期刊
JOURNAL OF COSMETIC DERMATOLOGY
卷 13, 期 4, 页码 277-287出版社
WILEY
DOI: 10.1111/jocd.12120
关键词
anti-aging; face volumes; hyaluronic acid; skin aging; skin wrinkles
类别
BackgroundHuman skin aging is a multifactorial and complex biological process affecting the different skin constituents. Even if the skin aging mechanism is not yet fully unravelled is evident that epidermis loses the principal molecule responsible for binding and retaining water molecules, resulting in loss of skin moisture and accounting for some of the most striking alterations of the aged skin. ObjectivesThis Study investigated the cosmetic filling efficacy of Fillerina((R)) in decreasing the skin aging signs and in improving facial volume deficiencies. MethodsA placebo-controlled, double-blind, randomized clinical trial was carried out on 40 healthy female subjects showing mild to moderate clinical signs of skin aging. The effect of the treatment on skin surface and on face volumes was assessed both in the short-term (3h after a single product application) and in the long-term (7, 14, and 30days after continuative daily use). ResultsThree hours after a single application and after 7, 14, and 30days of treatment the lips volume was increased by 8.5%, 11.3%, 12.8%, and 14.2%. After 7, 14, and 30days: (1) skin sagging of the face contours was decreased by -0.4430.286, -1.124 +/- 0.511, and -1.326 +/- 0.649mm, respectively; (2) skin sagging of the cheekbones contours was decreased by -0.989 +/- 0.585, -2.500 +/- 0.929, and -2.517 +/- 0.927mm, respectively; (3) cheekbones volume was increased by 0.875 +/- 0.519, 2.186 +/- 0.781, and 2.275 +/- 0.725mm, respectively; (4) wrinkle volume was decreased by -11.3%, -18.4%, and -26.3%, respectively; and (5) wrinkle depth was decreased by -8.4%, -14.5%, and -21.8% respectively. ConclusionThis study demonstrated the positive filling effect of Fillerina((R)) in decreasing the clinical signs of skin aging and in improving the face volumes.
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