Review
Virology
Seyed Keybud Katirachi, Mathias Peter Gronlund, Kathrine Kronberg Jakobsen, Christian Gronhoj, Christian von Buchwald
Summary: This study aimed to determine the prevalence of human papillomavirus (HPV) infection in oral cavity squamous cell carcinomas (OCSCC). A meta-analysis of 31 studies including 5007 patients revealed an overall HPV+ OCSCC prevalence of 6% (95% CI; 3-10%). The results suggest that HPV may not be a necessary or strong risk factor in OCSCC oncogenesis.
Article
Oncology
Marisa Mena, Xin Wang, Sara Tous, Beatriz Quiros, Omar Clavero, Maria Alejo, Francisca Morey, Miren Taberna, Xavier Leon Vintro, Belen Lloveras Rubio, Llucia Alos, Hisham Mehanna, Wim Quint, Michael Pawlita, Massimo Tommasino, Miguel Angel Pavon, Nubia Munoz, Silvia De Sanjose, Francesc Xavier Bosch, Laia Alemany
Summary: This study evaluated the utility of a diagnostic algorithm using HPV-DNA testing and p16(INK4a) immunohistochemistry in the detection of HPV-driven oral cavity, oropharyngeal, and laryngeal carcinomas. The results showed that the concordance of p16(INK4a) and E6*I mRNA was high in oral cavity and oropharyngeal carcinomas but low in laryngeal carcinomas. Different p16(INK4a) expression patterns were observed between HPV16-positive cases and cases positive for other HPV types.
Article
Oncology
Irene H. Nauta, Danielle A. M. Heideman, Arjen Brink, Berdine van der Steen, Elisabeth Bloemena, Senada Koljenovic, Robert J. Baatenburg de Jong, C. Rene Leemans, Ruud H. Brakenhoff
Summary: The prevalence of HPV in oral cavity squamous cell carcinoma is low, and neither HPV status nor p16 status affects outcome, making it seem irrelevant for clinical management to determine HPV status in OCSCC.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Environmental Sciences
Marcin Kolesnik, Ewa Stepie, Malgorzata Polz-Dacewicz
Summary: Human papillomavirus (HPV) is associated with both benign and neoplastic diseases. The occurrence of neoplasms is increasing globally, making it important to assess risk factors. A study in southeastern Poland found an 11.5% prevalence of oral HPV infection, with HPV 16, 18, and 45 being the most common types.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Virology
Farideh Aghaeipour, Hamid Salehiniya, Hamid Abbaszadeh
Summary: The prevalence of HPV in oral lesions in Iran was found to be 21%, with the highest rates in Rasht (50%) and lip lesions (40%), and the lowest in normal mucosa (8%). The highest prevalence was observed in precancerous lesions (29%) and hairy leukoplakia (70%). Considering the fairly high prevalence of HPV, it is recommended to pay more attention to vaccination and treatment for HPV in Iran.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Chemistry, Medicinal
Babatunde Y. Alli, Akshaya Upadhyay, Yuli Zhang, Belinda Nicolau, Simon D. Tran
Summary: This study evaluated the safety of using carrageenan in human oral cells and tissues. The results showed that carrageenan is safe to use in the oral cavity as it does not significantly decrease cell and tissue viability.
Review
Oncology
Vera Panzarella, Giuseppina Campisi, Ylenia Giardina, Laura Maniscalco, Giuseppina Capra, Vito Rodolico, Olga Di Fede, Rodolfo Mauceri
Summary: The study found a low frequency of HPV infection in oral squamous cell carcinoma, suggesting no significant role of HPV in oral carcinogenesis.
Article
Medicine, General & Internal
Giulia Ciccarese, Astrid Herzum, Gaetano Serviddio, Corrado Occella, Aurora Parodi, Francesco Drago
Summary: HPV vaccines may have a therapeutic role in addition to standard treatments for anogenital warts and oral warts, especially for persistent lesions.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Infectious Diseases
Shuting Yu, Yingying Zhu, Huijing He, Yaoda Hu, Xiaoli Zhu, Wenwen Diao, Shuguang Li, Guangliang Shan, Xingming Chen
Summary: The overall prevalence of oral HPV infection among healthy adults aged above 20 in northern China was 4.08%. The most prevalent HPV type detected was HPV-81 (1.35%), followed by HPV-16 (0.64%). Oral HPV infection exhibited a bimodal pattern with respect to age in both male and female participants. The prevalence of oral HPV infection was significantly higher in males than females (5.0% versus 3.6%, P = 0.041). Current smokers (OR = 1.59; P = 0.039) and current drinkers (OR = 1.60; P = 0.023) had a higher prevalence of oral HPV infection. Current alcohol consumption was independently associated with oral HPV infection (OR = 1.74; P = 0.010).
