Article
Zoology
David Leonardo Justinico Castro, Renata Maria P. Freitas, Stella Bicalho Silva, Fabiana Cristina Silveira Alves de Melo, Mariaurea M. Sarandy, Esteban Giraldo Ospina, Sirlene Rodrigues Sartori, Reggiani Vilela Goncalves, Mariella Bontempo Freitas
Summary: This study investigates the importance of glucose homeostasis in nectar-feeding bats, revealing the role of insulin in blood sugar regulation at rest and the potential renal protection during exercise through increased nitric oxide production in the kidneys. Insulin secretion appears to be crucial in maintaining glucose levels during rest periods, while oxidative stress and metabolic markers were analyzed in relation to glucose intake and exercise.
Article
Biochemistry & Molecular Biology
Xiao Han, Yang Yang, Sujuan Liu, Yanmei Niu, Heng Shao, Li Fu
Summary: Skeletal muscle insulin resistance is closely linked to hyperglycemia and metabolic disorders. Regular exercise can enhance insulin sensitivity in skeletal muscle, and this study aimed to explore the underlying mechanisms. The results showed that SESN3 plays a crucial role in amplifying the beneficial effects of exercise on insulin sensitivity in skeletal muscle and systemic glucose levels. The SESN3/mTORC2/AKT pathway mediated the effects of exercise on skeletal muscle insulin sensitivity.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Review
Endocrinology & Metabolism
Jean-Claude Henquin
Summary: Research on isolated human islets can be reliably translated to the in vivo situation, but concordance may fade out under extreme conditions. Perplexing differences exist between insulin secretion in subjects with Type 2 diabetes and their islets studied in vitro, especially concerning kinetics. Future projects should ensure experimental conditions resemble physiological conditions to maintain the function of normal and diabetic islets.
MOLECULAR METABOLISM
(2021)
Article
Endocrinology & Metabolism
Jean-Claude Henquin
Summary: Optimal metabolic homeostasis requires precise control of insulin secretion, which is influenced by various factors. Inconsistent findings between in vitro and clinical studies may result from extreme experimental conditions that do not reflect physiological relevance.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Biochemistry & Molecular Biology
Camila Pires Mendes, Barbara Graziela Postal, Marisa Jadna Silva Frederico, Rui Goncalves Marques Elias, Veronica Aiceles de Medeiros Pinto, Cristiane da Fonte Ramos, Patricia Devantier Neuenfeldt, Ricardo Jose Nunes, Fatima Regina Mena Barreto Silva
Summary: A new library of hybrid compounds was developed to optimize the pharmacological activities of two drugs for the treatment of type 2 diabetes, potentially minimizing adverse effects. Among the screened compounds, PTEBS was identified to effectively regulate glucose and lipid homeostasis.
BIOORGANIC CHEMISTRY
(2021)
Article
Environmental Sciences
Pengfei Gong, Danielle Bailbe, Stefania Tolu, Gaelle Pommier, Junjun Liu, Jamileh Movassat
Summary: Since the restricted use of BPA due to its endocrine disruptor properties, BPS has been widely used as a substitute. However, BPS has similar effects on metabolic health as BPA. Previous studies have documented the effects of maternal exposure to BPA and BPS on offspring, but the impact of preconceptional paternal exposure to BPS remains unexplored. This study showed that preconceptional paternal exposure to BPS had non-monotonic and sex-specific effects on the metabolic health of offspring, suggesting that BPS is not a safe substitute for BPA regarding the inter-generational transmission of metabolic disorders through the paternal lineage.
Article
Cardiac & Cardiovascular Systems
Chiao-Nan Chen, Kuo-Jen Hsu, Kuei-Yu Chien, Jeu-Jung Chen
Summary: This study investigated the effects of exercise alone or in combination with a high-protein diet on markers of cardiometabolic health in middle-aged adults with obesity. The results showed that the combined intervention significantly decreased fat mass and improved lipid profiles, insulin sensitivity, glucose tolerance, and inflammation in this population, highlighting the importance of lifestyle modifications in managing obesity-related health risks.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, Research & Experimental
Ana P. D. Taschetto, Priscila L. Zimath, Renata Silverio, Cristiane dos Santos, Antonio C. Boschero, Gustavo J. dos Santos, Alex Rafacho
Summary: The study showed that insulin sensitivity and clearance increase in early pregnancy but decrease in late pregnancy, possibly due to reduced hepatic insulin-degrading enzyme (IDE) activity and increased pancreatic beta-cell mass. This physiological process may be important in understanding gestational diabetes mellitus caused by inadequate insulin supply during pregnancy.
