Review
Pharmacology & Pharmacy
Marie-Josee Daly, Jamie Elvidge, Tracey Chantler, Dalia Dawoud
Summary: This review examines the economic models used in diabetes treatments in the UK, specifically T1DM and T2DM, and assesses their compliance with the guidelines on computer modeling. The study finds that there are key issues with the current models' structure and methods, and recommends regular reassessment and adjustment.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Nutrition & Dietetics
Ailton Santos Sena-Junior, Felipe Jose Aidar, Ana Mara de Oliveira e Silva, Charles dos Santos Estevam, Carla Roberta de Oliveira Carvalho, Fabio Bessa Lima, Jymmys Lopes dos Santos, Anderson Carlos Marcal
Summary: Curcumin, a plant extract, shows potential in attenuating hyperglycemia caused by diabetes mellitus. Supplementation of curcumin may have positive effects on antioxidant and hypoglycemic potential in Type 1 and Type 2 diabetes. The combination of curcumin and physical exercise could be beneficial in improving the quality of life and extending survival for diabetic patients.
Article
Biology
Mohammed Gollapalli, Aisha Alansari, Heba Alkhorasani, Meelaf Alsubaii, Rasha Sakloua, Reem Alzahrani, Mohammed Al-Hariri, Maiadah Alfares, Dania AlKhafaji, Reem Al Argan, Waleed Albaker
Summary: This study aims to utilize Machine Learning (ML) to distinguish and predict different types of diabetes and control their progression. Promising results were achieved by using various algorithms and balancing the dataset in a Saudi Arabian hospital dataset.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Biodiversity Conservation
Jose Martin, Gonzalo Rodriguez-Ruiz, Pilar Lopez
Summary: Chemosensory communication in lizards involves multiple compounds from external and internal glands and feces. While femoral gland secretions contain steroids and fatty acids, feces contain steroids, alkanes, and branched alkanes. The proportions of these compounds in feces and secretions predict body size in males, while the chemical profiles in feces may allow sex recognition. Therefore, the information conveyed by feces and femoral secretions differs in terms of chemical composition and provides different information about sex and body size.
Article
Pediatrics
Joaquim Calvo-Lerma, Maria Roca, Mieke Boon, Carla Colombo, Barbara de Koning, Victoria Fornes-Ferrer, Etna Masip, Maria Garriga, Anna Bulfamante, Andrea Asensio-Grau, Ana Andres, Kris de Boeck, Jessie Hulst, Carmen Ribes-Koninckx
Summary: This study found a positive correlation between faecal pH and fat absorption in CF patients. Higher faecal pH was associated with longer intestinal transit time and the use of proton pump inhibitors. Faecal pH could be used as a surrogate biomarker for intestinal pH and to monitor the efficacy of pancreatic enzyme replacement therapy.
PEDIATRIC RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Liang Yin, Gang Feng, Chun Huang, Weijuan Cai
Summary: This study investigated lysine acetylation in T2DM patients using quantitative proteomics, identifying differentially expressed acetylation sites and performing bioinformatics analysis. The results provide potential markers for prediabetes prediction and contribute to the understanding of T2DM pathogenesis.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Multidisciplinary Sciences
Marie Altendahl, Thalia Mok, Christine Jang, Seungjun Yeo, Austin Quach, Yalda Afshar
Summary: This study investigated the pathophysiology of COVID-19 in pregnant patients with different clinical trajectories. Severe COVID-19 was associated with distinct proteomic and lipidomic signatures related to complement and antibody activity. Mild/moderate COVID-19 did not show significant alterations compared to controls in serum protein, metabolite, or lipid metabolite levels.