BMC INFECTIOUS DISEASES
(2023)
Article
Ophthalmology
Ingvild Ramberg, Filipe Garrett Vieira, Peter Bjerre Toft, Christian von Buchwald, Mikkel Funding, Finn Cilius Nielsen, Steffen Heegaard
Summary: The study has identified two potentially distinct distributions of somatic mutations in conjunctival SCC based on HPV status, indicating the significant role of HPV in carcinogenesis in certain cases.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Oncology
Gypsyamber D'Souza, Sakshi R. Tewari, Tanya Troy, Tim Waterboer, Linda Struijk, Rachel Castillo, Hannah Wright, Michael Shen, Brett Miles, Mattias Johansson, Hilary A. Robbins, Carole Fakhry
Summary: The study evaluated the selection of screening population for oropharyngeal cancer and found that using risk factors for oral HPV can enrich the population with high-risk HPV biomarkers. The results showed that compared to the general population, the prevalence of HPV16 biomarkers in the eligible screening population was significantly elevated.
Article
Otorhinolaryngology
Evan J. Patel, Jamie R. Oliver, Alec Vaezi, Zujun Li, Michael Persky, Moses Tam, Kenneth S. Hu, Adam S. Jacobson, Babak Givi
Summary: A minority of T4b OCSCC patients undergo curative treatments, with some receiving primary surgical treatment associated with longer survival. Further studies on the heterogeneity of the T4b classification and potential revision might be justified.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Immunology
Stina Syrjanen, Marjut Rintala, Marja Sarkola, Jaana Willberg, Jaana Rautava, Hanna Koskimaa, Anna Paaso, Kari Syrjanen, Seija Grenman, Karolina Louvanto
Summary: Children can acquire oral HPV infection at an early age, and the HPV status of the mother, along with her seroconversion to high-risk HPV, significantly impacts the persistence of oral HPV in her offspring.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Oncology
Jorge Baquero, Xiao-Han Tang, Theresa Scognamiglio, Lorraine J. Gudas
Summary: Oral squamous cell carcinoma is an aggressive disease with low survival rates. Knockout of EZH2 in basal stem cells of tongue epithelia results in more aggressive carcinomas.
Article
Oncology
Dongbin Ahn, Ji-Hye Kwak, Gil-Joon Lee, Jin-Ho Sohn
Summary: This study evaluated the prevalence and characteristics of human papillomavirus (HPV) infection in oropharyngeal squamous papilloma (OPSP), showing an overall prevalence of 14.5%. High-risk HPV types accounted for 75% of all HPV infections, with HPV16 being the most prevalent genotype, accounting for 58.3% of all HPV infections. Patients with OPSP aged <= 45 years, never-smokers, and those with multifocal diseases had a higher prevalence of high-risk HPV infection. These findings could enhance our understanding of HPV infection in OPSP and provide valuable epidemiological data for the management of HPV-associated OPSP.
Editorial Material
Oncology
Patricia P. Reis, Wan L. Lam, Deilson Elgui de Oliveira
FRONTIERS IN ONCOLOGY
(2021)
Article
Virology
Swapnil Ganesh Sanmukh, Nilton Jose dos Santos, Caroline Nascimento Barquilha, Maira Smaniotto Cucielo, Marcio de Carvalho, Patricia Pintor dos Reis, Flavia Karina Delella, Hernandes F. Carvalho, Sergio Luis Felisbino
Summary: The study found that bacteriophages M13 and T4 can interact with LNCaP cells and promote gene expression changes related to anchorage-dependent survival and androgen signaling. In addition, genes AKT, ITGA5, ITGB1, ITGB3, ITGB5, MAPK3, and PI3K were significantly up-regulated, while genes AR, HSPB1, ITGAV, and PGC1A were down-regulated.
Article
Genetics & Heredity
Brenda C. Minatel, David E. Cohn, Michelle E. Pewarchuk, Mateus C. Barros-Filho, Adam P. Sage, Greg L. Stewart, Erin A. Marshall, Nikita Telkar, Victor D. Martinez, Patricia P. Reis, Wendy P. Robinson, Wan L. Lam
Summary: Dysregulation of ubiquitin-proteasome pathway genes is involved in cancer development and progression through copy number alteration, promoter hypomethylation, and miRNA deregulation. Characterizing alterations in these genes may uncover novel drug targets in HCC and other diseases.