Review
Obstetrics & Gynecology
Ezekiel Musa, Mushi Matjila, Naomi S. Levitt
Summary: Kisspeptin plays a significant role in gestational diabetes mellitus by stimulating insulin secretion, reducing insulin resistance, and regulating appetite and glucose homeostasis.
REPRODUCTIVE SCIENCES
(2022)
Article
Multidisciplinary Sciences
Rosa J. W. Li, Battsetseg Batchuluun, Song-Yang Zhang, Mona A. Abraham, Beini Wang, Yu-Mi Lim, Jessica T. Y. Yue, Tony K. T. Lam
Summary: The study found that the dorsal vagal complex (DVC) can sense nutrients, regulate hepatic nutrient metabolism, and impairment of DVC nutrient sensing may lead to the disruption of lipid and glucose homeostasis in metabolic syndrome.
Article
Endocrinology & Metabolism
Micaela Morettini, Laura Burattini, Christian Gobl, Giovanni Pacini, Bo Ahren, Andrea Tura
Summary: The study developed a mathematical model to describe glucagon kinetics during an oral glucose tolerance test, which is simple enough for clinical application. The model was validated and found to be reliable for estimating individual glucagon-related parameters.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Giovanna Zimatore, Lavinia Falcioni, Maria Chiara Gallotta, Valerio Bonavolonta, Matteo Campanella, Marco De Spirito, Laura Guidetti, Carlo Baldari
Summary: The study verified the effectiveness of Recurrence Quantification Analysis (RQA) method in determining ventilatory thresholds in individuals with different fitness levels, showing strong correlations between RQA and gas-exchange methods, with minimal errors and excellent correlation coefficients at both aerobic and anaerobic thresholds.
Article
Plant Sciences
Ji Hye Chun, Melissa M. Henckel, Leslie A. Knaub, Sara E. Hull, Greg B. Pott, David G. Ramirez, Jane E. -B. Reusch, Amy C. Keller
Summary: The study found that (-)-epicatechin can alleviate glucose intolerance induced by thermoneutral housing, and improve carbohydrate tolerance through increased insulin secretion.
Article
Endocrinology & Metabolism
Anne-Francoise Close, Heeyoung Chae, Jean-Christophe Jonas
Summary: The study compared the impact of Nnt(Tr) and other genetic variants between C57BL/6J and C57BL/6N mice on mitochondrial redox state, glucose-stimulated insulin secretion, and glucose tolerance. While NNT was found to play a crucial role in regulating mitochondrial redox state, its effects on GSIS and glucose tolerance were minimized, suggesting that the Nnt(WT) genotype in C57BL/6 mice may not necessarily indicate superior glucose tolerance compared to C57BL/6N mice.
Article
Nutrition & Dietetics
Shiqi Zhang, Lanlan Tang, Fanshu Xu, Yonghai Hui, Hongjia Lu, Xiong Liu
Summary: Capsaicin exhibits significant hypoglycemic effects by activating the TRPV1 channel, which is lost when the channel is blocked. The hypoglycemic effect of capsaicin is partially attributed to the combined up-regulation of TRPV1 receptors and PDX-1.
