Article
Endocrinology & Metabolism
Yuling Xing, Yunfeng Zhen, Liqun Yang, Lijing Huo, Huijuan Ma
Summary: This study aimed to explore the association between hemoglobin glycation index (HGI) and non-alcoholic fatty liver disease (NAFLD), and to provide new methods for identifying high-risk patients for NAFLD. The results showed a positive correlation between HGI levels and NAFLD occurrence. Body mass index (BMI) partly mediated the impact of HGI on NAFLD. Subgroup analyses indicated that HGI significantly correlated with NAFLD in certain patient populations.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Pediatrics
Mary Ellen Vajravelu, Joyce M. Lee, Sandra Amaral, Andrea Kelly
Summary: This study evaluated predictors of A1c-based type 2 diabetes screening in pediatric primary care and found that male adolescents were less likely to undergo screening due to differential ordering practices, but were more likely to complete screening if ordered.
Article
Health Care Sciences & Services
Li-Wei Chen, Cheng-Hung Chien, Chih-Lang Lin, Rong-Nan Chien
Summary: This study conducted a longitudinal community-based prospective study on the impact of H. pylori infection on metabolic parameters, finding that HBA1c was associated with new H. pylori infection and BMI was linked to H. pylori loss. Serial analyses within group 3 revealed increased HBA1c and HDL values, but decreased cholesterol and WBC values associated with H. pylori infection loss.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biology
Sumia F. Ahmed, Ahmed A. Hassan, Majdolin M. Eltayeb, Saeed M. Omar, Ishag Adam
Summary: This study found that the level of glycated hemoglobin is influenced by ethnicity and age, but has no significant association with gender.
Article
Oncology
Ji-Hyeon Park, Eunjung Kim, Eun-Mi Seol, Seong-Ho Kong, Do Joong Park, Han-Kwang Yang, Jong-Ho Choi, Shin-Hoo Park, Hwi-Nyeong Choe, Meera Kweon, Jiwon Park, Yunhee Choi, Hyuk-Joon Lee
Summary: A prediction model was accurately developed to identify gastric cancer patients at high risk of malnutrition 6 months after gastrectomy, with low preoperative BMI, female sex, and total or proximal gastrectomy being the three independent risk factors. The model showed significant BMI loss at 6 months after gastrectomy and had a high predictive accuracy with a C-index of 0.91.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Review
Multidisciplinary Sciences
Asmae Chaib, Btissame Zarrouq, Mohammed El Amine Ragala, Badiaa Lyoussi, John P. Giesy, Mourad A. M. Aboul-Soud, Karima Halim
Summary: This study evaluates the effect of a nutrition therapeutic education program on BMI and HbA1c in patients with type 2 diabetes. The results demonstrate that the program reduces the BMI and HbA1c levels of patients, indicating a positive impact on diabetic patients.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Endocrinology & Metabolism
Xinyue Wang, Simin Zhang, Wenlu Yu, Guohua Li, Jinglin Li, Jing Ji, Yang Mi, Xiaoqin Luo
Summary: Pre-pregnancy overweight/obesity and late-pregnancy high HbA1c increased the risk of other gestational metabolic diseases in women with GDM. Monitoring and controlling late-pregnancy HbA1c was effective in reducing metabolic diseases, particularly in those who were overweight/obese before conception.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Richard E. Pratley, Stephan Jacob, Seungjae Baek, Michael E. Trautmann, Marcus Hompesch, OakPil Han, John Stewart, Christopher H. Sorli, Alka Shaunik, Kun-Ho Yoon
Summary: This study conducted subanalyses to explore the efficacy and safety of Efpeglenatide in different subgroups. The results showed that Efpeglenatide can improve glycemic control and body weight in patients with pre-diabetes, regardless of age, BMI, or pre-diabetes status.
BMJ OPEN DIABETES RESEARCH & CARE
(2022)
Article
Medicine, General & Internal
Trinitat Cambras, Odile Romero, Antoni Diez-Noguera, Albert Lecube, Gabriel Sampol
Summary: The study revealed a high prevalence of sleep apnea and circadian rhythm abnormalities in patients with diabetes, which were associated with poor glycemic control.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Nutrition & Dietetics
Ji Hyun Lee, Ye An Kim, Young Sik Kim, Young Lee, Je Hyun Seo
Summary: This study examined the association between vitamin D deficiency and clinical parameters such as glycated hemoglobin, body mass index, and inflammatory markers. It found that vitamin D deficiency was associated with higher levels of glycated hemoglobin, body mass index, and inflammatory markers. Especially in older Korean women, vitamin D deficiency was related to higher levels of glycated hemoglobin, body mass index, and inflammatory markers.