FRONTIERS IN GENETICS
(2022)
Article
Otorhinolaryngology
Luis Eduardo Silva Moz, Regina Helena Garcia Martins, Rainer Marco Lopez Lapa, Rolando Andre Rios Villacis, Patricia Pintor dos Reis, Silvia Regina Rogatto
Summary: In this study, genomic imbalances were found in patients with Reinke's Edema, but with limited or no risk of cancer. The findings suggest that a long-term follow-up in a large series of patients could clarify the mechanisms involved in the malignant progression of Reinke's Edema.
BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY
(2023)
Article
Genetics & Heredity
S. S. Cury, J. S. Oliveira, C. A. O. Biagi-Junior, W. A. Silva Jr, P. P. Reis, O. Cabral-Marques, E. N. Hasimoto, P. P. Freire, R. F. Carvalho
Summary: Lung cancer patients with COVID-19 have an increased risk of severe disease and poor outcomes. Analyzing the interactions between SARS-CoV-2 and lung cancer cells may reveal molecular mechanisms associated with COVID-19 development and severity. Transcriptome data analysis showed that lung cancer cells infected with SARS-CoV-2 resembled primary lung tumors more than non-malignant lung tissues. Furthermore, the analysis identified cancer genes BRCA1 and CENPF, which are known or predicted to interact with SARS-CoV-2 proteins, as well as other potential host factors associated with COVID-19 infection and severity.
Review
Biochemistry & Molecular Biology
Aisling Forder, Rebecca Zhuang, Vanessa G. P. Souza, Liam J. Brockley, Michelle E. Pewarchuk, Nikita Telkar, Greg L. Stewart, Katya Benard, Erin A. Marshall, Patricia P. Reis, Wan L. Lam
Summary: Lung cancer risk is higher in individuals with chronic obstructive pulmonary disease (COPD), and this is influenced by genetic, immune, and microenvironment dysregulation. Factors such as genetic and epigenetic changes, oxidative stress from smoking, sex differences in tobacco metabolism, and dysregulation of the lung microenvironment contribute to the increased risk. It is important to better identify individuals with COPD who are at high risk for lung cancer and develop personalized screening strategies using biomarkers and exhaled breath analysis. Additionally, the use of corticosteroids and statins as chemopreventive agents should be considered. Optimization of current detection and management methods for lung cancer and COPD is crucial for improving health outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Rodrigo V. S. Bastos, Mariana S. Dorna, Fernanda Chiuso-Minicucci, Tainara F. Felix, Ana A. H. Fernandes, Paula S. Azevedo, Estefania T. Franco, Bertha F. Polegato, Marcelo M. Rogero, Gustavo A. F. Mota, Bruna J. Quintanilha, Sergio A. R. Paiva, Leonardo A. M. Zornoff, Patricia P. Reis, Marcos F. Minicucci
Summary: The objective of this study was to evaluate the effects of acute green tea supplementation on inflammatory and oxidative stress biomarkers induced by high-fat, high-saturated meals in obese women, and its ability to modulate circulating microRNA expression. The results showed that green tea inhibited the expression of microRNAs induced by the high-fat, high-saturated meal intake, shedding light on the mechanisms involved in the beneficial effects of green tea ingestion.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Review
Oncology
Vanessa G. P. Souza, Rachel Paes de Araujo, Mariana R. Santesso, Ana Laura Seneda, Iael W. Minutentag, Tainara Francini Felix, Pedro Tadao Hamamoto, Michelle E. Pewarchuk, Liam J. Brockley, Fabio A. Marchi, Wan L. Lam, Sandra A. Drigo, Patricia P. Reis
Summary: Patients with lung cancer frequently develop brain metastasis (BM), resulting in poor prognosis. Although genetic alterations associated with the spread of lung cancer cells have been identified, the exact mechanisms of BM remain unclear. This review comprehensively describes the steps of metastatic spread to the brain and explores the influence of tumor microenvironment and molecular determinants of progression. It also highlights the advancements in liquid biopsy-based molecular diagnostics and discusses novel treatment strategies.
