Article
Cardiac & Cardiovascular Systems
Qiang Zhu, Hong Hao, Huifang Xu, Yosef Fichman, Yuqi Cui, Chunlin Yang, Meifang Wang, Ron Mittler, Michael A. Hill, Peter J. Cowan, Guangsen Zhang, Xiaoming He, Shenghua Zhou, Zhenguo Liu
Summary: The study reveals that the survival rate of bone marrow mesenchymal stem cells is low in diabetic critical limb ischemia, however, simultaneous suppression of intracellular and extracellular reactive oxygen species can significantly enhance stem cell survival and improve therapeutic efficacy.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Cardiac & Cardiovascular Systems
Ying Zhao, Pengyu Wang, Zhe Chen, Manman Li, Dengfeng Zhang, Liming Yang, Hong Li
Summary: Ischemic heart disease is a significant global health burden with high mortality and morbidity. Current treatments focus on reducing oxygen demand or increasing myocardial oxygen supply, but have limitations. Therefore, finding a simple, effective, and economical treatment is crucial. Electrical stimulation as a non-invasive and safe physiotherapy shows promise in IHD treatment by influencing angiogenesis, autophagy, apoptosis, inflammatory response, and oxidative stress. Further research is needed to explore the potential of electrical stimulation therapy in IHD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Christian Savio-Silva, Poliana E. Soinski-Sousa, Antonio Simplicio-Filho, Rosana M. C. Bastos, Stephany Beyerstedt, Erika Bevilaqua Rangel
Summary: The study demonstrated that mesenchymal stem cells (MSCs) have therapeutic potential in treating diabetic kidney disease by inhibiting oxidative stress, apoptosis, regulating autophagy, and maintaining mitochondrial homeostasis to slow down the progression of the disease. In animal experiments, MSC therapy improved kidney function and structure, reduced urinary albumin-to-creatinine ratio, decreased mesangial expansion, upregulated mitochondria-related survival genes, and inhibited excessive autophagy activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Neurosciences
Jialin He, Jianyang Liu, Yan Huang, Xiangqi Tang, Han Xiao, Zhiping Hu
Summary: Ischemic stroke is a major cause of death worldwide, with limited treatment options focusing on restoring blood flow; autophagy plays a vital role in brain recovery post-stroke, while dysfunction can worsen cerebral injury; mesenchymal stem cells alleviate oxidative stress and inflammation, regulate autophagy imbalances, and show promise as a treatment for ischemic stroke.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Aruvi Vijikumar, Pushkar Saralkar, Scott D. Saylor, Patrick G. Sullivan, Jason D. Huber, Werner J. Geldenhuys
Summary: NL-1 is a potential drug target for treating ischemic stroke, as it reduces neuronal cell loss and brain injury, leading to improved survival rates. Encapsulating NL-1 in nanoparticles enhances its protective effects. Targeting the mitoNEET pathway may be a promising avenue for further research.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Biology
Takaaki Furihata, Shingo Takada, Naoya Kakutani, Satoshi Maekawa, Masaya Tsuda, Junichi Matsumoto, Wataru Mizushima, Arata Fukushima, Takashi Yokota, Nobuyuki Enzan, Shouji Matsushima, Haruka Handa, Yoshizuki Fumoto, Junko Nio-Kobayashi, Toshihiko Iwanaga, Shinya Tanaka, Hiroyuki Tsutsui, Hisataka Sabe, Shintaro Kinugawa
Summary: The study revealed the downregulation of a cardiac-specific mitochondrial component in aged mice, leading to heart failure. Mice with cardiac-specific deletion of CISD1 showed cardiac dysfunction after 12 months and developed HF after 16 months. These findings suggest that loss of mitoNEET expression may contribute to age-associated heart failure in older adults.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tongyu Zhang, Minghai Zhang
Summary: This study investigated the possible mechanism of NL-1 after subarachnoid hemorrhage (SAH) in rats. The results showed that NL-1 could improve neurological behavior, increase mitophagy, and reduce oxidative stress and apoptosis. However, liensinine may inhibit the treatment effect of NL-1.
NEUROCHEMICAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
M. C. Madsen, F. Podieh, M. C. Overboom, A. Thijs, M. den Heijer, P. L. Hordijk
Summary: This study investigates the mechanisms underlying the effects of iron on the barrier function of human endothelium. The experimental results suggest that exposure to iron leads to endothelial cell elongation, upregulation of stress-induced proteins, and a dose-dependent drop in endothelial integrity. Reactive oxygen species (ROS) production and the role of low-grade inflammation were also investigated. The findings indicate that iron-induced damage to the vascular endothelium could contribute to increased cardiovascular risk.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Anamaria Jurcau, Adriana Ioana Ardelean
Summary: This article discusses the application of recanalization therapy in the treatment of acute ischemic stroke and the potential ischemia/reperfusion injuries it may cause. Oxidative stress and mitochondrial dysfunction have been identified as significant factors in the pathogenesis of these injuries, but clinical studies targeting oxidative pathways have mostly been unsuccessful.
