Article
Chemistry, Multidisciplinary
Jin Hyeok Lee, You Seung Rim, Won Kyung Min, Kyungho Park, Hyung Tae Kim, Gyuho Hwang, Jaewhan Song, Hyun Jae Kim
Summary: Neurodegenerative disorders pose challenges for diagnosis and treatment, but neuromorphic devices based on hyaluronic acid show potential for implantable bioelectronics, with promising results in terms of synaptic behavior and biocompatibility tests. This research may lead to improved healthcare outcomes.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Oncology
Jeanne Carter, Raymond E. Baser, Deborah J. Goldfrank, Barbara Seidel, Lisania Milli, Cara Stabile, Jocelyn Canty, Sally Saban, Shari Goldfarb, Maura N. Dickler, Ginger J. Gardner, Elizabeth L. Jewell, Yukio Sonoda, Marisa A. Kollmeier, Kaled M. Alektiar
Summary: The study demonstrates that non-hormonal hyaluronic acid (HLA) vaginal gel is feasible and effective in improving vulvovaginal estrogen-deprivation symptoms in postmenopausal women with a history of hormone receptor-positive (HR+) cancer. The use of HLA significantly improved participants' vulvovaginal health, sexual function, and menopausal symptoms.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Pharmacology & Pharmacy
Huizhi Kang, Zhuo Zuo, Ru Lin, Muzi Yao, Yang Han, Jing Han
Summary: Microneedle patch (MNP) is an alternative drug delivery method with unique advantages, and hyaluronic acid microneedle patch (HA MNP) is a prominent strategy with various applications. In this review, the benefits and applications of HA MNP are summarized, highlighting its potential in drug delivery and disease treatment.
Article
Biochemical Research Methods
Chandrababu Rejeeth, Nipun Babu Varukattu, Raju Suresh Kumar, Abdulrahman I. Almansour, Natarajan Arumugam
Summary: This study outlines a unique technique for detecting and extracting human serum CD44 biomarkers through ligand-protein interactions using macropores silica particles modified with hyaluronic acid. The nanoreactors designed as micropipette tips demonstrated favorable sensitivity, selectivity, durability, reuse, and minimal memory impact in MS-based proteome analysis. Additionally, specific surface chemistries of nanoparticles were examined to profile the HA-binding serum proteome, setting a preliminary benchmark for future databases. This study not only establishes a new platform for the extraction/detection of CD44 and identification of the HA-binding proteome, but also provides design recommendations for ligand affinity-based techniques for antibody-free study of serum biomarkers for diagnostic applications.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Monika Michalczyk, Ewelina Humeniuk, Grzegorz Adamczuk, Agnieszka Korga-Plewko
Summary: Hyaluronic acid (HA) is an important component of the extracellular matrix (ECM) and is involved in various biological functions, including embryonic development, healing, inflammation, and cancerogenesis. This review highlights the metabolism and interactions of HA with its binding proteins, such as CD44 and RHAMM, and their implications in cancer development. The presence of HA on tumor cells is associated with a poor prognosis, and studying HA in cancer-free naked mole rats provides insights into its role in malignancy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Multidisciplinary Sciences
Siew-Li Goh, Zulkarnain Jaafar, Yan-Nee Gan, Alston Choong, Jaspreet Kaur, Burak Kundakci, Samihah Abdul Karim, Muhammad Rahmani Jaffar, Mohamad Shariff A. Hamid
Summary: This network meta-analysis compared prolotherapy with other injection therapies for chronic soft tissue injuries, finding that prolotherapy did not show statistically significant pain benefits over other therapies, but consistently had better effects on function compared to non-injections and corticosteroid injections.
Article
Multidisciplinary Sciences
Panjing Yin, Weiwei Su, Ting Li, Ling Wang, Jianying Pan, Xiaoqi Wu, Yan Shao, Huabin Chen, Lin Lin, Yang Yang, Xiulin Cheng, Yanbing Li, Yaobin Wu, Chun Zeng, Wenhua Huang
Summary: This study proposed a modular hydrogel-based bioink containing microsphere-embedded chondrocytes for 3D printing multi-scale scaffolds. The gelatin methacryloyl (GelMA)/alginate microspheres were prepared using a microfluidic approach and the chondrocytes remained viable after being frozen and resuscitated. The modular hydrogel bioink could be printed using the gel-in-gel 3D bioprinting strategy to fabricate the scaffolds, which showed good cell proliferation and differentiation in vitro and biocompatibility in vivo. These findings suggest that this modular hydrogel-based bioink has potential applications in articular cartilage tissue engineering.
