Martin Stroethoff, Annika Raupach, Giovanna Lurati Buse, Alexander M. Mathes, Markus W. Hollmann, Ragnar Huhn, Carolin Torregroza
Summary: The adverse impact of common diseases like diabetes mellitus and acute hyperglycemia on morbidity and mortality from myocardial infarction (MI) has been well documented. The relationship between blood glucose and mortality appears linear, and this seems to be independent of a diagnosis of diabetes. This study investigates the influence of acute and prolonged hyperglycemia on the protective effect of transferred human RIPC-plasma and suggests that hyperglycemia might obstruct translation into the clinical setting.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Helmut Raphael Lieder, Pia Tueller, Felix Braczko, Afsaneh Zandi, Markus Kamler, Matthias Thielmann, Gerd Heusch, Petra Kleinbongard
Summary: This study developed a cardiomyocyte bioassay to analyze the protective effects of remote ischemic conditioning (RIC). This new method reduces inter-individual variation and the use of animals.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS
(2022)
Article
Cardiac & Cardiovascular Systems
Yuni de Framond, Mathieu Schaaf, Sophie Pichot-Lamoureux, Gregoire Range, Olivier Dubreuil, Denis Angoulvant, Marc J. Claeys, David Garcia Dorado, Thomas Bochaton, Gilles Rioufol, Claire Jossan, Inesse Boussaha, Michel Ovize, Nathan Mewton
Summary: This study aimed to assess the association of pathological Q wave evolution after reperfusion with clinical outcomes in anterior ST-segment elevation myocardial infarction (STEMI) patients. The study found that persistent Q waves after reperfusion were associated with an increased risk of heart failure or death, while Q-wave regression was associated with a significantly lower risk of events.
JOURNAL OF ELECTROCARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Quentin Brana, Frederique Thibault, Maxime Courtehoux, Gilles Metrard, Maria Joao Ribeiro, Denis Angoulvant, Matthieu Bailly
Summary: This study compared the effects of dipyridamole and regadenoson on inducing hyperemia and found that they were equally effective in comparable patients.
JOURNAL OF NUCLEAR CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Laurent Fauchier, Arnaud Bisson, Alexandre Bodin, Julien Herbert, Denis Angoulvant, Nicolas Danchin, Yves Cottin
Summary: In patients with acute myocardial infarction, a history of atrial fibrillation or new onset atrial fibrillation during the early phase may be associated with a worse prognosis. New atrial fibrillation was found to be independently associated with higher risks of death and ischemic stroke compared to patients with no atrial fibrillation or previously known atrial fibrillation.
CLINICAL RESEARCH IN CARDIOLOGY
(2021)
Letter
Cardiac & Cardiovascular Systems
Pierre Lantelme, Arnaud Bisson, Thibaud Lacour, Julien Herbert, Fabrice Ivanes, Thierry Bourguignon, Denis Angoulvant, Brahim Harbaoui, Marc Bonnet, Dominique Babuty, Christophe Saint Etienne, Pierre Deharo, Laurent Fauchier
JACC-CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Medicine, General & Internal
Carl Semaan, Arthur Charbonnier, Jeremy Pasco, Walid Darwiche, Christophe Saint Etienne, Xavier Bailleul, Thierry Bourguignon, Laurent Fauchier, Denis Angoulvant, Fabrice Ivanes, Thibaud Genet
Summary: The study evaluated the performance of the ENCOURAGE score in predicting mortality in STEMI patients with refractory cardiogenic shock, showing that the ENCOURAGE score outperformed other risk scores in predicting mortality. It may assist decision-making teams in better selecting patients suitable for VA-ECMO therapy.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Nicolas Clementy, Alexandre Bodin, Arnaud Bisson, Ana-Paula Teixeira-Gomes, Sebastien Roger, Denis Angoulvant, Valerie Labas, Dominique Babuty
Summary: Implantable cardiac defibrillators (ICDs) are recommended for preventing sudden cardiac death, but shocks may increase mortality. Reducing electrical therapy burden improves patient prognosis. Though shocks save lives, they can also cause myocardial stunning, heart failure, and inflammatory effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Nicolas Clementy, Reda Bensaid, Jeremie Bouteau, Joel Fedida, Yoann Kiavue, Pierre Socie, Romain Ackermann, Marc Goralski, Laurent Fauchier, Anne Bernard, Denis Angoulvant, Dominique Babuty
Summary: After acute myocardial infarction, a discharge LVEF <= 25% and a CPK peak >4600 IU/L in the acute phase independently predicted non-recovery at 6 weeks post-MI. The IC-D score accurately predicted persistent LVEF <= 35% in both the study population and a multicenter validation cohort of 150 patients.