Article
Biochemical Research Methods
Tao Wu, Ming Yang, Hanchen Xu, Lei Wang, Huafeng Wei, Guang Ji
Summary: The study showed that serum bile acid profiles were significantly different in T2DM patients with NAFL compared to those without NAFL, suggesting potential biomarkers for identifying NAFL in T2DM patients. The addition of 5 bile acids to a model with clinical variables improved its predictive value, indicating the significance of these biomarkers in diagnosing NAFL and allowing earlier intervention in T2DM patients.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Lanlan Chen, Wei Qiu, Xiaodong Sun, Menghan Gao, Yuexuan Zhao, Mingyue Li, Zhongqi Fan, Guoyue Lv
Summary: Serum levels of LDL-C and HDL-C are inversely associated with the risk of cholelithiasis in a linear manner. However, the relationship between serum TC and cholelithiasis risk is non-linear, with lower TC being associated with higher risk, and serum TG has an inverted "U-shaped" relationship with cholelithiasis risk. MR analyses suggest that lower TC and higher TG levels are independent causal risk factors. Drug-target MR analysis indicates that inhibition of HMGCR can reduce the risk of cholelithiasis, which is supported by colocalisation analysis.
Article
Biochemistry & Molecular Biology
Hans-Frieder Schott, Esther W. L. Chua, Sartaj Ahmad Mir, Bo Burla, Anne K. Bendt, Markus R. Wenk
Summary: Quantitative analysis of bile acids in human feces can provide insights into the influence of gut microbiome and diet on human health. This study compared three normalization approaches for bile acid concentrations in feces and found that wet weight normalization yielded the most comparable results.
Article
Medicine, General & Internal
Agathi Thomaidou, Olga Deda, Olga Begou, Artemis Lioupi, Angeliki Kontou, Helen Gika, Eleni Agakidou, Georgios Theodoridis, Kosmas Sarafidis
Summary: This study evaluated the metabolic profile of neonates with late-onset sepsis (LOS) and necrotizing enterocolitis (NEC). The results revealed significant differences in the metabolic profile of neonates with LOS or NEC compared to controls, suggesting that certain phospholipids and their derivatives could be used as biomarkers for early detection of these diseases.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Microbiology
Leandro Honorato, Joana Feital Demetrio de Araujo, Cameron C. Ellis, Alicia Corbellini Piffer, Yan Pereira, Susana Frases, Glauber Ribeiro de Sousa Araujo, Bruno Pontes, Maria Tays Mendes, Marcos Dias Pereira, Allan J. Guimaraes, Natalia Martins da Silva, Gabriele Vargas, Luna Joffe, Maurizio Del Poeta, Joshua D. Nosanchuk, Daniel Zamith-Miranda, Flavia Coelho Garcia dos Reis, Haroldo Cesar de Oliveira, Marcio L. Rodrigues, Sharon de Toledo Martins, Lysangela Ronalte Alves, Igor C. Almeida, Leonardo Nimrichter
Summary: This study investigates the impact of fungal extracellular vesicles (EVs) on biofilm formation and virulence in Candida albicans. The researchers found that C. albicans EVs inhibit biofilm formation and promote pseudohyphae formation. EVs from different strains of C. albicans, S. cerevisiae, and H. capsulatum also inhibit yeast-to-hyphae differentiation. The inhibitory effect of C. albicans EVs is attributed to a combination of lipid compounds.
Article
Microbiology
Jessica S. Price, Melissa Fallon, Raquel Posso, Matthijs Backx, P. Lewis White
Summary: This study evaluated the performance of the commercially available OLM CandID real-time PCR in serum testing for invasive candidiasis (IC). The study found that CandID had excellent sensitivity and specificity, and when combined with (1-3)-beta-D-Glucan testing, it could accurately confirm or exclude IC.
Article
Environmental Sciences
Lidia Minguez-Alarcon, Paige L. Williams, Tamarra James-Todd, Irene Souter, Jennifer B. Ford, Kathryn M. Rexrode, Antonia M. Calafat, Russ Hauser, Jorge E. Chavarro
Summary: This study examined the association between urinary concentrations of phthalate and phthalate replacement metabolites and lipid biomarker levels among pregnant women. The findings suggest that certain phthalate and phthalate replacement metabolite concentrations are associated with lipid levels in these women, with higher concentrations linked to higher lipid levels in some biomarkers and lower concentrations associated with lower lipid levels in others.
Review
Nutrition & Dietetics
Simon Paquette, Sean C. Thomas, Krishnan Venkataraman, Vasu D. Appanna, Sujeenthar Tharmalingam
Summary: Clinical trials have shown that oral probiotics intervention can improve the management of T2DM by promoting a healthy gut microbiome. Studies have demonstrated improvements in glycemic and lipid parameters, but there is inconsistency among the studies, possibly due to differences in probiotic composition, duration, and dose. Co-administration of metformin and probiotics can enhance glycemic control in T2DM patients. The overall positive findings and minimal adverse effects support further high-quality clinical trials.
