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Medicine, General & Internal
Chao Yin, Zhishuai Ye, Jian Wu, Chenxing Huang, Le Pan, Huaiyu Ding, Lei Zhong, Lei Guo, Yan Zou, Xiang Wang, Ying Wang, Pan Gao, Xuejuan Jin, Xiaoxiang Yan, Yunzeng Zou, Rongchong Huang, Hui Gong
Summary: The study found that elevated levels of Wnt2 and Wnt4 in the serum of AMI patients were associated with adverse outcomes. Wnt2 and Wnt4 promote cardiac fibrosis by activating the beta-catenin/NF-kappa B signaling pathway, potentially impacting the cardiac function of AMI patients.
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Biochemistry & Molecular Biology
Ratul Datta Chaudhuri, Anirban Banik, Biswajit Mandal, Sagartirtha Sarkar
Summary: HIF-1α overexpression during MI reduces cardiomyocyte apoptosis by indirectly promoting HO-1-induced antioxidant response, which leads to decreased ROS accumulation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Medicine, General & Internal
Xiaosheng Fan, Yan Yang, Lin Qi
Summary: The protective role of Vildagliptin in hypoxia-reoxygenation (H/R)-induced injury of cardiac microvascular endothelial cells (CMECs) and its pharmacological mechanisms were investigated in this study. H/R resulted in upregulation of DPP-4 and Nox-4, increased LDH release, and decreased viability and GSH content in CMECs. Vildagliptin treatment relieved these changes and inhibited the activation of the p38/NF-kappa B signaling in H/R-induced CMECs. Overall, Vildagliptin protects CMECs from H/R injury through inactivating the p38/NF-kappa B signaling pathway.
Article
Pharmacology & Pharmacy
Laura Tesoro, Ignacio Hernandez, Rafael Ramirez-Carracedo, Javier Diez-Mata, Nunzio Alcharani, Beatriz Jimenez-Guirado, Karina Ovejero-Paredes, Marco Filice, Jose Luis Zamorano, Marta Saura, Carlos Zaragoza, Laura Botana
Summary: This study introduced a micelle-based nanoparticle called NIL10, which targets the IL-10 receptor and was found to induce cardiac protection in mice and pigs with acute myocardial infarction (AMI). The administration of NIL10 reduced inflammation and fibrosis, increased the population of M2-like macrophages, and elevated anti-inflammatory cytokines. Mechanistically, NIL10 activated the IL-10 receptor/STAT-3 signaling pathway and inhibited the nuclear translocation of pro-inflammatory NF-kappa B transcription factor. These findings suggest that NIL10 could be a potential therapeutic tool against AMI-induced cardiac damage.
Article
Chemistry, Multidisciplinary
Chenghu Guo, Wei Ji, Wei Yang, Qiming Deng, Tengfei Zheng, Zunzhe Wang, Wenhai Sui, Chungang Zhai, Fangpu Yu, Bo Xi, Xiao Yu, Feng Xu, Qunye Zhang, Wencheng Zhang, Jing Kong, Meng Zhang, Cheng Zhang
Summary: Myocardial infarction is a leading cause of death worldwide. Cardiac fibroblasts are responsible for cardiac repair post-MI. NF-κB-repressing factor plays a significant role in cardiac remodeling post-MI.
Article
Pharmacology & Pharmacy
Xiuying Zhang, Qilei Chen, Jia Zhao, Wei Zhao, Ni Fan, Yu Wang, Hubiao Chen, Jianhui Rong
Summary: This study aimed to investigate the cardioprotective activity of the herbal medicine formula Baoyuan Decoction (BYD), identify the active compounds and molecular targets. The results showed that BYD effectively reduced infarct size and preserved cardiac functions. Network pharmacology analysis revealed that BYD might control cardiac inflammation through targeting the TNF-alpha/NF-kappa B pathway and other related pathways.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Integrative & Complementary Medicine
Jing Li, Xuming Ma, Jun Yang, Luzhen Wang, Yan Huang, Yan Zhu
Summary: This study demonstrates for the first time that lupeol has a cardioprotective effect against I/R-induced myocardial infarction in rats, possibly due to its antioxidant, anti-inflammatory, and anti-apoptotic activities. The results also reveal the mechanisms of the NF-kappa B and Nrf2 signaling pathways.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Scott A. Hubers, John A. Schirger, S. Jeson Sangaralingham, Yang Chen, John C. Burnett, David Hodge, Horng H. Chen
Summary: Infusion of B-type natriuretic peptide (BNP) in patients with acute anterior myocardial infarction did not have significant effects on parameters of left ventricular remodeling. However, there was a trend towards reduced left ventricular infarction size in patients with a baseline left ventricular ejection fraction of <40% who were treated with BNP. These results do not support the use of intravenous BNP in patients after recent myocardial infarction.