Review
Medical Laboratory Technology
Neha Yadav, Amit Kumar Mandal
Summary: Fasting blood glucose and glycated hemoglobin (HbA1c) are widely used biomarkers for diabetes screening and monitoring. While blood glucose level reflects short-term control, HbA1c provides an average measure of long-term glucose control. However, quantification of HbA1c can be affected by genetic variants of hemoglobin. Mass spectrometry, which measures total glycation of hemoglobin, is not impacted by the presence of genetic variants and may be a better analytical choice for diabetes.
CLINICA CHIMICA ACTA
(2023)
Article
Nutrition & Dietetics
Marta Sanchez, Enric Sanchez, Marcelino Bermudez-Lopez, Gerard Torres, Cristina Farras-Salles, Reinald Pamplona, Eva Castro-Boque, Jose Manuel Valdivielso, Francisco Purroy, Montserrat Martinez-Alonso, Pere Godoy, Didac Mauricio, Elvira Fernandez, Marta Hernandez, Ferran Rius, Albert Lecube
Summary: The study found that all anthropometric indices, except for the A body adiposity index, were higher in individuals with prediabetes compared to controls. However, none of the measures were found to have acceptable levels of discrimination in predicting prediabetes in ROC analysis. Using BMI, the prevalence of prediabetes increased in both men and women around specific cutoff values.
Article
Endocrinology & Metabolism
Lu Lin, Anping Wang, Yan He, Weiqing Wang, Zhengnan Gao, Xulei Tang, Li Yan, Qin Wan, Zuojie Luo, Guijun Qin, Lulu Chen, Yiming Mu, Jingtao Dou
Summary: This study aimed to assess the effects of the hemoglobin glycation index (HGI) on hyperglycemia diagnosis and found that individuals with high HGI have similar clinical characteristics. Using HbA1c alone for diagnosis could lead to inappropriate diabetes management decisions in people with low or high HGI.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Endocrinology & Metabolism
Marie Parfaite Uwimana Muhuza, Lixia Zhang, Qi Wu, Lu Qi, Danqing Chen, Zhaoxia Liang
Summary: This study investigated the association between HbA1c levels and adverse outcomes in women with gestational diabetes mellitus (GDM), considering maternal age, pre-pregnancy BMI, and gestational weight gain (GWG). The results showed that HbA1c was significantly associated with macrosomia, pregnancy-induced hypertension (PIH), preterm birth, and primary Cesarean section. The associations varied with maternal age, pre-pregnancy BMI, and GWG.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Yang Niu, Yajie Zhang, Jinye Sheng, Wenyi Lu, Ji Li, Xiaomeng Mao, Wei Cai, Qingya Tang, Xiuhua Shen, Yi Feng
Summary: The study evaluated the efficiency of tri-ponderal mass index (TMI) in determining obesity in Chinese children aged 6-9 years. The results suggest that TMI holds great potential as an alternative screening method for identifying children at risk of obesity at an early stage.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Yukiko Onishi, Yoko Yoshida, Toshiko Takao, Tazu Tahara, Takako Kikuchi, Toshiko Kobori, Tetsuya Kubota, Asuka Shimmei, Masahiko Iwamoto, Masato Kasuga
Summary: This retrospective cohort study in a Tokyo diabetes clinic found that clinic visits and telemedicine were both independently effective in improving HbA1c levels for Japanese diabetes patients during the COVID-19 emergency period, especially for patients with higher pre-emergency HbA1c levels.
JOURNAL OF DIABETES INVESTIGATION
(2022)
Article
Endocrinology & Metabolism
Toshiko Kobori, Yukiko Onishi, Masahiko Iwamoto, Tetsuya Kubota, Takako Kikuchi, Tazu Tahara, Toshiko Takao, Hiroaki Fujiwara, Yoko Yoshida, Masato Kasuga
Summary: This study found that undergoing insulin treatment is a risk factor for gastric residue independent of age, sex, diabetes, or glycated hemoglobin.
JOURNAL OF DIABETES INVESTIGATION
(2022)
Article
Endocrinology & Metabolism
Toshiko Takao, Hiroyuki Yanagisawa, Machi Suka, Yoko Yoshida, Yukiko Onishi, Tazu Tahara, Takako Kikuchi, Akifumi Kushiyama, Motonobu Anai, Kazuyuki Takahashi, Sayaka Wakabayashi Sugawa, Hiroki Yamazaki, Shoji Kawazu, Yasuhiko Iwamoto, Mitsuhiko Noda, Masato Kasuga
Summary: This study found a significant association between copper/zinc ratio and inflammatory biomarker sTNF alpha R1 in patients with type 2 diabetes, and the two are synergistically related to the prevalence of DKD.
JOURNAL OF DIABETES INVESTIGATION
(2022)
Article
Endocrinology & Metabolism
Taichi Muramatsu, Masahiro Takahashi, Rena Kakinuma, Tomoyo Sato, Mitsuyo Yamamoto, Manabu Akazawa, Kentaro Tanaka, Takako Kikuchi, Akifumi Kushiyama
Summary: This study found that cardiovascular autonomic neuropathy (CAN) significantly increased the risk of a 40% decline in eGFR in patients with type 2 diabetes, especially in those with macroproteinuria.