Article
Biophysics
Natalia Janiszewska, Joanna Raczkowska, Karolina Grzegorczyk, Tomasz Gosiewski, Mateusz M. Marzec, Katarzyna Gajos, Kamil Awsiuk, Monika Brzychczy-Wloch
Summary: The study investigates the impact of polymer stereoregularity on its interactions with peptides, proteins, and bacteria strains, showing that different stereoregular forms of PtBMA affect the orientation and interactions with biomolecules differently. The stereoregularity influences the interactions with peptides, the orientation of immunoglobulin G, and the conformational changes in bovine serum albumin structure. Furthermore, Gram-positive bacteria (S. aureus) preferentially absorbed onto iso-PtBMA films compared to other stereoregularities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Anna Jagusiak, Tomasz Gosiewski, Dorota Romaniszyn, Malgorzata Lasota, Anna Wisniewska, Katarzyna Chlopas, Barbara Ostrowska, Izabela Koscik, Malgorzata Bulanda
Summary: According to a report from the World Health Organization, the increasing antibiotic resistance of microorganisms is a major global health problem. Our study found that a nanosystem based on ionic silver and a carrier showed strong antibacterial and antitumor effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Surgery
Tomasz Stefura, Barbara Zapala, Tomasz Gosiewski, Oksana Skomarovska, Michal Pedziwiatr, Piotr Major
Summary: This study aimed to assess the changes in composition of bacterial microbiota in the oral cavity and large intestine of patients 6 months after bariatric surgery. The results showed that the surgery led to significant changes in the composition of oral and intestinal microbiota.
Article
Virology
Adrianna Klajmon, Aldona Olechowska-Jarzab, Dominika Salamon, Agnieszka Sroka-Oleksiak, Monika Brzychczy-Wloch, Tomasz Gosiewski
Summary: This study compared a selected antigen test with quantitative polymerase chain reaction (qPCR) tests results and found that antigen tests have high enough effectiveness to be an alternative and support for nucleic acid amplification tests (NAAT) in the rapid laboratory diagnostics of COVID-19.
Article
Biochemistry & Molecular Biology
Agnieszka Gibala, Paulina Zeliszewska, Tomasz Gosiewski, Agnieszka Krawczyk, Dorota Duraczynska, Joanna Szaleniec, Maciej Szaleniec, Magdalena Ocwieja
Summary: The research showed that larger AgNPs possess stronger biocidal properties, with positively charged arginine-stabilized AgNPs and negatively charged EGCGAgNPs demonstrating the most significant antibacterial and fungicidal effects among the studied nanoparticles.
Article
Pharmacology & Pharmacy
Agata Ziomber-Lisiak, Katarzyna Talaga-Cwiertnia, Agnieszka Sroka-Oleksiak, Artur D. Surowka, Kajetan Juszczak, Magdalena Szczerbowska-Boruchowska
Summary: This study evaluated the effects of repetitive anodal tDCS on feeding behavior, metabolic status, and gut microbiota composition in rats with obesity induced by high-calorie diet. The results showed that AtDCS reduced appetite, body weight, and cholesterol levels, and modulated the ratio of Firmicutes to Bacteroidetes in the gut microbiome, suggesting its potential as a complementary treatment for obesity.
