Article
Neurosciences
Wan-Ling Tsai, Chih-Ju Chang, Chih-Yang Wang, Tsung- Hsu, Ming-Yuan Chang, Yi-Hsin Wu, Pei-Shan Chang, Kai-Lun Lin, Jian-Ying Chuang, Artur Kania, Tzu-Jen Kao
Summary: The study demonstrates the essential role of paxillin in motor axon guidance in both chick and mouse embryos. Paxillin is involved in the Ephrin-Eph signaling pathway, influencing the trajectory selection of LMC axons.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Biology
Felix Buchner, Zeynep Dokuzluoglu, Tobias Grass, Natalia Rodriguez-Muela
Summary: Motor neuron diseases (MNDs) are a group of disorders that affect motor neurons and the muscular system. Despite decades of research, there is still limited understanding of the underlying molecular mechanisms and lack of effective therapies. Human 3D in vitro models, including spinal cord organoids, have revolutionized disease modeling and offer new perspectives for studying neurodevelopmental and neurodegenerative diseases.
Article
Biology
Saul Bello-Rojas, Martha W. Bagnall
Summary: The study found that sister V2a/b neurons in the zebrafish spinal cord receive input from distinct presynaptic sources, do not communicate with each other, and connect to largely distinct targets.
Article
Neurosciences
Ryan W. Castro, Mikayla C. Lopes, Lindsay M. De Biase, Gregorio Valdez
Summary: Microglia display region-dependent deleterious features with age and diseases in the brain, and it remains unclear if similar phenotypic heterogeneity exists in the spinal cord. The study shows that regardless of regional location, spinal cord microglia become increasingly activated during aging. However, microglia in the ventral horn lose spatial organization and aggregate around motor neurons, potentially affecting motor neuron function.
Article
Developmental Biology
Fumiyasu Imai, Mike Adam, S. Steven Potter, Yutaka Yoshida
Summary: The study reveals the crucial role of HoxD family transcription factors in the specificity of monosynaptic sensory-motor connections in the spinal cord. Mice lacking Hoxd9, Hoxd10 and Hoxd11 show locomotion defects and aberrant axon development in quadriceps motor neurons.
Article
Biology
Arnault H. Caillet, Andrew T. M. Phillips, Dario Farina, Luca Modenese
Summary: The study focuses on deriving mathematical relationships between MN electrophysiological and anatomical properties by reprocessing data from 40 experimental studies in adult cat, rat, and mouse MN preparations. The validated mathematical framework provides a convenient tool for neuroscientists and experimenters. By using this framework, modelers can build profiles of inter-consistent MN-specific properties to scale pools of MN models, enhancing the accuracy and interpretability of simulations.
Article
Medicine, Research & Experimental
Haiyan Zhou, Ying Hong, Mariacristina Scoto, Alison Thomson, Emma Pead, Tom MacGillivray, Elena Hernandez-Gerez, Francesco Catapano, Jinhong Meng, Qiang Zhang, Gillian Hunter, Hannah K. Shorrock, Thomas K. Ng, Abedallah Hamida, Mathilde Sanson, Giovanni Baranello, Kevin Howell, Thomas H. Gillingwater, Paul Brogan, Dorothy A. Thompson, Simon H. Parson, Francesco Muntoni
Summary: This study reveals retinal vascular defects in patients with spinal muscular atrophy (SMA) and recapitulates these defects in SMA transgenic mice. The retinal vascular phenotype can be rescued by early SMN restoration therapy. Patients with SMA also exhibit an unfavorable balance between endothelial injury and repair, which improves with SMN restoration treatment. In addition, the study demonstrates autonomous defects in angiogenesis and blood vessel formation due to SMN deficiency in endothelial cells. These findings highlight the importance of microvasculopathy as a fundamental feature of SMA and provide new insights into its underlying mechanisms.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Anatomy & Morphology
Yi-Syue Tsou, Chih-Yang Wang, Ming-Yuan Chang, Tsung- Hsu, Meng-Ting Wu, Yi-Hsin Wu, Wan-Ling Tsai, Jian-Ying Chuang, Tzu-Jen Kao
Summary: Proper guidance of neuronal axons to their targets is crucial for neural circuit assembly during nervous system development, with Vav2 playing an essential role in motor axon pathfinding through interaction with the Src pathway and Netrin-1 regulation. Vav2 expression in LMC neurons is critical for the directional growth of axons, highlighting the importance of Vav proteins in mediating axonal trajectories.