FRONTIERS IN NUTRITION
(2021)
Article
Psychology, Biological
Francine Pereira De Carvalho, Izabelle Dias Benfato, Thais Ludmilla Moretto, Marcela Barthichoto, Camila Aparecida Machado De Oliveira
PHYSIOLOGY & BEHAVIOR
(2016)
Article
Geriatrics & Gerontology
Gabriel G. Dorighello, Bruno A. Paim, Ana Catarina R. Leite, Anibal E. Vercesi, Helena C. F. Oliveira
EXPERIMENTAL GERONTOLOGY
(2018)
Article
Physiology
Izabelle Dias Benfato, Thais Ludmilla Moretto, Francine Pereira de Carvalho, Marcela Barthichoto, Sandra Mara Ferreira, Jose Maria Costa Junior, Mariana Cruz Lazzarin, Flavia de Oliveira, Carolina Martinez, Carolina Prado de Franca Carvalho, Camila Aparecida Machado de Oliveira
EXPERIMENTAL PHYSIOLOGY
(2017)
Article
Medicine, Research & Experimental
Thais Ludmilla Moretto, Izabelle Dias Benfato, Francine Pereira de Carvalho, Marcela Barthichoto, Luciana Le Sueur-Maluf, Camila Aparecida Machado de Oliveira
Meeting Abstract
Sport Sciences
Francine P. Carvalho, Thais L. Moretto, Izabelle D. Benfato, Marcela Barthichoto, Camila A. M. Oliveira
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2017)
Meeting Abstract
Sport Sciences
Izabelle Dias Benfato, Francine Pereira De Carvalho, Thais Ludmilla Moretto, Marcela Barthichoto, Sandra Mara Ferreira, Jose Maria Costa Junior, Carolina Martinez, Carolina Prado de Franca Carvalho, Camila Aparecida Machado de Oliveira
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2017)
Article
Nutrition & Dietetics
Paula Bresciani Leite, Ana Raimunda Damaso, Vanessa Schoenardie Poli, Ricardo Badan Sanches, Stephan Garcia Andrade Silva, Joao Pedro Novo Fidalgo, Maythe Amaral Nascimento, Camila Aparecida Machado de Oliveira, Danielle Arisa Caranti
NUTRITION RESEARCH
(2017)
Article
Nutrition & Dietetics
Leonardo Marin, Hellen Barbosa Faria Silva, Gabriela Damin, Leticia Martins Ignacio-Souza, Silvia Regina de Lima Reis, Camila Aparecida Machado de Oliveira, Rosane Aparecida Ribeiro, Maiise Auxiliadora de Barros Reis, Marcia Queiroz Latorraca, Fabiano Ferreira, Vanessa Cristina Arantes
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2018)
Article
Biochemistry & Molecular Biology
Francine Pereira de Carvalho, Thais Ludmilla Moretto, Izabelle Dias Benfato, Marcela Barthichoto, Sandra Mara Ferreira, Jose Maria Costa-Junior, Camila Aparecida Machado de Oliveira
BIOSCIENCE REPORTS
(2018)
Article
Cell Biology
Vivianne Izabelle de Araujo Baptista, Hananiah Tardivo Quintana, Mariana Cruz Lazzarin, Izabelle Dias Benfato, Francine Pereira De Carvalho, Luciana Le Sueur-Maluf, Camila Aparecida Machado De Oliveira, Josemberg da Silva Baptista, Flavia De Oliveira
CONNECTIVE TISSUE RESEARCH
(2019)
Article
Medicine, Research & Experimental
Estela Lorza-Gil, Marta Garcia-Arevalo, Bianca Cristine Favero, Maria Cristina C. Gomes-Marcondes, Helena C. F. Oliveira
JOURNAL OF TRANSLATIONAL MEDICINE
(2019)
Review
Biochemistry & Molecular Biology
Helena C. F. Oliveira, Anibal E. Vercesi
MOLECULAR ASPECTS OF MEDICINE
(2020)
Article
Surgery
Hananiah Tardivo Quintana, Vivianne Izabelle de Araujo Baptista, Mariana Cruz Lazzarin, Hanna Karen Moreira Antunes, Luciana Le Sueur-Maluf, Camila Aparecida Machado de Oliveira, Flavia de Oliveira
Summary: Using short-term and long-term intensive insulin therapies can improve muscle regeneration and decrease muscle atrophy in young rats with extensive skin burns. Insulin benefits myogenic parameters during regeneration and modulates MuRF1, an important mediator of muscle atrophy.
JOURNAL OF SURGICAL RESEARCH
(2021)
Editorial Material
Cell Biology
Anibal E. Vercesi, Helena C. F. Oliveira
CELL BIOLOGY INTERNATIONAL
(2018)
Meeting Abstract
Endocrinology & Metabolism
J. M. Costa-Junior, S. M. Ferreira, G. J. dos Santos, M. A. Kurauti, E. G. Ruano, J. F. Vettorazzi, J. Schug, C. C. Zoppi, K. H. Kaestner, A. C. Boschero, C. A. M. de Oliveira, E. M. Carneiro