Review
Cell Biology
Rachel Howard, Runci Li, Kelly Harvey-Jones, Vinita Verma, Frederic Lange, Geraldine Boylan, Ilias Tachtsidis, Subhabrata Mitra
Summary: Neonatal seizures are a significant cause of morbidity and mortality worldwide. Optical monitoring techniques such as NIRS and broadband NIRS have shown promise in providing real-time, non-invasive monitoring of cerebral metabolism and hemodynamics. A systematic review of optical biomarkers found clear changes in cerebral hemodynamics and metabolism during the pre-ictal, ictal, and post-ictal phases of neonatal seizures. More research is needed to determine whether NIRS-based methods can be used in real-time at the cot-side to provide pathophysiological data during neonatal seizures.
Review
Chemistry, Analytical
Maria Roldan, Panayiotis A. Kyriacou
Summary: Traumatic brain injury (TBI) occurs when sudden trauma causes damage to the brain, with secondary injuries potentially affecting cerebral oxygenation and autoregulation. Near-infrared spectroscopy (NIRS) is a potential noninvasive monitoring technique for assessing TBI early, based on chromophore absorption of infrared light.
Article
Pediatrics
Carlo Dani, Caterina Coviello, Simona Montano, Giulia Remaschi, Chiara Petrolini, Maria Chiara Strozzi, Elena Maggiora, Miriam Sabatini, Diego Gazzolo
Summary: Using near-infrared spectroscopy, the study found that mother's own milk feeding had minimal impact on splanchnic oxygenation, while preterm formula feeding led to a persistent decrease in splanchnic oxygenation. Fortified human milk feeding transiently increased splanchnic energy expenditure.
PEDIATRIC RESEARCH
(2021)
Article
Pediatrics
Ena Pritisanac, Berndt Urlesberger, Bernhard Schwaberger, Gerhard Pichler
Summary: Limited data available currently suggest that fetal hemoglobin might affect peripheral muscle oxygen extraction but not cerebral oxygenation in preterm neonates. More studies are needed to reach a final conclusion, especially regarding the oxygenation changes driven by adult red blood cell transfusions.
FRONTIERS IN PEDIATRICS
(2021)
Article
Pediatrics
Bi Ze, Lili Liu, Ge Sang Yang Jin, Minna Shan, Yuehang Geng, Congle Zhou, Tianqi Wu, Hong Wu, Xinlin Hou
Summary: The study revealed that normal neonates at high-altitude areas have significantly lower rSO(2) and cFTOE levels compared to those at low-altitude areas, possibly due to an increase in blood flow to the brain. Neonates with underlying diseases may have an increased risk of brain injury.
Article
Chemistry, Analytical
Naser Hakimi, Mohammad Shahbakhti, Joern M. Horschig, Thomas Alderliesten, Frank Van Bel, Willy N. J. M. Colier, Jeroen Dudink
Summary: This study aimed to extract respiratory rate from neonatal NIRS signals to monitor the impact of breathing on cerebral hemodynamics. A novel algorithm called NRR was developed and showed high agreement with the reference respiratory rate (84.5%). The NRR algorithm outperformed existing methods in terms of accuracy and correlation.
Article
Medicine, General & Internal
Marinela Bakotin Jakovac, Andrea Etrusco, Mislav Mikus, Damir Roje, Jelena Marusic, Ivan Palada, Indira Kosovic, Nadja Aracic, Martina Sunj, Antonio Simone Lagana, Vito Chiantera, Zeljko Dujic
Summary: This prospective observational study aimed to compare placental oxygenation in low-risk, uncomplicated term pregnancies using near-infrared spectroscopy (NIRS) and ultrasound assessment. The results showed a correlation between placental maturity grade and placental oxygenation. However, due to technical limitations, NIRS cannot be implemented as a routine clinical tool yet.