Article
Cardiac & Cardiovascular Systems
Masum M. Mia, Dasan Mary Cibi, Siti Aishah Binte Abdul Ghani, Anamika Singh, Nicole Tee, Viswanathan Sivakumar, Hanumakumar Bogireddi, Stuart A. Cook, Junhao Mao, Manvendra K. Singh
Summary: Yap/Taz play an important regulatory role in MI-induced cardiac fibrosis by controlling fibroblast proliferation, transdifferentiation into myofibroblasts, and fibroinflammatory program.
CARDIOVASCULAR RESEARCH
(2022)
Article
Cell Biology
Yoshinori Aoki, Hongmei Dai, Fumika Furuta, Tomohisa Akamatsu, Takuya Oshima, Naoto Takahashi, Yu-ichi Goto, Akira Oka, Masayuki Itoh
Summary: Microglial cells have an important role in the brain's immune system. LOX-1 expression was confirmed in microglial cells in the neonatal hypoxic-ischemic encephalopathy model brain. LOX-1 activates cytokines and chemokines through intracellular pathways. This study investigated the role and molecular mechanism of LOX-1 gene transcription in microglial cells under hypoxic and ischemic conditions.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Cell Biology
Jia Li, Chenghui Yan, Yilong Wang, Can Chen, Haibo Yu, Dan Liu, Kai Huang, Yaling Han
Summary: Pathological cardiac hypertrophy is a major risk factor for heart failure, characterized by abnormal remodeling of cardiomyocytes in response to pressure overload or other stress stimuli. The study reveals that GCN5 plays a significant role in promoting cardiac hypertrophy through excessive activation of the TAK1-JNK/p38 signaling pathway.
CELL DEATH & DISEASE
(2022)
Article
Immunology
Lu Jiang, Aidi Yang, Xi Li, Ke Liu, Jin Tan
Summary: Transplanting VCAM-1-silenced BMSCs into MI rats resulted in more significant reductions in myocardial infarct size and myocardial cell apoptosis, improved cardiac function, increased number of rats surviving within 72 hours, and extended survival time within 72 hours, possibly due to the down-regulation of NF-kappa B-regulated gene products.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shusuke Yasuda, Mano Horinaka, Yosuke Iizumi, Wakana Goi, Mamiko Sukeno, Toshiyuki Sakai
Summary: Cellular senescence is a state of irreversible cell growth arrest that triggers the production of pro-inflammatory cytokines, known as SASP. Oridonin has been identified as a potential inhibitor of SASP, potentially through modulation of the NF-kappa B and p38 pathways.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Yang Yang, Wei Zhou, Xiuqi Xu, Xianxiu Ge, Fei Wang, Guang-Qin Zhang, Lin Miao, Xueting Deng
Summary: This study suggests that Aprepitant alleviates inflammatory pain in mice by inhibiting the phosphorylation of JNK and p38, as well as the NF-kappa B signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Xiaoqiong Wei, Song Zou, Zhonghui Xie, Zhen Wang, Nongyu Huang, Zhifu Cen, Yan Hao, Chengxin Zhang, Zhenyu Chen, Fulei Zhao, Zhonglan Hu, Xiu Teng, Yiyue Gui, Xiao Liu, Huaping Zheng, Hong Zhou, Shuwen Chen, Juan Cheng, Fanlian Zeng, Yifan Zhou, Wenling Wu, Jing Hu, Yuquan Wei, Kaijun Cui, Jiong Li
Summary: The study demonstrates the important role of EDIL3 in cardiac remodeling after myocardial infarction. EDIL3 deficiency improves adverse cardiac healing mainly through the mechanism of neutrophil extracellular trap-mediated pro-inflammatory macrophage polarization.
CARDIOVASCULAR RESEARCH
(2022)