Article
Biotechnology & Applied Microbiology
Joachim G. S. Veit, Morgan Weidow, Monica A. A. Serban
Summary: A medical device that can be used in austere environments should be biocompatible, bioresorbable, promote tissue healing, not require trained personnel for use, and enable drug delivery. In this study, a device made of silk fibroin and a hyaluronic acid derivative was developed, which showed good mechanical properties and protection against reactive oxygen species. The device also demonstrated improved drug delivery and self-adhesive properties.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Polymer Science
Ioana-Georgeta Grosu, Augustin Mot, Xenia Filip, Claudiu Filip
Summary: A systematic N-15/C-13 solid-state NMR investigation was conducted on three dopamine (DA) conjugates of hyaluronic acid (HA). The results revealed that the proposed covalent bond formation mechanisms for the HA(EDC)-DA and HA(Ox)-DA conjugates did not exist in practice, as the DA molecules were found to be in their charged -NH3+ form. The C-13 ss-NMR results provided useful insights into the structure and interaction patterns of the conjugates. These findings are of great importance for future practical applications, such as the development of novel HA-based hydrogels.
Article
Medicine, General & Internal
Young-Kyoung Lim, Chang-Jin Jung, Mi-Young Lee, Ik-Jun Moon, Chong-Hyun Won
Summary: The study evaluated an RFHI device that delivers both microneedle intradermal RF treatment and HA filler injection for rejuvenating the periorbital area. Results showed significant improvement in both IGA-LCL and GAIS at the 8-week follow-up, as well as statistically significant improvement in wrinkles, roughness, and pore volume measured by the Antera 3D image capture system (R). No serious adverse events were reported, indicating that the RFHI device is effective and safe for periorbital rejuvenation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Yelim Yi, Yuxi Lin, Jiyeon Han, Hyuck Jin Lee, Nahye Park, Geewoo Nam, Young S. Park, Young-Ho Lee, Mi Hee Lim
Summary: The study shows that sphingosine (SP) interacts with both amyloid-beta (Aβ) and metal ions, affecting their aggregation and potentially exacerbating the toxicity induced by Aβ in living cells. The acyl derivatives of SP also influence Aβ aggregation to different degrees, with slight structural modifications neutralizing their cytotoxic effects. These findings suggest that SP and its derivatives could directly interact with pathological factors in Alzheimer's disease and modify their pathogenic properties.
Article
Multidisciplinary Sciences
Joanna Czajkowska, Jan Juszczyk, Monika Natalia Bugdol, Malgorzata Glenc-Ambrozy, Anna Polak, Laura Piejko, Ewa Pietka
Summary: This paper discusses the usability of high-frequency ultrasound (HFUS) in assessing the effectiveness of anti-aging skin therapy. The fully automated algorithm used in this study enables qualitative and quantitative evaluation of anti-aging products. The clinical trial reveals that TCA-peel therapy can slow down the thinning process of the skin and improve its condition, suggesting a reduced photo-aging effect and increased water content.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Cyntanna C. Hawkins, Amber B. Jones, Emily R. Gordon, Sarah E. Williford, Yuvika Harsh, Julia K. Ziebro, Catherine J. Landis, G. C. Sajina, David K. Crossman, Sara J. Cooper, Sasanka Ramanadham, Ninh Doan, Anita B. Hjelmeland
Summary: In this study, the researchers found that acid ceramidase (ASAH1) is highly expressed in GBM and is associated with migration-related genes. Through shRNA knockdown and carmofur inhibition, they demonstrated the role of ASAH1 in GBM migration. Inhibition of ASAH1 using carmofur may be a potential clinically relevant treatment for GBM.
Retraction
Chemistry, Multidisciplinary
Pengying Wu, Yue Sun, Wei Dong, Huige Zhou, Shifang Guo, Lei Zhang, Xiaobing Wang, Mingxi Wan, Yujin Zong
Summary: The retraction of this article has caused controversy in the research community and serves as a warning to the importance of scientific integrity and rigor in publishing research findings. It reminds us to handle data processing and result interpretation carefully when publishing research results.
Article
Cell & Tissue Engineering
Yili Wang, Levinus Hendrik Koole, Chenyuan Gao, Dejun Yang, Lei Yang, Chunwu Zhang, Huaqiong Li
Summary: This study synthesized and characterized a set of new hydrogels consisting of gelatin, hyaluronic acid, and decellularized cartilage matrix, showing promising results for cartilage tissue engineering. The hydrogels were studied for their behavior with cells in vitro and in a rat knee cartilage defect model, indicating potential utility for tissue engineering and regenerative medicine.
NPJ REGENERATIVE MEDICINE
(2021)