DEVELOPMENTAL DYNAMICS
(2022)
Article
Neurosciences
Yuka Nakamura, Masaki Ueno, Jesse K. Niehaus, Richard A. Lang, Yi Zheng, Yutaka Yoshida
Summary: Deleting RhoA and RhoC genes to eliminate extrinsic inhibitory pathways, as well as deleting the PTEN gene to enhance intrinsic regenerative response, were found to promote neural circuit rewiring through a combinatorial approach. While this method increased the potential for rewiring, it did not significantly impact axon regrowth across the lesion and motor recovery.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Luciano E. Marasco, Gwendal Dujardin, Rui Sousa-Luis, Ying Hsiu Liu, Jose N. Stigliano, Tomoki Nomakuchi, Nick J. Proudfoot, Adrian R. Krainer, Alberto R. Kornblihtt
Summary: Spinal muscular atrophy (SMA) is a motor-neuron disease caused by gene mutations, and combination therapy using an antisense oligonucleotide (ASO) and a histone deacetylase inhibitor has been shown to significantly improve the treatment efficacy.
Review
Neurosciences
Giuliano Taccola, Ronaldo M. Ichiyama, V. Reggie Edgerton, Parag Gad
Summary: This review discusses the physiological states of spinal networks, highlighting the stochastic modulation by changing ensembles of proprioceptive and supraspinal input. Spinal epidural interfaces offer a platform for studying spinal network dynamics post-injury. Low-frequency epidural pulses can evoke motor responses with oscillatory patterns. The neural variability among spinal networks is seen as a fundamental mechanism of network design rather than noise interfering with movement control.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Cell Biology
Megan M. Nelson, J. Damon Hoff, Mya L. Zeese, Gabriel Corfas
Summary: PARP1 plays a novel role in brain development by regulating Cajal-Retzius (CR) cells, neuronal density, and cell adhesion.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Neurosciences
Zachary T. Olmsted, Cinzia Stigliano, Brandon Marzullo, Jose Cibelli, Philip J. Horner, Janet L. Paluh
Summary: This study evaluates the survival and integration of hiPSC-derived spinal motor neurons and oligodendrocyte progenitor cells in a rat model, demonstrating successful transplantation and meeting functional electrophysiology parameters. The findings provide a streamlined and predictable approach for neural cell-based therapies of spinal cord injury.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Wei-Fang Chang, Min Peng, Jing Hsu, Jie Xu, Huan-Chieh Cho, Hsiu-Mei Hsieh-Li, Ji-Long Liu, Chung-Hao Lu, Li-Ying Sung
Summary: SMN is crucial for RNA spliceosome assembly and plays important roles in stem cell biology. Overexpression of SMN enhances the proliferation and potency of SSCs, positively influencing spermatogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Rachel James, Helena Chaytow, Leire M. Ledahawsky, Thomas H. Gillingwater
Summary: SMA is an autosomal recessive motor neuron disease caused by mutations in the SMN1 gene. The development of combinatorial therapies for SMA is necessary, with mitochondria being a relevant target for such therapies. Understanding mitochondrial dysfunction in SMA may lead to the development of targeted mitochondrial therapies with potential benefits for other motor neuron diseases and neurodegenerative disorders.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Xinxing Zhu, Jiang Du, Jinjin Yu, Rui Guo, Yanyan Feng, Liang Qiao, Zhihao Xu, Fen Yang, Genshen Zhong, Fulong Liu, Fangfang Cheng, Maoping Chu, Juntang Lin
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Ciqing Yang, Xiaoying Li, Bichao Zhang, Sulei Fu, Shuanqing Li, Jianing Shen, Lihong Guan, Liang Qiao, Juntang Lin
JOURNAL OF MOLECULAR NEUROSCIENCE
(2019)
Article
Biology
Yuliang Sun, Yakun Ren, Fen Yang, Yanan He, Shengying Liang, Lihong Guan, Fangfang Cheng, Yanli Liu, Juntang Lin
Article
Cell Biology
Jinjin Yu, Lujun Shen, Yanli Liu, Hong Ming, Xinxing Zhu, Maoping Chu, Juntang Lin
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2020)
Review
Reproductive Biology
Yanli Liu, Zhiqin Zhang, Fen Yang, Hongmei Wang, Shengying Liang, Huiling Wang, Jun Yang, Juntang Lin
BIOLOGY OF REPRODUCTION
(2020)
Review
Gastroenterology & Hepatology
Jiang Du, Yu Ji, Liang Qiao, Yanli Liu, Juntang Lin
LIVER INTERNATIONAL
(2020)
Article
Neurosciences
Lu Wang, Dandan Zhao, Mengmeng Wang, Yuan Wang, Martin Vreugdenhil, Juntang Lin, Chengbiao Lu
FRONTIERS IN CELLULAR NEUROSCIENCE
(2020)
Review
Cell & Tissue Engineering
Jiang Du, Han Li, Jie Lian, Xinxing Zhu, Liang Qiao, Juntang Lin
STEM CELL RESEARCH & THERAPY
(2020)
Article
Cell & Tissue Engineering
Yanli Liu, Shengying Liang, Fen Yang, Yuliang Sun, Lidan Niu, Yakun Ren, Hongmei Wang, Yanan He, Jiang Du, Jun Yang, Juntang Lin
STEM CELL RESEARCH & THERAPY
(2020)
Review
Biochemistry & Molecular Biology
Xiaoying Li, Yunxiao Li, Shuanqing Li, Han Li, Ciqing Yang, Juntang Lin
Summary: The Sonic hedgehog (Shh) signaling pathway plays crucial roles in the development of the central nervous system (CNS) and related diseases. Abnormal signaling can lead to the occurrence of neurological disorders. Studies have classified the Shh signaling pathway into canonical and non-canonical pathways.
