Evidence for the involvement of GPR40 and NADPH oxidase in palmitic acid-induced superoxide production and insulin secretion

NADPH oxidase inhibition prevents beta cell dysfunction induced by prolonged elevation of oleate in rodents

(2013) K. Koulajian et al.   DIABETOLOGIA

Overexpression of the antioxidant enzyme catalase does not interfere with the glucose responsiveness of insulin-secreting INS-1E cells and rat islets

(2013) S. Lortz et al.   DIABETOLOGIA

NADPH Oxidase NOX2 Defines a New Antagonistic Role for Reactive Oxygen Species and cAMP/PKA in the Regulation of Insulin Secretion

(2012) N. Li et al.   DIABETES

G protein-coupled receptor (GPR)40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1

(2012) M. Ferdaoussi et al.   DIABETOLOGIA

Oleic Acid Modulates Metabolic Substrate Channeling during Glucose-Stimulated Insulin Secretion via NAD(P)H Oxidase

(2011) Laila R. B. Santos et al.   ENDOCRINOLOGY

Reactive oxygen species are produced at low glucose and contribute to the activation of AMPK in insulin-secreting cells

(2011) Alexandre Sarre et al.   FREE RADICAL BIOLOGY AND MEDICINE

Alterations of NADPH Oxidase Activity in Rat Pancreatic Islets Induced by a High-Fat Diet

(2011) Maíra Mello Rezende Valle et al.   PANCREAS

Regulation of insulin secretion and reactive oxygen species production by free fatty acids in pancreatic islets

(2011) Maria Fernanda Graciano et al.   Islets

Tiam1/Rac1 signaling pathway mediates palmitate-induced, ceramide-sensitive generation of superoxides and lipid peroxides and the loss of mitochondrial membrane potential in pancreatic β-cells

(2010) Ismail Syed et al.   BIOCHEMICAL PHARMACOLOGY

Effects of pharmacological inhibition of NADPH oxidase or iNOS on pro-inflammatory cytokine, palmitic acid or H2O2-induced mouse islet or clonal pancreatic β-cell dysfunction

(2010) Marta Michalska et al.   BIOSCIENCE REPORTS

Arachidonic acid actions on functional integrity and attenuation of the negative effects of palmitic acid in a clonal pancreatic β-cell line

(2010) Deirdre C. Keane et al.   CLINICAL SCIENCE

NAD(P)H oxidase participates in the palmitate-induced superoxide production and insulin secretion by rat pancreatic islets

(2010) Maria Fernanda R. Graciano et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Overexpression of GPR40 in Pancreatic  -Cells Augments Glucose-Stimulated Insulin Secretion and Improves Glucose Tolerance in Normal and Diabetic Mice

(2009) K. Nagasumi et al.   DIABETES

Insights into the critical role of NADPH oxidase(s) in the normal and dysregulated pancreatic beta cell

(2009) P. Newsholme et al.   DIABETOLOGIA

Association of NAD(P)H Oxidase with Glucose-Induced Insulin Secretion by Pancreatic β-Cells

(2009) D. Morgan et al.   ENDOCRINOLOGY

Acute administration of GPR40 receptor agonist potentiates glucose-stimulated insulin secretion in vivo in the rat

(2009) Lalit S. Doshi et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Palmitate Activates Insulin Signaling Pathway in Pancreatic Rat Islets

(2009) Maria Fernanda R. Graciano et al.   PANCREAS

Lack of FFAR1/GPR40 Does Not Protect Mice From High-Fat Diet-Induced Metabolic Disease

(2008) H. Lan et al.   DIABETES

Gpr40 Is Expressed in Enteroendocrine Cells and Mediates Free Fatty Acid Stimulation of Incretin Secretion

(2008) S. Edfalk et al.   DIABETES

Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells

(2008) H. E. Parker et al.   DIABETOLOGIA

Impaired Insulin Secretion by Diphenyleneiodium Associated with Perturbation of Cytosolic Ca2+Dynamics in Pancreatic β-Cells

(2008) Hirofumi Imoto et al.   ENDOCRINOLOGY

Loss-of-Function Mutation of theGPR40Gene Associates with Abnormal Stimulated Insulin Secretion by Acting on Intracellular Calcium Mobilization

(2008) Roberto Vettor et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM