期刊
NUCLEUS
卷 6, 期 3, 页码 166-171出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/19491034.2015.1017167
关键词
lamin A/C; lamins; intermediate filaments; laminopathy; phosphorylation; signaling
类别
Lamin A/C is part of the nuclear lamina, a meshwork of intermediate filaments underlying the inner nuclear membrane. The lamin network is anchoring a complex set of structural and linker proteins and is either directly or through partner proteins also associated or interacting with a number of signaling protein and transcription factors. During mitosis the nuclear lamina is dissociated by well established phosphorylation-dependent mechanisms. A-type lamins are, however, also phosphorylated during interphase. A recent study identified 20 interphase phosphorylation sites on lamin A/C and explored their functions related to lamin dynamics; movements, localization and solubility. Here we discuss these findings in the light of lamin functions in health and disease.
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