Article
Biochemistry & Molecular Biology
Denise Traxler, Varius Dannenberg, Katrin Zlabinger, Alfred Gugerell, Julia Mester-Tonczar, Dominika Lukovic, Andreas Spannbauer, Ena Hasimbegovic, Jens Kastrup, Mariann Gyoengyoesi
Summary: This study found that the administration of ADSCs via intramyocardial injection had no significant effect on cardiac function in patients with ischemic heart disease, and did not regulate the concentration of small EVs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Erliang Guo, Lu Sun, Wei Chen, Chang Liu, Kegong Chen, Xingpei Jiang, Xionghai Qin, Jianling Su, Fan Yang, Hai Tian
Summary: Bone marrow mesenchymal stem cell (BMSC) transplantation is an effective treatment for ischemic heart disease, but its effectiveness is limited in aging populations. This study investigated the use of platelet-rich plasma (PRP) to enhance the viability of elderly human BMSCs (hBMSCs) and found that PRP could improve the proliferation and rejuvenation of aged hBMSCs, with better results observed when using PRP from younger donors. In animal models, PRP-optimized hBMSCs resulted in a smaller infarct area and better recovery of cardiac function compared to using aged hBMSCs alone.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Medicine, Research & Experimental
Kowsar Amirzadeh Gougheri, Armin Ahmadi, Mohadeseh Ghafuri Ahmadabadi, Amirhesam Babajani, Ghasem Yazdanpanah, Soheyl Bahrami, Mohammad Hassani, Hassan Niknejad
Summary: Heart diseases are the primary cause of mortality and morbidity worldwide. Exosomes, as a new emerging agent, play significant roles in the diagnosis, treatment, and prognosis of heart diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Rafaela G. A. Costa, Suellen L. R. Silva, Ingrid R. S. B. Dias, Maiara de S. Oliveira, Ana Carolina B. da C. Rodrigues, Rosane B. Dias, Daniel P. Bezerra
Summary: Acute myeloid leukemia (AML) is a heterogeneous disease group with various mutations triggering malignant proliferation. AML relapse is mainly caused by leukemic stem cells (LSCs) with self-renewal capacity and resistance to traditional therapies. LSCs have low oxidative stress levels due to low mitochondrial activity and high ROS-removing pathway activity. Targeting oxidative stress could be a potential strategy to eliminate AML LSCs.
Article
Medicine, Research & Experimental
Qianqian Zhuang, Fengfeng Guo, Lei Fu, Yufei Dong, Shaofang Xie, Xue Ding, Shuangyi Hu, Xuanhao D. Zhou, Yangwei Jiang, Hui Zhou, Yue Qiu, Zhaoying Lei, Mengyao Li, Huajian Cai, Mingjie Fan, Lingjie Sang, Yong Fu, Dong Zhang, Aifu Lin, Xu Li, Tilo Kunath, Ruhong Zhou, Ping Liang, Zhong Liu, Qingfeng Yan
Summary: Hypertrophic cardiomyopathy (HCM) is a leading cause of sudden cardiac death in young individuals. In this study, a compound called 1-Deoxynojirimycin (DNJ) was found to rescue mitochondrial function in HCM cells by promoting the oligomerization of optic atrophy protein 1 (OPA1) and reconstructing the mitochondrial cristae. DNJ also improved the physiological properties of HCM cells and alleviated cardiac hypertrophy in a mouse model. These findings provide insights into the mechanism of HCM and offer a potential therapeutic strategy.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Cell Biology
Chuanbin Liu, Dong Han, Ping Liang, Yang Li, Feng Cao
Summary: Ischemic heart disease is the leading cause of mortality globally, and stem cell transplantation is considered a promising treatment approach. While preclinical studies have shown promising results, clinical studies still face challenges such as improving cell engraftment and understanding functional mechanisms.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Hematology
Yuh Fen Pung, Wai Johnn Sam, Kelly Stevanov, Molly Enrick, Chwen-Lih Chen, Christopher Kolz, Prashanth Thakker, James P. Hardwick, Yeong-Renn Chen, Jason R. B. Dyck, Liya Yin, William M. Chilian
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2013)
Article
Cardiac & Cardiovascular Systems
Liya Yin, Vahagn Ohanyan, Yuh Fen Pung, Angelo DeLucia, Erin Bailey, Molly Enrick, Kelly Stevanov, Christopher L. Kolz, Giacinta Guarini, William M. Chilian
CIRCULATION RESEARCH
(2012)
Article
Chemistry, Multidisciplinary
Frazier Nyasulu, Kelly Stevanov, Rebecca Barlag
JOURNAL OF CHEMICAL EDUCATION
(2010)
Article
Cardiac & Cardiovascular Systems
Anurag Jamaiyar, Weiguo Wan, Vahagn Ohanyan, Molly Enrick, Danielle Janota, Devan Cumpston, Hokyung Song, Kelly Stevanov, Christopher L. Kolz, Tatev Hakobyan, Feng Dong, Bi-min Zhang Newby, William M. Chilian, Liya Yin
BASIC RESEARCH IN CARDIOLOGY
(2017)