Article
Engineering, Electrical & Electronic
Naser Hakimi, Jorn M. M. Horschig, Thomas Alderliesten, Mathijs Bronkhorst, Marianne J. J. Floor-Westerdijk, Frank van Bel, Willy N. J. M. Colier, Jeroen Dudink
Summary: This study proposes a novel algorithm, NIRS HR (NHR), for extracting heart rate from NIRS signals in neonates. The results show that the NHR algorithm has a higher correlation and lower error rate compared to existing algorithms.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2023)
Article
Neurosciences
Alexander Avian, Christian Mattersberger, Lukas Schober, Johann Martensen, Martin Wolf, Wataru Kamo, Gerhard Pichler, Bernhard Schwaberger, Berndt Urlesberger
Summary: This study aimed to analyze the precision of time-resolved near-infrared spectroscopy (t-NIRS) measurements of cerebral oxygenation in preterm infants. The results showed low within-patient variation, indicating high precision of the measurement.
Review
Clinical Neurology
V. Zephaniah Phillips, Raymart Jay Canoy, Seung-ho Paik, Seung Hyun Lee, Beop-Min Kim
Summary: The growth of digital healthcare in neurology relies on portable and cost-effective brain monitoring tools like functional near-infrared spectroscopy (fNIRS). This review discusses the contribution of fNIRS to personalized digital healthcare in neurology, focusing on two major trends: multimodal monitoring and naturalistic experimental paradigms. Multimodal monitoring allows for a better understanding of the interconnection between cerebral hemodynamics and other physiological phenomena in patients, while naturalistic experimental paradigms provide insights into complex brain activities in everyday life. The scope of future fNIRS studies is also discussed to improve brain activation assessments and the wider clinical acceptance of fNIRS in digital healthcare.
JOURNAL OF CLINICAL NEUROLOGY
(2023)
Article
Biochemical Research Methods
Amanda Cheung, Lorna Tu, Andrew Macnab, Brian K. Kwon, Babak Shadgan
Summary: In this study, researchers compared the response of transcutaneous muscle NIRS measures with pulse oximetry SpO(2) during hypoxia in Yucatan miniature pigs. They found that transcutaneous muscle NIRS detected the effects of hypoxia significantly sooner than pulse oximetry. This suggests that a transcutaneous NIRS sensor may be a useful tool in clinical settings for detecting changes in oxygen saturation earlier than the standard pulse oximeter.
JOURNAL OF BIOMEDICAL OPTICS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chin-Kuo Lin, Shaw-Woei Leu, Ying-Huang Tsai, Shao-Kui Zhou, Chieh-Mo Lin, Shu-Yi Huang, Che-Chia Chang, Meng-Chin Ho, Wei-Chun Lee, Min-Chi Chen, Ming-Szu Hung, Yu-Ching Lin, Jhe-Ruei Li, Bor-Shyh Lin
Summary: The study used a wireless near-infrared spectroscopy device to estimate tissue water and hemoglobin content in patients with severe sepsis and healthy controls. It was found that severely septic patients had significantly higher tissue water content, lower hemoglobin oxygenation levels, and these were correlated with systemic hemodynamics, affecting tissue oxygenation.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Anesthesiology
Yasunori Yagi, Yasunori Kubo, Koji Hoshino, Kazufumi Okada, Kiyohiko Hotta, Nobuo Shinohara, Yuji Morimoto
Summary: It has been reported that cerebral oxygen saturation (rSO(2)) measured by near infrared spectroscopy is low in dialysis patients. This study compared the rSO(2) values of dialysis patients and living kidney donors using three different spectroscopes. The results showed significant differences in rSO(2) values among the spectroscopes, and the values in INVOS 5100C and tNIRS-1 were correlated with blood hemoglobin and serum albumin.
JOURNAL OF ANESTHESIA
(2023)
Article
Environmental Sciences
Eva-Maria Bonnelycke, Gordon D. Hastie, Kimberley A. Bennett, Jana M. Kainerstorfer, Ryan Milne, Simon E. W. Moss, Alexander Ruesch, Jingyi Wu, J. Chris McKnight
Summary: This study examined the effects of ketamine and midazolam on grey seals' physiological responses during prolonged anaesthesia trials using NIRS data. The results showed that both anesthetics led to apnoea in the seals, with an increase in Delta HHb while SpO(2) remained stable, indicating possible venous congestion. NIRS was found to be a valuable real-time monitoring tool for safe anaesthetic procedures in pinnipeds.