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
(2021)
Review
Ophthalmology
Nadege Ngo Ntjam, Marie Thulliez, Gilles Paintaud, Francesco Salvo, Denis Angoulvant, Pierre-Jean Pisella, Theodora Bejan-Angoulvant
Summary: Intravitreal anti-VEGF therapy did not show an increased risk of major cardiovascular events or total mortality, but may have an increased risk of mortality in patients with diabetic retinopathy and nonocular hemorrhages in patients with AMD. Continued surveillance of systemic adverse events is warranted.
JAMA OPHTHALMOLOGY
(2021)
Letter
Endocrinology & Metabolism
Gregoire Fauchier, Arnaud Bisson, Alexandre Bodin, Julien Herbert, Denis Angoulvant, Pierre Henri Ducluzeau, Gregory Y. H. Lip, Laurent Fauchier
Article
Cardiac & Cardiovascular Systems
Iris Ma, Thibaud Genet, Nicolas Clementy, Arnaud Bisson, Julien Herbert, Carl Semaan, Jeremie Bouteau, Denis Angoulvant, Fabrice Ivanes, Laurent Fauchier
Summary: The study found that among illicit drugs, only cannabis use was significantly associated with a higher risk of AMI. However, the prognosis of illicit drug users with AMI was similar to patients without illicit drug use.
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
(2021)
Review
Cardiac & Cardiovascular Systems
Matthieu Bailly, Maria Joao Ribeiro, Denis Angoulvant
Summary: Myocardial flow reserve, as a ratio of myocardial blood flow between stress and rest, provides important functional information and has been extensively studied in positron emission tomography. The authors reviewed the pathophysiology of myocardial blood flow and myocardial flow reserve, also discussing potential limitations to flow evaluation in single photon emission computed tomography.
ARCHIVES OF CARDIOVASCULAR DISEASES
(2021)
Review
Cardiac & Cardiovascular Systems
Amal Aidoud, Wassim Gana, Fanny Poitau, Camille Debacq, Victoire Leroy, Jacques-Alexis Nkodo, Pierre Poupin, Denis Angoulvant, Bertrand Fougere
Summary: As the population ages, the global burden of cardiovascular disease is increasing, especially in older adults. This review examines noncardiovascular factors that interact with health status and quality of life in older people with cardiovascular disease. The focus is on geriatric conditions that pose a major risk of decline in function and have a significant impact on overall prognosis.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Peripheral Vascular Disease
Jean-Michel Halimi, Jean-Baptiste de Freminville, Philippe Gatault, Arnaud Bisson, Benedicte Sautenet, Valentin Maisons, Pascal Vigny, Denis Angoulvant, Laurent Fauchier
Summary: This study investigated the characteristics and prognosis of hypertensive encephalopathy (HE) and found that HE had a poor prognosis with high risks of death and other complications. Hypertension and concomitant stroke significantly influenced the prognosis of HE.
Editorial Material
Medicine, General & Internal
Denis Angoulvant
Letter
Medicine, General & Internal
Laurent Fauchier, Gregoire Fauchier, Denis Angoulvant
NEW ENGLAND JOURNAL OF MEDICINE
(2021)