Article
Geriatrics & Gerontology
Juan Thomaz Gabriel de Souza Ramos, Amanda Gomes Pereira, Felipe Sanches Ferrari, Morganna Freitas Andrade, Caroline Souto de Melo, Paulo Jose Fortes Villas Boas, Tainara F. Felix, Marcio de Carvalho, Mariana Souza Dorna, Paula Schmidt Azevedo, Bethan E. Phillips, Bertha Furlan Polegato, Katashi Okoshi, Silmeia Garcia Zanati Bazan, Sergio Alberto Rupp Paiva, Leonardo Antonio Mamede Zornoff, Patricia P. Reis, Marcos Ferreira Minicucci
Summary: This study identified and compared circulating miRNA levels between frail and non-frail older adults following STEMI, and explored the regulatory miRNA-gene networks and pathways involved in this condition. The results showed that frail patients had higher levels of certain miRNAs, and that these miRNAs were predicted to modulate gene expression associated with aging. Pathway enrichment analyses further revealed specific pathways regulated by miRNA target genes.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2023)
Article
Biochemistry & Molecular Biology
Bruna Ribeiro Andrade Ramos, Julia Abbade Tronco, Marcio Carvalho, Tainara Francini Felix, Patricia Pintor Reis, Juliano Coelho Silveira, Marcia Guimaraes Silva
Summary: This study compared the expression of miRNAs in sEV from peripheral blood between term and preterm pregnancies. It found that miR-612 expression was increased in the preterm group, while miR-1253, miR-1283, miR378e, and miR-579-3p were downregulated in the preterm premature rupture of membranes (PPROM) group. The study suggests that miRNAs in circulating sEV play a regulatory role in the pathogenesis of preterm labor (PTL) and PPROM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Vanessa G. P. Souza, Aisling Forder, Liam J. Brockley, Michelle E. Pewarchuk, Nikita Telkar, Rachel Paes de Araujo, Jessica Trejo, Katya Benard, Ana Laura Seneda, Iael W. Minutentag, Melis Erkan, Greg L. Stewart, Erica N. Hasimoto, Cathie Garnis, Wan L. Lam, Victor D. Martinez, Patricia P. Reis
Summary: Liquid biopsies are a promising tool for detecting lung cancer metastases and recurrence. By analyzing biomarkers in blood or other body fluids, such as circulating tumor cells or tumor-derived DNA/RNA, these tests can accurately and sensitively detect metastases even before they are visible on imaging scans. Liquid biopsies offer a less invasive and more convenient option for patients, particularly those who are not good candidates for traditional tissue biopsies. The development of liquid biopsies holds great promise for improving the detection and treatment of lung cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Sarah Santiloni Cury, Diogo de Moraes, Jakeline Santos Oliveira, Paula Paccielli Freire, Patricia Pintor dos Reis, Miguel Luiz Batista Jr, Erica Nishida Hasimoto, Robson Francisco Carvalho
Summary: A prediction model was developed to identify patients with muscle loss in non-small lung cancer. Transcriptome and cellular composition analysis revealed an inflammatory and immunosuppressive tumor microenvironment in patients with low muscle mass.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Oncology
Liam J. Brockley, Vanessa G. P. Souza, Aisling Forder, Michelle E. Pewarchuk, Melis Erkan, Nikita Telkar, Katya Benard, Jessica Trejo, Matt D. Stewart, Greg L. Stewart, Patricia P. Reis, Wan L. Lam, Victor D. Martinez
Summary: A lack of sensitive biomarkers hampers lung cancer detection and monitoring, resulting in late diagnosis and difficulties in tracking treatment response. Liquid biopsies have emerged as a promising non-invasive method for detecting biomarkers in lung cancer patients. Advances in high-throughput sequencing technologies and bioinformatics tools have led to new approaches for biomarker discovery. This review comprehensively describes established and emerging methods for identifying lung cancer biomarkers using liquid biopsy, as well as advanced bioinformatics tools and software for processing NGS data specifically tailored for liquid biopsy biomarker detection.
Article
Cell Biology
Nathalia L. Santos, Silvina O. Bustos, Patricia P. Reis, Roger Chammas, Luciana N. S. Andrade
Summary: Restoring expression of miR-195-5p increases the release of tumor suppressor miRNAs in EVs, leading to decreased proliferation and viability of bystander tumor cells. Treatment with miR-195 EVs improves the efficacy of MAPK inhibitors and reduces tumor volume in vivo.
Article
Oncology
Vanessa G. P. Souza, Aisling Forder, Nikita Telkar, Greg L. Stewart, Robson F. Carvalho, Luis A. J. Mur, Wan L. Lam, Patricia P. Reis
Summary: This study investigates the molecular changes in brain metastases (BM) from lung adenocarcinoma (LUAD) patients using a comprehensive transcriptomic dataset. The research reveals an immunosuppressive tumor microenvironment in LUAD-BM and identifies key genes involved in the development of BM.