Article
Engineering, Biomedical
Jens-Christian Schewe, Silvia Schumacher, Felix Erdfelder, Stefan Felix Ehrentraut, Carsten Weissbrich, Felix Lehmann, Florian Koegl, Thomas Muders, Marcus Thudium, Christian Putensen, Stefan Kreyer
Summary: Extracorporeal membrane oxygenation (ECMO) is used in acute respiratory distress syndrome (ARDS) to aid oxygenation and lung ventilation. Near infrared spectroscopy (NIRS) can measure cerebral regional tissue oxygenation (rSO(2)) and may be useful for patient safety during interhospital transport under ECMO support. A study on 16 adult ARDS patients found that NIRS monitoring for rSO(2) during ECMO initiation and transport was feasible, and there was no significant difference in valid measurement percentages between rSO(2) and standard peripheral oxygen saturation (SpO(2)) monitoring. Overall, the measurement of cerebral rSO(2) with NIRS could contribute to improving patient safety during interhospital ECMO transport, especially in certain patients such as those in shock.
Article
Hematology
Sanne de Bruin, Dorus Eggermont, Robin van Bruggen, Dirk de Korte, Thomas W. L. Scheeren, Jan Bakker, Alexander P. J. Vlaar
Summary: Transfusion practices in ICU vary, with the study finding that the transfusion practice for massively bleeding critically ill patients is largely influenced by the presence of massive transfusion protocol (MTP), while general non-massively bleeding patients tend to have restrictive transfusion triggers.
Letter
Acoustics
Micah L. A. Heldeweg, Tomas T. R. Heldeweg, Patrick Schober, Pieter Roel Tuinman, Harm-Jan de Grooth
JOURNAL OF ULTRASOUND IN MEDICINE
(2023)
Article
Emergency Medicine
Sebastiaan M. Bossers, Robert Verheul, Erik W. van Zwet, Frank W. Bloemers, Georgios F. Giannakopoulos, Stephan A. Loer, Lothar A. Schwarte, Patrick Schober
Summary: The current data does not support the routine practice of prehospital intubation, and the effect of prehospital intubation on mortality might depend on the experience of EMS clinicians. Therefore, when intubation is required, it is advisable to involve prehospital personnel who are proficient in prehospital intubation.
PREHOSPITAL EMERGENCY CARE
(2023)
Article
Anesthesiology
Jayant S. Jainandunsing, Dario Massari, Jaap Jan Vos, Inez J. Wijdh-den Hamer, Ad F. M. van den Heuvel, Massimo A. Mariani, Feroze Mahmood, Wobbe Bouma, Thomas W. L. Scheeren
Summary: The objective of this study was to develop a mathematical model for simulating mitral annular dilatation and assess its effects on the individualized mitral valve coaptation reserve index. The study retrospectively analyzed intraoperative transesophageal 3-dimensional echocardiographic datasets of the mitral valve and created a mathematical model to evaluate the coaptation reserve index for different leaflet segments. The results showed that the A2-to-P2 region had the lowest coaptation reserve in the majority of patients and was also the most susceptible to mitral regurgitation after simulation of progressive annular dilation.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2023)
Article
Peripheral Vascular Disease
Cornelia K. Niezen, Jaap J. Vos, Arend F. Bos, Thomas W. L. Scheeren
Summary: This study aimed to investigate the effects of different inspiratory fraction of O2 (FiO2) and expiratory CO2 concentrations on changes in regional tissue oxygen saturation (StO2) during a vascular occlusion test (VOT). The results showed that common situations observed during anesthesia and intensive care such as hypoxia, hyperoxia, hypocapnia, or hypercapnia did not affect the changes in StO2 induced by VOT.
MICROVASCULAR RESEARCH
(2023)
Article
Anesthesiology
Ilonka N. De Keijzer, Dario Massari, Caren K. Niezen, Reinoud P. H. Bokkers, Jaap Jan Vos, Thomas W. L. Scheeren
Summary: This study validates the use of O3 regional oximetry for monitoring muscle saturation in the quadriceps and flank. However, it is important to note that there is a saturation-level dependent bias and the values obtained at the flank underestimate renal reference values.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2023)
Letter
Surgery
Jeroen Hermanides, Patrick Schober, Hans J. Avis
Article
Anesthesiology
Ramon Pierik, Thomas W. L. Scheeren, Michiel E. Erasmus, Walter M. van den Bergh
Summary: This study aimed to assess the predictive value of intra-operative neuromonitoring and blood pressure monitoring for peri-operative stroke after cardiothoracic surgery. The study found that cumulative intra-operative BIS values below 25 and longer duration of MAP below 60 mmHg were associated with the occurrence of peri-operative stroke.