PHARMACOLOGICAL REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Dominika Salamon, Barbara Zapala, Agnieszka Krawczyk, Agnieszka Potasiewicz, Agnieszka Nikiforuk, Anastazja Stoj, Tomasz Gosiewski
Summary: This study compared the accuracy and efficacy of two Illumina platforms (iSeq and MiSeq) in sequencing 16S rRNA and described some important similarities and differences in 20 fecal samples. The results showed that iSeq technology had lower species richness compared to MiSeq, and MiSeq had a higher number of taxa. Additionally, MiSeq performed better in the detailed analysis of microbiota composition.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Joanna Szaleniec, Agnieszka Gibala, Joanna Stalinska, Magdalena Ocwieja, Paulina Zeliszewska, Justyna Drukala, Maciej Szaleniec, Tomasz Gosiewski
Summary: This study assessed the biological activity of tannic acid-prepared silver nanoparticles (TA-AgNPs) on sinonasal pathogens and nasal epithelial cells. The results showed that TA-AgNPs were effective against most pathogens isolated from patients with acute exacerbations of chronic rhinosinusitis (AECRS) at non-toxic concentrations to human cells. However, prolonged exposure to TA-AgNPs increased toxicity to nasal epithelial cells and enabled some pathogens to resist their biocidal action. Sensitivity testing may be necessary before application.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Computer Science, Information Systems
Adriana Borowa, Dawid Rymarczyk, Dorota Ochonska, Agnieszka Sroka-Oleksiak, Monika Brzychczy-Wloch, Bartosz Zielinski
Summary: Preliminary microbiological diagnosis is time-consuming, but deep learning methods based on microscopic images have been introduced to replace bacteriological examination. In this study, we propose using multi-MIL, a multi-label classification method, to analyze polyculture images and further shorten the diagnosis time. We evaluate our approach using a dataset of microscopic images for four considered bacteria species, achieving an ROC AUC above 0.9 and proving the feasibility for future experiments.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2023)
Article
Gastroenterology & Hepatology
Agnieszka Krawczyk, Dominika Salamon, Kinga Kowalska-Duplaga, Barbara Zapala, Teofila Ksiazek, Marta Drazniuk-Warchol, Tomasz Gosiewski
Summary: The study found that the gut mycobiome of patients with Crohn's disease is different from that of healthy individuals, with certain fungal species being more abundant in CD patients. These findings suggest that fungi may play a crucial role in the development of the disease.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Medicine, General & Internal
Agnieszka Sroka-Oleksiak, Wojciech Pabian, Joanna Sobonska, Kamil Drozdz, Tomasz Bogiel, Monika Brzychczy-Wloch
Summary: The aim of this study was to evaluate the sensitivity of group B Streptococcus (GBS) detection using polymerase chain reaction primers and a preincubation step. Vaginal and rectal swabs were collected from 97 pregnant women and subjected to enrichment broth culture-based diagnostics and amplification using specific primers. The preincubation step increased the sensitivity of GBS detection, and additional GBS cases were identified using nucleic acid amplification techniques. The atr gene primers showed the highest number of true positive results compared to other primers.
Article
Medicine, General & Internal
Katarzyna Talaga-Cwiertnia, Agnieszka Sroka-Oleksiak, Barbara Zapala, Dominika Salamon, Agnieszka Krawczyk, Monika Brzychczy-Wloch, Tomasz Gosiewski
Summary: This study investigated the effects of SARS-CoV-2 infection on the composition of the upper respiratory tract microbiota and found a possible association between microbiota composition and viral load. The study analyzed samples from 60 patients and divided them into groups based on viral replication rate. The results showed significant differences in microbiota composition between groups with high and low replication rates, suggesting an association between viral load and microbiota composition.
POLISH ARCHIVES OF INTERNAL MEDICINE-POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ
(2023)
Review
Medicine, Research & Experimental
Agnieszka Krawczyk, Katarzyna Talaga-Cwiertnia, Katarzyna Biegun, Kamil Drozdz, Dominika Salamon, Tomasz Gosiewski, Agnieszka Sroka-Oleksiak
Summary: This study investigated the quantity of Bifidobacterium and total bacteria in the colon of patients with T1DM and T2DM as well as in healthy subjects. The results showed that the number of Bifidobacterium was significantly lower in T1DM and T2DM groups compared to the control group, while the total bacteria showed no statistical difference. Furthermore, correlations were found between the number of Bifidobacterium and age, ALT, triglycerides, HBA1, and glucose level in the specific diabetes groups.
POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ
(2023)
Article
Surgery
Tomasz Stefura, Maciej Zajac, Barbara Zapala, Tomasz Gosiewski, Oksana Skomarovska, Michal Pedziwiatr, Piotr Major
Summary: This study found that the composition of oral and gut microbiota is associated with weight loss following LRYGB surgery.
POLISH JOURNAL OF SURGERY
(2022)
