期刊
INTERFACE FOCUS
卷 1, 期 1, 页码 177-186出版社
ROYAL SOC
DOI: 10.1098/rsfs.2010.0007
关键词
balance equations; environmental perturbations; circadian clocks; mathematical models; sensitivity analysis; robustness
类别
资金
- BBSRC SABR [BB/F005261/1]
- EU BIOSIM Network [005137]
- EPSRC [EP/C544587/1]
- BBSRC [BB/F005261/1, BB/F005237/1] Funding Source: UKRI
- EPSRC [EP/C544587/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/F005237/1, BB/F005261/1] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/C544587/1] Funding Source: researchfish
We present a new approach to understanding how regulatory networks such as circadian clocks might evolve robustness to environmental fluctuations. The approach is in terms of new balance equations that we derive. We use it to describe how an entrained clock can buffer the effects of daily fluctuations in light and temperature levels. We also use it to study a different approach to temperature compensation where instead of considering a free-running clock, we study temperature buffering of the phases in a light-entrained clock, which we believe is a more physiological setting.
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