EUROPEAN JOURNAL OF ANAESTHESIOLOGY
(2023)
Article
Critical Care Medicine
M. T. Carvalho Mota, V. P. Goldfinger, R. Lokerman, M. Terra, K. Azijli, P. Schober, M. A. de Leeuw, M. van Heijl, F. W. Bloemers, G. F. Giannakopoulos
Summary: This study investigated the accuracy of (H)EMS assessment of unstable pelvic ring injuries and the application rate of NIPBD. The results showed that the prehospital sensitivity of (H)EMS for assessing unstable pelvic ring injuries and applying NIPBD is low. Roughly half of all unstable pelvic ring injuries were not recognized by (H)EMS. Further research is recommended to aid the routine use of NIPBD.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2023)
Article
Multidisciplinary Sciences
Jennifer S. Breel, Agnes G. C. L. Wensing, Susanne Eberl, Benedikt Preckel, Patrick Schober, Marcella C. A. Muller, Robert J. M. Klautz, Markus W. Hollmann, Henning Hermanns
Summary: This study aims to delineate the specific coagulation patterns and their clinical consequence in patients undergoing cardiac surgery due to infective endocarditis. The findings show significantly altered coagulation profiles in patients with infective endocarditis, with concomitant hyper- and hypocoagulability. The incidence of bleeding complications and transfusion requirements were also increased in patients with endocarditis.
Letter
Otorhinolaryngology
Patrick Schober, Lothar Andreas Schwarte, Stephan Alexander Loer
JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2023)
Article
Anesthesiology
Ilonka N. de Keijzer, Jaap Jan Vos, David Yates, Caroline Reynolds, Sally Moore, Rebecca J. Lawton, Thomas W. L. Scheeren, Simon J. Davies
Summary: Clinicians believed they had sufficient knowledge and skills, which could explain why no difference was found after the educational intervention. In the HPI cohort, IOH was significantly reduced compared to baseline, therefore HPI-software may help prevent IOH.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2023)
Article
Anesthesiology
Johannes Enevoldsen, Birgitte Brandsborg, Peter Juhl-Olsen, Stephen Edward Rees, Henriette Vind Thaysen, Thomas W. L. Scheeren, Simon Tilma Vistisen
Summary: Pulse pressure variation (PPV) is a method for predicting fluid responsiveness in mechanically ventilated patients. The accuracy of this method is disputed when ventilation has low tidal volume (VT) or low heart-rate-to-respiratory-rate ratio (HR/RR). This study investigated the effects of VT and RR on PPV and its ability to predict fluid responsiveness.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2023)
Review
Clinical Neurology
David J. Kopsky, Karolina M. Szadek, Patrick Schober, Alexander F. J. E. Vrancken, Monique A. H. Steegers
Summary: This review of 28 EERW pain trials found variations in primary endpoint selection, with NRS or VAS commonly used to measure pain intensity, and considerable differences in definitions of time to LTR across trials. Only a small proportion of trials using time to LTR as primary endpoint reported certain important outcomes, showing the complexity and diversity of this measure in EERW pain trials.
JOURNAL OF PAIN RESEARCH
(2022)
Article
Medicine, General & Internal
Paul Philipp Heinisch, Maks Mihalj, Elif Haliguer, Brigitta Gahl, Bernhard Winkler, Philipp Venetz, Hansjoerg Jenni, Patrick Schober, Gabor Erdoes, Markus M. Luedi, Joerg C. Schefold, Alexander Kadner, Christoph Huber, Thierry P. Carrel
Summary: This study analyzed the perioperative morbidity and mortality in adult patients undergoing reoperations for isolated CABG using either CECC or MiECC circuits. The results showed that MiECC can be an alternative strategy for redo-CABG, and there were no significant differences in most outcomes compared to CECC.
SWISS MEDICAL WEEKLY
(2022)
