期刊
INTERNATIONAL JOURNAL OF SURGERY
卷 11, 期 10, 页码 1078-1082出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijsu.2013.10.001
关键词
Hepatectomy; Hepatic resection; Hepatocellular carcinoma; Non-cirrhosis; Non-fibrosis
类别
资金
- Cancer Research UK [11883, 8968] Funding Source: Medline
- Cancer Research UK [11883, 8968, 16186] Funding Source: researchfish
Aims: The aims of this study were to assess the outcomes of patients who underwent potentially curative hepatic resection for hepatocellular carcinoma (HCC) in a background of non-cirrhotic/non-fibrotic livers, and to determine prognostic factors that influenced survival. Methods: Over a 15-year period, all patients undergoing hepatectomy for HCC were identified. Collated data included demographics, laboratory analysis, operative findings and histo-pathological data. Survival differences between these factors following liver resection were determined. Results: 57 patients were included with a median age of 70 years. The majority of patients underwent a hemi-hepatectomy or more radical resection (n = 37). Overall R0 resection rate was 90.4% (n = 51). The overall morbidity and mortality rates were 26.3% and 3.5%, respectively. The median follow-up period was 28 months. The 1-, 3- and 5-year disease-free survival was 65.4%, 41.8% and 39.1%, and the overall survival was 73.5%, 49.6% and 39.5%, respectively. AFP (p = 0.039) was the only predictor of poorer disease-free survival on univariate analysis. On multi-variable analysis, poorly differentiated tumour and large tumour size were independent predictors of overall survival. Conclusions: Liver resection is a feasible treatment option for HCC in non-cirrhotic/non-fibrotic livers with good survival outcome. Tumour size and differentiation are adverse predictors of outcome in these patients. (C) 2013 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.
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