JOURNAL OF DIABETES INVESTIGATION
(2022)
Article
Peripheral Vascular Disease
Kenya Kusunose, Hisako Yoshida, Atsushi Tanaka, Hiroki Teragawa, Yuichi Akasaki, Yoshihiro Fukumoto, Kazuo Eguchi, Haruo Kamiya, Kazuomi Kario, Hirotsugu Yamada, Masataka Sata, Koichi Node
Summary: The study evaluated the effect of febuxostat treatment on diastolic function in patients with asymptomatic hyperuricemia for 24 months. Results showed a significant increase in E/e' in the control group compared to the febuxostat group.
HYPERTENSION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Junya Hanaguri, Harumasa Yokota, Akifumi Kushiyama, Sakura Kushiyama, Masahisa Watanabe, Satoru Yamagami, Taiji Nagaoka
Summary: The study suggests that tofogliflozin improves retinal blood flow dysregulation, neural retinal dysfunction, and impaired neurovascular coupling in type 2 diabetic mice. Tofogliflozin treatment leads to sustained decrease in blood glucose levels and improves retinal neuronal function and blood flow responses. Additionally, tofogliflozin inhibits the activation of retinal glial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Shoko Hamano, Yukiko Onishi, Yoko Yoshida, Toshiko Takao, Tazu Tahara, Takako Kikuchi, Toshiko Kobori, Tetsuya Kubota, Masahiko Iwamoto, Masato Kasuga
Summary: This study aims to examine the association between self-stigma and HbA1c in Japanese people with type 1 diabetes. The results showed a significant positive association between self-stigma and HbA1c.
JOURNAL OF DIABETES INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Machi Kanna, Yusuke Nakatsu, Takeshi Yamamotoya, Akifumi Kushiyama, Midori Fujishiro, Hideyuki Sakoda, Hiraku Ono, Koji Arihiro, Tomoichiro Asano
Summary: Our previous studies have indicated that Pin1 plays an essential role in the development of non-alcoholic steatohepatitis (NASH) based on rodent models. Interestingly, elevation of serum Pin1 has been observed in NASH patients. However, the expression level of Pin1 in human NASH livers has not been investigated yet. In this study, we examined the expression level and subcellular distribution of Pin1 in NASH liver specimens and found that Pin1 expression was significantly higher, especially in nuclei, compared to healthy liver samples. Our findings also suggest that increased Pin1 expression, particularly in hepatic nuclei, is associated with lipid accumulation in NASH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Toshiko Kobori, Yukiko Onishi, Yoko Yoshida, Tazu Tahara, Takako Kikuchi, Tetsuya Kubota, Masahiko Iwamoto, Tomonobu Sawada, Reo Kobayashi, Hiroaki Fujiwara, Masato Kasuga
Summary: This study aimed to investigate the association between GLP-1RA treatment and gastric residue in an esophagogastroduodenoscopy in patients with diabetes. The study found that the proportion of gastric residue was significantly higher in the GLP-1RA treatment group compared to those without GLP-1RA treatment.
JOURNAL OF DIABETES INVESTIGATION
(2023)
Article
Pharmacology & Pharmacy
Shotaro Kobayashi, Norio Sugama, Hiroyuki Nagano, Ayaka Miyamori, Masahiro Takahashi, Akifumi Kushiyama
Summary: This study investigated the association between anti-dementia drugs and arrhythmia, as well as the effects of these drugs, used alone or in combination, on the likelihood of arrhythmia in dementia patients. The results showed that attention should be paid to the occurrence of arrhythmias, regardless of whether the anti-dementia drugs were used alone or in combination.
DRUGS-REAL WORLD OUTCOMES
(2023)
Article
Pharmacology & Pharmacy
Hiroyuki Nagano, Koji Tomori, Mano Koiwa, Shotaro Kobayashi, Masahiro Takahashi, Hideki Makabe, Hirokazu Okada, Akifumi Kushiyama
Summary: We investigated the relationship between multidrug administration and the characteristics, pathophysiology, and drug class in outpatients with hemodialysis. A retrospective cross-sectional study was conducted to determine the factors associated with multidrug administration in this population. We found that diabetes, old age, poor nourishment, a long history of dialysis, and chronic nephritis were associated with multidrug administration, and specific drug classes such as drugs for acid-related disorders, antidiarrheal agents, intestinal anti-inflammatory/anti-infective agents, antithrombotic agents, and psycholeptics were commonly used.
Meeting Abstract
Ophthalmology
Junya Hanaguri, Akifumi Kushiyama, Harumasa Yokota, Koyo Takase, Sakura Kushiyama, Masahisa Watanabe, Akira Ono, Satoru Yamagami, Taiji Nagaoka
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