CELL BIOCHEMISTRY AND FUNCTION
(2021)
Article
Cell & Tissue Engineering
Yonghai Li, Junzheng Yang, Meng Li, Xiaoyue Zhang, Jiang Du, Xinghua Zhao, Zhihao Xu, Juntang Lin
CELLULAR REPROGRAMMING
(2020)
Article
Obstetrics & Gynecology
Shenghui Zhang, Yuliang Sun, Dongli Jiang, Tongtong Chen, Ruihong Liu, Xinyi Li, Yilin Lu, Liang Qiao, Ying Pan, Yanli Liu, Juntang Lin
Summary: This study aimed to establish a stable animal model of intrauterine adhesion (IUA) using a minimally invasive method that recapitulates the clinicopathologic characteristics of IUA. The results showed a positive correlation between ethanol treatment time and severity of uterine damage and kidney dysfunction, particularly in the EtOH-40 s group. Overall, the study successfully established a mouse model of endometrial injury using a minimally invasive transcervical ethanol perfusion technique, providing a basis for further research on IUA pathogenesis and therapies.
REPRODUCTIVE SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Rui Guo, Yun Yang, Di Zhang, Jiang Du, Xinxing Zhu, Yanli Liu, Fen Yang, Juntang Lin
Summary: Multiple signaling pathways are involved in tumor development, making bispecific antibodies more suitable for treating complex tumor diseases. A novel PE-based bispecific immunotoxin designed in this study showed improved efficacy against HER2-positive tumors. Transcriptome sequencing and real-time PCR were used to verify the results, indicating the potential of these bispecific immunotoxins for anti-HER2 cancer therapeutics.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biotechnology & Applied Microbiology
Jie Lian, Xinxing Zhu, Jiang Du, Beijia Huang, Fengting Zhao, Chunya Ma, Rui Guo, Yangxia Zhang, Longkai Ji, Badrul Hisham Yahaya, Juntang Lin
Summary: Menstrual blood-derived stem cells can alleviate acute lung inflammation and injury through their extracellular vesicle-transmitted miR-671-5p. This miRNA directly targets AAK1 and regulates the activation of NF-kB signaling. This study provides insights into the molecular basis of how extracellular vesicles from mesenchymal stem cells improve pulmonary inflammatory injury and highlights the functional importance of the miR-671-5p/AAK1 axis.
Article
Biochemistry & Molecular Biology
Xinxing Zhu, Beijia Huang, Fengting Zhao, Jie Lian, Lixiang He, Yangxia Zhang, Longkai Ji, Jinghang Zhang, Xin Yan, Taoling Zeng, Chunya Ma, Yinming Liang, Chen Zhang, Juntang Lin
Summary: NF-kappa B activation leads to MRSA-induced lung inflammation, and FOXN3 can inhibit NF-kappa B signaling to reduce the inflammatory response. FOXN3 competes with I kappa B alpha for binding to hnRNPU, preventing I kappa B alpha degradation and NF-kappa B activation. Phosphorylation of FOXN3 by p38 induces dissociation from hnRNPU, leading to NF-kappa B activation. FOXN3 phosphorylation is clinically correlated with pulmonary inflammatory disorders.
NUCLEIC ACIDS RESEARCH
(2023)